@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK24_HUMAN: (2015-10-19 )
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISDTMVAQLVQRLQRYSLSGGGTSSH
Atome Classification :
(98 SA)
.........10........20.......--.30........40........50........60........70.-.----......80.......-.-90........100.------..-------....110......--.120.-.---------.---....130.......140.......150..-......160.......---170......------.180........190.......200.-----.-----.-....210.......220......----.230..-...----....------240--------.---.---...---...250-.--.---------..--....260.......270.......280.......290...---....300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDSRA
Q
L
W
G
L
A
LNKRRATLPHPGGSTNL--KA
D
P
E
E
L
F
T
K
L
E
K
IGKG
S
F
G
E
V
F
K
G
IDNR
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q-C-DS
P
Y
V
T
K
Y
Y
G
S
Y
LK------D
T
-------
K
L
W
I
I
M
E
Y
LGGG
S
--
A
L
DLL-E---------P---GPL
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
SEHG
E
---
V
K
L
A
DFGVA------GQL-TD
T
Q
I
KRNTFVGT
P
F
WM
A
P
E
V
I
-----
K
-----
Q
-SAYDSKA
D
I
W
S
LG
I
T
A
I
ELARGE----PP--HS-ELH----
P
M
K
V
------
L
F
---------
L
---
I
---PKN---NPPTL--E--G---------N
Y
--
S
K
P
L
K
E
F
V
E
A
C
LNKEPSFR
P
T
A
K
E
L
L
K
H
K
F
I
L
RNAK
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
WKAEQSHDDSSSEDSDAETDGQASGGSDSG
D
W
I
F
T
IREKDPKNLENGALQPSDL
D
R
N
K
M
K
DI
P
K
R
P
F
S
Q
C
L
S
T
I
I
S
P
L
F
A
E
L
K
E
K
S
Q
ACGGNLG
S
I
E
E
L
R
G
A
I
Y
L
A
E
EACPGI
S
D
T
M
V
A
Q
L
V
Q
R
L
Q
R
YSLSGGGTSSH
22
PsiBlast_CBE
89.19
98%
-84
- C2 -
3A7H
1
STK24_HUMAN
B:
[12-298]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.75
98%
-85
- C2 -
3A7H
1
STK24_HUMAN
A:
[12-298]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.64
98%
-84
- C2 -
3A7J
1
STK24_HUMAN
A:
[13-299]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.58
98%
-84
- C2 -
3A7I
1
STK24_HUMAN
A:
[13-299]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.36
99%
-88
- C2 -
4O27
1
STK24_HUMAN
B:
[2-281]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.36
98%
-88
- C2 -
3CKX
1
STK24_HUMAN
A:
[5-283]
---------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-------
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
88.35
97%
-84
- C2 -
3A7I
1
STK24_HUMAN
A:
[13-299]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
84.67
88%
-94
- C2 -
4FZD
1
STK26_HUMAN
B:
[4-283]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
M
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
84.36
84%
-85
- C2 -
2XIK
2
STK25_HUMAN
A:
[4-293]
--------------------
H
L
R
G
F
A
N
Q
H
S
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
-----
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
K
---------
P
---
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
L
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
S
P
P
T
L
--
E
--
G
---------
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
---
L
T
E
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
83.48
88%
-87
- C2 -
4FZA
3
STK26_HUMAN
B:
[4-283]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
M
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.05
88%
-90
- C2 -
4FZF
1
?
B:
[4-283]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
M
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
83.01
87%
-96
- C2 -
3GGF
1
STK26_HUMAN
A:
[18-298]
---------------------------
I
---
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
D
F
G
V
A
----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
M
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-----------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.94
87%
-97
- C2 -
3GGF
1
STK26_HUMAN
B:
[19-298]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
D
F
G
V
A
-----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
M
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
82.35
87%
-93
- C2 -
4NZW
1
STK25_HUMAN
B:
[15-294]
------------------------------
R
V
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
K
---------
P
---
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
---
V
K
L
A
A
F
G
V
A
------
G
---------------
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
---
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
-
D
L
H
----
P
M
R
V
------
L
F
---------
L
---
I
---
P
K
N
---
S
P
P
T
L
--
E
--
G
---------
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
---
L
T
E
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
73.08
42%
-85
- C2 -
4ZK5
2
?
A:
[21-312]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
----
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
72.17
42%
-94
- C2 -
4OBQ
2
M4K4_HUMAN
A:
[21-312]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
-----------------
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
72.10
42%
-87
- C2 -
4OBP
2
M4K4_HUMAN
A:
[21-311]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
----
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
71.57
42%
-85
- C2 -
4U45
1
M4K4_HUMAN
A:
[21-312]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
----
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
71.48
43%
-91
- C2 -
4RVT
2
M4K4_HUMAN
A:
[23-312]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
---------
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
-----------------------------------------------------------------------------------------------------------------------------------------
121
HHSearch
71.12
48%
-94
- C2 -
4OBO
2
M4K4_HUMAN
A:
[21-311]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
------------
E
I
K
L
E
I
N
M
L
K
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
N
TK------
G
---
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
--
K
S-
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
70.34
42%
-84
- C2 -
4U43
1
M4K4_HUMAN
A:
[21-312]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
----
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
70.04
42%
-92
- C2 -
4OBO
2
M4K4_HUMAN
A:
[21-311]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
----------
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
69.94
98%
-44
- C2 -
4W8D
1
STK24_HUMAN
A:
[4-290]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
69.92
42%
-84
- C2 -
4U44
2
M4K4_HUMAN
A:
[21-311]
--------------------------------
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
----
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
-------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
L
V
-
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
---
V
K
L
V
D
F
G
V
S
------
A
-----------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
-
D
M
H
----
P
M
R
A
------
L
F
---------
L
---
I
---
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
69.68
38%
-79
- C2 -
4FIE
1
PAK4_HUMAN
A:
[155-421]
---------------------------------------
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
F
L
E
G
G
A
--
L
T
D
I
V
-
T
---------
H
---
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
-
N
E
P
----
P
L
K
A
------
M
K
---------
M
---
I
---
R
D
N
---
L
P
P
R
L
--
K
--
N
LH-------
K
V
--
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
-
A
S
---
I
V
P
L
M
R
Q
N
R
T
------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.41
98%
-41
- C2 -
4QMO
4
STK24_HUMAN
A:
[19-304]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.00
98%
-42
- C2 -
4QMV
3
STK24_HUMAN
A:
[19-305]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
68.89
98%
-42
- C2 -
4W8E
1
STK24_HUMAN
A:
[4-291]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
68.55
98%
-43
- C2 -
4QMZ
1
STK24_HUMAN
A:
[20-306]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
68.54
98%
-43
- C2 -
4U8Z
1
STK24_HUMAN
A:
[4-290]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
68.29
98%
-42
- C2 -
4QMX
1
STK24_HUMAN
A:
[19-306]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
68.12
98%
-41
- C2 -
4QMU
2
STK24_HUMAN
A:
[19-305]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
67.91
98%
-40
- C2 -
4QMY
2
STK24_HUMAN
A:
[19-305]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.63
98%
-42
- C2 -
4QMP
2
STK24_HUMAN
A:
[19-305]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
67.62
41%
-90
- C2 -
4USF
1
?
B:
[13-294]
--------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
-
S
-
E
----
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
-------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
-
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
---
I
K
L
A
D
F
G
V
S
------
A
K
N
----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
-----
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
-----
I
R
E
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.45
98%
-39
- C2 -
4QNA
1
?
A:
[22-306]
--------------------------
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.37
98%
-44
- C2 -
4QMQ
3
STK24_HUMAN
A:
[19-305]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.37
98%
-41
- C2 -
4QMN
1
STK24_HUMAN
A:
[22-305]
--------------------------
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
67.34
98%
-39
- C2 -
4QO9
4
?
B:
[20-305]
------------------------
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
67.15
41%
-95
- C2 -
4USF
1
?
A:
[13-294]
--------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
-
S
-
E
----
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
-------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
-
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
---
I
K
L
A
D
F
G
V
S
------
A
K
--------------
T
P
Y
W
M
A
P
E
V
V
M
C
E----------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
-----
I
R
E
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.11
44%
-86
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[17-295]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
---------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
K
--------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.86
98%
-40
- C2 -
4QMW
2
STK24_HUMAN
A:
[19-305]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.64
98%
-41
- C2 -
4QML
2
STK24_HUMAN
A:
[25-305]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.59
98%
-44
- C2 -
4QMT
2
STK24_HUMAN
A:
[22-306]
--------------------------
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.58
98%
-41
- C2 -
4QMM
3
STK24_HUMAN
A:
[19-304]
-----------------------
G
M
Q
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
66.01
98%
-41
- C2 -
4QMS
2
STK24_HUMAN
A:
[22-305]
--------------------------
N
L
--
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.70
98%
-40
- C2 -
4QO9
4
?
A:
[25-305]
-------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
----
D
E
I
E
D
I
Q
Q
E
I
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
-------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
L
L
-
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
-
E
L
H
----
P
M
K
V
------
L
F
---------
L
---
I
---
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
65.68
45%
-92
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----------
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
65.30
45%
-93
- C2 -
4ZJI
1
PAK1_HUMAN
A:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
64.87
45%
-89
- C2 -
4P90
1
PAK1_HUMAN
B:
[17-286]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---------------
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
64.46
43%
-79
- C2 -
4O0R
1
PAK1_HUMAN
A:
[16-293]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
64.41
45%
-96
- C2 -
5AJQ
2
STK10_HUMAN
A:
[13-276]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
-------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
64.15
37%
-101
- C2 -
3SLS
2
MP2K1_HUMAN
A:
[27-285]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
IG-----
A
----
I
F
E
L
------
L
D
---------
Y
---
I
---
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
N
Q
---------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
63.97
46%
-92
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[16-286]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
I
I
-
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
-------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
63.89
43%
-78
- C2 -
4O0T
1
PAK1_HUMAN
A:
[16-294]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
----
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
K
--------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
63.80
45%
-83
- C2 -
3FXZ
1
?
A:
[17-293]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
-
P
-----
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
NP
E
---------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
63.30
46%
-88
- C2 -
5D9H
1
?
A:
[24-305]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
M
L
D
I
I
-
K
Y
I
V
N
R
GEHK
N
---
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
TG
G
D
V
-
T
R
--------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
T
L
--
E
--
T
GVKEMMK--
K
Y
--
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A
K
N
R
E
Y
---
L
I
E
K
L
L
----------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
63.27
46%
-95
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[16-286]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
I
I
-
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
----
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
63.19
44%
-83
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[17-294]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
63.14
45%
-92
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
62.91
44%
-76
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[17-295]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
----
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
---------------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
K
--------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
62.86
45%
-92
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
----------
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
62.00
34%
-99
- C2 -
4U81
2
MP2K1_HUMAN
A:
[8-304]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
--
D
A
K
E
L
E
L
M
FP
P
M
A
I
------
F
E
---------
L
L
D
Y
I
---
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
N
----------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
61.80
44%
-82
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[17-295]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-------
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
K
--------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
61.72
46%
-90
- C2 -
5D9H
1
?
B:
[24-305]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
M
L
D
I
I
-
K
YIVNRGEHK
N
---
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
AFLATG
G
D
V
-
T
R
N
--------
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
T
L
--
E
--
T
GVEDKEMMK
K
Y
--
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A
K
N
R
E
Y
---
L
I
E
K
L
L
T
---------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.48
46%
-93
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[16-286]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
I
I
-
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
I
T
R
N
-
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
61.18
37%
-91
- C2 -
4AN3
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
-
P
M
A
----
I
F
E
L
------
L
D
---------
Y
---
I
---
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
61.10
44%
-74
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[17-294]
-------------------------------
G
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
--
Q
----
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
61.00
44%
-84
- C2 -
2J7T
1
STK10_HUMAN
A:
[13-296]
---------------------------
R
--
D
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
--
V
D
A
I
M
-
L
E
L
-------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
-----
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
-
S
N
K
A
---
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
60.90
37%
-94
- C2 -
3ORN
3
MP2K1_HUMAN
A:
[8-272]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
--------
P
----
P
M
A
I
------
F
E
---------
L
L
D
Y
I
---
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
60.64
45%
-91
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M-------------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
60.30
38%
-85
- C2 -
3EQC
2
MP2K1_HUMAN
A:
[37-331]
---------------------------------------
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
-
K
---------
K
A
--
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
-
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
I
P
-
P
P
D
----
A
K
E
L
E
L
M
F
GC--PMA
I
F
E
L
L
D
Y
---
I
---
V
N
E
---
P
P
P
K
L
P-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
N
----------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
59.57
46%
-92
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[16-286]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
I
I
-
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
--------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
59.53
46%
-90
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[21-298]
-----------------------------------------
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
I
I
-
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
-----
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
K
N
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
59.24
37%
-92
- C2 -
3WIG
3
MP2K1_HUMAN
A:
[8-272]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
-------
P
----
P
M
A
I
------
F
E
---------
L
L
D
Y
I
---
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
59.16
45%
-98
- C2 -
4USD
1
?
B:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
MC-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
58.94
38%
-76
- C2 -
4JDI
1
PAK4_HUMAN
A:
[76-343]
-------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
F
L
E
G
G
A
--
L
T
D
I
V
-
T
---------
H
---
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
-
N
E
P
----
P
L
K
A
------
M
K
---------
M
---
I
---
R
D
N
---
L
P
P
R
L
--
K
--
N
LH-------
K
V
--
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
----
I
V
P
L
M
R
Q
N
R
-------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
58.84
37%
-88
- C2 -
4ANB
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
-
P
M
A
----
I
F
E
L
------
L
D
---------
Y
---
I
---
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
58.73
40%
-82
* C2 *
4KS7
2
A:
[20-282]
--------------------------------
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
-------
E
L
W
V
L
M
E
F
L
Q
G
G
A
--
L
T
D
I
V
-
S
---------
Q
---
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
I
-
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
-
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
-
S
D
S
----
P
V
Q
A
------
M
K
---------
R
---
L
---
R
D
S
---
P
P
P
K
L
--
K
NS
H
---------
K
V
--
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
C
L
---
V
P
L
I
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.72
45%
-90
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
--------------
G
T
P
Y
W
M
A
P
E
V
V
M--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
-----------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
58.32
45%
-85
- C2 -
4ZJI
1
?
D:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
-------
A
Q
I
-
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
58.29
37%
-88
- C2 -
4AN9
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
-
P
M
A
----
I
F
E
L
------
L
D
---------
Y
---
I
---
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
57.81
45%
-91
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
57.62
39%
-77
- C2 -
4KS8
1
A:
[18-279]
------------------------------
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
-
Q
----
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
-
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
------
G
E
-------
E
L
W
V
L
M
E
F
L
Q
G
G
A
--
L
T
D
I
V
-
S
---------
Q
---
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
I
-
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
-
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
-
S
D
S
----
P
V
Q
A
------
M
K
---------
R
---
L
---
R
D
S
---
P
P
P
K
L
--
K
--
N
---------
S
H
KV
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
T
G
L
P
E
C
L
---
V
P
L
I
------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
56.80
46%
-88
- C2 -
2VWI
1
OXSR1_HUMAN
B:
[21-292]
-----------------------------------------
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
-------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
I
I
-
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
--------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
-
K
Y
P
----
P
M
K
V
------
L
M
---------
L
---
T
---
L
Q
N
---
D
P
P
S
L
--
E
--
T
GMLK-----
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
56.45
41%
-75
- C2 -
2UV2
6
SLK_HUMAN
A:
[34-313]
--------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
-
E
----
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
-------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
-
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
---
I
K
L
A
D
F
G
V
S
------
A
K
N
-
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
-----
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
55.90
45%
-91
- C2 -
4EQU
2
STK10_HUMAN
A:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------------
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
M
E
E
--------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
55.80
45%
-83
- C2 -
4BC6
2
STK10_HUMAN
A:
[8-271]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
55.62
37%
-101
- C2 -
3OS3
2
MP2K1_HUMAN
A:
[8-272]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP---------------
M
A
I
------
F
E
---------
L
L
D
Y
I
---
V
N
E
---
P
P
P
K
L
P--------------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
--------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
55.23
37%
-89
- C2 -
4AN2
2
MP2K1_HUMAN
A:
[11-265]
-------------------------------------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
----
A
I
R
N
Q
I
I
R
E
L
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
------
D
G
-------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
V
L
K
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
-
P
M
A
----
I
F
E
L
------
L
D
---------
Y
---
I
---
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
55.12
45%
-84
- C2 -
4ZJI
1
?
C:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
-----------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
-------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
54.36
45%
-85
- C2 -
4USE
1
?
B:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
------------------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
54.23
45%
-88
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[19-288]
--------------------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
---------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
---------------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
V
V
-
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
---
V
K
L
T
D
F
G
--------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
--------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
-
N
E
N
----
P
L
R
A
------
L
Y
---------
L
---
I
---
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
53.69
30%
-79
- C2 -
3C0I
1
CSKP_HUMAN
A:
[21-293]
--------------------------------
L
F
E
D
V
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SPG
L
S
T
E
D
L
K
R
E
A
S
I
C
H
M
-
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
------
D
G
-------
M
L
Y
M
V
F
E
F
M
D
G
A
D
--
L
C
F
E
I
-
V
K
R
A
D
A
----
G
---
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
-
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
N
S
A
P
V
K
L
G
G
F
G
V
A
------
I
Q
L
-
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
-----
R
-
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
----
L
P
--
F
Y
-
G
T
K
----
E
-
R
L
------
F
E
---------
G
---
I
---
I
K
G
K
Y
K
M
N
P
R
Q
--
W
--
S
---------
H
I
--
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
---
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
----------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
53.69
45%
-83
- C2 -
4USE
1
?
A:
[16-279]
--------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
-------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
-
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
L
---
R
E
L
V
A
E
A
K
A
E
V
M
E
---------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
52.41
41%
-74
- C2 -
2J51
5
SLK_HUMAN
A:
[34-313]
--------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
-
E
----
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
-------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
E
-
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
---
I
K
L
A
D
F
G
V
S
------
A
K
N
-
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
-
E
L
N
----
P
M
R
V
------
L
L
---------
K
---
I
---
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
-----
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
51.33
32%
-97
- C2 -
2W5A
5
NEK2_HUMAN
A:
[10-273]
---------------------------------------
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
----
A
E
K
Q
M
L
V
S
E
V
N
L
L
R
E
-
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT----
N
T
-------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
--
L
A
S
V
I
-
T
K
G
T
K
E
----
R
---
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-
S
-
L
-
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
---
V
K
L
G
D
F
G
L
A
------
R
I
L
----
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-----
N
-----
R
-
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
----
P
P
--
F
T
-
A
F
S
----
Q
K
E
L
------
A
G
---------
K
---
I
---
R
E
G
---
K
F
R
R
I
--
P
--
Y
---------
R
Y
--
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
48.68
30%
-93
- C2 -
1ZY4
1
GCN2_YEAST
A:
[8-290]
-------------------------------------
F
E
E
I
A
V
L
G
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
S
R
Y
Y
A
I
K
K
I
R
H
--
T
-
E
----
E
K
L
S
T
I
L
S
E
V
M
L
L
A
S
-
L
-
N
H
Q
Y
V
V
R
Y
Y
A
A
W
L
E
------
R
R
N
F
VK
K
K
S
T
L
F
I
Q
M
E
Y
C
E
N
G
T
--
L
Y
D
L
I
-
H
---------
S
EN-
L
N
Q
Q
R
D
E
Y
W
R
L
F
R
Q
I
L
E
A
L
S
Y
I
H
S
Q
-
G
I
I
-
H
R
D
L
K
P
M
N
I
F
I
D
E
S
R
N
---
V
K
I
G
D
F
G
L
A
------
K
N
V
-
H
R
-----------
A
M
Y
V
A
T
E
V
L
-----
D
-----
G
T
G
H
Y
N
E
K
I
D
M
Y
S
L
G
I
I
F
F
E
M
I
Y
------
P
F
--
S
T
-
G
M
E
----
R
V
N
I
------
L
K
---------
K
---
L
R
SV
S
I
E
---
F
P
P
D
F
--
D
--
D
---------
N
K
--
M
K
V
E
K
K
I
I
R
L
L
I
D
H
D
P
N
K
R
P
G
A
R
T
L
L
N
S
G
W
L
P
V
K
H
Q
D
E
V
I
---
K
E
A
L
K
S
----------------------------------------------------------------------------------------------------------------------------------------------