@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RYK_HUMAN: (2015-10-18 )
MRGAARLGRPGRSCLPGPALRAAAAPALLLARCAVAAAAGLRAAARPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHNMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
Atome Classification :
(18 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340--.......350.......360..-.....370.......380...-....390.......400----...-....410.......420-.........430-........440.......450.......460.......470.......480.......490.......500-........510.......520.......530.......540.......550.......560.......570.......580.......590.......600..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRGAARLGRPGRSCLPG
P
A
L
R
A
A
A
A
P
A
L
L
L
A
R
C
A
V
A
A
A
AGLRAAARPRPPELQSASAGP
S
V
S
L
Y
L
S
E
D
E
V
R
R
L
IGLD
A
E
L
Y
Y
V
R
N
D
L
I
S
H
Y
A
L
S
F
N
L
LVPSET
N
F
L
H
F
T
W
HAK
S
K
V
E
Y
K
LG
F
Q
V
D
N
V
L
A
MDMP
Q
V
N
I
S
V
QGEVP
R
T
L
S
V
F
R
V
E
L
S
CTGKVD
S
E
V
M
I
L
M
Q
L
N
L
T
VNSSK
N
F
T
V
L
N
F
K
R
R
K
M
C
Y
K
K
L
E
E
V
K
T
S
ALDKNTSRTIYDPVHAAPTTS
T
R
V
F
Y
I
S
V
G
V
C
C
A
V
I
F
L
V
A
I
I
L
A
V
L
H
LHN
M
K
R
I
ELDDSISASSSSQGLSQPSTQT
T
Q
Y
L
RADTPNNATPITSY
P
T
L
R
I
EKNDL
R
S
V
T
L
LEAKGK
V
K
D
I
A
ISRER
I
T
L
K
D
V
L
QEGT
F
G
R
I
F
--
H
G
I
L
IDEKDP
N
K
E
K
Q
A
F
V
K
T
V
K
-DQAS
E
I
Q
V
T
M
M
LTESCKLRGL-HHRNLL
P
I
T
H
V
C
IEEGE----K
P
M
-
V
I
L
P
YMNW
G
N
L
K
L
F
L
---
R
Q
C
K
LVEANNP--QAI
S
Q
Q
D
L
V
H
M
A
I
Q
I
A
C
G
M
S
Y
L
A
R
R
E
V
I
H
K
D
L
AARNCVIDD
T
L
Q
V
K
ITDNALSRDLFP
M
D
Y
H
CLGDNENR--
P
V
R
W
M
A
L
E
S
L
VNNEFSSAS
D
V
W
A
F
G
V
T
L
W
E
L
M
TLGQTPYVDI
D
P
F
E
M
A
A
Y
L
KDG
Y
R
IAQPIN
C
P
D
E
L
F
A
V
M
A
C
C
WAL
D
P
E
E
R
P
K
F
Q
Q
L
V
Q
C
L
T
E
F
H
A
A
LGAYV
84
PsiBlast_CBE
86.04
37%
-120
- C2 -
4WUN
1
B:
[19-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
---
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
------
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
L
--
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
---
24
PsiBlast_CBE
85.89
40%
-114
- C2 -
3TCP
1
B:
[25-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
---
S
V
M
--
E
G
N
L
K
Q
E
-
D
G
T
S
L
K
V
A
-
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
-------------------
M
--
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----
23
PsiBlast_CBE
83.99
40%
-120
- C2 -
4M3Q
1
B:
[26-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
--
E
G
N
L
K
------
S
L
K
V
A
-
V
K
T
M
------------
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--------
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----
94
PsiBlast_CBE
83.92
37%
-110
- C2 -
4V04
6
B:
[17-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
------
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
--
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
3
PsiBlast_PDB
83.50
40%
-124
- C2 -
3TCP
1
MERTK_HUMAN
A:
[26-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
-----
S
V
M
--
E
G
N
L
K
Q
E
-
D
G
T
S
L
K
V
A
-
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
---P---
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
--
76
PsiBlast_CBE
82.88
37%
-110
- C2 -
5AM7
1
B:
[18-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
------
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
-------PE
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
N
G
R
L
--
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
---
96
PsiBlast_CBE
82.83
37%
-113
- C2 -
4V01
6
B:
[17-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
E
A
I
G
L
D
---
P
N
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
------
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
--
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
--
26
PsiBlast_CBE
82.27
40%
-116
- C2 -
3BPR
1
D:
[24-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
--
E
G
N
L
K
Q
E
-
D
G
T
S
L
K
V
A
-
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
--
2
PsiBlast_PDB
82.00
40%
-119
- C2 -
3BPR
1
MERTK_HUMAN
A:
[24-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
--
E
G
N
L
K
Q
E
-
D
G
T
S
L
K
V
A
-
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-----
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
S
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
--
1
PsiBlast_PDB
81.88
40%
-119
- C2 -
2P0C
2
MERTK_HUMAN
A:
[24-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
--
E
F
G
S
V
M
--
E
G
N
L
K
Q
E
-
D
G
T
S
L
K
V
A
-
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
-----IP--
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
----
25
PsiBlast_CBE
80.85
40%
-115
- C2 -
3BRB
2
B:
[24-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
--
E
G
N
L
K
Q
E
-
D
G
T
S
L
K
V
A
-
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
---
L
Y
S
R
L
--
E
T
G
P
--
K
H
I
P
L
Q
T
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
M
T
V
C
V
A
D
F
G
L
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
--
52
PsiBlast_CBE
78.31
39%
-115
- C2 -
4KNB
3
MET_HUMAN
A:
[19-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
L
-------
K
I
H
C
A
V
K
S
L
----
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
----
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
----
19
PsiBlast_PDB
78.23
39%
-112
- C2 -
3CD8
1
A:
[32-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
---------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--
34
PsiBlast_CBE
77.37
39%
-112
- C2 -
4R1Y
3
A:
[24-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
L
--------
I
H
C
A
V
K
S
L
N
---------
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
--
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--
36
PsiBlast_CBE
77.23
39%
-106
- C2 -
2WD1
3
A:
[24-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
L
D
--
N
D
G
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--
18
PsiBlast_PDB
76.39
39%
-116
- C2 -
3CCN
1
A:
[32-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
---------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
-
K
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--
10
PsiBlast_PDB
76.25
39%
-111
- C2 -
4DEG
1
A:
[31-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
--------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
--
45
PsiBlast_CBE
75.93
39%
-102
- C2 -
2WGJ
1
A:
[29-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
V
I
G
R
G
H
F
G
C
V
Y
--
H
G
T
L
L
------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
----
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
----
E
T
H
N
P
--
T
V
---
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
Y
S
V
H
N
K
T
G
A
KL
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
---