@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK10_HUMAN: (2015-10-19 )
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSPPVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKRDSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKEVKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQFSQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKREQEMFFKLSEEAECPNPSTPSKAAKFFPYSSADAS
Atome Classification :
(83 SA)
.........10........20........30........40........50........60........-70........80.........90-........100-----........110....-.-.-.120......------.130.......140.......150........160.......170.......180---.........190.......200.......210.......220.......230---...-.....240....--....250.......260-----.........270.......280.......290.......300-.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
F
A
N
F
R
R
I
L
R
L
S
T
F
E
K
R
K
S
R
E
Y
E
H
V
RRDL
D
P
N
E
V
W
E
I
V
G
ELGDGAFG
K
V
Y
KAKNKETG
A
L
A
A
A
K
V
IET-K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
TCD
H
P
-
Y
I
V
K
L
L
G
A
YY------HD
G
K
L
W
I
M
I
EFCPGG-
A
-
V
-
D
A
I
M
L
E
L
DRG------LT
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
DLKAG
N
V
L
M
T
LEG
D
I
R
L
A
DFGVS
A
-----
K
N
L
K
T
L
Q
K
R
DSFIGTPYWMAP
E
V
V
M
C
ETMKDTPYDYK
A
D
I
W
S
L
G
I
T
L
I
E
MA----QIE-PPHHEL
N
-
P
M
R
V
--
L
L
K
I
AKSDPP
T
L
LTP-------SKW
S
V
E
F
R
D
F
L
K
I
A
LDKNPETR
P
S
A
A
Q
L
L
EHP
F
V
S
S
ITS
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
I
EDGRDEGEEEDAV
D
A
A
S
T
L
E
NHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSP
P
V
VAPGNEN
G
L
A
VPVPLRKSRPVSMD
A
R
I
Q
V
A
Q
E
K
Q
V
A
E
QGGDLSPAANRSQKASQSRPN
S
S
A
L
E
T
LGGEKLANGSLEPPAQAAPGPSKRDS
D
C
S
S
LCTSESMDYGTNLSTD
L
S
LNKEMGSLSIK
D
P
K
L
Y
K
K
T
L
K
R
T
R
K
F
V
VDG
V
E
V
S
I
T
T
S
K
IISEDEK
K
D
E
E
M
R
F
L
R
R
Q
E
L
R
E
L
R
L
L
Q
K
E
EHRNQTQLSN
K
H
E
L
Q
L
E
Q
M
H
K
R
F
E
Q
E
I
N
A
K
KK
F
F
D
T
E
L
E
N
L
E
R
Q
Q
K
Q
Q
V
E
K
M
E
Q
D
H
A
V
R
R
R
E
E
A
R
R
I
RLEQDR
D
Y
T
R
F
Q
E
Q
L
K
L
M
K
K
E
V
K
N
E
V
E
K
L
P
R
Q
Q
R
K
E
S
M
K
Q
K
M
E
E
H
T
Q
K
K
Q
L
L
D
R
D
F
V
A
K
Q
K
E
D
L
E
L
A
M
K
R
LTTD
N
R
R
E
I
C
D
K
E
R
E
C
L
M
K
K
Q
E
L
L
R
D
R
E
A
A
L
W
E
M
E
E
H
Q
L
Q
E
R
H
Q
L
V
K
Q
Q
L
K
D
Q
Y
F
L
Q
R
H
E
L
L
R
K
H
E
K
E
R
E
Q
M
Q
R
Y
N
Q
R
M
I
E
Q
L
K
V
R
Q
Q
Q
E
K
ARLPKIQRSEG
K
T
R
M
A
M
Y
K
K
S
L
H
INGGG
S
A
A
E
Q
R
E
K
I
K
Q
F
S
Q
Q
E
E
K
R
Q
K
S
E
R
L
Q
Q
Q
Q
K
H
E
N
Q
M
R
D
M
L
A
Q
C
E
S
N
M
S
E
L
Q
Q
L
Q
NEK
C
H
L
L
V
EH
E
T
Q
K
L
K
A
L
D
E
SHNQ
N
L
K
E
W
R
D
KL
R
P
R
K
K
A
L
E
E
D
L
N
Q
K
K
R
E
Q
E
M
F
F
K
LSEEAECPNPSTP
S
K
A
A
K
FFPYSSADAS
5
PsiBlast_PDB
91.88
100%
-105
- C1 -
5AJQ
2
STK10_HUMAN
A:
[6-294]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.74
100%
-101
- C1 -
4AOT
1
STK10_HUMAN
A:
[3-299]
-----------------
R
K
S
R
E
Y
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
89.31
100%
-107
- C1 -
4USD
1
?
B:
[9-299]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
--------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
-------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
88.39
100%
-96
- C1 -
4AOT
1
STK10_HUMAN
B:
[3-299]
-----------------
R
K
S
R
E
Y
E
H
V
R
R
--
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
-----------
I
G
T
P
Y
W
M
A
P
E
V
V
M
-------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.91
100%
-103
- C1 -
4BC6
2
STK10_HUMAN
A:
[1-293]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.11
100%
-106
- C1 -
2J7T
1
STK10_HUMAN
A:
[10-302]
------------------------
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.23
100%
-103
- C1 -
4EQU
2
STK10_HUMAN
B:
[9-302]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.97
100%
-103
- C1 -
4EQU
2
STK10_HUMAN
A:
[9-302]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
81.97
74%
-98
- C1 -
4USF
1
?
B:
[3-294]
--------------------
K
Q
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
-
V
-
D
A
V
M
L
E
L
E
R
P
------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
-
I
R
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.45
100%
-98
- C1 -
4USE
1
?
A:
[9-301]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
-
K
S
E
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
------
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.06
100%
-97
- C1 -
4USE
1
?
B:
[9-301]
-----------------------
E
H
V
R
R
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
L
E
D
Y
I
V
-
E
I
E
I
L
A
T
C
D
H
P
-
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
-
A
-
V
-
D
A
I
M
L
E
L
D
R
G
------
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.37
74%
-95
- C1 -
2JFL
6
SLK_HUMAN
A:
[26-313]
----------------------
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
-
V
-
D
A
V
M
L
E
L
E
R
P
------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
-
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.34
74%
-95
- C1 -
2UV2
6
SLK_HUMAN
A:
[26-313]
----------------------
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
-
V
-
D
A
V
M
L
E
L
E
R
P
------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
-
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.00
74%
-93
- C1 -
2J51
5
SLK_HUMAN
A:
[26-313]
----------------------
Y
E
H
V
T
R
D
L
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
L
E
D
Y
M
V
-
E
I
D
I
L
A
S
C
D
H
P
-
N
I
V
K
L
L
D
A
F
Y
------
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-
A
-
V
-
D
A
V
M
L
E
L
E
R
P
------
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
-
P
P
H
H
E
L
N
-
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
V
D
S
N
K
P
-
I
R
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
64.78
40%
-80
- C1 -
4O0R
1
PAK1_HUMAN
A:
[17-290]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
64.75
42%
-80
- C1 -
2XIK
2
STK25_HUMAN
A:
[6-289]
--------------------
R
G
F
A
N
Q
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
-
E
E
A
E
-
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
I
T
R
Y
F
G
S
Y
L
------
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
K
P
G
P
------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
-
P
P
N
S
D
L
H
-
P
M
R
V
--
L
F
L
I
P
K
N
S
P
P
T
L
--
E
-------
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
64.29
40%
-83
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[18-291]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
63.93
40%
-86
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[18-291]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
63.91
40%
-87
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
----
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
63.25
40%
-85
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[18-291]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
Q
-
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
63.21
40%
-89
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
62.81
41%
-93
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
-------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
62.58
40%
-88
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
-----
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.45
40%
-84
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[18-291]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
Q
-
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.23
40%
-87
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
62.17
42%
-87
- C1 -
4NZW
1
STK25_HUMAN
B:
[13-286]
--------------------------
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
I
T
R
Y
F
G
S
Y
L
------
K
S
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
K
P
G
P
------
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-------------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
-
P
P
N
S
D
L
H
-
P
M
R
V
--
L
F
L
I
P
K
N
S
P
P
T
L
--
E
-------
G
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
62.12
40%
-87
- C1 -
4P90
1
PAK1_HUMAN
B:
[17-290]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
----------
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
----------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
62.07
40%
-82
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[18-291]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
------
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.62
41%
-87
- C1 -
4U44
2
M4K4_HUMAN
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S---
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
61.35
40%
-81
* C1 *
4O0T
1
PAK1_HUMAN
A:
[17-290]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-
Q
Q
Q
P
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
60.79
44%
-83
- C1 -
3A7H
1
STK24_HUMAN
B:
[19-274]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
60.74
41%
-89
- C1 -
4OBP
2
M4K4_HUMAN
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
59.75
44%
-77
- C1 -
3A7J
1
STK24_HUMAN
A:
[19-274]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
59.68
44%
-87
- C1 -
4O27
1
STK24_HUMAN
B:
[3-258]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
-
D
L
----
L
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
59.46
34%
-93
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[8-269]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
-
P
P
------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
59.45
41%
-84
- C1 -
4U45
1
M4K4_HUMAN
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
59.18
34%
-99
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[8-269]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
-
P
P
-----P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.17
41%
-86
- C1 -
4U43
1
M4K4_HUMAN
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.92
45%
-86
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-259]
-------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
--
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
-
L
-
D
L
----
L
E
P
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.79
41%
-84
- C1 -
4ZK5
2
?
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
E
D
E
E
E
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
A
--------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
58.37
44%
-82
- C1 -
3A7H
1
STK24_HUMAN
A:
[19-274]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.35
41%
-87
- C1 -
4FZF
1
?
B:
[5-260]
------------------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
-
A
-----
L
D
L
L
R
A
G
P
----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
-
P
P
N
S
D
M
H
-
P
M
R
V
--
L
F
L
I
P
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
-
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.06
41%
-87
- C1 -
4FZA
3
STK26_HUMAN
B:
[5-260]
------------------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
-
A
-----
L
D
L
L
R
A
G
P
----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
-
P
P
N
S
D
M
H
-
P
M
R
V
--
L
F
L
I
P
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
-
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.75
42%
-90
- C1 -
3GGF
1
STK26_HUMAN
A:
[20-275]
------------------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
-
A
-----
L
D
L
L
R
A
G
P
----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
--------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
-
P
P
N
S
D
M
H
-
P
M
R
V
--
L
F
L
I
P
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
-
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
57.70
42%
-89
- C1 -
3GGF
1
STK26_HUMAN
B:
[20-275]
------------------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
S
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
-
A
-----
L
D
L
L
R
A
GP----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
---------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
K
G
E
-
P
P
N
S
D
M
H
-
P
M
R
V
--
L
F
L
I
P
K
N
N
P
P
T
L
V
---------
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
-
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
57.54
41%
-91
- C1 -
4RVT
2
M4K4_HUMAN
A:
[23-292]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
----
E
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.17
41%
-93
- C1 -
4OBO
2
M4K4_HUMAN
A:
[21-290]
------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-----
E
I
K
L
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
-
I
T
D
L
V
K
N
T
K
G
N
T
------
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
----------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
A
C
D
E
N
P
D
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
----
E
G
A
-
P
P
L
C
D
M
H
-
P
M
R
A
--
L
F
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
56.68
40%
-81
- C1 -
4ZJI
1
?
D:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-
A
-----
Q
I
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
56.05
34%
-94
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[11-262]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
-
Y
P
R
---
P
-
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
55.48
34%
-97
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[27-282]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
--------
F
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
Y
P
I
G
-------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
54.99
40%
-81
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
-
Q
---
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
--
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
----
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
54.96
34%
-103
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[8-269]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
S
M
A
--
N
S
F
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
GRY
P
I
P
----------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
---------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
54.23
34%
-90
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[11-262]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
E
M
A
--
N
E
F
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
-
Y
P
R
---
P
-
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
53.91
34%
-91
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[11-262]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
E
M
A
--
N
E
--
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
-
Y
P
R
---
P
-
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
52.96
36%
-88
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[10-285]
------------------------------
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
-
V
L
D
I
I
K
H
I
V
A
K
G
EHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
52.81
40%
-78
- C1 -
4ZJI
1
?
C:
[19-292]
------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
K
E
L
I
I
N
-
E
I
L
V
M
R
E
N
K
N
P
-
N
I
V
N
Y
L
D
S
Y
L
------
V
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
-
S
-
L
-
T
D
V
V
T
E
--
T
C
------
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
A
-----
Q
-----
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
---
T
R
K
--
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
----
E
G
E
-
P
P
Y
L
N
E
N
-
P
L
R
A
--
L
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
S
S
-
L
T
P
L
I
A
A
A
K
E
A
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
52.01
35%
-84
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[15-298]
------------------------------
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
-
V
L
D
I
I
K
H
I
V
A
K
G
EHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
---------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
51.82
34%
-91
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[11-262]
-----------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
-
E
I
K
P
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
C
N
S
P
-
Y
I
V
G
F
Y
G
A
F
Y
------
S
D
G
E
I
S
I
C
M
E
H
M
D
G
G
-
S
-
L
-
D
Q
V
L
K
K
A
G
R
-------
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
G
-----
Q
L
I
D
E
M
A
--
N
E
-
V
G
T
R
S
Y
M
S
P
-----
E
R
L
Q
G
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
----
V
G
R
-
Y
P
R
---
P
-
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
-------
A
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
-
D
F
A
G
W
L
C
S
T
I
G
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
51.36
36%
-84
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[10-285]
------------------------------
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
-
V
L
D
I
I
K
H
I
V
A
K
G
EHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
N
-----
F
V
G
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
51.04
37%
-85
- C1 -
5D9H
1
?
A:
[26-293]
-----------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
S
H
P
-
N
V
V
T
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
M
L
-
D
I
I
K
Y
I
V
N
R
G
EHKNGV
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TG
G
D
V
T
R
-------
V
G
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
G
VKEMM--
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
-
L
I
E
K
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
50.63
36%
-87
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[10-285]
------------------------------
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
-
V
L
D
I
I
K
H
I
V
A
K
G
EHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-----------
V
G
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
50.08
36%
-84
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[10-285]
------------------------------
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
-
V
L
D
I
I
K
H
I
V
A
K
G
EHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
------------
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
49.71
37%
-88
- C1 -
5D9H
1
?
B:
[26-293]
-----------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
S
H
P
-
N
V
V
T
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
M
L
-
D
I
I
K
Y
I
V
N
R
G
EHKNGV
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
FLATG
G
D
V
T
R
N
-------
G
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
T
L
E
T
G
VEDKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
-
L
I
E
K
L
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
47.36
35%
-89
- C1 -
2VWI
1
OXSR1_HUMAN
B:
[15-292]
------------------------------
D
D
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
--
V
A
I
K
R
I
N
L
E
-
K
C
Q
T
S
M
D
E
L
L
K
-
E
I
Q
A
M
S
Q
C
H
H
P
-
N
I
V
S
Y
Y
T
S
F
V
------
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
-
S
-
V
L
D
I
I
K
H
I
V
A
K
G
EHKSGV
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
------------
T
P
C
W
M
A
P
E
V
M
--
E
Q
V
R
G
--
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
----
T
G
A
-
A
P
Y
H
K
Y
P
-
P
M
K
V
--
L
M
L
T
L
Q
N
D
P
P
S
L
E
T
G
ML-----
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
42.15
44%
-38
- C1 -
4QMU
1
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
41.24
44%
-37
- C1 -
4QMX
1
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
40.36
44%
-36
- C1 -
4QMT
2
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
40.32
44%
-41
- C1 -
4W8D
1
STK24_HUMAN
A:
[11-266]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
40.16
44%
-41
- C1 -
4QMW
2
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
40.14
44%
-36
- C1 -
4QMN
1
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
39.97
44%
-39
- C1 -
4QMO
3
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
39.39
44%
-39
- C1 -
4QMV
3
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
39.37
44%
-35
- C1 -
4QNA
1
?
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
39.24
44%
-36
- C1 -
4QML
2
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
39.22
44%
-40
- C1 -
4U8Z
1
STK24_HUMAN
A:
[11-266]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
39.05
44%
-38
- C1 -
4W8E
1
STK24_HUMAN
A:
[11-266]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
38.86
44%
-38
- C1 -
4QMY
2
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
38.79
44%
-39
- C1 -
4QO9
4
?
B:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
38.57
44%
-41
- C1 -
4QMQ
3
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
38.38
44%
-39
- C1 -
4QMP
2
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
38.10
44%
-38
- C1 -
4QO9
4
?
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
37.62
44%
-35
- C1 -
4QMS
2
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
36.61
44%
-38
- C1 -
4QMM
3
STK24_HUMAN
A:
[26-281]
------------------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
-
E
E
A
E
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
-
Y
V
T
K
Y
Y
G
S
Y
L
------
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
-
S
----
A
L
D
L
L
E
P
G
P
------
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
G
-----
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
----
R
G
E
-
P
P
H
S
E
L
H
-
P
M
K
V
--
L
F
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
-
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------