@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ST32B_HUMAN: (2015-10-19 )
MGGNHSHKPPVFDENEEVNFDHFQILRAIGKGSFGKVCIVQKRDTKKMYAMKYMNKQKCIERDEVRNVFRELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLDEHGHVHITDFNIATVVKGAERASSMAGTKPYMAPEVFQVYMDRGPGYSYPVDWWSLGITAYELLRGWRPYEIHSVTPIDEILNMFKVERVHYSSTWCKGMVALLRKLLTKDPESRVSSLHDIQSVPYLADMNWDAVFKKALMPGFVPNKGRLNCDPTFELEEMILESKPLHKKKKRLAKNRSRDGTKDSCPLNGHLQHCLETVREEFIIFNREKLRRQQGQGSQLLDTDSRGGGQAQSKLQDGCNNNLLTHTCTRGCSS
Atome Classification :
(25 SA)
.........10........20........30........40.---..---.....50........60-........70...-.-.-...80........90........100.......110.......120.......130.......-140.......150.......160.......--170-........180.......190.......200.......210.......220..-.....230.......240.......250.......260.......270----.----.-----..----...280.......290.......300.-...---...310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGGNHSHKPPVFDENEEV
N
F
D
H
F
Q
I
L
R
A
I
GKGSFG
K
V
C
I
V
QK---RD---
T
K
K
M
Y
A
M
K
Y
M
N
K
Q
KCI
E
-
R
D
E
V
R
N
V
F
R
E
L
Q
I
-
M
-Q-GLEH
P
F
L
V
N
L
W
Y
SFQDEE
D
M
F
M
V
V
D
L
L
LGG
D
L
R
Y
H
L
QQN
V
H
FTEG
T
V
K
L
Y
I
C
E
L
A
L
A
L
E
Y
L
Q
R
-
Y
H
I
I
HRDIKPD
N
I
L
LDEHG
H
V
H
I
T
DF
N
I
A
T
--
V
-V-K
G
A
E
R
A
S
SMAGTKPYM
A
P
E
V
F
Q
V
Y
MDRGPGYSY
P
V
D
W
W
S
L
G
I
T
A
Y
E
L
L
RGWRP-
Y
E
I
HSVT
P
I
D
E
I
L
N
M
F
K
V
E
R
V
HYS
S
T
W
C
K
G
M
V
A
L
L
R
K
L
LTKD
P
E
S
R
V
S
----
S
----
L
-----
H
D
----
I
QSVPYLADM
N
W
D
A
V
F
K
K
A
LMPGFVPN-KGR---LNCDP
T
F
E
L
E
E
M
I
LESKP
L
H
K
K
K
K
R
L
A
KNRSRDGTKDSCPL
N
G
H
L
Q
H
C
L
E
T
V
R
E
E
F
I
IF
N
R
E
K
L
R
R
QQGQGSQLLDTDSRGGG
Q
A
Q
S
K
L
Q
DGCNNNL
L
T
H
T
CTRGCSS
3
PsiBlast_PDB
67.96
35%
-124
- C1 -
5D9K
2
?
A:
[26-323]
----------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
---------------
C
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
-
T
-----
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
66.07
33%
-122
- C1 -
2OH0
1
KAPCA_BOVIN
E:
[39-317]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
--
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNGV-
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------
60
HHSearch
65.87
33%
-122
- C1 -
1RDQ
3
KAPCA_MOUSE
E:
[37-319]
----------------
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
A
L
A
P
E
I
I
L
-----
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
F
A
---
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
NLKN
G
----
V
-----
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
------------------------------------------------------------------------------
26
PsiBlast_CBE
65.83
35%
-123
- C1 -
5D9K
2
?
B:
[26-323]
----------------
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------------
C
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
R
-
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-----T--
F
Y
F
D
P
-------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
64.78
33%
-123
- C1 -
2UZT
1
KAPCA_BOVIN
A:
[24-302]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
--
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KDG
V
-
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------
43
PsiBlast_CBE
64.60
32%
-119
- C1 -
3TXO
1
A:
[23-325]
--------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
V
---
K
E
---
T
G
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
-
D
D
D
V
E
C
T
M
T
E
K
R
I
-
L
-
S
L
A
R
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
G
H
C
K
L
A
D
F
G
M
C
K
EG
I
-
C
-----------
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
A
P
-
F
E
A
E
N
E
---
D
D
L
F
E
A
I
L
N
D
E
V
V
Y
P
T
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
----
S
----
L
TQGG
E
H
A
----
I
L
R
H
P
F
F
K
E
I
D
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
EDV
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
V
S
P
----------------------------------------------------------------------
4
PsiBlast_PDB
64.59
35%
-116
- C1 -
5D9L
2
?
A:
[24-314]
--------------
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
I
S
G
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
T
K
M
-
E
R
D
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPDG
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
-
T
G
R
---
P
E
D
T
F
Y
F
D
P
---------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
64.39
33%
-119
- C1 -
3AGM
1
KAPCA_HUMAN
A:
[39-317]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
--
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KN
G
V
-
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------
45
PsiBlast_CBE
63.82
32%
-120
- C1 -
4EJN
3
AKT1_HUMAN
A:
[144-438]
----------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
---
K
A
---
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
-
L
-
Q
-
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
K
--
E
G
I
-
K
-----
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
-----
D
N
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
-
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
M
---
E
E
I
R
F
P
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
----
G
GSE
D
A
-----
K
E
----
I
M
Q
H
R
F
F
A
G
I
V
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
-
V
T
S
---
E
T
D
T
R
Y
F
-----------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
63.15
33%
-118
- C1 -
2UZV
1
KAPCA_BOVIN
A:
[24-302]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
M
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
--
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KDG
V
-
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------
2
PsiBlast_PDB
62.88
35%
-124
- C1 -
3G51
1
KS6A3_MOUSE
A:
[18-304]
--------------
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
----------
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E-
S
-
I
------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
62.24
33%
-116
- C1 -
3AGL
1
KAPCA_HUMAN
A:
[39-317]
-----------------
A
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
--
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KNG
V
-
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
S
E
F
------------------------------------------------------------------------------
13
PsiBlast_PDB
60.64
35%
-116
- C1 -
4GUE
1
KS6A3_MOUSE
A:
[19-305]
--------------
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
----------
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
59
HHSearch
60.35
34%
-124
- C1 -
2R5T
1
SGK1_HUMAN
A:
[33-320]
---------------
P
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
-
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
-
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
-----
K
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
-
F
Y
S
---
R
N
T
A
E
M
Y
D
N
I
L
N
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
KDD-
F
-----
M
E
----
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
-
V
S
G
---------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
59.76
33%
-116
- C1 -
3FHI
1
KAPCA_MOUSE
A:
[41-316]
--------------------
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
---
K
E
---
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
-
L
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
-
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
--
R
-
V
-
K
G
--
R
T
W
T
L
A
G
T
P
E
Y
L
A
P
E
I
I
-----
L
S
K
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
-
F
--
F
A
D
Q
P
I
-
Q
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
----
N
----
L
KN
G
V
-
N
D
----
I
K
N
H
K
W
F
A
T
T
D
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-
F
K
G
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
C
G
K
E
F
T
E
F
------------------------------------------------------------------------------
73
HHSearch
59.37
31%
-117
- C1 -
3WF7
2
KS6B1_HUMAN
A:
[13-304]
--------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
K
VTG
A
N
---
T
G
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
-
E
-
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
--
E
-
S
I
H
D
---
T
H
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
-----
R
S
G
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
-
F
T
G
E
---
N
R
K
K
T
I
D
K
I
L
K
C
K
L
N
L
P
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
AGP
G
D
----
A
-----
G
E
----
V
Q
A
H
P
F
F
R
H
I
N
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
-
L
Q
----------------------------------------------------------------------------------------------------------------
79
HHSearch
58.87
36%
-116
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[14-304]
----------
V
K
E
G
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
---
I
S
GSD
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
-------
D
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
--
E
------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
-----
R
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
---
K
D
R
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
AGPD
G
----
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
57.45
36%
-121
- C1 -
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
----------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
-------------------
I
-
L
-
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E---------------
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
---
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
----
G
-----
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
57.37
35%
-112
- C1 -
4EL9
1
KS6A3_MOUSE
A:
[19-305]
--------------
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
R
------
D
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
-
S
-----
E
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
56.90
35%
-115
- C1 -
3UBD
1
KS6A3_MOUSE
A:
[18-304]
--------------
H
E
K
A
D
P
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
K
ISG
S
D
---
A
R
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-
R
D
R
V
-------
D
I
-
L
-
V
-
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E--------
K
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
-
R
G
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
-
F
Q
G
K
D
R
---
K
E
T
M
T
M
I
L
K
A
K
L
G
M
P
Q
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
----
A
GPD
G
V
-----
E
E
----
I
K
R
H
S
F
F
S
T
I
D
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.85
36%
-113
- C1 -
2Z7R
1
KS6A1_HUMAN
A:
[22-308]
--------------
S
E
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
D
---
S
G
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-------------
I
-
L
-
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E---------------
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
---
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
----
G
-----
P
D
GA
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
54.75
35%
-118
- C1 -
2R5T
1
SGK1_HUMAN
A:
[40-320]
----------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
-
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
----
L
H
K
Q
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
-
V
S
G
---------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.23
36%
-122
- C1 -
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
----------------
K
A
D
P
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
K
VTR
P
D
---
S
G
H
L
Y
A
M
K
V
L
--------------------
I
-
L
-
A
-
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E---------------
G
T
V
E
Y
M
A
P
E
V
----
V
N
R
-
Q
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
-
F
Q
G
K
D
R
K
E
T
M
T
L
I
L
K
A
K
L
G
M
P
Q
F
L
S
T
E
A
Q
---
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
----
S
----
G
-----
P
D
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
--------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
53.17
35%
-111
- C1 -
3HDM
1
SGK1_HUMAN
A:
[40-320]
----------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
-
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
----
L
H
K
Q
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
-
V
S
G
---------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
52.48
35%
-114
- C1 -
3HDN
1
SGK1_HUMAN
A:
[40-316]
----------------------
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
---
K
A
---
E
E
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
-
N
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
-
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
----
L
H
K
Q
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
L
N
----
K
P
L
Q
L
K
P
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
----
A
----
K
-----
D
D
F
M
E
-
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
--------------------------------------------------------------------------------------------------------------------