@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK25_HUMAN: (2015-10-20 )
MAHLRGFANQHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSPHSKLHKGTALHSSQKPAEPVKRQPRSQCLSTLVRPVFGELKEKHKQSGGSVGALEELENAFSLAEESCPGISDKLMVHLVERVQRFSHNRNHLTSTR
Atome Classification :
(100 SA)
------------------------------------------------.........10..--..--....20...-.....30........40........50.....-..----.60......-..70.-.-......80......--..------90........100--...---..-----.---------.---110.......120.......130..-...-..140.......150-.---......160------...-....170.......180.....-----.-----.-190.......200.......210----..--..---------...220-------....---------....230-.....--.--.---------..--240.......250.......260.......270.......---280.......290........300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------M
A
H
L
R
G
F
A
N
QHSR--V
D
--
P
E
E
L
F
T
K
L
D
-
R
IGKG
S
F
G
E
V
Y
K
G
IDNHT
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q-C-D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--S
T
------
K
L
W
I
I
M
E
Y
LGGG
S
--
A
L
D---LL-----K---------P---GPL
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
LSEQG-
D
---
V
K
L
ADFGVA------GQL-TD
T
Q
I
KRNTFVGT
P
F
WM
A
P
E
V
I
-----
K
-----Q-SAYDF
K
A
D
I
W
S
LG
I
T
A
I
E
LAKGE----PP--NS---------DLH
P
M
--------
R
V
L
F
---------
L
I
PKN---SPPTL--E--G---------QH--SK
P
F
K
E
F
V
E
A
C
LNKDPRFR
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
---
L
T
E
L
I
D
R
Y
K
R
W
-KSEGHGEESSSEDSDIDGEAEDGEQGPIWTFPPTIRPSP
H
S
K
LHKGTALHSSQKPA
E
P
V
KRQ
P
R
S
Q
C
L
S
T
L
V
R
P
V
F
G
E
L
K
E
K
H
K
QSGGSVG
A
L
E
E
L
E
N
A
F
S
L
A
E
ESCPG
I
S
D
K
L
M
V
H
L
V
E
R
V
Q
R
FSHNRNHLTSTR
2
PsiBlast_PDB
88.83
99%
-94
- C1 -
2XIK
2
STK25_HUMAN
A:
[4-293]
--------------------------------------------------
H
L
R
G
F
A
N
Q
H
S
R
--
V
D
--
P
E
E
L
F
T
K
L
D
-
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
-----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
K
---------
P
---
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
L
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
S
P
P
T
L
--
E
--
G
---------
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
S
--------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.77
99%
-101
- C1 -
4NZW
1
STK25_HUMAN
B:
[13-294]
----------------------------------------------------------
H
S
R
--
V
D
--
P
E
E
L
F
T
K
L
D
-
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
--
S
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
K
---------
P
---
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
A
F
G
V
A
------
G
---------------
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
---
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
L
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
S
P
P
T
L
--
E
--
G
---------
Q
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
T
S
F
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
S
--------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.07
84%
-98
- C1 -
4FZD
1
STK26_HUMAN
B:
[3-283]
------------------------------------------------------------
M
--
A
D
--
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
M
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
82.27
85%
-87
- C1 -
3A7H
1
STK24_HUMAN
B:
[14-298]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.93
85%
-87
- C1 -
3A7I
1
STK24_HUMAN
A:
[14-299]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
81.88
87%
-90
- C1 -
3CKX
1
STK24_HUMAN
A:
[5-282]
-------------------------------------------------------------------
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
---
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
120
HHSearch
81.73
84%
-86
- C1 -
3A7I
1
STK24_HUMAN
A:
[13-299]
--------------------------------------------------------
M
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.39
85%
-88
- C1 -
3A7H
1
STK24_HUMAN
A:
[14-298]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.92
88%
-90
- C1 -
4O27
1
STK24_HUMAN
B:
[3-281]
----------------------------------------------------------------
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.84
85%
-88
- C1 -
3A7J
1
STK24_HUMAN
A:
[14-299]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
80.63
84%
-97
- C1 -
3GGF
1
STK26_HUMAN
A:
[18-300]
------------------------------------------------------------
I
--
A
D
--
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
D
F
G
V
A
----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
M
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
-
K
A
E
G
H
S
----------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.69
84%
-93
- C1 -
4FZF
1
?
B:
[3-283]
------------------------------------------------------------
M
--
A
D
--
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
M
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
79.18
84%
-90
- C1 -
4FZA
3
STK26_HUMAN
B:
[3-283]
------------------------------------------------------------
M
--
A
D
--
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
M
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
78.09
84%
-99
- C1 -
3GGF
1
STK26_HUMAN
B:
[19-298]
---------------------------------------------------------------
A
D
--
P
E
E
L
F
T
K
L
E
-
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
R
---------
A
---
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
-
D
---
V
K
L
A
D
F
G
V
A
-----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
--
N
S
---------
D
M
H
P
M
--------
R
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
V
--
G
---------
D
F
--
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
T
S
Y
---
L
T
E
L
I
D
R
F
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
73.44
44%
-100
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[21-312]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
-----------------
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
PPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.28
44%
-92
- C1 -
4U45
1
M4K4_HUMAN
A:
[21-312]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
D
----
E
E
E
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
PPD
D
--
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
71.79
44%
-94
- C1 -
4OBP
2
M4K4_HUMAN
A:
[21-311]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
D
----
E
E
E
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
D
D
----
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R----------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
71.59
44%
-93
- C1 -
4ZK5
2
?
A:
[21-312]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
D
----
E
E
E
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
71.04
44%
-97
- C1 -
4RVT
2
M4K4_HUMAN
A:
[23-312]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
---------
E
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
-----------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
69.77
44%
-97
- C1 -
4OBO
2
M4K4_HUMAN
A:
[21-311]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
----------
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
D
D
----
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R----------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
69.55
44%
-90
- C1 -
4U43
1
M4K4_HUMAN
A:
[21-312]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
D
----
E
E
E
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
PPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
68.95
49%
-99
- C1 -
4OBO
2
M4K4_HUMAN
A:
[21-311]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
------------
E
I
K
L
E
I
-
N
M
L
K
K
-
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
------
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
N
TK------
G
---
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
--
K
S-
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
67.59
44%
-89
- C1 -
4U44
2
M4K4_HUMAN
A:
[21-311]
----------------------------------------------------------------
D
--
P
A
G
I
F
E
L
V
E
-
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--
T
-
E
D
----
E
E
E
E
I
K
L
E
I
-
N
M
L
K
K
Y
S
-
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
HD
D
---
Q
L
W
L
V
M
E
F
C
G
A
G
S
--
I
T
D
---
L
V
-----
K
---------
N
TKG
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
-
E
---
V
K
L
V
D
F
G
V
S
------
A
-----------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
-
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
----
P
P
--
L
C
---------
D
M
H
P
M
--------
R
A
L
F
---------
L
I
P
R
N
---
P
P
P
R
L
K-
S
--
K
---------
K
W
--
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
R
D
Q
P
N
E
R
Q
V
---
R
I
Q
L
K
D
H
I
D
R
T
R----------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.87
43%
-90
- C1 -
5AJQ
2
STK10_HUMAN
A:
[6-293]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
65.06
86%
-50
- C1 -
4W8D
1
STK24_HUMAN
A:
[6-289]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.53
85%
-46
- C1 -
4QMO
4
STK24_HUMAN
A:
[21-304]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
64.31
44%
-98
- C1 -
4ZJI
1
PAK1_HUMAN
A:
[19-296]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
63.89
44%
-97
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[19-294]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----------
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.88
85%
-48
- C1 -
4QMV
3
STK24_HUMAN
A:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.85
85%
-48
- C1 -
4QMZ
1
STK24_HUMAN
A:
[21-306]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
63.84
86%
-49
- C1 -
4U8Z
1
STK24_HUMAN
A:
[6-289]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
63.74
44%
-96
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[19-293]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
----------
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
63.69
44%
-91
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[18-295]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
---------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
63.41
44%
-85
- C1 -
4O0R
1
PAK1_HUMAN
A:
[17-293]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
---------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
63.40
44%
-97
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[19-293]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
63.16
32%
-95
- C1 -
3EQG
2
MP2K1_HUMAN
A:
[17-330]
---------------------------------------------------
L
E
A
F
L
T
Q
K
Q
K
--
V
G
EL
K
D
D
D
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
--
D
A
K
E
L
E
L
M
FGC----
P
--------
M
A
I
F
E
L
L
D
-----
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.16
85%
-47
- C1 -
4QMX
1
STK24_HUMAN
A:
[21-306]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
63.01
85%
-46
- C1 -
4QMN
1
STK24_HUMAN
A:
[22-305]
----------------------------------------------------------
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
62.87
44%
-89
- C1 -
3FXZ
1
?
A:
[15-293]
------------------------------------------------------------
V
--
G
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
Q
-
P
-----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
NP
E
---------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
-
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
---------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
62.85
43%
-91
- C1 -
4P90
1
PAK1_HUMAN
B:
[17-294]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---------------
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
62.65
86%
-48
- C1 -
4W8E
1
STK24_HUMAN
A:
[6-289]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
62.45
44%
-88
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[18-294]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
---------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
62.43
43%
-81
- C1 -
4AOT
1
STK10_HUMAN
B:
[2-296]
------------------------------------------------
M
R
K
S
R
E
Y
E
H
V
R
R
----
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M-------------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
---------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
62.14
85%
-46
- C1 -
4QMM
3
STK24_HUMAN
A:
[21-304]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.14
85%
-47
- C1 -
4QML
2
STK24_HUMAN
A:
[25-305]
---------------------------------------------------------------
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
62.12
85%
-47
- C1 -
4QMU
2
STK24_HUMAN
A:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
61.99
85%
-45
- C1 -
4QO9
4
?
B:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
61.95
85%
-48
- C1 -
4QMP
2
STK24_HUMAN
A:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.89
85%
-46
- C1 -
4QMY
2
STK24_HUMAN
A:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
61.85
85%
-50
- C1 -
4QMQ
3
STK24_HUMAN
A:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
61.77
35%
-104
- C1 -
3SLS
2
MP2K1_HUMAN
A:
[9-284]
---------------------------------------------------
L
E
A
F
L
T
Q
K
Q
K
--
V
G
EL
K
D
D
D
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
--------
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
IG-------------
A
I
F
--------
E
L
L
D
---------
Y
I
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-
N
Q
--------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
61.75
43%
-87
- C1 -
4USD
1
?
B:
[9-296]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
MC-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
---------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
61.69
44%
-84
- C1 -
4O0T
1
PAK1_HUMAN
A:
[17-294]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
Q
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
61.53
38%
-87
- C1 -
4KS7
2
A:
[10-290]
-------------------------------------------------
A
A
L
R
M
V
V
D
Q
G
-----
D
--
P
R
L
L
L
D
S
Y
V
-
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
-
Q
R
----
R
-
E
L
L
F
N
E
V
-
V
I
M
R
D
-
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
------
E
L
W
V
L
M
E
F
L
Q
G
G
A
--
L
T
D
---
I
V
-----
S
---------
Q
---
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
-
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
I
-
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
-
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
---------
S
D
S
P
V
--------
Q
A
M
K
---------
R
L
R
D
S
---
P
P
P
K
L
--
K
--
N
---------
S
H
KV
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
-
T
G
L
P
E
C
---
L
V
P
L
I
Q
----------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
61.48
85%
-46
- C1 -
4QO9
4
?
A:
[25-305]
---------------------------------------------------------------
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.45
85%
-45
- C1 -
4QMW
2
STK24_HUMAN
A:
[21-305]
---------------------------------------------------------
Q
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
60.72
85%
-43
- C1 -
4QNA
1
?
A:
[22-306]
----------------------------------------------------------
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
60.65
44%
-87
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[18-295]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
---
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
60.42
32%
-92
- C1 -
3EQI
1
MP2K1_HUMAN
A:
[17-330]
---------------------------------------------------
L
E
A
F
L
T
Q
K
Q
K
--
V
G
EL
K
D
D
D
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
--
D
A
K
E
L
E
L
M
FGC----
P
--------
M
A
I
F
E
L
L
D
-----
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-
N
---------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
60.33
85%
-45
- C1 -
4QMS
2
STK24_HUMAN
A:
[22-305]
----------------------------------------------------------
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
60.30
32%
-91
- C1 -
3EQH
2
MP2K1_HUMAN
A:
[17-330]
---------------------------------------------------
L
E
A
F
L
T
Q
K
Q
K
--
V
G
EL
K
D
D
D
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
--
D
A
K
E
L
E
L
M
F
GC----
P
--------
M
A
I
F
E
L
L
D
-----
Y
I
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
60.18
38%
-97
- C1 -
3EQC
2
MP2K1_HUMAN
A:
[35-332]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
-----
K
K
--------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
-
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
I
P
---------
P
P
D
A
K
E
L
E
L
M
F
GC----PMA
I
F
E
L
L
D
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-
N
---------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
60.10
85%
-48
- C1 -
4QMT
2
STK24_HUMAN
A:
[22-306]
----------------------------------------------------------
N
L
K
--
A
D
--
P
E
E
L
F
T
K
L
E
-
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
-
E
D
----
E
I
E
D
I
Q
Q
E
I
-
T
V
L
S
Q
-
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
--
A
L
D
---
L
L
-----
E
---------
P
---
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
-
E
---
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
-
S
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
--
H
S
---------
E
L
H
P
M
--------
K
V
L
F
---------
L
I
P
K
N
---
N
P
P
T
L
--
E
--
G
---------
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
---
L
T
E
L
I
D
R
Y
K
R
W
-
K
A
E
Q
S
-----------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
59.86
44%
-87
- C1 -
2J7T
1
STK10_HUMAN
A:
[10-297]
--------------------------------------------------------
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
--
V
D
A
---
I
M
-----
L
E
L
-------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
-----
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-
K
A
---
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
59.70
38%
-86
- C1 -
4KS8
1
A:
[10-289]
-------------------------------------------------
A
A
L
R
M
V
V
D
Q
G
-----
D
--
P
R
L
L
L
D
S
Y
V
-
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
K
Q
-
Q
R
----
R
-
E
L
L
F
N
E
V
-
V
I
M
R
D
-
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
V
--
G
E
------
E
L
W
V
L
M
E
F
L
Q
G
G
A
--
L
T
D
---
I
V
-----
S
---------
Q
---
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
-
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
I
-
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
-
S
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
---------
S
D
S
P
V
--------
Q
A
M
K
---------
R
L
R
D
S
---
P
P
P
K
L
--
K
--
N
---------
S
H
KV
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
L
Q
-
T
G
L
P
E
C
---
L
V
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
59.34
43%
-82
- C1 -
4AOT
1
STK10_HUMAN
A:
[2-296]
------------------------------------------------
M
R
K
S
R
E
Y
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
--------------
G
T
P
Y
W
M
A
P
E
V
V
M--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
---------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
59.23
43%
-94
- C1 -
4USF
1
?
A:
[12-282]
---------------------------------------------------------------
L
N
--
P
E
D
F
W
E
I
I
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
-
E
E
----
E
L
E
D
Y
M
V
E
I
-
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
---
L
E
-----
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
-
D
---
I
K
L
A
D
F
G
V
S
------
A
K
--------------
T
P
Y
W
M
A
P
E
V
V
M
C
E----------
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
---
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
59.09
43%
-89
- C1 -
4USF
1
?
B:
[12-282]
---------------------------------------------------------------
L
N
--
P
E
D
F
W
E
I
I
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
-
E
E
----
E
L
E
D
Y
M
V
E
I
-
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
---
L
E
-----
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
-
D
---
I
K
L
A
D
F
G
V
S
------
A
K
N
----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
-----
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
---
E
L
I
A
E
A
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.04
44%
-83
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[18-295]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
58.71
47%
-96
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[18-288]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
---
I
I
-----
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
----
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
58.43
37%
-101
- C1 -
3WIG
3
MP2K1_HUMAN
A:
[8-271]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
---
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
P
----------------
P
P
--------
M
A
I
F
E
L
L
D
-----
Y
I
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.22
44%
-82
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[18-294]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
--
Q
P
----
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
---------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
58.03
44%
-99
- C1 -
5D9H
1
?
B:
[26-309]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
M
L
D
---
I
I
-----
K
YIVNRGEHK
N
---
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
AFLATG
G
D
V
-
T
R
N
--------
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
T
L
--
E
--
T
GVEDKEMMK
K
Y
--
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
---
I
E
K
L
L
T
----------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
57.97
47%
-92
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[18-288]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
---
I
I
-----
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
I
T
R
N
-
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
57.96
43%
-84
- C1 -
4EQU
2
STK10_HUMAN
B:
[9-296]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
57.95
37%
-101
- C1 -
3ORN
3
MP2K1_HUMAN
A:
[8-271]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP
P
-----------------
P
P
--------
M
A
I
F
E
L
L
D
-----
Y
I
V
N
E
---
P
P
P
K
L
P
-
S
--
G
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
57.80
37%
-100
- C1 -
4AN3
2
MP2K1_HUMAN
A:
[11-264]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
--
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
---------
P
M
A
I
F
--------
E
L
L
D
---------
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
57.39
47%
-93
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[23-298]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
---
I
I
-----
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
-----
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
K
N
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.21
44%
-95
- C1 -
5D9H
1
?
A:
[26-308]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
M
L
D
---
I
I
-----
K
Y
I
V
N
R
GEHK
N
---
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
A
F
L
A
TG
G
D
V
-
T
R
--------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
T
L
--
E
--
T
GVKEMMK--
K
Y
--
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
E
Y
L
---
I
E
K
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
57.13
43%
-83
- C1 -
4EQU
2
STK10_HUMAN
A:
[9-296]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------------
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
56.99
47%
-92
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[18-288]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
---
I
I
-----
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
-------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
56.11
37%
-107
- C1 -
3OS3
2
MP2K1_HUMAN
A:
[8-271]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
--
A
N
S
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
YPIP----------------------------
M
A
I
F
E
L
L
D
-----
Y
I
V
N
E
---
P
P
P
K
L
P--------------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
--------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
56.11
44%
-88
- C1 -
4ZJI
1
?
D:
[19-295]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
-----------
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
-------
A
Q
I
-
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
---------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
55.74
44%
-78
- C1 -
4BC6
2
STK10_HUMAN
A:
[1-288]
---------------------------------------------------------
E
H
V
R
RD
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
55.54
43%
-78
- C1 -
4USE
1
?
B:
[9-296]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-------------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
55.07
43%
-81
- C1 -
2J7T
1
STK10_HUMAN
A:
[10-296]
--------------------------------------------------------
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
54.80
44%
-90
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[19-296]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
---------
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
----------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
--------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
--------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
K
--------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
54.63
37%
-95
- C1 -
4ANB
2
MP2K1_HUMAN
A:
[11-264]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
---------
P
M
A
I
F
--------
E
L
L
D
---------
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
54.41
43%
-76
- C1 -
4USE
1
?
A:
[9-296]
-------------------------------------------------------
E
H
V
R
R
D
--
L
D
--
P
N
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
-
E
E
----
E
L
E
D
Y
I
V
E
I
-
E
I
L
A
T
-
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
---
L
E
-----
L
---------
D
---
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
-
D
---
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
D
P
P
T
L
LT
P
--
S
---------
K
W
--
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
K
A
----
L
R
E
L
V
A
E
A
K
A
E
-
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
54.13
36%
-84
* C1 *
4JDI
1
PAK4_HUMAN
A:
[72-334]
-------------------------------------------------------------------
P
R
S
Y
L
D
N
F
I
-
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--
Q
----
R
R
E
L
L
F
N
E
V
-
V
I
M
R
D
-
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
--
L
T
D
---
I
V
-----
T
---------
H
---
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
-
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
-
R
---
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
-
L
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
----
P
P
--
Y
F
---------
N
E
P
P
L
--------
K
A
M
K
---------
M
I
R
D
N
---
L
P
P
R
L
--
K
--
N
LH-------
K
V
--
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
A
K
A
G
P
P
A
S
I
---
V
P
L
M
R
Q
N
R
--------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
53.96
37%
-95
- C1 -
4AN9
2
MP2K1_HUMAN
A:
[11-264]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
-
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
---------
P
M
A
I
F
--------
E
L
L
D
---------
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
52.91
44%
-86
- C1 -
4ZJI
1
?
C:
[19-295]
----------------------------------------------------------------
D
--
P
K
K
K
Y
T
R
F
E
-
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
-----------
K
K
E
L
I
I
N
E
I
-
L
V
M
R
E
-
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
--
L
T
D
---
V
V
-----
T
---------
E
---
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
-
S
---
V
K
L
T
D
F
G
F
C
------
A
Q
------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
-
K
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
----
P
P
--
Y
L
---------
N
E
N
P
L
--------
R
A
L
Y
---------
L
I
A
T
N
---
G
T
P
E
L
--
Q
--
N
PE-------
K
L
--
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
I
A
K
P
L
S
S
---
L
T
P
L
I
A
A
A
K
E
A
-
T
---------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
52.40
47%
-91
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[18-288]
------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
-
Q
T
----
S
M
D
E
L
L
K
E
I
-
Q
A
M
S
Q
-
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
--
V
L
D
---
I
I
-----
K
H
I
V
A
K
GEHK
S
---
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
-
S
---
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
--------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
----
A
P
--
Y
H
---------
K
Y
P
P
M
--------
K
V
L
M
---------
L
T
L
Q
N
---
D
P
P
S
L
--
E
--
T
GVQDKEMLK
K
Y
--
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
51.44
30%
-101
- C1 -
2W5A
5
NEK2_HUMAN
A:
[8-272]
-----------------------------------------------------------------------
Y
E
V
L
Y
-
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
E
A
----
E
K
Q
M
L
V
S
E
V
-
N
L
L
R
E
-
L
-
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
------
T
L
Y
I
V
M
E
Y
C
E
G
G
D
--
L
A
S
---
V
I
-----
T
K
G
T
K
E
----
R
---
Q
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
-
S
-
L
-
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
---
V
K
L
G
D
F
G
L
A
------
R
I
L
----
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-----
N
-----
R
-
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
----
P
P
--
F
T
---------
A
F
S
Q
K
--------
E
L
A
G
---------
K
I
R
E
G
---
K
F
R
R
I
--
P
--
Y
---------
R
Y
--
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
51.24
37%
-96
- C1 -
4AN2
2
MP2K1_HUMAN
A:
[11-264]
-----------------------------------------------------------------------
F
E
K
I
S
-
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
-
P
A
----
I
R
N
Q
I
I
R
E
L
-
Q
V
L
H
E
-
C
-
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
--
L
D
Q
---
V
L
K
----
K
---------
A
---
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
-
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
-
E
---
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
E
M
--
A
N
E
F
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
-
T
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
----
Y
P
--
R
P
---------
P
M
A
I
F
--------
E
L
L
D
---------
Y
I
V
N
E
---
P
P
P
K
L
P-
S
--
A
---------
V
F
--
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
---
F
A
G
W
L
C
S
T
I
G
L
-----------------------------------------------------------------------------------------------------------------------------------------
110
Fugue
50.44
30%
-65
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
L
T
E
K
L
K
P
V
D
Y
E
--
Y
R
--
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
-----------
F
R
A
E
E
L
-
M
A
C
A
G
-
L
-
T
S
P
R
I
V
P
L
Y
G
A
V
R
E
--
G
P
------
W
V
N
I
F
M
E
L
L
E
G
G
S
--
L
G
Q
---
L
V
-----
K
---------
E
Q
--
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
-
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
H
---
A
A
L
C
D
F
G
H
A
------
V
C
L
-
Q
--------
I
P
G
T
E
T
H
M
A
P
E
V
V
-----
L
-----
G
-
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
----
H
P
--
W
T
---------
Q
F
F
R
G
--------
P
L
C
L
---------
K
I
A
S
E
---
P
P
P
V
R
--
E
IP
P
---------
S
C
--
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
E
L
G
G
K
V
N
R
A
L
Q
Q
V
-
G
G
L
---
K
S
P
W
R
G
E
Y
K
E
P
-
R
H
P
-------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
50.15
43%
-77
- C1 -
2UV2
6
SLK_HUMAN
A:
[33-303]
---------------------------------------------------------------
L
N
--
P
E
D
F
W
E
I
I
G
-
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
-
E
E
----
E
L
E
D
Y
M
V
E
I
-
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
---
L
E
-----
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
-
D
---
I
K
L
A
D
F
G
V
S
------
A
K
N
-
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
---
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------
138
HHSearch
49.24
35%
-96
- C1 -
3ALN
1
MP2K4_HUMAN
A:
[24-296]
-----------------------------------------------------------------------
L
K
D
L
G
-
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
-
E
K
----
E
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
-
S
-
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
--
E
G
------
D
C
W
I
C
M
E
L
M
S
T
S
F
D
K
F
Y
K
Y
V
Y
S
V
-----
L
---------
D
---
D
V
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
-
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
-
N
---
I
K
L
C
D
F
G
I
S
------
G
Q
---------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
----
F
P
--
Y
P
---------
K
W
--------------
T
---------
Q
V
V
K
G
---
D
P
P
Q
L
--
S
--
N
SEER-----
E
F
--
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
---
V
A
C
Y
V
C
K
I
L
D
Q
-
M
P
--------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
49.07
30%
-84
- C1 -
3C0I
1
CSKP_HUMAN
A:
[21-294]
----------------------------------------------------------------
L
--
F
E
D
V
Y
E
L
C
E
-
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
-
T
S
SPGL
S
T
E
D
L
K
R
E
A
-
S
I
C
H
M
-
L
-
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
------
M
L
Y
M
V
F
E
F
M
D
G
A
D
--
L
C
F
---
E
I
V
K
R
A
D
A
---------
G
---
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
-
N
I
I
-
H
R
D
V
K
P
H
C
V
L
L
A
S
K
E
-
N
S
A
P
V
K
L
G
G
F
G
V
A
------
I
Q
L
-
G
E
S
G
L
V
A
G
G
R
V
G
T
P
H
F
M
A
P
E
V
V
-----
K
-----
R
-
E
P
Y
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
----
L
P
--
F
Y
---------
G
T
K
E
---------
R
L
F
E
---------
G
I
I
K
G
K
Y
K
M
N
P
R
Q
--
W
--
S
---------
H
I
--
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
---
I
H
L
P
E
T
V
E
Q
L
R
-
K
F
N
A
R
R
K
---------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
46.35
43%
-76
- C1 -
2J51
5
SLK_HUMAN
A:
[33-303]
---------------------------------------------------------------
L
N
--
P
E
D
F
W
E
I
I
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
-
T
K
S
-
E
E
----
E
L
E
D
Y
M
V
E
I
-
D
I
L
A
S
-
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
---
L
E
-----
L
---------
E
---
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
-
D
---
I
K
L
A
D
F
G
V
S
------
A
K
N
-
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
----
P
P
--
H
H
---------
E
L
N
P
M
--------
R
V
L
L
---------
K
I
A
K
S
---
E
P
P
T
L
--
A
QP
S
---------
R
W
--
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
P
I
R
---
E
L
I
A
E
A
K
---------------------------------------------------------------------------------------------------------------------------------------------