@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SGK2_HUMAN: (2015-10-18 )
MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
Atome Classification :
(65 SA)
.........10........20........30........40........50........60........70........80........90........100..-.....110.---.---..---..---.120.......130..-.....140.......-150.......160.....-..170.......180.....-..190.......200.......210-.......220.......230........240.......250--.-.-.....260.....-----..-----270.......280.......290...----...---..300----........310....---..---...320---.........330.......--340.-...-.....350....---...360.......370.......380.......390.......400-.-......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQGLLTSGRKPSGGGRCTGRGGWRG
Q
W
C
LKPWMGGADPPTP
T
L
S
C
L
L
LPVPPEL
P
D
H
C
Y
RMNSSPAGTPSPQPSRANG
N
I
NLGPSANPNAQPT
D
F
D
F
L
K
V
IGKG-NY
G
K
V
L
L
A
K
---R---KS---DG---A
F
Y
A
V
K
V
L
Q
K
K
S
I
L
K
K
-
K
E
Q
S
H
I
M
A
E
R
S
V
L
L
K
-NVRH
P
F
L
V
G
L
R
YSFQTP
E
-
K
L
Y
F
V
L
D
Y
VNGG
E
L
F
F
H
L
Q
R
-
E
R
R
F
L
E
P
R
A
R
F
Y
A
A
E
V
A
S
A
I
G
Y
L
H
S
-
L
N
I
I
Y
RDLKPE
N
I
L
L
DCQ-G
H
V
V
L
T
D
F
G
L
CKEGVEPEDTTS--T-F-CG
T
P
E
Y
L
A
P
E
V
L
R-----KE-----PYDR
A
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
HGL-PP
F
----
Y
S
Q
---
D
V
S
Q
-----
M
Y
E
N
I
L
HQP--LQIP---GG---R
T
V
A
-----
A
C
D
L
L
Q
S
L
L
H
K
D
Q
R
Q
RLGS--K--A-
D
F
L
-
E
IKN
H
V
F
FSPI
N
---
W
D
D
L
Y
H
KRLTPPFNPNVTGPADLKHF
D
P
E
F
T
Q
E
A
V
S
KSIGCTPDTV-A-SSSGAS
S
A
F
L
G
F
SYAPEDDDILDC
1
PsiBlast_PDB
83.87
72%
-132
- C1 -
2R5T
1
SGK1_HUMAN
A:
[25-320]
-------------------------------------------------------------------------------
I
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
---
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
-----
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
---
N
T
A
E
-----
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
---
I
T
N
S
-----
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
--
D
-
D
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------
73
HHSearch
83.69
72%
-132
- C1 -
2R5T
1
SGK1_HUMAN
A:
[24-320]
------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
---
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
-----
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
---
N
T
A
E
-----
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
---
I
T
N
S
-----
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
--
D
-
D
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------
3
PsiBlast_PDB
80.43
72%
-130
- C1 -
3HDN
1
SGK1_HUMAN
A:
[25-316]
-------------------------------------------------------------------------------
I
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
---
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
-----
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
---
N
T
A
E
-----
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
---
I
T
N
S
-----
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
--
D
-
D
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
----------------------------------------------------------
2
PsiBlast_PDB
79.63
72%
-127
- C1 -
3HDM
1
SGK1_HUMAN
A:
[25-320]
-------------------------------------------------------------------------------
I
N
L
G
P
S
S
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
---
K
A
---
E
E
---
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
-----
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
----
Y
S
R
---
N
T
A
E
-----
M
Y
D
N
I
L
N
K
P
--
L
Q
L
K
---
P
N
---
I
T
N
S
-----
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
--
K
--
D
-
D
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------
7
PsiBlast_PDB
77.67
52%
-121
- C1 -
3E8D
1
AKT2_HUMAN
A:
[6-323]
---------------------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
-
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
R
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
S
P
E
-----
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
P-
S
-
D
A
K
-
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
H
F
P
Q
F
D
Y
S
A
S
-
I
-
R
-----------------------
74
HHSearch
76.79
50%
-117
- C1 -
4GV1
5
AKT1_HUMAN
A:
[6-337]
------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
S-
E
-
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
-
E
C
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
S
A
S
-------
9
PsiBlast_PDB
76.57
52%
-116
- C1 -
3OW4
1
AKT1_HUMAN
A:
[5-309]
----------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
--
S
E
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
R
P
H
F
P
Q
F
D
Y
S
-
A
-
S
S
----------------------
87
HHSearch
76.12
54%
-126
- C1 -
4EJN
3
AKT1_HUMAN
A:
[146-438]
------------------------------------------------------------------------------------------
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
-
L
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
S-
E
-
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
-----------------------------------------------
12
PsiBlast_PDB
75.85
52%
-124
- C1 -
3QKM
1
AKT1_HUMAN
A:
[5-309]
----------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
--
S
E
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
S
M
E
C
V
D
S
-
E
-
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
----------
13
PsiBlast_PDB
74.04
52%
-122
- C1 -
4EKL
1
AKT1_HUMAN
A:
[5-309]
----------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
--
S
E
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
S
M
E
C
V
D
S
-
E
-
R
R
P
H
F
P
Q
F
D
Y
S
A
S
S
----------
11
PsiBlast_PDB
73.81
52%
-116
- C1 -
3QKL
1
AKT1_HUMAN
A:
[5-309]
----------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
--
S
E
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
R
P
H
F
P
Q
F
D
Y
S
-
A
-
S
S
----------------------
6
PsiBlast_PDB
73.41
52%
-122
- C1 -
3E88
1
AKT2_HUMAN
A:
[6-304]
---------------------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
-
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
R
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
S
P
E
-----
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
P-
S
-
D
A
K
-
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
Q
R
T
H
F
P
Q
F
-
D
-
Y
S
A
S
I
R
------------------
5
PsiBlast_PDB
72.91
52%
-124
- C1 -
3E87
1
AKT2_HUMAN
A:
[6-304]
---------------------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
-
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
R
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
S
P
E
-----
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
P-
S
-
D
A
K
-
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
Q
R
T
H
F
P
-
Q
-
F
D
Y
S
A
S
I
R
----------------
8
PsiBlast_PDB
72.22
52%
-121
- C1 -
3D0E
1
AKT2_HUMAN
A:
[6-304]
---------------------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
-
S
R
V
L
Q
-
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
R
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
S
P
E
-----
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
P-
S
-
D
A
K
-
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
P
P
D
Q
R
T
H
F
-
P
-
Q
F
D
Y
S
A
S
I
R
---------------
10
PsiBlast_PDB
72.01
52%
-121
- C1 -
3QKK
1
AKT1_HUMAN
A:
[5-309]
----------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
---
K
A
---
T
G
---
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
-
F
-
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
----
Y
N
Q
---
D
H
E
K
-----
L
F
E
L
I
L
M
E
E
--
I
R
F
P
---
R
T
---
L
G
P
E
-----
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
G
--
G
--
S
E
D
A
K
-
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
M
E
C
V
D
S
E
R
R
-
P
-
H
F
P
Q
F
D
Y
S
A
S
S
-------------
82
HHSearch
71.94
38%
-113
- C1 -
4AW2
3
MRCKA_RAT
A:
[72-406]
------------------------------------------------------------------------------------------
H
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
L
---
K
N
---
A
D
---
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
-
V
-
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
--
S
V
A
-
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
E
GG
K
G
-----
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
K
ER
F
Q
F
P
TQV
T
D
---
V
S
E
N
-----
A
K
D
L
I
R
R
L
I
C
-
S
R
E
H
R
L
G
Q
-----
N
-
G
I
E
-
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
--
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
----------------------
S
G
H
H
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
15
PsiBlast_PDB
71.78
45%
-117
- C1 -
4L43
1
KS6B1_HUMAN
A:
[10-343]
---------------------------------------------------------------------------------
R
G
P
E
---
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
----------------
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
------
19
PsiBlast_PDB
70.61
45%
-114
- C1 -
4L46
1
KS6B1_HUMAN
A:
[9-343]
--------------------------------------------------------------------------------
N
R
G
P
E
---
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
----
H
--
T
-
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
P
V
-------------------
Q
V
F
L
G
F
T
Y
V
A
P
S
------
80
HHSearch
70.26
45%
-106
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-387]
-----------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
---
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
-
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
-----
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
----
D
I
V
GSN
T
E
D
Y
-----
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
---
L
S
V
K
-----
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
HP
Q
--
T
-
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
----
P
D
D
D
-
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
-------
16
PsiBlast_PDB
69.59
45%
-110
- C1 -
4L44
1
KS6B1_HUMAN
A:
[10-343]
---------------------------------------------------------------------------------
R
G
P
E
---
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-----
H
--
T
-
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
----------------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
V
A
P
S
------
22
PsiBlast_CBE
69.41
44%
-115
- C1 -
4L42
1
KS6B1_HUMAN
A:
[13-342]
------------------------------------------------------------------------------------
E
---
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
-
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
-----------------------------------------
E
M
F
R
D
F
E
Y
I
A
D
W
------
58
PsiBlast_CBE
68.97
34%
-111
- C1 -
4UAL
2
MRCKB_HUMAN
A:
[72-409]
----------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
---
K
N
---
T
E
---
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
------
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
D
G--
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
E
ER
F
Q
F
P
---
S
H
VTD
V
S
E
E
-----
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
R
L
G
Q
--
N
--
G
--
I
E
-
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-----------
I
L
P
P
--
H
-
T
-
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
17
PsiBlast_PDB
67.92
44%
-112
- C1 -
4DC2
1
KPCI_MOUSE
A:
[53-384]
---------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
---
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
-
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
-----
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIVG
S
---------NT
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
---
L
S
V
K
-----
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
HP
Q
--
T
-
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
--
Q
L
T
P
D
D
D
D
I
-
V
-
R
K
I
D
Q
S
E
-
F
E
G
F
E
Y
I
N
P
-------
59
PsiBlast_CBE
66.97
34%
-115
- C1 -
4UAK
2
MRCKB_HUMAN
A:
[72-409]
----------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
---
K
N
---
T
E
---
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
DG
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
E
ER
F
Q
F
P
---
S
H
VTD
V
S
E
E
-----
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
R
L
G
Q
--
N
--
G
--
I
E
-
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-----------------
S
H
-
T
-
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
90
HHSearch
66.78
47%
-112
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[13-304]
-----------------------------------------------------------------------------------
P
---
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
---
T
H
--
T
-
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-------------------------------------------------------
56
PsiBlast_CBE
66.70
34%
-110
- C1 -
3TKU
3
MRCKB_HUMAN
B:
[86-423]
----------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
---
K
N
---
T
E
---
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
EDGMG
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
E
ER
F
Q
F
P
---
S
H
VTD
V
S
E
E
-----
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
R
L
G
Q
--
N
--
G
--
I
E
-
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
-----------------------
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
31
PsiBlast_CBE
66.08
45%
-128
- C1 -
5D9K
2
?
A:
[26-323]
----------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
----------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
---------------------------------------------
46
PsiBlast_CBE
65.37
45%
-112
- C1 -
4NW6
1
KS6A3_HUMAN
A:
[22-323]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------------
76
HHSearch
65.27
44%
-105
- C1 -
3TXO
1
KPCL_HUMAN
A:
[23-349]
--------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
---
K
E
---
T
G
---
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
L
S
L
-
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
-
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
C
-------------
G
T
P
D
Y
I
A
P
E
I
L
Q
-----
E
M
-----
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
----
E
A
E
---
N
E
D
D
-----
L
F
E
A
I
L
N
D
E
--
V
V
Y
P
---
T
W
---
L
H
E
D
-----
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
S
--
L
TQ
G
-
G
E
H
-
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
----
P
I
D
E
G
H
-
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
-------
26
PsiBlast_CBE
65.03
47%
-115
- C1 -
4L3L
1
KS6B1_HUMAN
A:
[14-300]
----------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
-
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------
57
PsiBlast_CBE
64.90
34%
-107
- C1 -
3TKU
3
MRCKB_HUMAN
A:
[86-423]
----------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
---
K
N
---
T
E
---
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
D
G
M
G
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
E
ER
F
Q
F
P
---
S
H
VTD
V
S
E
E
-----
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
R
L
G
Q
--
N
--
G
--
I
E
-
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-----------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
61
PsiBlast_CBE
64.74
34%
-111
- C1 -
3QFV
2
MRCKB_HUMAN
A:
[70-407]
----------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
---
K
N
---
T
E
---
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
E
DGMG
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
E
ER
F
Q
F
P
---
S
H
VTD
V
S
E
E
-----
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
R
L
G
Q
--
N
--
G
--
I
E
-
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
-----------------------
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
33
PsiBlast_CBE
64.56
44%
-129
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
----------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
---
P
D
---
S
G
---
H
L
Y
A
M
K
V
L
-
K
------------------
I
L
-
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
Q
-----
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
L
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
T
E
-----
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
--
G
--
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------
77
HHSearch
64.38
41%
-107
- C1 -
1XJD
1
A:
[16-335]
-------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
---
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
T
-
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
Q
-----
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
---
D
E
E
E
-----
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
---
L
E
K
E
-----
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
--
G
-----
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
-------------------------------------------
Q
N
M
F
R
N
F
S
F
----------
30
PsiBlast_CBE
64.21
45%
-127
- C1 -
5D9K
2
?
B:
[26-323]
----------------------------------------------------------------------------------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
---------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------------
85
HHSearch
64.08
44%
-106
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[38-338]
-----------------------------------------------------------------------------------------
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
K
E
---
S
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
---
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
A
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
--
L
K-
N
-
G
V
N
-
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
T
E
F
---------------------
27
PsiBlast_CBE
63.88
47%
-117
- C1 -
4L3J
1
KS6B1_HUMAN
A:
[14-300]
----------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
-
F
-
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
------------------------------------------------------
38
PsiBlast_CBE
63.81
42%
-105
- C1 -
2UZU
1
KAPCA_BOVIN
E:
[20-326]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
--
L
--
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
39
PsiBlast_CBE
63.78
42%
-108
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[20-326]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
--
L
--
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
36
PsiBlast_CBE
63.64
42%
-105
- C1 -
2UZW
1
KAPCA_BOVIN
E:
[20-326]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
--
L
--
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
41
PsiBlast_CBE
63.63
42%
-107
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[35-341]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L-
K
--
N
-
G
V
N
-
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
40
PsiBlast_CBE
63.57
42%
-106
- C1 -
2OJF
1
KAPCA_BOVIN
E:
[35-341]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L-
K
--
N
-
G
V
N
-
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
47
PsiBlast_CBE
63.20
45%
-111
- C1 -
4NW5
1
KS6A3_HUMAN
A:
[22-323]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
---------------------------------------------
42
PsiBlast_CBE
63.20
42%
-110
- C1 -
2F7Z
1
KAPCA_BOVIN
E:
[35-341]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L-
K
--
N
-
G
V
N
-
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
44
PsiBlast_CBE
63.19
42%
-106
- C1 -
2F7E
1
KAPCA_BOVIN
E:
[35-341]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L-
K
--
N
-
G
V
N
-
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
60
PsiBlast_CBE
62.83
34%
-106
- C1 -
3QFV
3
MRCKB_HUMAN
B:
[70-407]
----------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
---
K
N
---
T
E
---
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
--
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
-
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
-----
A
M
EDGMG
K
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
----
Y
A
E
---
S
L
V
E
-----
T
Y
G
K
I
M
N
H
E
ER
F
Q
F
P
---
S
H
VTD
V
S
E
E
-----
A
K
D
L
I
Q
R
L
I
C
S
-
R
E
R
R
L
G
Q
--
N
--
G
--
I
E
-
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
----------------------
G
F
S
G
L
H
L
P
F
I
G
F
T
F
T
T
E
S
C
F
S
D
R
G
51
PsiBlast_CBE
62.49
43%
-103
- C1 -
4Q9Z
1
KPCT_HUMAN
A:
[6-298]
---------------------------------------------------------------------------------------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
---
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
-
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
Q
-----
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
---
D
E
E
E
-----
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
---
L
E
K
E
-----
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
--
G
-
D
----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
-
S
-
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
--
48
PsiBlast_CBE
62.32
45%
-115
- C1 -
4NUS
1
KS6A3_HUMAN
A:
[22-323]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
------
F
Y
F
D
P
---------------------------------------------
23
PsiBlast_CBE
62.22
46%
-123
- C1 -
3A61
1
KS6B1_HUMAN
A:
[15-299]
------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
G
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
---------------
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
--------------------
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------
43
PsiBlast_CBE
62.17
42%
-104
- C1 -
2F7X
1
KAPCA_BOVIN
E:
[35-341]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L-
K
--
N
-
G
V
N
-
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
25
PsiBlast_CBE
61.99
46%
-119
- C1 -
3A60
1
KS6B1_HUMAN
A:
[13-299]
----------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
G
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
-----------------
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
----------------------------------------------------------
37
PsiBlast_CBE
61.66
42%
-103
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[20-326]
-------------------------------------------------------------------------------------
A
Q
N
T
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
---
M
E
---
T
G
---
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
---
R
V
K
G
R
T
W
--
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
H
---
F
S
S
D
-----
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
--
L
--
K
-
D
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
-
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
-
F
-
S
E
F
---------------------
45
PsiBlast_CBE
61.60
45%
-113
- C1 -
5D9L
2
?
A:
[22-323]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
E
R
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
P
---------------------------------------------
34
PsiBlast_CBE
60.49
44%
-122
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
-------------------------------------------------------------------------------------
G
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
VT
R
---
P
D
---
S
G
---
H
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
------------
I
L
-
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
Q
-----
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
L
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
T
E
-----
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
--
G
--
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------
20
PsiBlast_PDB
60.13
44%
-108
- C1 -
3ZH8
4
KPCI_HUMAN
A:
[6-337]
---------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---
K
K
---
T
D
---
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
F
E
Q
-
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
-
F
-
C
G
T
P
N
Y
I
A
P
E
I
L
R
-----
G
E
-----
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
DIV-----------
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
--
I
R
I
P
---
R
S
---
L
S
V
K
-----
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
C
HP
Q
--
T
-
G
F
A
-
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
-----------------
Q
L
T
P
D
D
D
D
I
-
V
-
R
K
I
D
-
Q
S
E
F
E
G
F
E
Y
I
N
P
L
L
M
----
50
PsiBlast_CBE
59.59
43%
-104
- C1 -
4RA5
3
KPCT_HUMAN
A:
[6-298]
---------------------------------------------------------------------------------------------
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
---
K
K
---
T
N
---
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
L
S
L
-
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
-
F
-
C
G
T
P
D
Y
I
A
P
E
I
L
L
-----
G
Q
-----
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
----
H
G
Q
---
D
E
E
E
-----
L
F
H
S
I
R
M
D
N
--
P
F
Y
P
---
R
W
---
L
E
K
E
-----
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
--
R
--
G
-
D
----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
I
N
-
S
-
M
D
Q
N
M
F
R
N
F
S
F
M
N
P
G
M
E
R
L
I
S
H
--
35
PsiBlast_CBE
58.36
44%
-129
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
----------------------------------------------------------------------------------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
K
VT
R
---
P
D
---
S
G
---
H
L
Y
A
M
K
V
L
--------------------
I
L
-
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
Q
-----
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
L
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
T
E
-----
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
S
--
G
--
P
-
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
----------------------------------------------------------
32
PsiBlast_CBE
58.04
45%
-117
- C1 -
3G51
1
KS6A3_MOUSE
A:
[16-304]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
---------
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
---------------
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------
69
Fugue
55.47
39%
-104
- C1 -
1CDK
2
KAPCA_PIG
A:
[8-350]
------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
-----------
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
H
--
K
---
E
T
---
G
----
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
L
Q
A
V--
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
-Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
TW
T
-
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-----
S
-KGY----
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-Y
P
P
F
----
F
A
D
---
Q
P
I
Q
-----
I
Y
E
K
I
V
S
G
K
--
V
R
F
P
---
S
--------HF
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L-
K
--
D
-
G
V
N
-
D
I
K
N
H
K
W
F
A
---TT
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
---------
N
-
E
K
C
G
--
K
E
F
S
E
F
------------
53
PsiBlast_CBE
55.09
45%
-113
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[17-305]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
R
-----
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------
24
PsiBlast_CBE
55.04
46%
-115
- C1 -
3A60
1
KS6B1_HUMAN
B:
[13-300]
----------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
--------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------
28
PsiBlast_CBE
54.36
48%
-124
- C1 -
4RLO
4
KS6B1_HUMAN
B:
[3-287]
------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
N
---
T
G
---
K
I
F
A
M
K
V
L
K
K
-------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
---------------
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
-----
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
----
T
G
E
---
N
R
K
K
-----
T
I
D
K
I
L
K
C
K
--
L
N
L
P
---
P
Y
---
L
T
Q
E
-----
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
A
--
G
P-
G
-
D
A
G
-
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---------------------------------------------------------
52
PsiBlast_CBE
53.89
45%
-113
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[17-305]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
--------
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------
95
HHSearch
53.09
46%
-113
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[19-304]
---------------------------------------------------------------------------------------
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
GSD
A
R
---
Q
L
Y
A
M
K
V
L
K
K
A
T
L
-
K
V
-
R
D
R
V
------
D
I
-
L
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
P-
D
-
G
V
E
-
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------
54
PsiBlast_CBE
53.04
45%
-113
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[16-304]
------------------------------------------------------------------------------------
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
---
K
---
I
S
---
G
S
DAR
Q
L
Y
A
M
K
V
L
-
K
K
A
T
L
K
V
-
R
D
R
V
------
D
I
L
V
E
--
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----
K
K
A
Y
--
S
-
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
----
Q
G
K
---
D
R
K
E
-----
T
M
T
M
I
L
K
A
K
--
L
G
M
P
---
Q
F
---
L
S
P
E
-----
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
A
--
G
--
P
-
D
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
----------------------------------------------------------