@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SLK_HUMAN: (2015-10-19 )
MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
Atome Classification :
(79 SA)
.........10........20........30.....-------...40........50......-..60....---..-..70.......-.80...-.-....-90........------100.......110..-.---.-...120.-------..--.------.--..130.......140......-.-150.......160.-......170......--.180....-...190.......200.......210.......220.......----230..-----------.....-240-.--.....--.250......-------.260.......270.......280.......290-.......--300---.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
F
F
N
F
R
K
I
F
K
LG
S
E
K
K
K
K
Q
Y
E
H
V
KRDL
N
P
E
D
F
W
E
I
-------
I
G
ELGDGAFG
K
V
Y
KAQNKET
S
-
V
L
A
A
A
K
VI---DT-K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A-S-CDH
P
-
N
I
V
K
L
L
D
A
F
Y
------YEN
N
L
W
I
L
I
E
FCAGG-
A
---
V
-
D
A
V
M
L
E
L
-------ER--P------L--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
HD-N-
K
I
I
H
R
DLKAG
N
I
L
F
-TLDG
D
I
K
L
A
D
FGVSA--KN
T
R
T
I
Q
R
-
R
DSFIGTPYWMA
P
E
V
V
M
CETSKDRPYDYKA
D
V
W
S
L
G
I
T
L
I
E
M
A----EIEPP-----------HHEL
N
-
P
M
R
-
V
--
L
L
K
I
A--KSEPPTLAQP-------SRW
S
S
N
F
K
D
F
L
K
K
C
L
EKNVDARW
T
T
S
Q
L
LQHP
F
V
-
T
VDSNK
P
--
I
R
E
---
L
I
A
E
A
K
A
E
V
T
E
E
V
EDGKEE
D
E
E
EETENSLPIPASKRASSDLSIASS
E
E
D
KLSQ
N
A
C
I
L
E
S
V
S
E
K
TERSNS
E
D
K
L
N
S
K
ILNEKPTTD
E
P
E
K
A
V
E
D
I
N
E
H
I
T
D
A
Q
L
E
A
M
T
E
L
H
D
R
T
A
V
IKEN
E
R
EKRPKLENLPDTEDQ
E
T
V
DINSVSEGKEN
N
I
M
I
T
L
ETNIEHNLKS
E
E
E
K
D
Q
E
K
Q
Q
M
F
E
N
KLI
K
S
E
E
I
K
D
T
I
L
Q
T
V
D
L
V
S
QETGEKEA
N
I
Q
A
VDSEVGLT
K
E
D
T
Q
E
KLGEDDK
T
Q
K
D
VISNTSD
V
I
GTC
E
A
A
D
V
A
Q
K
VDEDSAEDTQSND
G
K
E
V
V
E
V
G
Q
K
L
I
NKPMVGPEAGGTKEV
P
I
K
E
I
V
E
M
N
E
I
EEGK
N
K
E
QAINSSEN
I
M
DINEEPGTTEGEEITESSST
E
E
M
E
V
R
S
V
VADT
D
Q
K
A
L
G
S
E
V
Q
D
A
S
K
V
T
T
Q
I
DKEKKEIPVSIKKEP
E
V
T
V
V
SQPTEPQ
P
V
L
I
P
S
I
N
INSDSGE
N
K
E
E
IGSLSKTETILPPESENPKENDNDSGTGSTADT
S
S
I
D
L
N
L
S
I
S
S
F
L
S
KTKDSG
S
I
S
L
Q
E
T
R
R
Q
K
K
T
L
K
K
T
R
K
F
I
VDG
V
E
V
S
V
T
T
S
K
I
V
TDSDS
K
T
E
E
L
R
F
L
R
R
Q
E
L
R
E
L
R
F
L
Q
K
E
E
Q
R
A
Q
Q
Q
L
N
S
K
L
Q
Q
Q
R
E
Q
I
F
R
R
F
E
Q
E
M
M
S
K
K
R
Q
Y
D
Q
E
I
E
N
L
E
K
Q
Q
K
Q
T
I
E
R
L
E
Q
E
H
T
N
R
L
R
D
E
A
K
R
IKG
E
Q
E
K
E
L
S
K
F
Q
N
M
L
K
N
R
K
K
E
V
I
N
E
V
E
K
A
P
K
E
L
R
K
E
L
M
K
R
R
K
E
E
L
A
Q
S
QH
A
Q
E
Q
E
F
V
Q
K
Q
Q
Q
E
L
D
G
S
L
K
K
I
I
Q
Q
Q
K
A
E
L
A
N
I
E
R
E
C
LN
N
K
Q
Q
L
M
R
A
R
E
A
A
I
W
E
L
E
E
R
H
L
Q
E
K
H
Q
L
L
K
Q
Q
L
K
D
Q
Y
F
M
Q
R
H
Q
L
L
K
R
H
E
K
E
T
E
Q
M
Q
R
Y
N
Q
R
L
I
E
E
L
KN
R
Q
T
Q
E
R
ARLP
K
I
Q
R
S
E
A
K
T
R
M
A
M
F
K
K
S
LRINSTATPD
Q
D
R
D
K
I
K
Q
F
A
A
Q
E
E
K
R
Q
K
N
E
R
M
A
Q
H
Q
K
H
E
N
Q
M
R
D
L
Q
L
Q
CE
A
N
V
R
E
L
H
Q
L
QNEK
C
H
L
L
V
EH
E
T
Q
K
L
K
E
L
D
E
E
H
S
Q
E
L
K
E
W
R
E
KLR
P
R
K
K
T
L
E
E
E
F
A
R
K
L
Q
EQ
E
V
F
F
K
MTGESECLNP
S
T
Q
S
R
I
S
KFYPIPSLHSTGS
21
PsiBlast_CBE
89.99
99%
-79
- C1 -
4USF
1
?
B:
[3-294]
------------------
K
Q
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
---
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
-
S
-
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
---
V
-
D
A
V
M
L
E
L
-------
E
R
--
P
------
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
--
I
R
E
---
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.21
75%
-84
- C1 -
5AJQ
2
STK10_HUMAN
A:
[6-294]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
----
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
K
T
-------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.07
74%
-82
- C1 -
4AOT
1
STK10_HUMAN
A:
[1-299]
-------------
S
M
R
K
S
R
E
Y
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
----------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.11
74%
-87
- C1 -
4USD
1
?
B:
[9-299]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
-------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.73
98%
-75
- C1 -
2UV2
6
SLK_HUMAN
A:
[26-313]
--------------------
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
---
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
-
S
-
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
---
V
-
D
A
V
M
L
E
L
-------
E
R
--
P
------
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
--
I
R
E
---
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.65
97%
-73
- C1 -
2J51
5
SLK_HUMAN
A:
[26-313]
--------------------
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
---
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
-
S
-
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
---
V
-
D
A
V
M
L
E
L
-------
E
R
--
P
------
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
--
I
R
E
---
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.58
96%
-75
- C1 -
2JFL
6
SLK_HUMAN
A:
[26-313]
--------------------
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
---
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
-
S
-
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
---
V
-
D
A
V
M
L
E
L
-------
E
R
--
P
------
L
--
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
--
K
N
T
R
T
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
--
I
R
E
---
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
82.82
74%
-74
- C1 -
4AOT
1
STK10_HUMAN
B:
[1-299]
-------------
S
M
R
K
S
R
E
Y
E
H
V
R
R
--
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
80.33
74%
-79
- C1 -
2J7T
1
STK10_HUMAN
A:
[10-302]
----------------------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
K
T
L
Q
K
-----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
80.05
74%
-76
- C1 -
4EQU
2
STK10_HUMAN
B:
[9-302]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.84
75%
-76
- C1 -
4BC6
2
STK10_HUMAN
A:
[1-293]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
K
T
L
Q
---------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.66
74%
-74
- C1 -
4EQU
2
STK10_HUMAN
A:
[9-302]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
-------
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.96
74%
-71
- C1 -
4USE
1
?
A:
[9-301]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
K
T
L
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.34
74%
-68
- C1 -
4USE
1
?
B:
[9-301]
---------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
-
A
L
A
A
A
K
V
I
---
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
-
T
-
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
-
A
---
V
-
D
A
I
M
L
E
L
-------
D
R
--
G
------
L
--
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
--
K
N
L
K
T
L
Q
K
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
-----------
H
H
E
L
N
-
P
M
R
-
V
--
L
L
K
I
A
--
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
--
L
R
E
---
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
69.46
38%
-62
- C1 -
4O0R
1
PAK1_HUMAN
A:
[9-290]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
69.25
41%
-60
- C1 -
3A7I
1
STK24_HUMAN
A:
[19-299]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
K
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
---
L
-
D
--
L
L
E
--------
P
G
--
P
------
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-----------
H
S
E
L
H
-
P
M
K
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
E
---------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
SY
L
T
E
---
L
I
D
R
Y
K
R
W
K
A
E
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.49
38%
-67
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[10-291]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
-
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.05
41%
-60
- C1 -
3A7H
1
STK24_HUMAN
A:
[19-298]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
K
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
---
L
-
D
--
L
L
E
--------
P
G
--
P
------
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-----------
H
S
E
L
H
-
P
M
K
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
E
---------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
SY
L
T
E
---
L
I
D
R
Y
K
R
W
K
A
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
66.82
39%
-67
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
66.57
38%
-66
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[10-291]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
----------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
65.70
38%
-66
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[10-291]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
-
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
65.68
34%
-73
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[2-269]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
S
M
A
---
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
P
P
-----------------
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
65.49
38%
-62
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[10-291]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
----------
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
65.00
38%
-60
- C1 -
4O0T
1
PAK1_HUMAN
A:
[9-290]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
64.92
42%
-65
- C1 -
4O27
1
STK24_HUMAN
B:
[3-264]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
K
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
---
L
-
D
--
L
L
E
--------
P
G
--
P
------
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-----------
H
S
E
L
H
-
P
M
K
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
E
---------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
--
S
Y
L
---
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
64.33
31%
-75
- C1 -
3ZLY
1
MP2K1_HUMAN
A:
[30-326]
------------------------------
D
D
D
F
E
K
-------
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
S
M
A
------
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
P
P
D
A
K
E
L
E
L
M
FGC------
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
L
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
64.33
39%
-65
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
-----
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
64.19
34%
-76
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[2-269]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
S
M
A
---
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
P
P
----------------P
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
64.14
39%
-65
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
----
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
63.82
40%
-67
- C1 -
3Q4Z
1
PAK1_HUMAN
A:
[29-291]
----------------------------------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-----
Q
E
V
A
I
R
Q
M
---
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
63.82
42%
-68
- C1 -
2XIK
2
STK25_HUMAN
A:
[15-272]
---------------------------
V
D
P
E
E
L
F
T
K
-------
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
-
E
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
P
-
Y
I
T
R
Y
F
G
S
Y
L
------
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
------
A
L
D
L
L
K
-------
P
G
--
P
------
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-----------
N
S
D
L
H
-
P
M
R
-
V
--
L
F
L
I
P
--
K
N
S
P
P
T
L
E
---------
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
T
R
Y
T
K
K
T
--
S
F
L
---
T
E
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
63.77
39%
-66
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
--------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
63.62
39%
-63
- C1 -
4RVT
2
M4K4_HUMAN
A:
[23-312]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
----
E
E
I
K
L
-
E
I
N
M
L
K
-
K
Y
S
H
H
R
-
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
----
R
Q
---
V
R
I
Q
L
K
D
H
I
D
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.53
38%
-61
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[10-291]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
---------
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
I
T
P
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
62.67
38%
-65
- C1 -
4P90
1
PAK1_HUMAN
B:
[9-290]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
L
----------
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
-------------
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.44
42%
-65
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-265]
-----------------------------
P
E
E
L
F
T
K
-------
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
K
V
V
A
I
K
I
I
---
D
L
-
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
---
L
-
D
--
L
L
E
--------
P
G
--
P
------
L
--
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
P
P
-----------
H
S
E
L
H
-
P
M
K
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
E
---------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
L
R
N
A
K
K
T
--
S
Y
L
---
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
62.07
41%
-75
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
-------------
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
61.48
41%
-71
- C1 -
4NZW
1
STK25_HUMAN
B:
[16-273]
---------------------------
V
D
P
E
E
L
F
T
K
-------
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
-
E
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
P
-
Y
I
T
R
Y
F
G
S
Y
L
------
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
------
A
L
D
L
L
K
-------
P
G
--
P
------
L
--
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-----------
N
S
D
L
H
-
P
M
R
-
V
--
L
F
L
I
P
--
K
N
S
P
P
T
L
E
---------
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
T
R
Y
T
K
K
T
--
S
F
L
---
T
E
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.43
41%
-70
- C1 -
4U44
2
M4K4_HUMAN
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S---
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
-------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
61.10
40%
-62
- C1 -
4FZF
1
?
B:
[5-266]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
-
Q
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
---
A
-----
L
D
L
-------
L
R
A
G
P
------
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-----------
N
S
D
M
H
-
P
M
R
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
--
S
Y
L
---
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
61.09
34%
-80
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[2-269]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
S
M
A
---
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
--------------------
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
---------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.89
41%
-70
- C1 -
4U43
1
M4K4_HUMAN
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
60.69
41%
-72
- C1 -
4OBP
2
M4K4_HUMAN
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
60.39
34%
-72
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[5-262]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
E
M
A
---
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-----------
R
---
P
-
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
60.04
34%
-68
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[5-262]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
E
M
A
---
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-----------
R
---
P
-
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
59.55
34%
-69
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[5-262]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
E
M
A
---
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-----------
R
---
P
-
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
59.46
40%
-61
- C1 -
4FZA
3
STK26_HUMAN
B:
[5-266]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
Q
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
---
A
-----
L
D
L
-------
L
R
A
G
P
------
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
--
Q
L
T
D
T
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-----------
N
S
D
M
H
-
P
M
R
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
--
S
Y
L
---
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
59.23
41%
-65
- C1 -
4U45
1
M4K4_HUMAN
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.20
39%
-56
- C1 -
4ZJI
1
?
D:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
--
Q
I
T
---
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
LTP
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
58.98
41%
-68
- C1 -
4ZK5
2
?
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
58.97
41%
-61
- C1 -
3GGF
1
STK26_HUMAN
A:
[20-281]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
Q
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
---
A
-----
L
D
L
-------
L
R
A
G
P
------
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-----------
N
S
D
M
H
-
P
M
R
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
--
S
Y
L
---
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
58.63
41%
-62
- C1 -
3GGF
1
STK26_HUMAN
B:
[20-281]
----------------------------
D
P
E
E
L
F
T
K
-------
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
-
Q
V
V
A
I
K
I
I
---
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
-
Q
-
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
---
A
-----
L
D
L
-------
L
R
AG
P
------
F
--
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
-------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
P
P
-----------
N
S
D
M
H
-
P
M
R
-
V
--
L
F
L
I
P
--
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
-
V
K
N
S
K
K
T
--
S
Y
L
---
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.38
39%
-58
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
---
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
---
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
---------
E
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
58.35
35%
-58
- C1 -
4BIE
2
B:
[27-282]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
ER--------
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
58.04
35%
-56
- C1 -
4BHN
2
B:
[43-295]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
ER-----
S
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
57.64
35%
-61
- C1 -
4BF2
2
M3K5_HUMAN
A:
[43-296]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E-----------
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
-------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
57.63
35%
-63
- C1 -
4BID
1
M3K5_HUMAN
A:
[27-280]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E---------
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
57.59
34%
-69
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[5-262]
--------------------------
E
L
K
D
D
D
F
-
E
K
-------
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
-
L
V
M
A
R
K
L
I
---
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
-
E
-
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
---
L
-
D
Q
V
L
K
K
A
-------
G
R
---------
I
--
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
H
R
D
V
K
P
S
N
I
L
V
-
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
--
Q
L
I
D
E
M
A
---
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
-----------
R
---
P
-
P
M
A
-
I
F
E
L
L
D
Y
I
--
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
R
S
D
A
E
E
--
V
D
F
---
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
57.42
39%
-55
- C1 -
4ZJI
1
?
C:
[11-292]
-----
L
R
S
I
V
S
V
G
D
P
K
K
K
--
Y
T
R
F
E
K
--------------------
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
-
Q
E
V
A
I
K
Q
M
---
N
------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
-
E
-
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
---
L
-
T
D
V
V
T
E
---------
T
--
C
------
M
--
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
--
Q
-----
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
P
P
-----------
Y
L
N
E
N
-
P
L
R
-
A
--
L
Y
L
I
A
--
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
--
K
P
--
L
S
S
LTP
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.22
35%
-60
- C1 -
4BIC
2
M3K5_HUMAN
A:
[27-281]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E------
S
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
57.20
35%
-61
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[30-284]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E
R
D
S
----
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
G
------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.08
35%
-59
- C1 -
4BIE
2
M3K5_HUMAN
A:
[27-281]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E---------
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
G
-------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
57.05
35%
-60
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[16-285]
----------------------------------
E
V
-------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
---
V
A
I
K
R
I
N
---
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
---
V
-
L
D
I
I
K
H
I
V
A
K
GEHK
S
G
--
V
------
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N---
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
56.98
35%
-64
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[16-285]
----------------------------------
E
V
-------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
---
V
A
I
K
R
I
N
---
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
---
V
-
L
D
I
I
K
H
I
V
A
K
GEHK
S
G
--
V
------
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
----------
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
56.86
35%
-62
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[16-285]
----------------------------------
E
V
-------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
---
V
A
I
K
R
I
N
---
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
---
V
-
L
D
I
I
K
H
I
V
A
K
GEHK
S
G
--
V
------
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
---------
V
G
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
56.81
35%
-59
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[21-297]
----------------------------------
E
V
-------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
---
V
A
I
K
R
I
N
---
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
---
V
-
L
D
I
I
K
H
I
V
A
K
GEHK
S
G
--
V
------
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
N
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
56.80
35%
-56
- C1 -
4BIC
2
B:
[27-282]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E
R-----
S
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
----------
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
56.70
41%
-72
- C1 -
4OBO
2
M4K4_HUMAN
A:
[21-290]
----------------------------
D
P
A
G
I
F
E
L
-------
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
-
Q
L
A
A
I
K
V
M
---
D
V
--
T
-----
E
I
K
L
-
E
I
N
M
L
K
-
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
---
I
T
D
L
V
K
N
T
K
-------
G
N
--
T
------
L
--
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
--------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
P
P
-----------
L
C
D
M
H
-
P
M
R
-
A
--
L
F
L
I
P
--
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
--
Q
V
R
---
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
56.49
35%
-57
- C1 -
4BIB
1
B:
[27-281]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E
R-----
S
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
56.28
35%
-59
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[16-285]
----------------------------------
E
V
-------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
---
V
A
I
K
R
I
N
---
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
---
V
-
L
D
I
I
K
H
I
V
A
K
GEHK
S
G
--
V
------
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
K
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
55.96
35%
-56
- C1 -
4BID
1
B:
[27-281]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
ER-----
S
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
----------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
55.86
36%
-60
- C1 -
5D9H
1
?
A:
[18-293]
-------------------------------
D
A
Y
E
L
-------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
-
E
R
V
A
I
K
R
I
---
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
S
H
P
-
N
V
V
T
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
M
--
L
-
D
I
I
K
Y
I
V
-------
N
R
--
G
EHKNGV
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
-
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
-----
V
G
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
T
L
E
T
G
VKEMM--
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
K
A
K
N
R
E
--
Y
L
I
---
E
K
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.72
35%
-57
* C1 *
2CLQ
1
B:
[30-284]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E
R-----
S
Q
P
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
---------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
55.67
35%
-58
- C1 -
4BF2
1
B:
[43-297]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
ER----------
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
L
A
----------
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
55.07
35%
-61
- C1 -
4BIB
3
M3K5_HUMAN
A:
[27-280]
----------------------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
-
V
R
I
A
I
K
E
I
P
E---------
L
H
E
----
E
I
A
L
H
K
-
H
-
L
K
H
K
-
N
I
V
Q
Y
L
G
S
F
S
------
E
N
G
F
I
K
I
F
M
E
Q
V
P
G
G
-
S
---
L
-
S
A
L
L
R
S
K
-------
W
G
--
P
------
L
KD
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
--
R
---------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
---
D
K
G
P
R
G
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
----
T
G
K
P
P
-----------
F
Y
E
L
G
E
P
Q
A
-
A
--
M
F
K
V
G
M
F
K
V
H
P
E
I
---
P
-------
E
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
53.66
35%
-61
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[21-292]
----------------------------------
E
V
-------
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
---
V
A
I
K
R
I
N
---
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
---
V
-
L
D
I
I
K
H
I
V
A
K
GEHK
S
G
--
V
------
L
--
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
----------
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
S
L
E
T
G
ML-----
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
52.71
36%
-62
- C1 -
5D9H
1
?
B:
[18-293]
-------------------------------
D
A
Y
E
L
-------
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
-
E
R
V
A
I
K
R
I
---
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
-
Q
-
C
S
H
P
-
N
V
V
T
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
M--
L
-
D
I
I
K
Y
I
V
-------
N
R
--
G
EHKNGV
L
--
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
-
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
FL
A
T
G
G
D
V
T
R
N-----
G
T
P
C
W
M
A
P
E
V
M
----
E
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
A
P
-----------
Y
H
K
Y
P
-
P
M
K
-
V
--
L
M
L
T
L
--
Q
N
D
P
P
T
L
E
T
G
VEDKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
K
A
K
N
R
E
--
Y
L
I
---
E
K
L
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
47.19
33%
-58
- C1 -
3ALN
1
MP2K4_HUMAN
B:
[8-291]
------------------------
K
L
K
I
S
P
E
Q
H
W
D
F
T
AEDLKD
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
---
S
T
-
V
D
E
K
E
Q
K
Q
L
L
M
-
D
L
D
V
V
M
R
S
-
S
D
C
P
-
Y
I
V
Q
F
Y
G
A
L
F
------
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
-
F
D
K
F
Y
-
K
Y
V
Y
S
V
L
-------
D
D
--
V
------
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
--
Q
L
--------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
----
T
G
R
F
P
-----------
Y
P
--------------------
D
P
P
Q
L
S
N
S
EE-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
-
L
M
Y
E
E
R
A
--
V
E
V
---
A
C
Y
V
C
K
I
L
D
Q
M
P
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
45.42
33%
-59
- C1 -
3ALO
1
MP2K4_HUMAN
A:
[17-291]
---------------------------------
W
D
F
TAEDLKD
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
---
S
T
-
V
D
E
K
E
Q
K
Q
L
L
M
-
D
L
D
V
V
M
R
S
-
S
D
C
P
-
Y
I
V
Q
F
Y
G
A
L
F
------
R
E
G
D
C
W
I
C
M
E
L
M
S
T
S
-
F
D
K
F
Y
-
K
Y
V
Y
S
V
L
-------
D
D
--
V
------
I
--
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
-
D
R
S
G
N
I
K
L
C
D
F
G
I
S
G
--
Q
L
V
D
S
I
A
K
T
R
D
A
--
G
C
R
P
Y
M
A
P
E
R
I
D
P
-------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
----
T
G
R
F
P
-----------
Y
P
K
W
N
-
S
V
F
D
Q
--
L
T
Q
V
V
--
K
G
D
P
P
Q
L
S
N
S
EE-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
-
L
M
Y
E
E
R
A
--
V
E
V
---
A
C
Y
V
C
K
I
L
D
Q
M
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------