@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK11_HUMAN: (2015-10-19 )
MEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGADEDEDLFDIEDDIIYTQDFTVPGQVPEEEASHNGQRRGLPKAVCMNGTEAAQLSTKSRAEGRAPNPARKACSASSKIRRLSACKQQ
Atome Classification :
(22 SA)
.........10........20........30........40.......-.50........60...---.....70........80....-....90..-......100..-.....110.......120.......130..-.....140----..-..----------------.----------------..--------.150-.......160.......170.......180.---.---....--.190.......200.......210.......220.-......-230.......240.......250.......260........270..--.----.----...280.......290.......300........310..-.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEVV
D
P
Q
Q
LGMFTE
G
E
L
M
S
V
G
M
D
T
F
I
H
RIDS
T
E
V
I
Y
Q
P
R
R
K
R
A
K
L
I
G
K
-
Y
L
M
G
D
L
LGEGSY
G
K
V
K
---
E
V
L
D
S
E
T
L
C
R
R
A
V
K
I
L
K
K
K
K
L
-
R
RIPNGE
A
-
N
V
K
K
E
I
Q
L
L
R
R
-
L
R
H
K
N
V
I
Q
L
V
D
V
L
Y
N
E
E
K
Q
K
M
Y
M
V
M
E
Y
C
V
C
-
G
M
Q
E
M
L
D
-----SV-
P
E
----------------K----------------RF--------P
V
C
Q-AH
G
Y
F
C
Q
L
I
D
G
L
E
Y
L
H
SQG
I
V
HKDIKPG
N
L
L
---
L
---TTG
G
--
T
L
K
I
SDL
G
V
A
E
A
LHPFAADDTCRTSQGSPAFQP
P
E
-
I
ANGLD-TFS
G
F
K
V
D
I
W
SA
G
V
T
L
Y
N
ITTGLYPFEG
D
N
I
-
Y
K
L
F
E
N
IGKGSYAI--P----G----DCGP
P
L
S
D
L
L
K
G
M
L
EYEPAK
R
F
S
I
R
-
Q
I
R
Q
H
S
W
F
RKKHP-PAEAPVPIPPSPD
T
K
D
R
WRS
M
T
V
V
P
Y
L
E
D
LHGADEDEDLFDIED
D
I
I
Y
TQDFTVPGQV
P
E
E
E
ASHNGQRRGL
P
K
A
V
CMNGT
E
A
A
QLSTKSRAEGRAPN
P
A
R
K
AC
S
A
S
S
K
I
R
R
L
S
A
CKQQ
101
HHSearch
61.19
37%
-93
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[10-298]
-------------------------------------------
V
Q
L
N
Q
-
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
----------
E
-
Q
V
Y
Q
E
I
A
I
L
K
K
-
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
-
G
--
P
V
M
E
-----
V
P
-
T
L
----------------
K
----------------
P
L
--------
S
E
D
Q
-
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
---
G
E
D
G
--
H
I
K
I
A
D
F
G
V
S
N
E
F
K
G
--
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
-
S
L
S
E
T
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
----
D
QP--
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
-
E
I
K
L
H
P
W
V
T
R
---------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
58.81
34%
-94
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[12-298]
---------------------------------------------
L
N
Q
-
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
---
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------E
Q
V
Y
Q
E
I
A
I
L
K
K
-
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
-
G
--
P
V
M
E
-----
V
P
-
T
L
----------------
K
----------------
P
L
--------
S
E
D
Q
-
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
---
G
E
D
G
--
H
I
K
I
A
D
F
G
V
S
N
E
F
K
--
G
S
D
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
R
K
-
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
-
M
C
L
H
S
K
I
K
S
Q
A
L
E
F
--
P
----
D
QP--
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
-
E
I
K
L
H
P
W
V
T
R
---------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
56.77
35%
-86
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[10-275]
---------------------------------------------
I
G
H
-
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
---
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
-
R
S
L
-
D
V
V
G
-
K
I
K
R
E
I
Q
N
L
K
L
-
F
R
H
P
H
I
I
K
L
Y
Q
V
I
--
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
-
G
--
E
L
F
D
-----
Y
I
-
C
K
----------------
H
G---------------
R
V
--------
E
E
M
E
-
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
M
--
N
A
K
I
A
D
F
G
L
S
N
M
M
---
S
D
G
E
F
L
------
P
N
Y
A
A
P
E
-
V
I
S
G
-
R
-
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
-
P
T
L
F
K
K
I
R
G
G
V
F
Y
I
--
P
----
E
----
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
-
D
I
R
E
H
E
W
F
K
Q
D
L
P
-
S
Y
L
F
P
E
-----------------------------------------------------------------------------------------------------------------
102
HHSearch
56.13
33%
-85
- C1 -
3HKO
2
?
A:
[23-338]
-------------------------------------------
E
L
Q
K
K
-
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
---
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
-
R
Q
--
K
D
V
E
-
R
I
K
T
E
V
R
L
M
K
K
-
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
-
G
--
H
L
L
D
-----
K
L
-
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KT
Q
ICPC
P
E
C
N
E
E
A
I
N
G
SI-
F
R
E
S
L
D
F
V
Q
R
E
K
L
-
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
---
F
---
S
T
N
K
SF
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
N
N
G
------
A
G
T
P
Y
F
V
A
P
E
-
V
L
N
T
T
N
-
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
-
A
D
T
I
S
Q
V
L
N
K
K
L
C
F
EN
P
----
N
YN--
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
-
R
A
L
Q
H
P
W
I
S
Q
F
S
D
-
K
I
Y
K
M
S
-----------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.27
33%
-81
- C1 -
4CZT
4
CIPKN_ARATH
D:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
------------------------------------------------------------------------------------------
12
PsiBlast_PDB
53.89
33%
-80
- C1 -
4CZU
3
CIPKN_ARATH
A:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
-----------------------------------------------------------------------------------------------
27
PsiBlast_CBE
53.56
33%
-79
- C1 -
4CZU
3
CIPKN_ARATH
B:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------
106
HHSearch
53.53
32%
-80
- C1 -
1XJD
1
A:
[16-275]
---------------------------------------------
I
E
D
-
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
---
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
A
L
K
K
D
V
V
-
L
M
D
-
D
D
V
E
-
C
T
M
V
E
K
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
--
K
E
N
L
F
F
V
M
E
Y
L
N
G
-
G
--
D
L
M
Y
-----
H
I
-
Q
S
C
---------------
H
----------------
K
F
--------
D
L
S
R
-
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
L
---
L
---
D
K
D
G
--
H
I
K
I
A
D
F
G
M
C
K
E
N
M
--
L
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
-
I
L
L
G
-
Q
-
K
Y
-
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
-
E
E
L
F
H
S
I
R
M
D
N
P
F
Y
--
P
----
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
-
E
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
----------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
52.76
33%
-76
- C1 -
4CZT
2
CIPKN_ARATH
B:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
52.49
33%
-85
- C1 -
4CQG
1
MELK_MOUSE
A:
[6-292]
-------------------------------------------
E
L
L
K
Y
-
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
---
A
I
K
I
M
D
K
N
A
L
G
S
D
L
P
R
-----
V
K
T
E
I
D
A
L
K
S
-
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
--
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
-
G
--
E
L
F
D
-----
Y
I
I
S
Q
----------------
D
----------------
R
L
--------
S
E
E
E
-
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
N
H
--
K
L
K
L
I
D
F
G
L
C
-
A
K
------------
C
G
S
L
A
Y
A
A
P
E
-
L
I
Q
G
-------
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
D
D
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
----
K
----
W
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
R
-
N
L
L
N
H
P
W
V
M
Q
D
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
V
T
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
L
E
H
H
H
---------------------------------------------------------
8
PsiBlast_PDB
51.28
33%
-77
- C1 -
4CZT
3
CIPKN_ARATH
A:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
51.25
32%
-98
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-276]
--------------------------------------
R
W
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
---
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
--------------
S
M
E
N
E
I
A
V
L
H
K
-
I
K
H
P
N
I
V
A
L
D
D
I
Y
--
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
-
G
--
E
L
F
D
-----
R
I
-
V
E
----------------
K
----------------
G
F
--------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
S
--
K
I
M
I
S
D
F
G
L
S
K
M
E
D
P
G
-----------
T
P
G
Y
V
A
P
E
-
V
L
-
A
Q
K
---
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
Y
E
F
--
D
----
S
PYWD
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
-
Q
A
L
Q
H
P
W
I
A
----------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
51.18
33%
-82
- C1 -
4CZT
3
CIPKN_ARATH
C:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
50.81
33%
-83
- C1 -
4CZU
3
CIPKN_ARATH
C:
[10-272]
---------------------------------------------
V
G
K
-
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
---
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
-
L
K
-
N
K
M
I
A
-
Q
I
K
R
E
I
S
T
M
K
L
-
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
--
K
T
K
I
Y
F
V
L
E
F
V
T
G
-
G
--
E
L
F
D
-----
K
I
-
S
S
----------------
N
G---------------
R
L
--------
K
E
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
G
--
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
-
V
I
N
N
-
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
F
T
C
--
P
----
P
----
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
-
E
V
I
E
N
E
W
F
K
K
G
Y
K
-
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
48.39
31%
-77
- C1 -
4I6F
1
PLK2_HUMAN
A:
[29-288]
-----------------------------------------------
R
-
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
---
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
-
S
K
-
P
H
Q
R
E
-
K
I
D
K
E
I
E
L
H
R
I
-
L
H
H
K
H
V
V
Q
F
Y
H
--
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
KVL
T
E
-
P
E
----------------
V
----------------
R
Y
----------------
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
---
I
---
N
E
S
M
--
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
--
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
-
V
L
N
K
Q
G
---
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
-
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
--
P
----
S
----
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
-
D
I
I
R
H
D
F
F
T
Q
G
F
T
-
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
48.24
31%
-75
- C1 -
4I6B
1
PLK2_HUMAN
A:
[29-288]
-----------------------------------------------
R
-
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
---
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
-
S
K
-
P
H
Q
R
E
-
K
I
D
K
E
I
E
L
H
R
I
-
L
H
H
K
H
V
V
Q
F
Y
H
--
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
KVL
T
E
-
P
E
----------------
V
----------------
R
Y
----------------
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
---
I
---
N
E
S
M
--
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
--
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
-
V
L
N
K
Q
G
---
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
-
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
--
P
----
S
----
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
-
D
I
I
R
H
D
F
F
T
Q
G
F
T
-
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
47.49
31%
-75
- C1 -
4I5P
1
PLK2_HUMAN
A:
[29-288]
-----------------------------------------------
R
-
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
---
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
-
S
K
-
P
H
Q
R
E
-
K
I
D
K
E
I
E
L
H
R
I
-
L
H
H
K
H
V
V
Q
F
Y
H
--
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
KVL
T
E
-
P
E
----------------
V
----------------
R
Y
----------------
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
---
I
---
N
E
S
M
--
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
--
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
-
V
L
N
K
Q
G
---
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
-
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
--
P
----
S
----
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
-
D
I
I
R
H
D
F
F
T
Q
G
F
T
-
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
--------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
46.45
32%
-83
- C1 -
3MA6
1
?
B:
[39-292]
------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
-
T
D
K
E
S
--
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
-
G
--
E
L
F
D
-----
E
I
I
S
R
----------------
K
----------------
R
F
--------
S
E
V
D
-
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
ESK
S
K
D
A
--
N
I
R
I
I
D
F
G
L
S
T
---
H
F
E
A
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
---
T
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
--
E
LPQW
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
Q
T
Y
T
-------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
46.13
31%
-75
- C1 -
4I6H
1
PLK2_HUMAN
A:
[29-288]
-----------------------------------------------
R
-
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
---
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
-
S
K
-
P
H
Q
R
E
-
K
I
D
K
E
I
E
L
H
R
I
-
L
H
H
K
H
V
V
Q
F
Y
H
--
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
KVL
T
E
-
P
E
----------------
V
----------------
R
Y
----------------
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
---
I
---
N
E
S
M
--
E
L
K
V
G
D
F
G
L
A
A
R
L
E
P
L
--
E
H
R
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
-
V
L
N
K
Q
G
---
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
E
T
T
N
L
-
K
E
T
Y
R
S
I
R
E
A
R
Y
T
M
--
P
----
S
----
S
L
L
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
P
S
L
D
-
D
I
I
R
H
D
F
F
T
Q
G
F
T
-
P
D
R
L
S
S
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
45.87
32%
-87
- C1 -
3MA6
1
?
A:
[39-292]
------------------------------------------------------
V
L
G
K
G
S
F
G
E
V
I
---
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
-
K
Q
K
T
D
K
E
S
--
L
L
R
E
V
Q
L
L
K
Q
-
L
D
H
P
N
I
M
K
L
Y
E
--
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
-
G
--
E
L
F
D
-----
E
I
I
S
R
----------------
K
----------------
R
F
--------
S
E
V
D
-
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
ESK
S
K
D
A
--
N
I
R
I
I
D
F
G
L
S
T
---
H
F
E
-
S
K
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
-
V
L
H
G
---
T
Y
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
G
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
Y
T
F
--
E
L
P
Q
W
K
----
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
-
D
A
L
D
H
E
W
I
Q
T
Y
T
K
------------------------------------------------------------------------------------------------------------------------
111
HHSearch
43.72
30%
-83
- C1 -
3TKI
1
CHK1_HUMAN
A:
[4-271]
-------------------------------------------
P
F
V
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
--
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
-
G
--
E
L
F
D
-----
R
I
-
E
P
D---------------
I
----------------
G
M
--------
P
E
P
D
-
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
--
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
-
L
L
K
-
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
----
P
WK--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
-
K
G
A
K
R
P
R
V
T
S
-------------------------------------------------------------------------------------------------------------
97
HHSearch
42.18
30%
-75
- C1 -
2YEX
8
CHK1_HUMAN
A:
[4-270]
-------------------------------------------
P
F
V
E
D
-
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
---
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
----
V
D
C
P
E
-
N
I
K
K
E
I
C
I
N
K
M
-
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
--
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
-
G
--
E
L
F
D
-----
R
I
-
E
P
D---------------
I
----------------
G
M
--------
P
E
P
D
-
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
D
--
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
-
L
L
K
-
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
T
Y
L
--
N
----
P
WK--
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
-
D
I
K
K
D
R
W
Y
N
K
P
L
K
------------------------------------------------------------------------------------------------------------------------