@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SBK1_HUMAN: (2015-10-18 )
MSVGCPEPEPPRSLTCCGPGTAPGPGAGVPLLTEDMQALTLRTLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKSKTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEDCYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPEVCQAGRADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKGQVVLATAIEICV
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------.........10........20........30........40........50.-....-...60........70........80.......---.---90--.......--.100-....---...110.......120.......130.......140..----------------.----------------...--------...150.......160.......170.......180...-....190.......--200----...---.....210.......220.......230.......240.......250.......260.......270.......280.......290.......300.--......--310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------MSVGCPEPEPP
R
S
L
TCCGPGTAPGPGAGVP
L
L
T
E
D
M
Q
A
L
T
L
R
T
L
A
A
S
D
V
T
K
H
-
Y
E
L
V
-
R
E
LGKGTYG
K
V
D
L
V
V
YKGTGT
K
M
A
L
K
F
V
NK
S
K
---
T
---
K
L
--
K
N
F
L
R
E
V
--
S
ITN-SLSS---S
P
F
I
I
K
V
F
D
V
V
FETE
D
C
Y
V
F
A
Q
EYAPAGD
L
F
DII--PP----------------Q----------------VGL--------
P
E
D
T
V
K
R
C
V
Q
Q
L
G
L
A
L
D
F
M
HG
R
Q
L
V
H
RDIKPE
N
V
L
L
FDR-EC
R
R
V
K
LADFGMTR--RV-----G
C
R
---
V
K
RVSGTIPYT
A
P
E
V
C
QAGRAD
G
L
A
VDTG
V
D
V
W
A
F
G
V
L
I
F
C
VLTGNFPWEAAS
G
A
D
A
F
F
E
E
F
V
R
W
QRGRLPGL
P
S
Q
W
R
R
F
T
E
P
A
L
R
M
F
Q
R
L
LALEPERR--G
P
A
K
E
V
--
F
R
F
L
K
H
E
L
T
S
E
L
R
RRPSHRARKPPGDRPPAAG
P
L
RLEAPGPL
K
R
T
V
L
TESGSGSRPAPPAVGSVPLPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSK
G
Q
V
V
L
A
T
A
I
E
ICV
116
HHSearch
74.07
27%
-108
- C2 -
3HKO
2
?
A:
[22-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
L
Q
K
K
-
Y
H
L
K
-
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q
K
---
D
V
--
E
R
I
K
T
E
V
--
R
L
M
K
-
K
L
-
H
---
H
P
N
I
A
R
L
Y
E
V
-
Y
E
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
--
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KT
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SI--
F
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
-
K
S
F
E
I
K
L
V
D
F
G
L
S
K
--
E
F
YKLNN
G
---------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
---
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
----
D
T
I
S
Q
V
L
N
K
K
L
C
F
E
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
--
F
D
A
M
R
A
--
L
---
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
-----------------------------------------------------------------------------------------------
124
HHSearch
72.10
27%
-112
- C2 -
3LM5
1
ST17B_HUMAN
A:
[25-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
N
F
N
N
F
-
Y
I
L
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
R
---
R
GQD
C
R
--
A
E
I
L
H
E
I
--
A
V
L
E
-
L
A
K
S
---
C
P
R
V
I
N
L
H
E
V
-
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
--
L
P
----------------
E
L---------------
E
M
V
--------
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
P
L
G
D
I
K
I
V
D
F
G
M
S
R
--
K
I
---------------
M
G
T
P
E
Y
L
A
P
E
I
L
N
Y
D
-----
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
----
N
Q
E
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
--
P
T
A
E
I
C
-----
L
S
H
S
W
L
Q
Q
W
D
F
E
N
L
--------------------------------------------------------------------------------------------------
111
Fugue
69.39
23%
-69
- C2 -
2ACX
1
GRK6_HUMAN
A:
[14-532]
KARKGKSKK
W
R
Q
M
L
QFPHISQC
E
E
L
R
L
S
LERD
Y
H
S
L
C
ERN
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
TPDDK
R
K
A
C
G
R
N
L
T
Q
N
FLSHTGPDLIPEVP
R
Q
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
D
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
Q
P
V
T
K
N
T
F
R
Q
Y
-
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
V
R
A
T
G
K
M
Y
A
C
K
K
L
E
K
K
R
---
I
---
K
K
--
R
K
G
E
A
M
A
--
L
N
E
K
-
Q
I
L
E
K
VN
S
R
F
V
V
S
-
L
A
Y
A
Y
E
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
M
G
----------------
Q
----------------
A
G
F
--------
P
E
A
R
A
V
F
Y
A
A
E
I
C
C
G
L
E
D
L
H
R
E
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
D
H
---
G
H
I
R
I
S
D
L
G
L
A
V
--
H
V
P
E---
G
Q
T
---
I
K
G
R
V
G
T
V
G
Y
M
A
P
E
V
V
K
-----
N
E
R
Y
T
F
S
P
D
W
W
A
L
G
C
L
L
Y
E
M
I
A
G
Q
S
P
F
Q
Q
-
R
K
K
K
I
K
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
---
E
R
F
S
P
Q
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
LG
C
R
G
G
S
A
--
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
G
M
L
E
P
P
F
K
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
---------------------
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
V
F
G
L
D
G
S
------------------
46
PsiBlast_CBE
66.91
31%
-115
- C2 -
2CGV
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------C
P
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
66.55
31%
-113
- C2 -
4QYH
1
CHK1_HUMAN
B:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
66.21
31%
-115
- C2 -
2E9V
1
CHK1_HUMAN
B:
[8-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
A
---
V
D
CP
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
65.86
31%
-111
- C2 -
4QYG
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
65.38
31%
-112
- C2 -
4QYG
1
CHK1_HUMAN
B:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
64.82
31%
-115
- C2 -
4RVK
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
64.80
31%
-112
- C2 -
4HYH
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
64.73
31%
-111
- C2 -
4HYI
4
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------C
P
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
----------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
64.65
31%
-114
- C2 -
4FTR
3
CHK1_HUMAN
A:
[8-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.57
31%
-112
- C2 -
2CGW
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---------P-
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
62.88
31%
-112
- C2 -
1NVQ
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
62.87
31%
-112
- C2 -
3U9N
1
CHK1_HUMAN
A:
[8-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
62.87
31%
-117
- C2 -
2YM7
5
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
-------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
62.40
31%
-115
- C2 -
1NVR
1
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
-----------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
62.17
31%
-118
- C2 -
2YM8
10
CHK1_HUMAN
A:
[9-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
K
--------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
61.92
31%
-113
- C2 -
2E9V
1
CHK1_HUMAN
A:
[8-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
D
L
V
-
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
---
A
---
V
D
CP
E
N
I
K
K
E
I
--
C
I
-
N
-
K
M
L
N
---
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
-
E
Y
C
S
G
G
E
L
F
D
R
I
--
E
P
----------------
D
----------------
I
G
M
--------
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
-
D
--
N
L
K
I
S
D
F
G
L
A
T
VF
R
Y
-----
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
----
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
---
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
P
--
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
--
I
T
I
P
D
I
--
K
K
D
R
W
Y
N
K
P
L
---------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
59.61
31%
-101
- C2 -
3AQV
1
AAPK2_HUMAN
A:
[12-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-
Y
V
L
G
-
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
---
I
---
R
S
--
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
---
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
-
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
--
C
K
----------------
H
----------------
G
R
V
--------
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
--
D
-
A
H
M
N
A
K
I
A
D
F
G
L
S
N
--
M
M
S
D
---
G
E
F
---
L
------
P
N
Y
A
A
P
E
V
I
-
S
G
R
---
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-----
D
E
H
V
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
---
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
--
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
----------------------------------------------------------------------------------------------------