@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ST32A_HUMAN: (2015-10-19 )
MGANTSRKPPVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINWDAVFQKRLIPGFIPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKKEKDMRKCDSSQTCLLQEHLDSVQKEFIIFNREKVNRDFNKRQPNLALEQTKDPQGEDGQNNNL
Atome Classification :
(24 SA)
.........10........20........30........40.---..---.....50........60-........70...-.-...-.80........90........100.......110.......120.......130.......140........150.......160.......-170-........180.......190.......200.......210.......220.......230.......240.......250.......260.......270--.-----.-----.----.----.....280.......290.......300.----.----.....310.......320.......330.......340.......350.......360.......370.......380.......390....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGANTSRKPPVFDENEDVN
F
D
H
F
E
I
L
R
A
I
GKGSF
G
K
V
C
I
V
QK---ND---T
K
K
M
Y
A
M
K
YM
N
K
Q
K
C
V
E
-
R
N
E
V
R
N
V
F
K
E
L
Q
I
-
M
-QGL-EH
P
F
L
V
N
L
W
Y
SFQDEE
D
M
F
M
V
V
D
L
L
LGG
D
L
R
Y
H
L
Q
QNV
H
F
K
E
E
T
V
K
L
F
I
C
E
L
V
M
A
L
D
Y
L
QN
Q
R
-
I
I
HRDMKPD
N
I
L
LDEHG
H
V
H
I
T
DF
N
I
A
A-M-L-PRE
T
Q
I
T
TMAGTKPYM
A
P
E
M
F
SSRKGAG
Y
S
F
A
V
D
W
W
S
L
G
V
T
A
Y
E
L
LRGRR
P
Y
H
IRSSTSSK
E
I
V
H
T
FE
T
T
V
V
TYP
S
A
W
S
Q
E
M
V
S
L
L
K
K
L
LEPN
P
D
Q
R
F
S
----
Q
-----
L
-----
S
----
D
----VQNFPYMNDI
N
W
D
A
V
F
Q
K
RLIPGFIPNKG----R----LNCDP
T
F
E
L
E
E
M
I
LESKP
L
H
K
K
K
K
R
L
A
K
K
E
K
D
M
R
KCDSS
Q
T
C
L
L
Q
E
H
L
D
S
V
Q
K
E
F
I
I
F
N
R
E
K
VNRDFNKRQPNLALEQTKDPQGEDGQNNNL
50
HHSearch
62.56
33%
-119
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[37-319]
----------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
-
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
---
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
---
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
NLKN
G
-----
V
-----
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
----
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
--------------------------------------------------------------
14
PsiBlast_PDB
61.93
33%
-116
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[39-317]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
-
R
-
V
-
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
-----
L
KNGV-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
----
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------
3
PsiBlast_PDB
61.27
35%
-119
- C1 -
5D9K
2
?
A:
[26-323]
----------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
----------
F
Y
F
D
P
---------------------------------------------------------------------------------------
63
HHSearch
60.31
36%
-113
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[13-303]
--------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
-
E
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
-
E
-
S
I
H
D
---
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
G
---
E
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
AGP
G
D
-----
A
-----
G
----
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
-----------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
60.12
35%
-118
- C1 -
5D9K
2
?
B:
[26-323]
----------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E-------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------T---
F
Y
F
D
P
---------------------------------------------------------------------------------------
54
HHSearch
58.82
34%
-121
- C1 -
4DC2
1
KPCI_MOUSE
A:
[49-356]
-----------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
L
---
K
K
---
T
D
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
-
F
-
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
-
E
G
L
-
R
P
G
D
T
T
S
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
D
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
D
I
V
G
S
N
T
E
D
Y
L
F
Q
V
I
L
E
K
Q
I
R
I
P
R
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
----
C
HPQT
G
F
-----
A
----
D
----
I
Q
G
H
P
F
F
R
N
V
D
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
----
G
EFGL
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
R
K
I
D
Q
S
E
F
E
G
F
E
Y
I
N
P
------------------------------------------------------
2
PsiBlast_PDB
58.19
35%
-120
- C1 -
3G51
1
KS6A3_MOUSE
A:
[14-304]
----------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
----------
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
-
I
------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
58.04
36%
-107
- C1 -
5D9L
2
?
A:
[20-314]
----------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPDG-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
----
R
----
P
E
D
T
F
Y
F
D
P
-----------------------------------------------------------------------------------
17
PsiBlast_PDB
58.02
33%
-116
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[24-302]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
-
R
-
V
-
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
-----
L
KDG
V
-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
----
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------
19
PsiBlast_PDB
56.19
33%
-112
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[24-302]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
-
R
-
V
-
K
G
R
T
W
--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
---
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
---
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
-----
L
KDG
V
-
N
----
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
G
----
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
--------------------------------------------------------------
48
HHSearch
55.79
33%
-120
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
--------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
-
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
-
E
-
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
---
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
---
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
KDD--
F
-----
M
----
E
----
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
----
G
------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.61
36%
-120
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
----------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
-------------------
I
-
L
-
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
-----
G
-----
P
----
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
54.82
34%
-121
- C1 -
3O96
1
AKT1_HUMAN
A:
[148-430]
-----------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----------
N
R
V
-
L
-
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-
E
---------------
P
E
Y
L
A
P
E
V
L
E
D
N
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
---
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
-----
G
-----
S
ED
A
K
E
----
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
------------------------------------------------------------------------------------------------------
67
HHSearch
54.48
37%
-110
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[15-304]
-----------
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
-------
D
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-
E
------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
G
---
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
AGPD
G
-----
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
54.39
31%
-117
- C1 -
2R5T
1
SGK1_HUMAN
A:
[32-320]
--------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
-
E
N
I
-
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
-----
K
-----
D
----
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
----
G
------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.38
34%
-122
- C1 -
4EJN
3
AKT1_HUMAN
A:
[145-427]
-----------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
-
L
-
Q
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
-
E
-
G
-
I
K
----
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
---
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
E
---
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
-----
G
-----
S
E
D
A
K
E
----
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
----
S
----
E
T
D
T
R
Y
F
-------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.14
36%
-112
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[22-308]
--------------
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-------------
I
-
L
-
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
-----
G
-----
P
----
D
GA
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
52.34
35%
-108
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[14-304]
----------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
-------
D
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E-------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
52.03
36%
-125
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
----------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
D
---
S
G
H
L
Y
A
M
K
V
L
--------------------
I
-
L
-
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
---
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
-----
G
-----
P
----
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
51.06
35%
-107
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[15-305]
----------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
------
D
I
-
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
-----
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
49
HHSearch
50.91
32%
-111
- C1 -
3TXO
1
A:
[23-321]
--------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
-
L
-
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
-
E
-
G
I
C
---------
G
T
P
D
Y
I
A
P
E
I
L
Q
---
E
M
L
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
F
E
A
---
E
N
E
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
----
S
-----
L
TQGG
E
H
----
A
----
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
SRED
V
----
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
------------------------------------------------------
7
PsiBlast_PDB
50.72
35%
-110
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[15-305]
----------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
----------
L
-
V
E
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E-------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
---
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
---
G
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
-
V
-----
E
----
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
50.56
31%
-114
- C1 -
3HDM
1
SGK1_HUMAN
A:
[32-320]
--------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
-
E
N
I
-
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
-----
K
-----
D
----
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
----
G
------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
49.89
31%
-115
- C1 -
3HDN
1
SGK1_HUMAN
A:
[32-316]
--------------
N
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
-
E
N
I
-
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
P
---
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
-----
K
-----
D
----
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--------------------------------------------------------------------------------------------------------