@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SNRK_HUMAN: (2015-10-19 )
MAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSPATKYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATYFLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDDLTATPLSHATVPQSPARAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASLKPTASGRKCLFRVEEDEEEDEEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDDEFDMDENLPPKLSRLKMNIASPGTVHKRYHRRKSQGRGSSCSSSETSDDDSESRRRLDKDSGFTYSWHRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTRRCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTKYIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERIKSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASSPASCCHVI
Atome Classification :
(49 SA)
.........10.-......-.20--........30.....---...40........50-.--..---.----....-60......-..70........80...----.....90........100.......---110........120.......130.......140......--.-150.--.----.......160...-...---.170-.........180.......190.......200.......210.......220----.-......230...----.----...240.......250......-----.260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGFKRGYDG
K
I
-
A
G
L
Y
D
L
-
D
K
T
--LGR
G
H
F
A
V
V
K
L
A
R
H
V---FTG
E
K
V
A
V
K
V
IDKTK-L--
D
T
---
L
----
A
T
G
H
-
L
F
Q
E
V
R
C
M
-
K
L
VQHP
N
I
V
R
L
Y
E
V
IDT----Q
T
K
L
Y
L
I
L
E
LGDG
G
D
M
F
D
Y
I
M
K
H
EE---GL-
N
E
D
L
A
K
K
Y
F
A
Q
I
V
H
A
I
S
Y
C
H
K
L
H
V
V
HRDLKPE
N
V
V
F
F
--E-K--Q--G----
L
V
K
LTDFGFSNKF-QPG---K
K
---
L
T
T
SCGSLAYSAP
E
I
L
LGDEYDAP
A
V
D
I
W
S
L
G
V
I
L
F
M
L
VCGQPPFQEANDS
E
----
T
-
L
T
M
I
M
DCKYTV
P
----
S
----
H
V
S
K
E
C
K
D
L
I
T
R
M
L
QRDPKRRA-----
S
L
E
E
IENHPWLQGVDPSPATKYNI
P
L
V
SYKNL
S
E
E
E
H
N
S
I
I
Q
R
M
V
L
GDIA
D
R
D
A
I
V
E
A
L
E
TNRYN
H
I
T
A
T
Y
F
L
L
A
E
R
I
L
R
E
K
Q
E
K
E
I
QTRSASP
S
N
I
K
A
Q
F
R
QSWPTKIDVPQDLEDDLTATPLSHATVPQS
P
A
R
A
A
D
S
V
L
NGHRSKGLCDSAKKDD
L
P
E
LAGPALSTVPPASLKPTASG
R
K
C
L
F
R
VEEDEEE
D
E
EDKKPMSL
S
T
Q
V
V
L
RRKPSV
T
N
R
LTSRKSA
P
V
L
N
Q
I
F
EEGESDDEFDMDENLPP
K
L
S
R
L
KMNIASP
G
T
V
H
K
R
Y
H
R
R
KSQGRGSSCSSSETSDD
D
S
E
S
R
RRLDKDSG
F
T
Y
S
W
HRRDSSEGPPGSEGDGGGQSKPSNASGGVDKASPSENNAGGGSPSSGSGGNPTNTSGTTRRCAGPSN
S
M
Q
L
A
S
R
S
A
G
E
L
V
E
S
L
K
L
M
S
L
C
LGSQLHGS
T
K
Y
I
IDPQNGLSFS
S
V
K
V
Q
EKS
T
W
K
M
C
I
SSTGNAGQVPAVG
G
I
K
F
F
S
D
HMAD
T
T
T
E
L
E
R
I
K
SKNLKNNVLQLPLCE
K
T
I
S
V
N
I
QRNPKE
G
L
L
CASSP
A
S
CCHVI
119
HHSearch
72.45
37%
-104
- C2 -
4BKY
1
MELK_HUMAN
A:
[6-331]
---------
D
E
L
-
L
K
Y
Y
E
L
-
H
E
T
--
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
---
L
T
G
E
M
V
A
I
K
I
M
D
K
N
T
-
L
------------
D
L
P
R
-
I
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
----
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
----
L
-
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
-
E
--
Y
--
H
----
K
L
K
L
I
D
F
G
L
C
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
---
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
M
A
----
L
-
Y
K
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
P
W
I
M
Q
D
Y
N
Y
P
V
E
W
Q
-----
S
K
N
P
F
I
H
L
D
D
-
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
68.02
35%
-118
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[6-279]
--------
Q
E
N
V
-
D
D
Y
Y
D
T
-
G
E
E
--
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
---
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
-
T
--
K
S
---
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
----
L
-
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
----
D
--
R
--
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
-
D
F
G
---
N
E
---
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
P
L
G
-
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
----
T
-
L
A
N
V
S
A
V
N
Y
E
F
E
----
D
EYFS
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.95
36%
-117
- C2 -
3F3Z
5
?
A:
[6-266]
----------
D
I
-
N
Q
Y
Y
T
L
-
E
N
T
--
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
---
G
T
R
I
R
R
A
A
K
K
I
P
K
Y
F
-
V
--
E
D
---
V
------
D
R
-
F
K
Q
E
I
E
I
M
-
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
----
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
-
H
K
R
---
V
F
-
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
L
--
T
-
D
--
S
PD
S
----
P
L
K
L
I
D
F
G
L
A
A
R
F
-
K
P
G
---
K
M
---
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
G
--
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
S
A
P
T
D
S
E
----
V
-
M
L
K
I
R
E
G
T
F
T
F
P
----
E
KDWL
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
-----
T
S
L
Q
A
L
E
H
E
W
F
E
K
Q
L
S
S
S
P
R
N
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
67.67
41%
-108
- C2 -
3AQV
1
AAPK2_HUMAN
A:
[4-271]
-------
H
D
G
R
V
K
I
G
H
Y
V
L
-
G
D
T
--
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
---
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
-
I
--
R
S
---
L
D---
V
V
G
K
-
I
K
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
----
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
----
V
-
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
-
A
--
H
--
M
----
N
A
K
I
A
D
F
G
L
S
N
M
M
-
S
D
G
---
E
F
---
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
----
L
-
F
K
K
I
R
G
G
V
F
Y
I
P
----
E
----
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
66.74
36%
-109
- C2 -
3WF7
2
KS6B1_HUMAN
A:
[14-286]
---------
E
K
I
R
P
E
C
F
E
L
-
L
R
V
--
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
V
TGA
N
T
G
K
I
F
A
M
K
V
L
K
K
A
M
-
I
V
R
N
A
---
K
----
D
T
A
H
-
T
K
A
E
R
N
I
L
-
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
----
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
----
F
-
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
-
H
--
Q
--
G
----
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
---------
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
G
H
N
-
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
E
N
R
K
K
----
T
-
I
D
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
GAGP
G
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
66.59
35%
-113
- C2 -
2WTW
1
AURKA_HUMAN
A:
[15-271]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
65.95
35%
-124
- C2 -
2X81
1
AURKA_HUMAN
A:
[14-269]
----------------
F
E
I
-
G
R
P
--
L
G
---
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
65.49
37%
-136
- C2 -
4FG8
1
KCC1A_HUMAN
A:
[16-278]
-----------
I
-
R
D
I
Y
D
F
-
R
D
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
----------------------
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
---
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
SL
D
-
E
--
D
--
S
----
K
I
M
I
S
D
F
------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
----
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
65.11
35%
-127
- C2 -
3EFW
1
AURKA_HUMAN
A:
[133-388]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
-------------------------
L
D
Y
L
P
P
E
M
I
E
-------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
65.09
36%
-110
- C2 -
3DJ7
1
AURKA_MOUSE
A:
[14-269]
----------------
F
D
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
----
T
-
Y
R
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
65.01
35%
-112
- C2 -
4BYI
1
AURKA_HUMAN
A:
[15-270]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
---------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
64.98
36%
-108
- C2 -
3D14
1
AURKA_MOUSE
A:
[14-269]
----------------
F
D
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
----
T
-
Y
R
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
64.91
35%
-113
- C2 -
1MUO
1
AURKA_HUMAN
A:
[27-282]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
64.88
36%
-109
- C2 -
3D2I
1
AURKA_MOUSE
A:
[14-269]
----------------
F
D
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
-------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
----
T
-
Y
R
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
64.88
36%
-118
- C2 -
3DJ5
1
AURKA_MOUSE
A:
[14-269]
----------------
F
D
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
N
--
G
----
E
L
K
I
A
D
F
G
W
-----------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
----
T
-
Y
R
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
64.85
35%
-108
- C2 -
4UZD
1
AURKA_HUMAN
A:
[10-265]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
-------------
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
64.78
37%
-131
- C2 -
4FG7
1
KCC1A_HUMAN
A:
[16-277]
-----------
I
-
R
D
I
Y
D
F
-
R
D
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
--------------------
S
-
M
E
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
---
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
SL
D
-
E
--
D
--
S
----
K
I
M
I
S
D
F
G
L
S
K
M
E
-
D
P
--------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
---
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
----
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
64.76
36%
-116
- C2 -
3DJ6
1
AURKA_MOUSE
A:
[14-269]
----------------
F
D
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
N
--
G
----
E
L
K
I
A
D
F
G
W
-----------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
----
T
-
Y
R
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
64.42
35%
-126
- C2 -
3EFW
1
AURKA_HUMAN
B:
[133-389]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
-------------------------
L
D
Y
L
P
P
E
M
I
E
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
64.32
41%
-113
- C2 -
4CZT
3
CIPKN_ARATH
C:
[10-269]
-------------
V
G
K
Y
E
L
-
G
R
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
---
K
----
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
----
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
-
A
--
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
-
Q
Q
V
---
R
E
DG
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
----
L
-
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
63.93
35%
-120
- C2 -
3W16
1
AURKA_HUMAN
A:
[8-263]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
63.82
35%
-117
- C2 -
4BYJ
1
AURKA_HUMAN
A:
[15-270]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
63.76
36%
-108
- C2 -
3D15
1
AURKA_MOUSE
A:
[14-269]
----------------
F
D
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
R
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
-------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
E
A
H
T
Y
Q
E
----
T
-
Y
R
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
63.73
35%
-107
- C2 -
4UZD
1
AURKA_HUMAN
B:
[10-266]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
------------
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
63.63
35%
-105
- C2 -
4JAJ
1
AURKA_HUMAN
A:
[21-277]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
63.55
35%
-115
- C2 -
4B0G
1
AURKA_HUMAN
A:
[13-271]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
-------------
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
63.44
40%
-116
- C2 -
4CZU
3
CIPKN_ARATH
C:
[10-269]
-------------
V
G
K
Y
E
L
-
G
R
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
---
K
----
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
----
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
-
A
--
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
-
Q
Q
V
---
R
E
DG
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
----
L
-
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.37
35%
-113
- C2 -
3W18
1
AURKA_HUMAN
B:
[8-263]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
------------------
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
---------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
63.36
35%
-103
- C2 -
1MQ4
1
AURKA_HUMAN
A:
[14-269]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
-----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
63.33
37%
-122
- C2 -
4FG8
1
KCC1A_HUMAN
B:
[16-278]
-----------
I
-
R
D
I
Y
D
F
-
R
D
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----------------------
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
---
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
SL
D
-
E
--
D
--
S
----
K
I
M
I
S
D
F
G
--------
G
---
S
V
---
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
----
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
63.24
37%
-136
- C2 -
4FG9
1
KCC1A_HUMAN
A:
[16-278]
-----------
I
-
R
D
I
Y
D
F
-
R
D
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
---------------------
E
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
---
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
SL
D
-
E
--
D
--
S
----
K
I
M
I
S
D
F
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
----
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
63.21
35%
-109
- C2 -
2X6D
1
AURKA_HUMAN
A:
[15-270]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
-----------
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
63.06
35%
-97
- C2 -
4UTD
1
?
A:
[12-272]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
62.80
35%
-112
- C2 -
4JAI
1
AURKA_HUMAN
A:
[21-278]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
62.65
41%
-108
- C2 -
4CZT
2
CIPKN_ARATH
B:
[10-269]
-------------
V
G
K
Y
E
L
-
G
R
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
---
K
----
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
----
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
-
A
--
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
-
Q
Q
V
---
R
E
DG
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
----
L
-
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
62.13
36%
-115
- C2 -
1NXK
1
MAPK2_HUMAN
A:
[57-334]
---------
N
A
I
-
I
D
D
Y
K
V
T
S
Q
V
--
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
---
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
-----------------
P
K
-
A
R
R
E
V
E
L
H
W
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
R
-----
A
F
-
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
--
S
-
K
RP
N
--
A
----
I
L
K
L
T
D
F
G
F
A
K
E
T
-
T
-----------------
P
Y
Y
V
A
P
E
V
L
G
P
E
K
Y
D
-
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
ISPG
M
-
K
T
R
I
R
M
G
Q
Y
E
F
P
NPEW
S
----
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
-----
T
I
T
E
F
M
N
H
P
W
I
M
Q
S
T
K
V
P
Q
T
P
L
H
T
S
R
V
L
K
E
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
61.93
40%
-107
- C2 -
4CZU
3
CIPKN_ARATH
B:
[10-269]
-------------
V
G
K
Y
E
L
-
G
R
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
---
K
----
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
----
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
-
A
--
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
-
Q
Q
V
---
R
E
DG
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
----
L
-
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.89
41%
-102
- C2 -
4CZT
3
CIPKN_ARATH
A:
[10-269]
-------------
V
G
K
Y
E
L
-
G
R
T
--
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
---
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
--
K
N
---
K
----
M
I
A
Q
-
I
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
----
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
----
L
-
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
-
A
--
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
L
P
-
Q
Q
V
---
R
E
DGL
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
----
L
-
Y
K
K
I
F
K
A
E
F
T
C
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
61.74
35%
-112
- C2 -
3MYG
2
AURKA_HUMAN
A:
[14-269]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
-------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
61.33
32%
-112
- C2 -
2X4F
4
MYLK4_HUMAN
A:
[82-349]
--------
Q
G
A
V
-
N
S
F
Y
T
V
-
S
K
T
EI
L
G
-----
Q
V
H
K
C
E
E
T
---
A
T
G
L
K
L
A
A
K
I
I
K
T
R
G
-
M
--
K
---------
D
K
E
E
-
V
K
N
E
I
S
V
M
-
N
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
Y
---
N
L
-
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
--
N
R
D
--
A
--
K
----
Q
I
K
I
I
D
F
G
L
A
R
R
Y
-
K
P
R
---
E
K
---
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
N
Y
D
F
V
S
-
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
----
T
-
L
N
N
I
L
A
C
R
W
D
L
E
----
D
EEFQ
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
-----
S
A
S
E
A
L
K
H
P
W
L
S
D
H
K
L
H
S
R
L
S
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.21
35%
-103
- C2 -
4O0S
1
AURKA_HUMAN
A:
[12-270]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
---
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.09
37%
-128
- C2 -
4FG9
1
KCC1A_HUMAN
B:
[16-278]
-----------
I
-
R
D
I
Y
D
F
-
R
D
V
--
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
---
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------------
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--
E
K
---
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
SL
D
-
E
--
D
--
S
----
K
I
M
I
S
D
F
--------------
V
---
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
----
L
-
F
E
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
60.92
35%
-110
- C2 -
3C0I
1
CSKP_HUMAN
A:
[23-294]
-------------
E
D
V
Y
E
L
-
C
E
V
--
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
---
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
-
F
--
T
S
SPG
L
----
S
T
E
D
-
L
K
R
E
A
S
I
C
-
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
----
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
A
D
A
G
F
V
Y
-
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
L
A
--
S
-
K
EN
S
--
A
----
P
V
K
L
G
G
F
G
V
A
I
Q
L
-
G
E
S
G--
L
V
---
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
K
R
E
P
Y
G
-
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
-
K
E
R
----
L
-
F
E
G
I
I
K
G
K
Y
K
M
N
----
P
RQWS
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
-----
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
60.76
35%
-116
- C2 -
3W18
1
AURKA_HUMAN
A:
[8-263]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
-----------
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
---
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
60.40
35%
-107
- C2 -
4C3P
1
AURKA_HUMAN
D:
[12-269]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
60.38
35%
-108
- C2 -
2X6E
1
AURKA_HUMAN
A:
[15-270]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
-------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
59.28
35%
-102
- C2 -
4C3P
1
AURKA_HUMAN
A:
[12-267]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
----
T
-
Y
K
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
55.06
30%
-95
- C2 -
2YEX
8
CHK1_HUMAN
A:
[6-269]
-------------
V
E
D
W
D
L
-
V
Q
T
--
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
---
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
-
A
--
V
----
D
----
C
P
E
N
-
I
K
K
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
----
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
----
G
M
-
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
-
E
--
R
--
D
----
N
L
K
I
S
D
F
G
L
A
T
V
F
-
R
Y
N
N
R
E
R
L
---
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
----
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
N
PW--
K
----
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
27.06
35%
-75
- C2 -
2NP8
1
AURKA_HUMAN
A:
[14-166]
----------------
F
E
I
-
G
R
P
--
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
---
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
-
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
----
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
----
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
--
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
H
--
A
P
S
---
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------