@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ROR2_HUMAN: (2015-10-18 )
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
Atome Classification :
(81 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460....---...470.......480.......490..--.-----------....500..--.....510.-.....-.520.......530.......540.......550.......560.......570.......580...-....590--..---.......600.......610.......620.......630....--...640......--.650.......660.......670.......680......-.690.......700----.....--..710........720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MARGSALPRRP
L
L
C
I
P
A
V
W
A
A
A
A
L
L
L
S
VSRTSG
E
V
E
V
LDPNDPLGPLDGQDGPI
P
T
L
K
G
Y
F
L
N
F
L
EPVN
N
I
T
I
VQG
Q
T
A
I
L
H
C
K
VAGNPPPN
V
R
W
LKNDAPVVQEP
R
R
I
I
I
R
KTEYG
S
R
L
R
I
Q
DLDTTDTG
Y
Y
Q
C
V
ATNG
M
K
T
I
T
A
T
G
V
L
F
V
R
LGPTHSPNHNFQDDYHEDGFCQ
P
Y
R
G
I
A
C
A
R
F
IGN
R
T
I
Y
V
D
S
L
Q
MQ
G
E
I
EN
R
I
T
A
A
F
T
M
IGTSTH
L
S
D
Q
C
S
QFA
I
P
S
F
C
H
F
V
F
P
LCDARSRTP
K
P
R
E
L
C
R
D
E
C
E
V
L
E
S
D
L
C
R
Q
E
Y
T
IARSN
P
L
I
L
M
R
LQLPKCEALPMPESPDAA
N
C
M
RIGI
P
A
E
R
L
G
R
Y
H
Q
CYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGH
A
Y
CRNPGGQMEG
P
W
C
FTQNK
N
V
R
M
E
L
CDVPSCSPRDSSK
M
G
I
L
Y
I
LVPS
I
A
I
P
L
V
I
A
C
L
F
F
L
V
C
M
CRNKQKASAS
T
P
Q
R
R
Q
LMASPSQDMEMP
L
I
N
Q
H
K
Q
A
K
L
K
---
E
I
S
L
S
A
V
R
F
M
E
E
LGE
D
R
F
G
K
VYKGHLFG--P-----------APGEQ
T
Q
A
V
--
A
I
K
T
L
K
D
KA-EG
P
L
R
-
E
E
F
R
H
E
A
M
L
R
A
R
LQHP
N
V
V
C
L
L
G
VVTKDQ
P
L
S
M
I
F
S
Y
CSHG
D
L
H
E
F
L
V
MRSPHSDVGSTDD
D
R
T
V
K
S-ALEP
P
----
D
F
---
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
SH
H
V
V
H
K
DLATR
N
V
L
V
Y
D
KL
N
V
K
I
S
D
L
G
L
--
F
R
E
V
Y
A
A
D
Y
Y
K
L
--LGNSLL
P
I
R
WMAP
E
A
I
M
Y
GKFSID
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
Y-GLQPYCGYS
N
Q
D
V
V
----
E
M
I
RN--RQV-LPCPDD
C
P
A
W
V
Y
A
L
M
I
E
C
W
N
EFPSRR
P
R
F
K
D
I
H
S
R
L
R
AWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQP
Q
F
IPMKGQIRPMVPPP
Q
L
Y
V
PVNGYQPVPAYGAYLPN
F
Y
P
V
QI
P
M
QMAPQQVPPQMVPKPSSHHSGSGSTST
G
Y
V
T
TAPSNT
S
M
A
D
R
A
A
L
L
SEGADDTQNAPED
G
A
Q
S
T
V
Q
E
A
E
E
EEEGSVP
E
T
E
LLGDCDT
L
Q
VDE
A
Q
V
Q
LEA
5
PsiBlast_PDB
77.91
44%
-109
- C2 -
4AT3
1
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
-----------
C
----
K
I
L
V
--
A
V
K
T
L
--
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
--
N
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
--
Y
S
T
D
Y
Y
R
V
--
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
----
E
C
I
T
Q
--
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
77.46
39%
-111
- C2 -
2Y6O
1
A:
[4-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
---
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
----
K
-----------
V
P
G
K
R
E
I
C
V
--
A
I
K
T
L
K
A
G
Y
-
T
D
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
----------
R
K
N
D
G
R
F
T
V
I
-
Q
L
------------
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
K
A
I
E
E
--
G
Y
R
-
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
--
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
76.87
39%
-111
- C2 -
2Y6M
3
A:
[4-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
---
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
----
K
-----------
V
P
G
K
R
E
I
C
V
--
A
I
K
T
L
K
A
G
Y
-
T
D
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
----------
R
K
N
D
G
R
F
T
V
I
-
Q
L
------------
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
K
A
I
E
E
--
G
Y
R
-
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
--
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
75.26
37%
-118
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[43-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
--
P
V
----------
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
75.09
40%
-114
- C2 -
1MQB
1
EPHA2_HUMAN
A:
[38-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
T
-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
--
T
--------------
K
K
E
V
P
V
--
A
I
K
T
L
K
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
---------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
-
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
----
K
A
I
N
D
--
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
L
A
D
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.02
37%
-111
- C2 -
3I81
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
E
N
N
P
V
----------
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
-------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
74.92
39%
-115
- C2 -
4G2F
1
A:
[28-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
----
K
-----------
L
P
S
K
K
E
I
S
V
--
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
-
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
---------------
R
K
H
D
A
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
----------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
-
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
----
K
A
V
D
E
--
G
Y
R
-
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
P
S
N
L
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
74.88
40%
-114
- C2 -
1MQB
1
B:
[35-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
F
T
T
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
--
T
---------------
K
E
V
P
V
--
A
I
K
T
L
K
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
---------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
-
G
E
R
P
Y
W
E
L
S
N
H
E
V
M
----
K
A
I
N
D
--
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
A
P
D
S
L
K
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
74.53
39%
-111
- C2 -
2XYU
7
A:
[3-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
----
K
-----------
V
P
G
K
R
E
I
C
V
--
A
I
K
T
L
K
A
G
Y
-
T
D
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
----------
R
K
N
D
G
R
F
T
V
I
-
Q
L
------------
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
-----------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
K
A
I
E
E
--
G
Y
R
-
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
--
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.53
44%
-108
- C2 -
4AT4
1
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
-----------
C
----
K
I
L
V
--
A
V
K
T
L
K
D
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
S
T
D
Y
Y
R
V
--
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
----
E
C
I
T
Q
--
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.52
42%
-118
- C2 -
3V5Q
1
NTRK3_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
--
L
-----------
S
P
T
K
D
K
M
L
V
--
A
V
K
A
L
--
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----------------
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
----
D
V
Y
S
T
D
Y
Y
R
------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
C
I
T
Q
--
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.49
43%
-114
- C2 -
4AOJ
1
NTRK1_HUMAN
B:
[48-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
--
L
-----------
L
P
---
K
M
L
V
--
A
V
K
A
L
K
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
-------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
-----------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
74.44
38%
-113
- C2 -
3EKK
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
----------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.40
44%
-106
- C2 -
4AT5
2
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
----------------
K
I
L
V
--
A
V
K
T
L
K
D
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
E
G
N
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
S
T
D
Y
Y
R
V
--
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
----
E
C
I
T
Q
--
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
74.30
38%
-112
- C2 -
3LW0
2
IGF1R_HUMAN
A:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P
-----------------
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
73.85
37%
-110
- C2 -
3NW7
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
N
N
P
V
----------
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
73.79
38%
-112
- C2 -
3LW0
3
IGF1R_HUMAN
C:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P
-----------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.78
40%
-114
- C2 -
4BB4
1
A:
[9-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
---
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
---------------
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
73.73
38%
-111
- C2 -
3LW0
3
IGF1R_HUMAN
B:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P
-----------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
73.69
38%
-110
- C2 -
3EKN
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
73.68
37%
-110
- C2 -
3NW6
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
N
N
P
V
----------
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
73.66
40%
-114
- C2 -
2X9F
1
A:
[11-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
---
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
-------------
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.64
40%
-117
- C2 -
2XVD
1
A:
[10-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
---
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
---------SS
L
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
73.56
41%
-111
- C2 -
2HEN
1
EPHB2_MOUSE
B:
[2-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
----
K
-----------
L
P
G
K
R
E
I
F
V
--
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
---------------
R
Q
N
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
73.46
41%
-109
- C2 -
2HEN
1
D:
[2-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
----
K
-----------
L
P
G
K
R
E
I
F
V
--
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
---------------
R
Q
N
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
73.35
37%
-111
- C2 -
2OJ9
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
------------------
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
73.22
38%
-104
- C2 -
3ETA
1
INSR_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
----------
N
N
-
P
G
R
P
P
PT
L
Q
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.15
42%
-104
- C2 -
4PMP
1
A:
[15-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
--
L
-----------
L
----
K
M
L
V
--
A
V
K
A
L
K
-----
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
-
I
Y
S
T
D
Y
Y
R
V
--
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.10
43%
-109
- C2 -
4AOJ
1
C:
[48-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
--
L
-----------
L
P
-
Q
D
K
M
L
V
--
A
V
K
A
L
K
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
-------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
--------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
72.87
38%
-107
- C2 -
1I44
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
T
------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
72.67
38%
-110
- C2 -
3LW0
2
D:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P
-----------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
72.54
37%
-107
- C2 -
3NW5
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
N
N
P
V
----------
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.51
41%
-112
- C2 -
4AW5
1
A:
[9-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
-------
I
----
Q
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
---------------------
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
72.46
39%
-113
- C2 -
3DZQ
1
A:
[28-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
----
K
-----------
L
P
S
K
K
E
I
S
V
--
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
-
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
---------------
R
K
H
D
A
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
----------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
-
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
----
K
A
V
D
E
--
G
Y
R
-
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
L
K
I
I
T
N
L
L
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
72.39
40%
-111
- C2 -
2VWX
1
A:
[11-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
E
N
S
S
D
-------
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
72.12
37%
-111
- C2 -
1JQH
1
IGF1R_HUMAN
B:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
-------------------
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
-------
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
72.05
38%
-103
- C2 -
3ETA
1
B:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
----------
N
N
-
P
G
R
P
P
PT
L
Q
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
----
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
72.03
41%
-113
- C2 -
2HEN
1
EPHB2_MOUSE
A:
[2-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
----
K
-----------
L
P
G
K
R
E
I
F
V
--
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
---------------
R
Q
N
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.95
39%
-100
- C2 -
4IBM
1
?
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
71.83
37%
-112
- C2 -
3QQU
1
IGF1R_HUMAN
A:
[8-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
--------------------
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.66
43%
-109
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[48-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
--
L
-----------
L
P
---
K
M
L
V
--
A
V
K
A
L
K
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.61
37%
-109
- C2 -
3QQU
1
D:
[8-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
---------------
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.58
40%
-111
- C2 -
2VX0
1
A:
[11-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
E
N
S
S
D
--------
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
71.54
38%
-105
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--
P
QDLVSLDFPLN
V
R
K
G
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
-------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
A
G
D
Y
Y
------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.54
40%
-106
- C2 -
1JPA
1
EPHB2_MOUSE
A:
[20-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
A
V
R
E
F
A
K
---
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
----
K
-----------
L
---
R
E
I
F
V
--
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
---------------
R
Q
N
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
71.52
39%
-115
- C2 -
4TWN
1
A:
[28-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
----
K
-----------
L
P
S
K
K
E
I
S
V
--
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
-
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
---------------
R
K
H
D
A
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
--------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
-
G
E
R
P
Y
W
E
M
S
N
Q
D
V
I
----
K
A
V
D
E
--
G
Y
R
-
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
N
L
L
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
71.50
41%
-110
- C2 -
2HEN
1
EPHB2_MOUSE
C:
[2-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
----
K
-----------
L
P
G
K
R
E
I
F
V
--
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
T
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
---------------
R
Q
N
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
A
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
T
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
A
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.46
37%
-109
- C2 -
3QQU
1
IGF1R_HUMAN
B:
[8-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
---------------------
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
71.39
40%
-111
- C2 -
2VX1
1
A:
[11-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
E
N
S
S
D
-------
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
71.21
40%
-112
- C2 -
2YN8
1
B:
[12-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
A
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
-------
I
----
Q
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
71.18
40%
-115
- C2 -
3DKO
1
A:
[38-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
L
D
A
S
C
I
K
I
E
R
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
----
K
-----------
L
P
G
K
R
D
V
A
V
--
A
I
K
T
L
K
V
G
Y
-
T
E
K
Q
R
-
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
---------------
R
K
H
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
-----------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
K
A
I
E
E
--
G
Y
R
-
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
G
I
L
D
K
M
I
R
N
P
N
S
A
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
71.09
40%
-110
- C2 -
2VWY
1
A:
[11-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
E
N
S
S
D
-------
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
70.71
38%
-107
- C2 -
5BVN
1
?
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
------------------
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
A
G
D
Y
Y
R
V
--
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
70.60
39%
-103
- C2 -
4IBM
1
?
B:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
--
I
-----------
I
K
G
E
A
E
T
R
V
--
A
V
K
T
V
N
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
---
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
N
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
F
V
M
D
--
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
70.39
40%
-108
- C2 -
1JPA
1
B:
[20-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
A
V
R
E
F
A
K
---
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
----
K
---------------
R
E
I
F
V
--
A
I
K
T
L
K
S
G
Y
-
T
E
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-
P
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
---------------
R
Q
N
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
-
G
E
R
P
Y
W
D
M
T
N
-
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
N
P
N
S
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.32
42%
-106
- C2 -
4PMT
1
A:
[15-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
--
L
---------------
D
K
M
L
V
--
A
V
K
A
L
------------
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
----
S
R
D
I
Y
S
T
D
Y
Y
R
V
-----
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
70.22
40%
-109
- C2 -
2VWZ
1
A:
[11-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
----
K
-----------
A
P
G
K
K
E
S
C
V
--
A
I
K
T
L
K
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
R
L
---------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
E
N
S
S
D
-------
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
A
W
S
Y
G
I
V
M
W
E
V
M
S
F
-
G
E
R
P
Y
W
D
M
S
N
Q
D
V
I
----
N
A
I
E
Q
--
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
V
V
S
A
L
D
K
M
I
R
N
P
A
S
L
K
I
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.21
38%
-112
- C2 -
5BVW
1
?
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
------------------
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
------
L
Y
A
G
D
Y
Y
R
V
--
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
69.87
38%
-100
- C2 -
3ZOS
3
B:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--
P
QDLVSLDFPLN
V
R
K
G
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
----------
Q
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
A
G
D
Y
Y
R
V
--
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
69.77
38%
-102
- C2 -
3ZOS
4
DDR1_HUMAN
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--
P
QDLVSLDFP
L
N
V
R
K
G
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
---------
A
A
Q
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
A
G
D
Y
Y
R
V
--
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
69.40
38%
-102
- C2 -
4BKJ
10
B:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--
P
QDLVSLDFPLN
V
R
K
G
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
-----------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
A
G
D
Y
Y
------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
T
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
69.24
38%
-106
- C2 -
4J98
1
FGFR2_HUMAN
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
--
I
-----------
D
K
D
K
P
K
E
A
V
TV
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
N
I
D
Y
Y
K
Q
--
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
L
L
K
E
--
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
69.08
43%
-107
- C2 -
4YNE
2
A:
[22-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
--
L
-----------
L
P
--
D
K
M
L
V
--
A
V
K
A
L
K
E
-------
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
-----
T
D
Y
Y
------
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
69.07
38%
-104
- C2 -
5BVK
1
?
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
------------------
H
P
L
L
V
--
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
A
G
D
Y
Y
R
V
--
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
QG
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
68.97
38%
-107
- C2 -
4J96
1
FGFR2_HUMAN
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
--
I
-----------
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
N
I
D
Y
Y
K
M
--
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
L
L
K
E
--
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
68.90
38%
-107
- C2 -
4J99
1
?
C:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
--
I
-----------
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
--------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
N
I
D
Y
Y
K
T
--
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
L
L
K
E
--
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
68.11
38%
-108
- C2 -
4J99
1
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
--
I
-----------
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
G
M
E
Y
S
Y
D
--------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
N
I
D
Y
Y
K
T
--
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
L
L
K
E
--
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
67.60
38%
-113
- C2 -
4J99
1
FGFR2_HUMAN
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
--
I
-----------
D
K
D
K
P
K
E
A
V
T
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
----------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
--
D
Y
Y
K
T
----
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
L
L
K
E
--
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
67.54
38%
-114
- C2 -
4J99
1
?
D:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
--
I
-----------
D
K
D
K
P
K
E
A
V
TV
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-----------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
N
I
D
Y
Y
K
T
-----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
L
L
K
E
--
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
67.26
37%
-104
- C2 -
3QQU
1
IGF1R_HUMAN
C:
[8-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
--
V
-----------
V
K
D
E
P
E
T
R
V
--
A
I
K
T
V
N
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
--------------
V
L
A
P
P
----
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
F
V
M
E
--
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.87
43%
-103
- C2 -
4YPS
1
A:
[22-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
--
L
-----------
L
---
D
K
M
L
V
--
A
V
K
A
L
---
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
A
K
L
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
--
M
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
-----
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
C
I
T
Q
--
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
66.82
40%
-107
- C2 -
4QQC
1
A:
[43-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
MD----------------
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
---------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
66.81
40%
-108
- C2 -
4R6V
1
A:
[43-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
MD----------------
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--
A
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
66.45
40%
-105
- C2 -
4QQ5
1
A:
[43-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
MD----------------
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--
A
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
66.29
39%
-111
- C2 -
4CSV
1
?
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
------------------
R
N
Y
N
I
E
V
--
A
V
K
T
L
K
----
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
-------------------
V
N
A
Q
----
A
L
---
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
----
E
Q
V
E
R
--
G
Y
R
-
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
66.25
40%
-98
- C2 -
4QRC
1
A:
[43-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
MD
P
-----------
A
R
P
D
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
D
L
S
P
D
G
P
R
S
S
E
G
-
P
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
G
V
H
H
I
D
Y
Y
K
K
--
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
65.24
40%
-102
- C2 -
4UXQ
1
A:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
MD
P
-----------
A
R
P
D
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
P
--------------
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
G
V
H
H
I
D
Y
Y
K
K
--
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
65.15
40%
-110
- C2 -
4TYJ
2
A:
[31-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
MD
P
-----------
A
R
P
D
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
----------------
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.42
40%
-104
- C2 -
4TYI
1
A:
[31-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
MD
P
-----------
A
R
P
D
Q
A
S
T
V
--
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
---------------
P
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
G
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
L
L
R
E
--
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.02
39%
-111
- C2 -
4UEU
1
?
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
------------------
R
N
Y
N
I
E
V
--
A
V
K
T
L
K
----
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
H
T
---------------
V
N
A
Q
----
A
L
---
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
--
A
R
L
I
-------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
----
E
Q
V
E
R
--
G
Y
R
-
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
58.79
43%
-70
- C2 -
4YMJ
4
NTRK3_HUMAN
A:
[9-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
-----------
S
P
T
K
D
K
M
L
V
--
A
V
K
A
L
K
D
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
--------------
G
-
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
-----
D
V
Y
S
T
D
Y
Y
R
-----
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
C
I
T
Q
--
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------