@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK36_HUMAN: (2015-10-20 )
MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM
Atome Classification :
(72 SA)
----------------------------------------------------------------........-.10........20........30..--......-40........50....-..-..60........70-.........80-..-.-.-....--90..----.-...-..100.......110.......-120.......130.---.-.....140.....-..150.......160.......170-----..-.....180.......190.......200.......210-------..-------------------.---.---.-..220-----------.-----------------------........230.......240....-...250.......260----------.........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------MEK
Y
H
V
L
E
-MIGEGSFG
R
V
YKGRRKY
S
A
Q
V
V
A
L
K
--
F
I
P
KLG-R
S
E
K
E
L
R
N
L
Q
R
E
I
E
I
M
-
R
G-LRHP
N
I
V
H
M
LDSF--ETDK
E
V
V
V
V
T
D-YA-E-
G
-
E
L
F
Q
--
I
L
ED----D-GKL-
P
E
D
Q
V
Q
A
I
A
A
Q
L
V
S
A
L
Y
Y
L
H
S
H
-
R
I
L
H
RDMKPQ
N
I
L
L
---A-KGG
G
I
K
L
CDF
G
F
A
-RAMST
N
T
M
V
L
T
SIKGTPLYM
S
P
E
L
V
-----
E
E-RPYDH
T
A
D
L
W
S
V
G
C
I
L
Y
E
LAVGTP
P
F
Y
A
T
S
I
F
Q
L
V
S
L
I
-------
L
K-------------------D---P---V-RWP-------------S-----------------------T
I
S
P
C
F
K
N
F
L
Q
G
L
LTK
D
P
R
QRLSW
P
-
D
L
L
Y
HPFIAG
H
V
T
I
------------
I
TEPAGPDLGTPFTSRLPP
E
L
Q
V
LKDEQAHRLAPKGN
Q
S
R
I
L
T
Q
A
Y
K
R
M
A
E
E
A
M
Q
K
K
HQNTGPALEQEDKTSKVAPGTAPLPRLGATP
Q
E
S
S
L
L
A
G
I
L
A
S
E
L
K
S
S
W
AKSGTGEVPSAPRENRTTP
D
C
E
RAFP
E
E
R
P
E
V
LGQRST
D
V
V
DLENEEPDS
D
N
E
W
Q
H
L
L
ETTEP
V
P
I
Q
LKA
P
L
T
L
L
CN
P
D
F
C
Q
R
I
Q
S
Q
L
H
E
A
G
G
Q
I
L
K
G
I
L
E
G
A
S
H
I
L
P
A
F
R
V
L
S
S
L
L
S
SCSD
S
V
A
L
Y
S
F
C
R
EAG
L
P
G
L
L
L
S
L
L
RHSQESNS
L
Q
Q
Q
S
W
Y
G
T
F
L
Q
D
L
M
A
V
I
Q
A
Y
F
A
C
T
F
NLERSQT
S
D
S
L
Q
V
F
Q
E
A
A
N
L
F
L
D
L
L
G
K
L
LAQPDD
S
E
Q
T
L
R
R
D
S
L
M
C
F
T
V
L
C
E
AMDGN
S
R
A
I
S
K
A
F
Y
S
S
L
L
T
T
Q
Q
V
V
L
D
G
L
L
HGLTVPQLPVHTPQGAP
Q
V
S
Q
P
L
R
E
Q
SEDI
P
G
A
I
S
S
A
L
A
A
I
CTAPVGLPDCW
D
A
K
E
Q
V
C
W
H
L
A
N
Q
LTE
D
S
S
QL
R
P
S
L
I
S
GLQ
H
P
I
L
C
L
H
L
L
K
V
L
Y
S
C
C
L
V
S
E
G
L
C
R
L
LGQEP
L
A
L
E
S
L
F
M
L
IQG
K
V
K
V
V
DWEEST
E
V
T
L
Y
F
L
S
L
L
V
F
R
L
QNLPC
G
M
E
K
L
G
S
D
V
A
T
L
F
T
H
S
H
V
V
S
L
V
S
A
A
A
C
L
L
G
QLGQQGVTFDL
Q
P
M
E
W
M
A
A
A
T
H
ALSAP
A
E
V
R
LTPPGSCG
F
Y
D
G
L
L
I
L
L
L
Q
L
L
T
EQ
G
K
A
S
L
I
R
D
MSSS
E
M
W
T
V
L
W
H
R
F
S
M
V
L
RLPEEASAQEG
E
L
SLSSPPSPEP
D
W
T
L
I
S
P
Q
G
M
A
A
L
L
S
L
A
M
A
TFTQ
E
P
Q
L
C
L
S
C
L
S
Q
H
G
S
I
L
M
S
I
L
K
H
LL
C
P
S
F
L
N
Q
L
RQAPHGSE
F
L
P
V
V
V
L
S
V
C
Q
L
L
C
F
P
FALDM
D
A
D
L
L
I
G
V
L
A
DLR
D
S
E
V
A
A
H
L
L
Q
V
C
C
Y
HLP
L
M
Q
V
EL
P
I
S
L
L
T
R
L
ALMD
P
T
S
L
N
Q
F
V
N
T
VSA
S
P
R
T
I
V
S
F
L
S
V
A
LLSDQPL
L
T
S
D
L
L
S
L
L
A
H
T
A
R
VL
S
P
S
H
L
S
F
I
Q
E
L
LAGSDE
S
Y
R
P
L
R
S
L
LGHPEN
S
V
R
A
H
T
Y
R
L
L
G
H
L
L
Q
H
S
M
A
L
R
G
A
L
QSQ
S
G
L
L
S
L
L
L
L
GLGDKD
P
V
V
R
CSASFAVGNAAYQAGPL
G
P
A
L
A
A
A
V
P
S
M
T
Q
L
LGD
P
Q
A
G
I
R
R
N
V
A
S
A
L
GNLG
P
E
G
L
G
E
E
L
L
Q
C
E
V
P
Q
R
L
L
E
M
ACGDPQP
N
V
K
E
A
A
L
I
A
L
R
S
L
Q
QEP
G
I
H
Q
V
L
V
SLGASE
K
L
S
L
L
SLGNQSLPHSSPRP
A
S
A
K
H
C
R
K
L
I
H
L
LRPAHSM
129
HHSearch
78.68
34%
-95
- C1 -
4BGQ
3
CDKL5_HUMAN
A:
[11-300]
----------------------------------------------------------------
M
N
K
F
E
I
L
G
-
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
T
H
E
I
V
A
I
K
--
K
F
K
--------
V
K
E
T
T
L
R
E
L
K
M
L
-
R
T
-
L
K
Q
E
N
I
V
E
L
K
E
A
F
--
R
R
R
G
K
L
Y
L
V
F
E
-
Y
V
-
E
-
K
-
N
M
L
E
--
L
L
E
E
M
---
P
-
N
G
V
-
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
-
D
I
V
H
R
D
I
K
P
E
N
L
L
I
---
S
-
H
N
D
V
L
K
L
C
D
F
G
F
A
-
R
N
L
S
E
----------
T
R
W
Y
R
S
P
E
L
L
-----
L
G
-
A
P
Y
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
-------
Q
K
V
LGPLP
S
E
Q
M
K
L
F
Y
S
NPRF
H
---
G
---
L
-
R
F
P
AV
N
H
P
Q
S
L
E
R
R
Y
L
G
-----------------------
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
-
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
72.35
33%
-90
- C1 -
4JBQ
1
AURKA_HUMAN
A:
[8-264]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
---------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
71.50
33%
-86
- C1 -
3FDN
1
AURKA_HUMAN
A:
[8-264]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
--------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
N
C
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
70.99
33%
-94
- C1 -
1OL6
1
AURKA_HUMAN
A:
[9-265]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
-
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
--
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
N
F
G
W
S
---
V
H
-----------
T
L
D
Y
L
P
P
E
M
I
-----
E
G
--
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
70.98
33%
-90
- C1 -
2W1E
1
AURKA_HUMAN
A:
[10-266]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
-----------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
70.49
33%
-92
- C1 -
3MYG
2
AURKA_HUMAN
A:
[11-267]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
-----------
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.14
34%
-89
- C1 -
2WTW
1
AURKA_HUMAN
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
P
R
-
G
-
E
V
Y
K
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
69.85
33%
-96
- C1 -
3EFW
1
AURKA_HUMAN
A:
[130-386]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
--------------------
L
D
Y
L
P
P
E
M
I
-----
E
-------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
69.72
33%
-94
- C1 -
3EFW
1
AURKA_HUMAN
B:
[130-386]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
--------------------
L
D
Y
L
P
P
E
M
I
-----
E
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
69.70
33%
-90
- C1 -
4UYN
1
AURKA_HUMAN
A:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
--
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
-------------------
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
69.66
33%
-90
- C1 -
3K5U
1
AURKA_HUMAN
A:
[8-264]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
---------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
N
C
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
69.48
33%
-88
- C1 -
2W1D
1
AURKA_HUMAN
A:
[10-266]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
-----------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
69.26
33%
-92
- C1 -
5AAD
1
?
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
----------
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
68.95
35%
-87
- C1 -
4USF
1
?
A:
[18-276]
-------------------------------------------------------------------
W
E
I
I
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
--
V
I
D
T
---
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
-
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
-
A
-
G
-
G
A
V
D
A
V
M
L
E
L
----
E
-
R
P
L
-
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
-
L
D
G
D
I
K
L
A
D
F
G
V
S
-
A
K
-------------
T
P
Y
W
M
A
P
E
V
V
M
C
E-----
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
SEPPT
L
A
-------------------
Q
---
P
---
S
-
R
W
S
-------------
S
-----------------------
N
----
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
-
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
------------
P
I
R
E
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
68.79
33%
-94
- C1 -
2X81
1
AURKA_HUMAN
A:
[11-267]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
--------------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
68.72
33%
-91
- C1 -
4B0G
1
AURKA_HUMAN
A:
[10-266]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
-----
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
------------
T
L
D
Y
L
P
P
E
M
I
-----
E
----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
68.68
36%
-88
- C1 -
2W5A
5
NEK2_HUMAN
A:
[5-273]
----------------------------------------------------------------
A
E
D
Y
E
V
L
Y
-
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
--
E
L
D
Y
G
S
-
M
T
E
A
E
K
Q
M
L
V
S
E
V
N
L
L
-
R
E
-
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
R
T
N
T
T
L
Y
I
V
M
E
-
Y
C
-
E
G
G
-
D
L
A
S
--
V
I
T
K
G
T
K
E
R
-
Q
Y
L
-
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S--
L
H
R
D
L
K
P
A
N
V
F
L
---
D
-
G
K
Q
N
V
K
L
G
D
F
G
L
A
-
R
I
L
---
T
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
-----
N
R
-
M
-
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
-------
R
E
-------------------
G
---
K
---
F
R
R
I
P
-------------
Y
-----------------------
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
-
E
I
L
E
N
P
L
I
L
E
H
H
H
H
------------
H
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
68.67
35%
-90
- C1 -
2WEI
1
?
A:
[22-280]
-----------------------------------------------------------------
E
R
Y
N
I
V
C
-
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
--
V
I
N
K
A
S
-
A
K
N
K
D
T
S
T
I
L
R
E
V
E
L
L
-
K
K
-
L
D
H
P
N
I
M
K
L
F
E
I
L
--
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
-
G
-
G
-
E
L
F
D
--
E
I
I
K
----
R
-
K
R
F
-
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
-
N
I
V
H
R
D
L
K
P
E
N
I
L
L
ESK
E
-
K
D
C
D
I
K
I
I
D
F
G
L
S
-
T
C
F
Q
Q
N
T
K
M
K
D
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
-----
R
G
--
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
G
K
N
E
Y
D
I
L
K
R
V
-------
E
T
GKYAF--------------
D
---
L
---
P
-
Q
W
--------------
R
-----------------------
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
-
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
68.64
33%
-87
- C1 -
3O50
1
AURKA_HUMAN
A:
[6-262]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
-----------------
T
L
D
Y
L
P
P
E
M
I
-----
E
----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
68.33
33%
-84
- C1 -
2J4Z
4
AURKA_HUMAN
A:
[33-289]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
68.25
33%
-93
- C1 -
2X6D
1
AURKA_HUMAN
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-----
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
----
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
68.19
35%
-84
- C1 -
4AOT
1
STK10_HUMAN
A:
[19-280]
-----------------------------------------------------------------
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
--
V
I
E
T
---
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
-
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
-
F
C
-
P
-
G
-
G
A
V
D
A
I
M
L
E
L
----
D
-
R
G
L
-
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
-
L
E
G
D
I
R
L
A
D
F
G
V
S
-
A
-------------
G
T
P
Y
W
M
A
P
E
V
V
M---------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-------
A
K
S------------------
D
---
P
PT-
L
-
L
T
P
-------------
S
-----------------------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
-
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
------------
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
67.77
33%
-86
- C1 -
4BYI
1
AURKA_HUMAN
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
---------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
67.69
33%
-90
- C1 -
2XNG
1
AURKA_HUMAN
A:
[10-266]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
----------
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
67.67
34%
-86
- C1 -
3NRM
1
AURKA_HUMAN
A:
[10-266]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
VL
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
S
R
R
A
A
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
67.49
33%
-83
- C1 -
4UZD
1
AURKA_HUMAN
A:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
-----------
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
67.45
33%
-89
- C1 -
4UZH
1
AURKA_HUMAN
A:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
--------------------
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
67.41
33%
-89
- C1 -
5AAG
1
?
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
---------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.27
33%
-87
- C1 -
5AAF
1
?
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
---------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
67.16
33%
-84
- C1 -
3HDN
1
SGK1_HUMAN
A:
[40-316]
-------------------------------------------------------------------
F
H
F
L
K
-
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
E
V
F
Y
A
V
K
--
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
--
Q
T
A
D
K
L
Y
F
V
L
D
-
Y
I
-
N
-
G
G
E
L
F
Y
--
H
L
Q
R
----
E
-
R
C
F
-
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
---
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
-----
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
-------
L
N
-------------------
K
---
P
---
L
-
Q
L
K
-------------
P
-----------------------
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
--
I
K
S
H
V
F
F
SLIN
W
D
D
L
I
N
KK
I
T
P
P
F
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.11
33%
-84
- C1 -
2J4Z
2
AURKA_HUMAN
B:
[33-289]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
VL
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
N
C
Q
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
67.03
33%
-84
- C1 -
4JAJ
1
AURKA_HUMAN
A:
[18-274]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
67.00
33%
-86
- C1 -
1MQ4
1
AURKA_HUMAN
A:
[11-267]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
--
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
66.78
33%
-82
- C1 -
3HDM
1
SGK1_HUMAN
A:
[40-320]
-------------------------------------------------------------------
F
H
F
L
K
-
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
E
V
F
Y
A
V
K
--
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
--
Q
T
A
D
K
L
Y
F
V
L
D
-
Y
I
-
N
-
G
G
E
L
F
Y
--
H
L
Q
R
----
E
-
R
C
F
-
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
---
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
-----
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
-------
L
N
-------------------
K
---
P
---
L
-
Q
L
K
-------------
P
-----------------------
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
--
I
K
S
H
V
F
F
SLIN
W
D
D
L
I
N
KK
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
66.72
33%
-83
- C1 -
4UZD
1
AURKA_HUMAN
B:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
----------
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
66.68
33%
-90
- C1 -
5AAE
1
?
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
VL
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
-----------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
66.63
35%
-80
- C1 -
4USF
1
?
B:
[18-276]
-------------------------------------------------------------------
W
E
I
I
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
--
V
I
D
T
---
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
-
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
-
A
-
G
-
G
A
V
D
A
V
M
L
E
L
----
E
-
R
P
L
-
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
-
L
D
G
D
I
K
L
A
D
F
G
V
S
-
A
K
N
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
SEPPT
L
A
-------------------
Q
---
P
---
S
-
R
W
S
-------------
S
-----------------------
N
----
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
-
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
------------
P
I
R
E
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
66.57
33%
-86
- C1 -
2XRU
1
AURKA_HUMAN
A:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
----------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
66.54
33%
-91
- C1 -
3W16
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
-----------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
66.48
33%
-90
- C1 -
2J50
1
AURKA_HUMAN
B:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
VL
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
--------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
-----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
66.41
33%
-88
- C1 -
3LAU
1
AURKA_HUMAN
A:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
--------------------
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Fugue
66.32
30%
-60
- C1 -
4DN5
7
M3K14_HUMAN
A:
[8-351]
S
V
E
E
Y
L
V
H
A
L
QG
S
V
S
S
G
Q
A
H
S
L
T
S
L
A
K
T
W
A
A
R
G
S
RSREPSPKTE
D
N
E
G
V
L
LTEK
L
K
P
V
DY
E
Y
R
E
E
V
H
W
A
T
H
Q
L
R
L
G
R
G
S
F
G
E
V
H
R
M
E
D
K
Q
T
G
F
Q
C
A
V
K
--
K
V
R
L
E
--------
V
F
R
A
E
E
L
M
A
C
-
A
G
-
L
T
S
P
R
I
V
P
L
Y
G
A
V
--
R
E
G
P
W
V
N
I
F
M
E
-
L
L
-
E
G
G
-
S
L
G
Q
--
L
V
K
E
----
Q
-
G
C
L
-
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
S
R
-
R
I
L
H
G
D
V
K
A
D
N
V
L
L
---
S
S
D
G
S
H
A
A
L
C
D
F
G
H
A
-
V
C
--------
L
Q
I
P
G
T
E
T
H
M
A
P
E
V
V
-----
L
G
-
R
S
C
D
A
K
V
D
V
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
F
F
R
G
P
L
C
L
K
I
-------
A
S
-------------------
E
---
P
PPV
R
-
E
I
P
-------------
P
-----------------------
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
I
H
R
V
S
A
A
-
E
L
G
G
K
V
N
R
A
L
Q
Q
V
--------------
G
G
L
K
S
P
W
R
G
E
Y
K
E
P
R
H
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
66.20
33%
-86
- C1 -
4BYJ
1
AURKA_HUMAN
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
--------------------
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.84
36%
-91
- C1 -
4B9D
2
NEK1_HUMAN
B:
[23-290]
----------------------------------------------------------------
M
E
K
Y
V
R
L
Q
-
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
--
E
I
N
I
S
R
-
M
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
-
A
N
-
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
-
Y
C
-
E
-
G
G
D
L
F
K
R
-
I
N
A
Q
----
K
-
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
-
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
---
T
-
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
-----
E
N
-
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
-------
I
S
-------------------
G
SFP
P
---
V
-
S
L
H
-------------
Y
-----------------------
S
Y
D
--
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
-
S
I
L
E
K
G
F
I
A
K
R
I
E
K
------------
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.66
33%
-84
- C1 -
2R5T
1
SGK1_HUMAN
A:
[40-320]
-------------------------------------------------------------------
F
H
F
L
K
-
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
E
E
V
F
Y
A
V
K
--
V
L
Q
K
K
A
I
L
-------------
V
L
L
K
N
-
V
K
H
P
F
L
V
G
L
H
F
S
F
--
Q
T
A
D
K
L
Y
F
V
L
D
-
Y
I
-
N
-
G
G
E
L
F
Y
--
H
L
Q
R
----
E
-
R
C
F
-
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
---
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
-
K
E
N
I
E
H
N
S
T
T
S
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
-----
H
K
-
Q
P
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
M
Y
D
N
I
-------
L
N
-------------------
K
---
P
---
L
-
Q
L
K
-------------
P
-----------------------
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
-
D
D
F
M
E
--
I
K
S
H
V
F
F
SLIN
W
D
D
L
I
N
KK
I
T
P
P
F
N
P
N
V
S
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
65.65
33%
-85
- C1 -
4JBO
1
AURKA_HUMAN
A:
[8-264]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
T
D
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
65.59
33%
-90
- C1 -
2J50
1
AURKA_HUMAN
A:
[7-263]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
--------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
-----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
65.46
30%
-75
- C1 -
1XJD
1
A:
[16-275]
----------------------------------------------------------------
I
E
D
F
I
L
H
K
-
M
L
G
K
G
S
F
G
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
--
A
L
K
K
D
V
V
L
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
-
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
--
Q
T
K
E
N
L
F
F
V
M
E
-
Y
L
-
N
G
G
-
D
L
M
Y
--
H
I
Q
S
----
C
-
H
K
F
-
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
---
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
-
K
E
N
M
L
G
D
A
K
T
N
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
-----
L
G
-
Q
K
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
G
Q
D
E
E
E
L
F
H
S
I
-------
R
M
-------------------
D
---
N
---
P
-
F
Y
P
-------------
R
-----------------------
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
V
R
G
D
I
R
Q
H
P
L
F
R
E
I
N
W
E
------------
E
L
E
R
K
E
I
D
P
Q
N
M
F
R
N
F
S
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
65.28
33%
-88
- C1 -
3W18
1
AURKA_HUMAN
B:
[5-261]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-------------
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
----------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
65.23
33%
-82
- C1 -
3O51
1
AURKA_HUMAN
A:
[6-262]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
--------------------
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
64.99
33%
-83
- C1 -
3O50
1
AURKA_HUMAN
B:
[6-262]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
--------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
-----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.76
33%
-78
- C1 -
4UTD
1
?
A:
[9-265]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
N
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
64.41
34%
-82
- C1 -
3W10
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
S
R
R
A
A
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
64.36
33%
-90
- C1 -
2X6E
1
AURKA_HUMAN
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
-----------
T
L
D
Y
L
P
P
E
M
I
-----
E
----
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
64.29
36%
-89
- C1 -
4B9D
1
NEK1_HUMAN
A:
[23-290]
----------------------------------------------------------------
M
E
K
Y
V
R
L
Q
-
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
--
E
I
N
I
S
R
-
M
S
S
K
E
R
E
E
S
R
R
E
V
A
V
L
-
A
N
-
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
-
Y
C
-
E
-
G
G
D
L
F
K
R
-
I
N
A
Q
----
K
-
G
V
L
F
Q
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
-
K
I
L
H
R
D
I
K
S
Q
N
I
F
L
---
T
-
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
N
S
T
V
E
L
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
C
-----
E
N
-
K
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
H
A
F
E
A
G
S
M
K
N
L
V
L
K
I
-------
I
S
-------------------
G
SFP
P
---
V
-
S
L
H
-------------
Y
-----------------------
S
Y
D
--
L
R
S
L
V
S
Q
L
F
K
R
N
P
R
D
R
P
S
V
N
-
S
I
L
E
K
G
F
I
A
K
R
I
E
K
------------
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
64.28
33%
-84
- C1 -
2C6E
1
AURKA_HUMAN
B:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
-------------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
63.98
33%
-82
- C1 -
2C6E
1
AURKA_HUMAN
A:
[12-268]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
63.46
35%
-87
- C1 -
4USD
1
?
B:
[19-280]
-----------------------------------------------------------------
E
V
W
E
I
V
G
-
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
--
V
I
E
T
---
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
-
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
-
F
C
-
P
-
G
-
G
A
V
D
A
I
M
L
E
L
----
D
-
R
G
L
-
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
-
L
E
G
D
I
R
L
A
D
F
G
V
----------------
G
T
P
Y
W
M
A
P
E
V
V
MC--------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-------
A
K
S------------------
D
---
P
PT-
L
-
L
T
P
-------------
S
-----------------------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
-
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
------------
K
A
L
R
E
L
V
A
E
A
K
A
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
63.40
33%
-86
- C1 -
4O0S
1
AURKA_HUMAN
A:
[9-265]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.04
34%
-79
- C1 -
3QBN
1
AURKA_HUMAN
A:
[8-264]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
----------------
T
L
S
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
62.64
33%
-81
- C1 -
1MUO
1
AURKA_HUMAN
A:
[24-280]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
VL
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
-------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
62.46
33%
-84
- C1 -
4C3P
1
AURKA_HUMAN
D:
[9-265]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
VL
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
------
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.27
33%
-88
- C1 -
3W18
1
AURKA_HUMAN
A:
[5-261]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
--------
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
--------------------
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
----
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
HHSearch
62.16
34%
-81
- C1 -
1UA2
1
CDK7_HUMAN
A:
[13-299]
--------------------------------------------------------------------
E
K
L
D
-
F
L
G
E
G
Q
F
A
T
V
Y
K
A
R
D
K
N
T
N
Q
I
V
A
I
K
--
K
I
----------
N
R
T
A
L
R
E
I
K
L
L
-
Q
E
-
L
S
H
P
N
I
I
G
L
L
D
A
F
--
G
H
K
S
N
I
S
L
V
F
D
-
F
M
-
E
-
T
-
D
L
E
V
--
I
I
K
D
----
N
S
L
V
L
-
T
P
S
H
I
K
A
Y
M
L
M
T
L
Q
G
L
E
Y
L
H
Q
H
-
W
I
L
H
R
D
L
K
P
N
N
L
L
L
---
D
-
E
N
G
V
L
K
L
A
D
F
G
L
A
-
K
S
F
G
S
P
N
R
A
Y
T
H
Q
V
V
T
R
W
Y
R
A
P
E
L
L
-----
F
G
A
R
M
Y
G
V
G
V
D
M
W
A
V
G
C
I
L
A
E
L
L
L
R
V
P
F
L
P
G
D
S
D
L
D
Q
L
T
R
I
-------
F
E
TLGTP--------------
T
---
E
---
E
-
Q
W
P
-------------
D
MCSLP
D
Y
V
T
FKSFPGI
P
L
H
H
I
F
S
A
A
G
D
D
L
L
D
L
I
Q
G
L
F
L
F
N
P
C
A
R
I
T
A
T
-
Q
A
L
K
M
K
Y
F
S
N
R
P
G
P
------------
T
P
G
C
Q
L
P
R
P
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.99
33%
-88
- C1 -
4JAI
1
AURKA_HUMAN
A:
[18-274]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
-------------------
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
K
------------
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
61.85
35%
-83
- C1 -
4EQU
2
STK10_HUMAN
B:
[19-280]
-----------------------------------------------------------------
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
--
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
-
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
-
F
C
-
P
-
G
-
G
A
V
D
A
I
M
L
E
L
----
D
-
R
G
L
-
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
-
L
E
G
D
I
R
L
A
D
F
G
V
S
-
A
K
N
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-------
A
K
S------------------
D
---
P
PT-
L
-
L
T
P
-------------
S
-----------------------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
-
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
------------
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
60.40
33%
-78
- C1 -
4C3P
1
AURKA_HUMAN
A:
[9-265]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
-
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
-
E
V
L
E
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
58.39
35%
-73
- C1 -
2J51
5
SLK_HUMAN
A:
[39-297]
-------------------------------------------------------------------
W
E
I
I
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
--
V
I
D
T
---
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
-
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
-
A
-
G
-
G
A
V
D
A
V
M
L
E
L
----
E
-
R
P
L
-
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
-
L
D
G
D
I
K
L
A
D
F
G
V
S
-
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
SEPPT
L
A
-------------------
Q
---
P
---
S
-
R
W
S
-------------
S
-----------------------
N
----
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
-
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
------------
P
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
58.16
35%
-74
- C1 -
2UV2
6
SLK_HUMAN
A:
[39-297]
-------------------------------------------------------------------
W
E
I
I
G
-
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
--
V
I
D
T
---
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
-
A
S
-
C
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
-
F
C
-
A
-
G
-
G
A
V
D
A
V
M
L
E
L
----
E
-
R
P
L
-
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
---
T
-
L
D
G
D
I
K
L
A
D
F
G
V
S
-
A
K
N
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
D
-
R
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
A
K
SEPPT
L
A
-------------------
Q
---
P
---
S
-
R
W
S
-------------
S
-----------------------
N
----
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
-
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
------------
P
I
R
E
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
56.74
35%
-74
- C1 -
4USE
1
?
B:
[19-280]
-----------------------------------------------------------------
E
V
W
E
I
V
G
-
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
--
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
-
A
T
-
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
-----
W
I
M
I
E
-
F
C
-
P
-
G
-
G
A
V
D
A
I
M
L
E
L
----
D
-
R
G
L
-
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
---
T
-
L
E
G
D
I
R
L
A
D
F
G
V
S
-
A
K
N
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
-
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-------
A
K
S------------------
D
---
P
PT-
L
-
L
T
P
-------------
S
-----------------------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
-
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
------------
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
56.40
33%
-80
- C1 -
3W2C
1
AURKA_HUMAN
A:
[3-259]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
--------------
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
--------------------
T
L
D
Y
L
P
P
E
M
I
-----
E
--------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
--
Y
K
R
I
-------
S
R
-------------------
V
---
E
---
F
-
T
F
P
-------------
D
-----------------------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------
H
P
W
I
T
A
N
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
21.12
33%
-23
- C1 -
2NP8
1
AURKA_HUMAN
A:
[11-166]
----------------------------------------------------------------
L
E
D
F
E
I
G
R
-
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
G
V
E
-
H
Q
L
R
R
E
V
E
I
Q
-
S
H
-
L
R
H
P
N
I
L
R
L
Y
G
Y
F
--
H
D
A
T
R
V
Y
L
I
L
E
-
Y
A
-
P
L
G
-
T
V
Y
R
--
E
L
Q
K
----
L
-
S
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
-
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
-
S
A
G
E
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------