@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ST17A_HUMAN: (2015-10-19 )
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
Atome Classification :
(42 SA)
.........10........20........30.....---...40........50....-----....60........70........80........90....-----...-------.----100--....-.....110-.-......120.......130--.........140.......150-----------------------..-------------.....160.......170.......180.......190......-.200.......210.....---...220.......230...------.------.--..240.......250.......260.......270----.......280.--......290.......300.......310.......320-----........330........340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPP
P
---
P
Q
A
R
G
L
L
T
E
I
R
A
V
V
RTEPF-----QDGYSLCPGRELGR
G
K
F
A
V
V
R
K
C
I
KKDS
G
K
E
F
A
A
K
F
M
R
K
R-----RKG-------
Q
----
D
----
C
R
M
E
-
I
I
H
E
I
A
V
L
-
E
-LAQDN
P
W
V
I
N
L
H
E
V
Y
E
T
----
A
S
E
M
I
L
V
L
E
YAA
G
G
E
I
F
D
Q
C
V
A
-----------------------
D
R
-------------
E
E
A
F
K
E
K
D
V
Q
R
L
M
R
Q
I
L
E
G
V
H
F
LHTR
D
V
V
H
L
DLKP
Q
N
I
L
LTSES-PLG
D
I
K
I
V
D
F
G
L
S
-
R
I
LK
N
---
S
E
E
L
R
E
I
MGTP
E
Y
VA
P
E
IL------S------Y--DP
I
S
M
A
T
D
M
W
S
I
G
V
L
T
Y
V
M
L
TGI
S
P
FLGNDKQ
E
T
F
----
L
N
I
S
Q
MNLSY
S
--
E
E
E
F
D
V
L
S
E
S
A
V
D
F
I
R
T
L
L
VKKPED
R
A
T
A
E
E
C
L
KHPWL------TQSSIQEP
S
F
-
R
M
E
K
A
L
E
E
A
N
A
L
QEGHSVPEINSDTD
K
S
E
T
K
E
SIVT
E
E
L
I
V
V
T
S
Y
T
L
G
Q
C
R
Q
S
E
K
E
K
M
E
Q
K
A
I
S
K
RFKFEE
P
L
L
Q
EIPGEFIY
119
HHSearch
83.05
64%
-117
- C1 -
3LM5
1
ST17B_HUMAN
A:
[23-299]
------------------------------------------------------
M
E
N
F
-----
N
N
F
Y
I
L
T
-
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
-----
R
R
G
-------
Q
----
D
----
C
R
A
E
-
I
L
H
E
I
A
V
L
-
E
-
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
-----------------------
E
L
--------------
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
K
I
------------
M
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
--
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
T
Y
----
L
N
I
S
Q
V
N
V
D
Y
S
--
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
------
Q
Q
W
D
F
E
N
L
--------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.12
60%
-115
- C1 -
3LM0
2
ST17B_HUMAN
A:
[24-302]
-------------------------------------------------------
E
N
F
-----
N
N
F
Y
I
L
-
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
-----
R
R
G
-------
Q
----
D
----
C
R
A
E
-
I
L
H
E
I
A
V
L
-
E
-
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
-----------------------
E
L
-------------
A
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
K
I
------------
M
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
--
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
T
Y
----
L
N
I
S
Q
V
N
V
D
Y
S
--
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
------
Q
Q
W
D
F
-
E
N
L
F
-
H
P
---------------------------------------------------------------------------------
2
PsiBlast_PDB
79.55
60%
-118
- C1 -
3LM5
1
ST17B_HUMAN
A:
[24-299]
-------------------------------------------------------
E
N
F
-----
N
N
F
Y
I
L
-
T
S
K
E
L
G
R
G
K
F
A
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
K
R
-----
R
R
G
-------
Q
----
D
----
C
R
A
E
-
I
L
H
E
I
A
V
L
-
E
-
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
----
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
-----------------------
E
L
--------------
E
M
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
L
L
S
S
I
Y
-
P
L
G
D
I
K
I
V
D
F
G
M
S
-
R
K
I
------------
M
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
--
D
P
I
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
G
E
D
N
Q
E
T
Y
----
L
N
I
S
Q
V
N
V
D
Y
S
--
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
E
I
C
L
S
H
S
W
L
------
Q
Q
W
D
F
-
E
N
L
-------------------------------------------------------------------------------------
11
PsiBlast_PDB
76.74
45%
-114
- C1 -
2YAK
1
DAPK1_HUMAN
A:
[2-278]
--------------------------------------------------
T
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
-------------------------------------------------------------------------------------------
122
HHSearch
75.56
47%
-110
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-280]
---------------------------------------------------
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
T
--
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
SRRG
V
----
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------------------------------------
K
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
D
T
Q
Q
A
L
S
-
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------------------------------------------
14
PsiBlast_PDB
75.22
45%
-110
- C1 -
4TXC
7
DAPK1_HUMAN
A:
[21-296]
--------------------------------------------------
T
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
--------------------------------------------------------------------------------------------
28
PsiBlast_CBE
75.03
46%
-107
- C1 -
2W4J
1
DAPK1_HUMAN
A:
[2-275]
--------------------------------------------------
T
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
--------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.12
45%
-102
- C1 -
2W4K
1
DAPK1_HUMAN
A:
[2-291]
--------------------------------------------------
T
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
D
T
Q
Q
A
L
S
-
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------------------------------------------
19
PsiBlast_PDB
73.86
46%
-114
- C1 -
1WVY
1
DAPK1_HUMAN
A:
[4-275]
----------------------------------------------------
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
---------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.62
45%
-109
- C1 -
4UV0
1
?
A:
[5-284]
---------------------------------------------------
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
D
T
Q
Q
A
L
S
-
R
K
A
C
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------------------------------------------
6
PsiBlast_PDB
73.25
45%
-101
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[3-291]
---------------------------------------------------
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
D
T
Q
Q
A
L
S
-
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------------------------------------------
5
PsiBlast_PDB
71.47
45%
-100
- C1 -
4B4L
3
DAPK1_HUMAN
A:
[7-293]
-----------------------------------------------------
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
D
T
Q
Q
A
L
S
-
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
A
K
-----------------------------------------------------------------
26
PsiBlast_CBE
71.26
45%
-120
- C1 -
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
-----------------------------------------------------
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
--------------
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
---------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.25
44%
-99
- C1 -
2XUU
1
DAPK1_HUMAN
A:
[2-291]
--------------------------------------------------
T
V
F
R
Q
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
----
S
RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
F
---
G
N
E
F
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
P
K
D
T
Q
Q
A
L
S
-
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
------------------------------------------------------------------
40
PsiBlast_CBE
68.43
44%
-97
- C1 -
2CKE
1
DAPK2_HUMAN
A:
[3-296]
-------------------------------------------------------
E
P
F
KQQK
V
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-------------------------
Q
-------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
---
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
P
V
D
N
Q
Q
A
M
V
-
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-------------------------------------------------------------------
38
PsiBlast_CBE
68.43
44%
-96
- C1 -
2CKE
1
DAPK2_HUMAN
C:
[3-296]
-------------------------------------------------------
E
P
F
KQQKV
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-------------------------
Q
-------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
---
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
P
V
D
N
Q
Q
A
M
V
-
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-------------------------------------------------------------------
22
PsiBlast_CBE
67.49
43%
-94
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[6-296]
-----------------------------------------------------
K
Q
Q
K
V
-----
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
C
R
E
E
-
I
E
R
E
V
S
I
L
-
R
-
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
--
F
L
-----------------------
A
Q
-------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
---
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
I
T
A
V
S
Y
D
F
D
--
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
P
V
D
T
Q
Q
A
M
V
-
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-------------------------------------------------------------------
137
HHSearch
66.77
37%
-108
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
---------------------------------------------------------
F
-----
Y
E
N
Y
E
P
--
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
-----
G
G
G
SFS
A
E
E
V
Q
----
E
----
L
R
E
A
-
T
L
K
E
V
D
I
L
-
R
-
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
-------------------------
E
-------------
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
----
M
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
D
P
---
G
E
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
------
E
C
S
M
N
DN
H
--
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
----
R
M
I
M
S
G
N
Y
Q
F
G
--
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
------
Q
Q
Y
V
------------------------------------------------------------------------------------------
37
PsiBlast_CBE
66.57
44%
-94
- C1 -
2CKE
1
DAPK2_HUMAN
D:
[3-296]
-------------------------------------------------------
E
P
F
KQQKV
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-------------------------
Q
-------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
---
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
P
V
D
N
Q
Q
A
M
V
-
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-------------------------------------------------------------------
107
PsiBlast_CBE
65.80
35%
-108
- C1 -
1PHK
1
PHKG1_RABIT
A:
[15-291]
---------------------------------------------------------
F
-----
Y
E
N
Y
E
--
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
-----
G
G
G
SFS
A
E
E
V
Q
----
E
----
L
R
E
A
-
T
L
K
E
V
D
I
L
-
R
-
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
----
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
-------------------------
E
-------------
K
V
T
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
D
M
----
N
I
K
L
T
D
F
G
F
S
-
C
Q
L
D
P
---
G
E
K
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
N
------
H
--
P
G
Y
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
H
R
K
Q
M
L
M
L
----
R
M
I
M
S
G
N
Y
Q
F
G
--
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
E
E
A
L
A
H
P
F
F
------
Q
Q
Y
V
------------------------------------------------------------------------------------------
4
PsiBlast_PDB
65.68
43%
-94
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[6-296]
-----------------------------------------------------
K
Q
Q
K
V
-----
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
C
R
E
E
-
I
E
R
E
V
S
I
L
-
R
-
Q
V
L
-
H
P
N
I
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
--
F
L
-----------------------
A
Q
-------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
---
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
I
T
A
V
S
Y
D
F
D
--
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
P
V
D
T
Q
Q
A
M
V
-
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-------------------------------------------------------------------
135
HHSearch
65.16
32%
-97
- C1 -
3HKO
2
?
A:
[24-337]
---------------------------------------------------------
L
-----
Q
K
K
Y
H
L
--
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
-----
K
I
R
Q-----------
K
----
D
V
E
R
-
I
K
T
E
V
R
L
M
-
K
-
K
L
-
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
----
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
N
K
--
S
F
E
I
K
L
V
D
F
G
L
S
-
K
E
F
Y
K
LNN
G
------
A
G
T
P
Y
F
V
A
P
E
V
L
------
N
------
T
TN
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
T
I
----
S
Q
V
L
N
K
K
L
C
F
E
--
N
P
N
Y
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
------
S
Q
F
S
D
K
I
Y
K
M
-
S
----------------------------------------------------------------------------------
27
PsiBlast_CBE
65.12
45%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
-------------------------------------------------------
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
K
-------
S
-----RRGV
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
----------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
-
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
---
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
---------------------------------------------------------------------------------------------
66
PsiBlast_CBE
64.89
31%
-108
- C1 -
3LIJ
1
?
A:
[15-329]
-------------------------
Y
F
Q
G
D
L
Q
A
T
P
G
M
F
I
T
S
K
K
G
H
L
S
E
M
Y
Q
R
V
K
-------------------
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
---------------------
S
----
S
N
S
K
-
L
L
E
E
V
A
V
L
-
K
-
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
----
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
-------------------------
H
-------------
R
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
E
-
K
D
A
L
I
K
I
V
D
F
G
L
S
-
A
V
F
E
N
---
Q
K
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
K----
K
------
Y
--
D
E
---
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
----
R
K
V
E
K
G
K
Y
T
F
D
--
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
M
C
S
K
K
E
S
---
L
P
S
---
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
K
L
T
S
Q
E
E
T
K
E
L
T
D
I
F
R
H
I
D
K
N
G
D
G
Q
L
D
R
Q
E
L
I
D
G
Y
S
K
L
S
G
E
E
V
A
V
F
P
Q
I
E
S
E
V
D
A
39
PsiBlast_CBE
64.25
44%
-97
- C1 -
2CKE
1
DAPK2_HUMAN
B:
[3-296]
-------------------------------------------------------
E
P
F
KQQK
V
E
D
F
Y
D
I
--
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
QSRAS
R
R
G
-------
V
---------
S
R
E
E
-
I
E
R
E
V
S
I
L
R
Q
-
V
L
H
H
N
--
V
I
T
L
H
D
V
Y
E
N
----
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
-------------------------
Q
-------------
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
-
H
E
I
E
D
---
G
V
E
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
I
T
S
V
S
Y
D
F
D
--
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
------
T
P
V
D
N
Q
Q
A
M
V
-
R
R
E
S
V
V
N
L
E
N
F
R
K
Q
Y
V
-------------------------------------------------------------------
25
PsiBlast_CBE
64.03
45%
-124
- C1 -
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
-------------------------------------------------------
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
------------------------V---
S
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
-------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
---------------------------------------------------------------------------------------------
45
PsiBlast_CBE
62.61
38%
-100
- C1 -
2X4F
3
MYLK4_HUMAN
B:
[69-352]
---------------------------------
P
P
A
---
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
----------
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
-------
G
-------
M
----
K
----
D
K
E
E
-
V
K
N
E
I
S
V
M
-
N
--
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
------------------------
D
E
-------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
---
R
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
--
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
----
N
N
I
L
A
C
R
W
D
L
E
--
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------
S
D
H
K
L
H
S
R
L
-------------------------------------------------------------------------------------
129
HHSearch
62.39
40%
-111
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[81-349]
-----------------------------------------------------
K
Q
G
A
V
-----
N
S
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
-----
G
---------
M
----
K
----
D
K
E
E
-
V
K
N
E
I
S
V
M
-
N
-
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
------------------------
E
-------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
--
A
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
---
R
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
--
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
----
N
N
I
L
A
C
R
W
D
L
E
--
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------
S
D
H
K
L
H
S
R
L
S
-
A
Q
---------------------------------------------------------------------------------
46
PsiBlast_CBE
60.74
38%
-99
- C1 -
2X4F
4
MYLK4_HUMAN
A:
[69-352]
---------------------------------
P
P
A
---
P
F
D
H
R
I
V
T
A
K
Q
G
A
V
N
S
----------
F
Y
T
V
S
K
T
E
I
L
G
-----
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
T
R
-------
G
-------
M
----
K
----
D
K
E
E
-
V
K
N
E
I
S
V
M
-
N
--
Q
L
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
----
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
------------------------
D
E
-------------
S
Y
N
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
L
C
V
N
R
D
-
A
-
K
Q
I
K
I
I
D
F
G
L
A
-
R
R
Y
K
P
---
R
E
K
L
K
V
N
F
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
--
D
F
V
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
G
D
N
D
A
E
T
L
----
N
N
I
L
A
C
R
W
D
L
E
--
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
S
E
A
L
K
H
P
W
L
------
S
D
H
K
L
H
S
R
L
S
-
A
Q
---------------------------------------------------------------------------------
13
PsiBlast_PDB
59.10
45%
-116
- C1 -
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
-------------------------------------------------------
E
N
V
-----
D
D
Y
Y
D
--
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
-----
R
T
-------------------
R
E
D
-
I
E
R
E
V
S
I
L
-
K
-
E
I
Q
-
H
P
N
V
I
T
L
H
E
V
Y
E
N
----
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
-----------------------
E
K
-------------
E
-
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
-V
P
K
P
R
I
K
I
I
D
F
G
L
A
-
H
K
I
D
---------------
E
F
V
A
P
E
I
V
------
N
------
Y
--
E
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
----
A
N
V
S
A
V
N
Y
E
F
E
--
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
------
K
---------------------------------------------------------------------------------------------
98
PsiBlast_CBE
57.02
38%
-119
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[26-277]
--------------------------------------------------------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
----------------------------
S
M
E
---
N
E
I
A
V
L
-
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
-------------------------
E
-------------
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
L
S
-
K
M
E
D
P
---
G
--------
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
--
K
--
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
----
E
Q
I
L
K
A
E
Y
E
F
D
--
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
------
A
---------------------------------------------------------------------------------------------
65
PsiBlast_CBE
56.99
34%
-103
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[29-295]
---------------------------------------------------------
F
-----
T
D
D
Y
Q
L
F
--
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
T
K
-----
K
L
S
-------
A
----
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
C
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
E
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
--
D
P
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
K
L
Y
----
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
A
L
K
H
P
W
V
------
C
Q
R
S
T
V
A
S
M
M
-
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
---------------------------------------------------------------
97
PsiBlast_CBE
54.21
35%
-95
- C1 -
3MA6
1
?
A:
[29-291]
--------------------------------------------------------
I
F
-----
S
D
R
Y
K
--
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
-----
Q
V
K
-------
Q
----
K
----
T
D
K
E
S
L
L
R
E
V
Q
L
L
-
K
--
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
-----------------------
R
K
-------------
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
----
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G----
T
------
Y
--
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
----
K
K
V
E
K
G
K
Y
T
F
E
--
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------
Q
T
Y
T
K
-----------------------------------------------------------------------------------------
104
PsiBlast_CBE
53.02
38%
-119
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[26-277]
--------------------------------------------------------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
--------------------------------
N
E
I
A
V
L
-
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
-------------------------
E
-------------
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
---------------------
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
----
E
Q
I
L
K
A
E
Y
E
F
D
--
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
------
A
G
D
T
A
L
D
K
N
I
-
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------------------------------------------------------------------
103
PsiBlast_CBE
52.19
38%
-113
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[26-277]
--------------------------------------------------------------------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------------
N
E
I
A
V
L
-
H
-
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
E
S
----
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
-------------------------
E
-------------
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
L
D
-
E
D
S
K
I
M
I
S
D
F
G
-----------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
K
L
F
----
E
Q
I
L
K
A
E
Y
E
F
D
--
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
------
A
G
D
T
A
L
D
K
N
I
-
H
Q
S
V
S
E
Q
I
K
K
N
F
A
----------------------------------------------------------------------
63
PsiBlast_CBE
48.76
35%
-100
- C1 -
2VN9
1
KCC2D_HUMAN
B:
[11-268]
-------------------------------------------------------------------------
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
-----
K
L
S
-------
A
----
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
----
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
------
C
Q
R
S
T
V
A
S
M
M
-
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
--------------------------------------------------------
96
PsiBlast_CBE
48.69
35%
-89
- C1 -
3MA6
1
?
B:
[29-291]
--------------------------------------------------------
I
F
-----
S
D
R
Y
K
--
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
-----
Q
V
K
-------
Q
---------
T
D
K
E
S
L
L
R
E
V
Q
L
L
-
K
--
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
----
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
-----------------------
R
K
-------------
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
K
S
-
K
D
A
N
I
R
I
I
D
F
G
L
S
-
T
H
F
E
A
---
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G----
T
------
Y
--
D
E
---
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
Y
D
I
L
----
K
K
V
E
K
G
K
Y
T
F
E
--
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
------
Q
T
Y
T
------------------------------------------------------------------------------------------
61
PsiBlast_CBE
47.60
34%
-91
- C1 -
2WEI
1
?
A:
[30-286]
--------------------------------------------------------------------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
-----
S
A
K
-------
N
----
K
----
D
T
S
T
-
I
L
R
E
V
E
L
L
-
K
--
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
----
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
-------------------------
K
-------------
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
K
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
---
N
T
K
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G----
T
------
Y
--
D
E
---
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
----
K
R
V
E
T
G
K
Y
A
F
D
--
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
------
Q
K
Y
S
S
E
----------------------------------------------------------------------------------------
64
PsiBlast_CBE
47.27
35%
-101
- C1 -
2VN9
2
KCC2D_HUMAN
A:
[11-268]
-------------------------------------------------------------------------
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
-----
K
L
S
-------
A
----
R
----
D
H
Q
K
-
L
E
R
E
A
R
I
C
-
R
-
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
----
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------------------------------------
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
K
S
-
K
G
A
A
V
K
L
A
D
F
G
L
A
I
E
V
Q
G
D
---
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
--
D
P
Y
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
L
Y
----
Q
Q
I
K
A
G
A
Y
D
F
P
--
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
S
E
A
L
K
H
P
W
I
------
C
Q
R
S
T
V
A
S
M
M
-
H
R
Q
E
T
V
D
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
--------------------------------------------------------
57
PsiBlast_CBE
46.05
37%
-104
- C1 -
2W4O
1
KCC4_HUMAN
A:
[60-331]
-------------------------------------------------------------------------
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
-------------------------------
I
----
G
V
L
---
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
----
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
-------------------------
E
-------------
K
G
Y
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
A
T
P
A
-
P
D
A
P
L
K
I
A
D
F
--------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
------
G
--
C
A
Y
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
-
D
E
R
G
D
Q
F
----
M
F
R
R
I
L
N
C
E
Y
Y
FI
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
F
Q
A
L
Q
H
P
W
V
------
T
G
K
A
A
N
F
V
H
M
D
T
A
Q
K
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
---------------------------------------------------------
134
HHSearch
45.89
30%
-103
- C1 -
1NXK
1
MAPK2_HUMAN
A:
[53-328]
---------------------------------------------------
Q
I
K
K
N
A
I
-----
I
D
D
Y
K
V
T
-
S
Q
V
L
G
L
G
I
N
G
K
V
L
Q
I
F
N
K
R
T
Q
E
K
F
A
L
K
M
L
Q
D
C
---------------------------
P
K
-
A
R
R
E
V
E
L
H
-
W
-
R
A
S
Q
C
P
H
I
V
R
I
V
D
V
Y
E
N
LYAG
R
K
C
L
L
I
V
M
E
C
L
D
G
G
E
L
F
S
R
I
Q
D
-----------------------
R
----------------
A
F
T
E
R
E
A
S
E
I
M
K
S
I
G
E
A
I
Q
Y
L
H
S
I
N
I
A
H
R
D
V
K
P
E
N
L
L
Y
T
S
K
R
-
P
N
A
I
L
K
L
T
D
F
G
F
A
-
K
E
T
T
--------------
P
Y
Y
V
A
P
E
V
L
------
G
------
P
--
E
K
Y
D
K
S
C
D
M
W
S
L
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
Y
S
N
H
G
L
A
I
S
PG
M
K
T
R
I
R
M
G
Q
Y
E
F
P
--
N
P
E
W
S
E
V
S
E
E
V
K
M
L
I
R
N
L
L
K
T
E
P
T
Q
R
M
T
I
T
E
F
M
N
H
P
W
I
------
M
Q
S
T
K
V
P
Q
T
P
-
L
H
T
S
R
V
L
K
E
D
-------------------------------------------------------------------------
99
PsiBlast_CBE
41.19
38%
-104
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[17-265]
--------------------------------------------------------------------------
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
S
--------------------------
S
L
E
---
N
E
I
A
V
L
-
K
K
I
K
H
E
N
--
I
V
T
L
E
D
I
Y
E
S
----
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
-------------------------
E
-------------
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
E
-
E
N
S
K
I
M
I
T
D
F
G
L
S
-
K
M
E
Q
N
---
G
I
-
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
--
K
P
Y
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
L
F
----
E
K
I
K
E
G
Y
Y
E
F
E
--
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
------
D
G
N
T
A
L
H
R
D
I
-
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
---------------------------------------------------------------------