@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SIK1_HUMAN: (2015-10-19 )
MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ
Atome Classification :
(29 SA)
.........10........20........30........40........50........60--.-..-..----..-.-70.----.......-80........90........100.......110.......120........130.......140.......150..-..---...---160--........170.---...-...180.......190.......200----........210.......220.......230....--.--..240...--...--...250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
I
M
SEFSADPAGQGQGQQK
P
L
R
V
G
F
Y
D
I
E
R
T
LGKG
N
F
A
V
V
K
L
A
R
HRVT
K
T
Q
V
A
I
K
I
I
D
KT--R-L
D
-
S
S
----
N
L
-
E
-
K
I
Y
----
R
E
V
Q
L
M
K
-
L
LNHP
H
I
I
K
L
Y
Q
V
METK
D
M
L
Y
I
V
T
E
F
AKNG
E
M
F
D
Y
LTSNGH-L
S
E
N
E
A
R
K
K
F
W
Q
I
L
S
A
V
E
Y
C
H
DH
H
I
V
H
RDLKTE
N
-
L
L
---LDG---NM---
D
I
K
L
A
DFGFGNF---YKS-GE
P
L
S
T
WCGSPPYAAPEVFEGKEYE-----GPQ
L
D
I
W
S
L
G
V
V
L
Y
V
L
V
CGSLPFDGPN
L
P
T
L
R
Q
R
V
--
L
--EGR--FRI--P
F
F
--
M
S
Q
D
C
E
S
L
I
R
R
M
L
VVDPARR
I
T
I
A
Q
I
R
Q
H
RWMRAEPCLPGPACPAFSAHSYTSNLGD
Y
D
E
Q
A
L
G
I
M
Q
T
LGV
D
R
Q
R
T
V
E
S
L
QNSSY
N
H
F
A
A
I
Y
Y
L
L
L
E
R
L
K
E
Y
RNAQCARPGPARQPRPRSSDLSGLEV
P
Q
EGLSTDPFRPALLCP
Q
P
Q
T
L
V
Q
S
V
L
Q
A
E
M
D
C
E
L
Q
SSLQW
P
L
F
F
PVDASCSGVFRPRPV
S
P
S
S
L
L
D
T
A
I
S
E
E
A
RQGPGLE
E
E
Q
D
T
Q
E
SLPSSTGRR
H
T
L
A
E
V
S
TRLSPLTA
P
C
I
V
VSPSTTASPAEGTSSD
S
C
L
T
F
SASKSPAGLSGTPATQ
G
L
L
GACSP
V
R
LASPFLGSQSAT
P
V
L
Q
AQGGLG
G
A
V
L
L
P
V
S
F
QEGRRAS
D
T
S
L
T
Q
G
L
K
A
F
R
Q
Q
L
R
K
T
TRTKGFL
G
L
N
K
I
K
G
L
A
R
Q
V
C
QA
P
A
S
RASRGGLSPFHAPAQSPGLHGGAAGSR
E
G
W
S
L
L
E
E
V
L
E
Q
Q
R
L
L
Q
L
QHHPAAAPGCSQAPQPAPA
P
F
V
I
A
PCDGPGAAPL
P
S
T
L
L
TSGLPLLP
P
P
L
L
QTGA
S
P
V
A
S
A
A
Q
L
L
D
T
H
L
HIGTGPTALPAVP
P
P
R
L
A
R
LAPGCE
P
L
GLLQGDC
E
M
E
DLMPCSL
G
T
F
V
L
VQ
17
PsiBlast_PDB
74.53
47%
-120
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[4-268]
-----------------
H
D
G
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
--
K
-
I
R
-
S
L
----
D
V
-
V
G
K
I
K
----
R
E
I
Q
N
L
K
-
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
-
V
L
---
L
D
A
---
H
M
---
N
A
K
I
A
D
F
G
L
S
N
M
---
M
S
D
-
G
E
F
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
L
F
K
K
I
--
R
--
G
G
V
--
F
Y
I
--
P
E
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
69.54
43%
-108
- C1 -
4CZT
4
CIPKN_ARATH
D:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
69.31
43%
-107
- C1 -
4CZT
3
CIPKN_ARATH
A:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.25
43%
-109
- C1 -
4CZU
3
CIPKN_ARATH
D:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.07
43%
-109
- C1 -
4CZU
3
CIPKN_ARATH
A:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.86
43%
-114
- C1 -
4CZT
3
CIPKN_ARATH
C:
[10-277]
-----------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
67.82
43%
-109
- C1 -
4CZT
2
CIPKN_ARATH
B:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
67.48
43%
-114
- C1 -
4CZU
3
CIPKN_ARATH
C:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
67.27
43%
-109
- C1 -
4CZU
3
CIPKN_ARATH
B:
[9-277]
----------------------
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
--
K
V
L
K
-
N
K
----
M
I
-
A
-
Q
I
K
----
R
E
I
S
T
M
K
-
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
-
L
L
---
L
D
A
---
N
G
---
A
L
K
V
S
D
F
G
L
S
A
L
PQQ
V
R
E
-
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
L
Y
K
K
I
--
F
--
K
A
E
--
F
T
C
--
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
-----
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
65.46
37%
-128
* C1 *
4FG7
1
KCC1A_HUMAN
A:
[19-277]
-------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--------------------
S
M
E
----
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
YYS
L
D
E
---
D
S
---
K
I
M
I
S
D
F
G
L
S
K
M
---
E
D
P
-
G
--------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
--
L
K
A
E
Y
E
--
F
D
S
--
P
Y
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
64.80
32%
-117
- C1 -
3D2I
1
AURKA_MOUSE
A:
[8-269]
--------------------
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
--
Q
-
L
E
-
K
A
----
G
V
-
E
H
Q
L
R
----
R
E
V
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
---
L
G
S
---
N
G
---
E
L
K
I
A
D
F
G
W
-
S
V
---
H
A
P
--------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
--
S
--
R
V
E
--
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
64.74
38%
-116
- C1 -
2Y7J
1
PHKG2_HUMAN
C:
[96-360]
--------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
AE
R
-
L
S
-
P
E
----
Q
L
-
E
-
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
---
L
D
D
---
N
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
---
L
E
P
-
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
--
M
--
E
G
Q
--
Y
Q
F
SS
P
E
W
DD
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
64.65
38%
-110
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[14-278]
-------------------------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
--
R
-
T
K
-
S
S
RRGV
S
R
-
E
-
D
I
E
----
R
E
V
S
I
L
K
-
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
---
I
D
F
-
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
---
N
Y
E
PL---
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
--
N
Y
E
--
F
E
D
--
E
Y
F
SN
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
64.13
37%
-132
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[19-282]
-------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-------------------------
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
YYS
L
D
E
---
D
S
---
K
I
M
I
S
D
F
---------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
--
L
K
A
E
Y
E
--
F
D
S
--
P
Y
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
64.02
32%
-110
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[7-269]
-------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
--
Q
-
L
E
-
K
A
----
G
V
-
E
H
Q
L
R
----
R
E
V
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
---
L
G
S
---
N
G
---
E
L
K
I
A
D
F
G
W
-
S
V
---
H
A
P
-
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
--
S
--
R
V
E
--
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.98
38%
-116
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[96-360]
--------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
-
L
S
-
P
E
----
Q
L
-
E
-
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
---
L
D
D
---
N
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
---
L
E
P
-
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
--
M
--
E
G
Q
--
Y
Q
F
SS
P
E
W
DD
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
63.96
37%
-109
- C1 -
3MA6
1
?
A:
[34-293]
--------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
-
V
K
Q
K
T
----
D
K
-
E
-
S
L
L
----
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
---
L
E
S
KSK
D
A
---
N
I
R
I
I
D
F
G
L
S
T
H
---
F
E
--
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
--
E
--
K
G
K
YT
F
E
L
--
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
63.69
38%
-114
- C1 -
2Y7J
1
PHKG2_HUMAN
D:
[96-360]
--------------------------
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
V
---
R
-
L
S
-
P
E
----
Q
L
-
E
-
E
V
R
EATR
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
-
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
-
I
L
---
L
D
D
---
N
M
---
Q
I
R
L
S
D
F
G
F
S
C
H
---
L
E
P
-
G
E
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
E
THPGY
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
--
M
--
E
G
Q
--
Y
Q
F
SS
P
E
W
DD
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
E
Q
A
L
Q
H
P
F
F
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
63.46
38%
-107
- C1 -
2WEI
1
?
A:
[24-281]
--------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
--
S
-
A
K
-
N
K
----
D
T
-
S
-
T
I
L
----
R
E
V
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
-
I
L
---
L
E
S
KEK
D
C
---
D
I
K
I
I
D
F
G
L
S
T
C
---
F
Q
Q
-
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
T
Y
D
E
-------
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
--
E
--
T
G
K
YA
F
D
L
--
P
Q
W
RT
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
63.41
37%
-126
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[19-282]
-------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
YYS
L
D
E
---
D
S
---
K
I
M
I
S
D
F
G
-----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
--
L
K
A
E
Y
E
--
F
D
S
--
P
Y
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
63.34
32%
-111
- C1 -
3D15
1
AURKA_MOUSE
A:
[7-269]
-------------------
R
Q
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
--
Q
-
L
E
-
K
A
----
G
V
-
E
H
Q
L
R
----
R
E
V
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
---
L
G
S
---
N
G
---
E
L
K
I
A
D
F
G
W
-
S
V
---
H
A
P
-
S
-------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
--
S
--
R
V
E
--
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
63.14
37%
-107
- C1 -
3MA6
1
?
B:
[34-293]
--------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
--
Q
-
V
K
Q-
T
----
D
K
-
E
-
S
L
L
----
R
E
V
Q
L
L
K
-
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
-
L
L
---
L
E
S
KSK
D
A
---
N
I
R
I
I
D
F
G
L
S
T
H
---
F
E
A
-
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
Y
D
E
-------
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
K
K
V
--
E
--
K
G
K
YT
F
E
L
--
P
Q
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
61.87
36%
-130
- C1 -
4YUR
1
PLK4_HUMAN
A:
[11-268]
----------------------
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
--
A
-
M
Y
-
K
A
----
G
M
V
Q
-
R
V
Q
----
N
E
V
K
I
H
C
-
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
-
L
L
---
L
T
R
---
N
M
---
N
I
K
I
A
D
F
------------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
V
K
N
T
L
N
K
V
--
V
--
L
A
D
--
Y
E
M
--
P
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
61.68
37%
-126
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[19-282]
-------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
YYS
L
D
E
---
D
S
---
K
I
M
I
S
D
F
--------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
--
L
K
A
E
Y
E
--
F
D
S
--
P
Y
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
61.60
37%
-131
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[19-282]
-------------------------
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
--------------------
E
----
N
E
I
A
V
L
H
-
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
-
L
L
YYS
L
D
E
---
D
S
---
K
I
M
I
S
D
F
----------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
E
Q
I
--
L
K
A
E
Y
E
--
F
D
S
--
P
Y
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
61.47
37%
-124
- C1 -
4JXF
2
PLK4_HUMAN
A:
[9-262]
--------------------------
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
--
A
-
M
Y
-
K
A
----
G
M
V
Q
-
R
V
Q
----
N
E
V
K
I
H
C
-
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
-
L
L
---
L
T
R
---
N
M
---
N
I
K
I
A
D
F
G
L
A
T
Q
---
L
K
M
P
H
E
-------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
N
T
L
N
K
V
--
V
--
L
A
D
--
Y
E
M
--
P
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
59.62
36%
-129
- C1 -
3COK
1
PLK4_HUMAN
A:
[9-266]
----------------------
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
--
A
-
M
Y
-
K
A
----
G
M
V
Q
-
R
V
Q
----
N
E
V
K
I
H
C
-
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
-
L
L
---
L
T
R
---
N
M
---
N
I
K
I
A
D
F
G
L
A
T
Q
---
L
K
----------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----
V
--
V
--
L
A
D
--
Y
E
M
--
P
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
58.12
32%
-115
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[9-269]
---------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
--
Q
-
L
E
-
K
A
----
G
V
-
E
H
Q
L
R
----
R
E
V
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
---
L
G
S
---
N
G
---
E
L
K
I
A
D
F
G
W
--------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
--
S
--
R
V
E
--
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
57.94
32%
-117
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[9-269]
---------------------
W
T
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
--
Q
-
L
E
-
K
A
----
G
V
-
E
H
Q
L
R
----
R
E
V
E
I
Q
S
-
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
-
L
L
---
L
G
S
---
N
G
---
E
L
K
I
A
D
F
G
W
--------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
T
Y
R
R
I
--
S
--
R
V
E
--
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------