@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK39_HUMAN: (2015-10-20 )
MAEPSGSPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQGPPNANEDYREASSCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGSEIPDEVKLIGFAQLSVS
Atome Classification :
(90 SA)
.........10........20........30........40........50........60........70.--.......80........90........100-.......110-....-..-.-120.......130-----........140.......150.......160...--....170.......180...-.-...-190.......---200-.......210.......220...--...-.230.......240..----.----.----.-..----250.......260.......270.......-280...------------.....290.......300.......310.......320.......330....-...340..----......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAEPSGS
P
V
H
V
QLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGW
P
I
C
R
D
A
Y
E
L
Q
E
V
IGS
G
--
A
T
A
V
V
Q
A
A
LCK
P
R
Q
E
R
V
A
I
K
RI
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
QC-SH-P-
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
LSGG
S
M
L
D
I
I
K
Y
I
V
NRGEHKN
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R-N-G
Q
I
-
H
R
DLKAG
N
I
L
---LGE-DG
S
V
Q
I
A
D
FG
V
S
A
F
LATGGD
V
T
R
--
N
K
V
-
R
K
TFVGTPCWM
A
P
E
V
M
----
E
----
Q
----V-RG----YDFK
A
D
M
W
SFG
I
T
A
I
E
LATGAAPYHKYPP
M
-
K
V
-
L
M
L
------------
T
LQNDPPTLETGV
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
QKDPSKR
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A-K
N
R
----
E
Y
L
I
E
K
L
L
TRT
P
D
I
A
Q
R
A
K
K
V
R
RVPGSSGHLHKTEDGDWEWSDDEMD
E
K
SEEG
K
A
A
F
S
Q
E
K
S
R
RVKEENP
E
I
A
V
S
A
S
T
I
P
E
Q
I
Q
S
LSVHDSQGPPNA
N
E
D
Y
R
E
A
S
S
C
A
V
N
L
V
L
R
L
R
NSRKELN
D
I
R
F
E
FTPGRDT
A
D
G
V
S
Q
E
L
F
S
AGLVDGH
D
V
V
I
V
A
A
N
L
Q
K
IVD
D
P
K
A
L
K
T
L
T
F
K
LASGCDGSEIP
D
E
V
K
L
I
G
F
A
Q
L
SVS
1
PsiBlast_PDB
91.18
100%
-119
- C2 -
5D9H
1
?
A:
[10-308]
----------------------------------------------------
A
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
S
H
-
P
-
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
----------
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
T
L
E
T
G
V
--
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A
-
K
N
R
----
E
Y
L
I
E
K
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
89.94
100%
-118
- C2 -
5D9H
1
?
B:
[10-309]
----------------------------------------------------
A
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
S
H
-
P
-
N
V
V
T
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
G
E
H
K
N
G
V
L
E
--
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
-
N
-
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
V
T
R
--
N
--------
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
T
L
E
T
G
V
E
D
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
-
F
Q
K
A
-
K
N
R
----
E
Y
L
I
E
K
L
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.99
87%
-120
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[2-290]
----------------------------------------------------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
H
H
-
P
-
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
--------------
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
86.75
87%
-117
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[2-290]
----------------------------------------------------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
H
H
-
P
-
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
T
R
--
N
------
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
86.49
87%
-117
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[2-290]
----------------------------------------------------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
H
H
-
P
-
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
-----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
85.48
87%
-120
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[2-290]
----------------------------------------------------
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
H
H
-
P
-
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
---------------
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
-
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.03
86%
-115
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[6-298]
---------------------------------------------------
S
A
L
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
--
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
H
H
-
P
-
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
------------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
V
Q
D
K
E
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
K
A
-
K
N
K
----
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.67
86%
-123
- C2 -
2VWI
1
OXSR1_HUMAN
B:
[9-292]
------------------------------------------------------
P
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
-----
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
-
M
D
E
L
L
K
E
I
Q
A
-
M
S
Q
C
-
H
H
-
P
-
N
I
V
S
Y
Y
T
S
F
V
V
K
------
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
G
E
H
K
S
G
V
L
D
--
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
-
N
-
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
---
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
---------------
T
P
C
W
M
A
P
E
V
M
----
E
----
Q
----
V
-
R
G
----
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
-
L
M
L
------------
T
L
Q
N
D
P
P
S
L
E
T
G
-----
M
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
70.67
40%
-111
- C2 -
4OBO
2
M4K4_HUMAN
A:
[19-303]
-------------------------------------------------------
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--------
E
I
K
L
E
I
N
M
-
L
K
K
Y
S
H
H
-
R
-
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
-------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
DENP
D
-
A
T
----
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
--------
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
70.48
35%
-99
- C2 -
3GNI
2
STRAA_HUMAN
B:
[18-389]
-----------------------------------------------------
S
S
F
L
P
E
G
G
C
Y
E
L
L
T
V
I
G
K
G
FE
D
L
M
T
V
N
L
A
R
Y
K
P
T
G
E
Y
V
T
V
R
R
I
N
L
E
A
C
S
N
E
M
V
T
F
L
Q
G
E
L
H
V
-
S
K
L
F
-
N
H
-
P
-
N
I
V
P
Y
R
A
T
F
I
A
D
------
N
E
L
W
V
V
T
S
F
M
A
Y
G
S
A
K
D
L
I
C
T
------
H
F
M
D
G
M
N
--
E
L
A
I
A
Y
I
L
Q
G
V
L
K
A
L
D
Y
I
H
H
-
M
-
G
Y
V
-
H
R
S
V
K
A
S
H
I
L
---
I
S
V
-
D
G
K
V
Y
L
S
G
L
R
S
N
L
S
M
I
S
H
G
Q
R
Q
R
V
V
H
D
F
-
P
K
Y
S
V
K
V
L
P
W
L
S
P
E
V
L
----
Q
----
Q
----
N
L
Q
G
----
Y
D
A
K
S
D
I
Y
S
V
G
I
T
A
C
E
L
A
N
G
H
V
P
F
K
D
M
P
A
T
-
Q
M
-
L
L
E
------------
K
--------------------
F
S
P
H
F
H
H
F
V
E
Q
C
L
Q
R
N
P
D
A
R
P
S
A
S
T
L
L
N
H
S
F
-
F
K
Q
I
----A
S
--
E
A
L
P
E
L
L
R
P
V
T
P
I
T
--------------------
E
V
D
D
W
E
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
67.12
38%
-107
- C2 -
4ZJI
1
PAK1_HUMAN
A:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.10
38%
-105
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-------
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
---------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
65.68
48%
-106
* C2 *
3A7I
1
STK24_HUMAN
A:
[17-286]
-------------------------------------------------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
-------
Q
I
K
-
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
Y
---------
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
L
R
N
A
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
65.55
38%
-100
- C2 -
4P90
1
PAK1_HUMAN
B:
[14-277]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
------
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-----------
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
------------------
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.14
44%
-105
- C2 -
4NZW
1
STK25_HUMAN
B:
[28-288]
--------------------------------------------------------------------
I
G
K
G
--
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
----------------
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
S
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
-
T
K
K
----
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
64.04
38%
-108
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
-------
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
63.80
44%
-95
- C2 -
2XIK
2
STK25_HUMAN
A:
[27-287]
--------------------------------------------------------------------
I
G
K
G
--
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
-
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
I
T
R
Y
F
G
S
Y
L
K
S
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
K
---------
P
G
P
L
E
--
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
R
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
S
P
P
T
L
E
G
---------
Q
H
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
T
R
Y
-
T
K
K
----
T
S
F
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.46
36%
-86
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[15-295]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
---------------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
63.39
38%
-105
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
---------------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
62.69
44%
-104
- C2 -
4FZD
1
STK26_HUMAN
B:
[14-276]
------------------------------------------------------------------
E
R
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
--------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
-
S
K
K
----
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
62.45
37%
-103
- C2 -
4OBQ
2
M4K4_HUMAN
A:
[26-295]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
-------------
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
62.43
36%
-81
- C2 -
4O0R
1
PAK1_HUMAN
A:
[14-293]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
61.71
44%
-103
- C2 -
3GGF
1
STK26_HUMAN
B:
[29-291]
------------------------------------------------------------------
E
R
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
------------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
-
S
K
K
----
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
61.54
36%
-84
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[15-295]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
61.32
41%
-97
- C2 -
3FXZ
1
?
A:
[19-282]
-----------------------------------------------------------
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
Q
-
Q
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
E
---------
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
-------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
-------
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
61.22
35%
-106
- C2 -
4USF
1
?
A:
[16-282]
------------------------------------------------------------
D
F
W
E
I
I
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
-
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
-
D
H
-
P
-
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
-
V
D
A
V
M
L
E
L
E
R
P
------
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
---
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
----------------
T
P
Y
W
M
A
P
E
V
V
M
C
E-------------
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
-
S
N
K
----
P
I
R
E
L
I
A
E
A
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
60.94
36%
-83
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[15-294]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
--
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
60.75
37%
-95
- C2 -
4ZK5
2
?
A:
[26-295]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
-
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
60.27
44%
-102
- C2 -
3GGF
1
STK26_HUMAN
A:
[29-291]
------------------------------------------------------------------
E
R
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
-----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
-
S
K
K
----
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
60.20
33%
-106
- C2 -
3ALN
1
MP2K4_HUMAN
A:
[15-311]
-----------------------------------------------------
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
--
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
-
Q
K
Q
L
L
M
D
L
D
V
V
M
R
S
S
-
D
C
-
P
-
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
L
K
I
I
-
H
R
D
I
K
P
S
N
I
L
---
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
--------
T
Q
------------
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
Y
-
E
E
R
AVE
V
A
C
Y
V
C
K
I
L
D
Q
M
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
60.20
46%
-100
- C2 -
4O27
1
STK24_HUMAN
B:
[12-270]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
--
N
E
-----
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
60.18
38%
-101
- C2 -
4ZJI
1
?
C:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
------------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.68
35%
-98
- C2 -
4USF
1
?
B:
[16-282]
------------------------------------------------------------
D
F
W
E
I
I
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
-
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
-
D
H
-
P
-
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
-
V
D
A
V
M
L
E
L
E
R
P
------
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
---
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCET
S
----
K
----
D
-
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
-
S
N
K
----
P
I
R
E
L
I
A
E
A
K
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
59.65
36%
-81
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[15-295]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-------
Q
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
59.57
38%
-101
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
----
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
------------
E
--
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
------------
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
59.15
37%
-99
- C2 -
4RVT
2
M4K4_HUMAN
A:
[28-297]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
----
E
-
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
59.02
30%
-102
- C2 -
3EQC
2
MP2K1_HUMAN
A:
[28-333]
-------------------------------------------------------
G
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
--
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
I
-
R
N
Q
I
I
R
E
L
Q
V
-
L
H
E
C
-
N
S
-
P
-
Y
I
V
G
F
Y
G
A
F
Y
S
D
------
G
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
K
--------
A
G
R
I
P
--
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
-
K
I
M
-
H
R
D
V
K
P
S
N
I
L
---
V
N
S
-
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
I
D
---------
S
M
-
A
---
V
G
T
R
S
Y
M
S
P
E
R
L
----
Q
----
G
------
T
H
----
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
-
E
L
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
-
I
K
R
S
-
D
A
E
----
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
58.97
37%
-96
- C2 -
3Q4Z
1
PAK1_HUMAN
A:
[15-278]
----------------------------------------------------
S
V
G
D
P
--
K
-----
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
-------
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
58.86
35%
-102
- C2 -
5AJQ
2
STK10_HUMAN
A:
[16-287]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
---------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MC--
E
----
T
----
M
-
K
D
TP--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
58.85
36%
-80
- C2 -
4O0T
1
PAK1_HUMAN
A:
[14-294]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
Q
-
Q
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
58.76
35%
-100
- C2 -
4AOT
1
STK10_HUMAN
B:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
--------------
I
G
T
P
Y
W
M
A
P
E
V
V
M-----------------P---
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
58.58
38%
-104
- C2 -
4ZJI
1
?
D:
[16-279]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
D
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
----------
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
P
L
----
S
S
L
T
P
L
I
A
A
A
K
E
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
58.42
44%
-95
- C2 -
4FZA
3
STK26_HUMAN
B:
[14-276]
------------------------------------------------------------------
E
R
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
-
S
K
K
----
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
58.19
35%
-105
- C2 -
4USD
1
?
B:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
----
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
-----------------------
G
T
P
Y
W
M
A
P
E
V
V
MC--------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
58.00
37%
-89
- C2 -
4U43
1
M4K4_HUMAN
A:
[26-295]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
-
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
57.90
37%
-95
- C2 -
4OBP
2
M4K4_HUMAN
A:
[26-295]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
-
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SD----
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
57.68
35%
-99
- C2 -
4AOT
1
STK10_HUMAN
A:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
---------------------
G
T
P
Y
W
M
A
P
E
V
V
M---------------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
57.52
37%
-92
- C2 -
4U44
2
M4K4_HUMAN
A:
[26-295]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
-
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SHD---
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
------------------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PDAT
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
57.50
36%
-78
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[15-294]
----------------------------------------------------
S
V
G
D
P
--
K
K
K
Y
T
R
F
E
K
I
G
Q
G
--
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----
Q
-
Q
P
K
-
K
E
L
I
I
N
E
I
L
V
-
M
R
E
N
-
K
N
-
P
-
N
I
V
N
Y
L
D
S
Y
L
V
G
------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
---------
E
T
C
M
D
--
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
-
N
-
Q
V
I
-
H
R
N
I
K
S
D
N
I
L
---
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-----
P
E
--
Q
S
K
-
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
----
T
----
R
------
K
A
----
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
-
L
Y
L
------------
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
-
K
-----------
P
L
S
S
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
57.13
37%
-91
- C2 -
4U45
1
M4K4_HUMAN
A:
[26-295]
--------------------------------------------------------------
F
E
L
V
E
V
V
G
N
G
--
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
-
E
I
K
L
--
E
I
N
M
-
L
K
K
Y
-
S
H
-
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SPPD--
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
------
N
T
K
G
N
T
L
K
--
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
-
H
-
H
V
I
-
H
R
D
I
K
G
Q
N
V
L
---
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
-----------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
----
A
----
C
----
D
-
E
N
PD
A
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
-
L
F
L
------------
I
P
R
N
P
P
P
R
L
K
S
K
K
W
S
K
K
F
F
S
F
--------
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
Q
-
P
N
E
----
R
Q
V
R
I
Q
L
K
D
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
55.64
36%
-99
- C2 -
2J7T
1
STK10_HUMAN
A:
[15-292]
--------------------------------------------------------
L
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
E
L
-------
D
R
G
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
-----
T
--
L
Q
K
-----
I
G
T
P
Y
W
M
A
P
E
V
V
----
M
C
E
T
M
K
----
D
-
T
P
----
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
55.14
32%
-100
- C2 -
4BIB
1
B:
[26-281]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
-----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
54.59
32%
-101
- C2 -
2CLQ
1
B:
[29-284]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
-----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
54.15
44%
-92
- C2 -
4FZF
1
?
B:
[14-276]
------------------------------------------------------------------
E
R
I
G
K
G
----
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
S
-
Y
V
T
K
Y
Y
G
S
Y
L
K
G
------
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
R
---------
A
G
P
F
D
--
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
Q
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
---------
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
V
K
N
-
S
K
K
----
T
S
Y
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
54.14
32%
-100
- C2 -
4BIE
2
B:
[26-282]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
--------
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
54.02
32%
-99
- C2 -
4BF2
1
B:
[42-297]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
----------
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------------
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
53.96
32%
-100
- C2 -
4BIC
2
B:
[26-282]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
-----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----------------
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
53.83
32%
-99
- C2 -
4BHN
2
B:
[42-295]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
-----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
53.83
35%
-99
- C2 -
4EQU
2
STK10_HUMAN
B:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
-----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
-
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
53.43
33%
-105
- C2 -
3ALN
1
MP2K4_HUMAN
B:
[30-295]
--------------------------------------------------------------------
I
G
R
G
--
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
-
Q
K
Q
L
L
M
D
L
D
V
-
V
M
R
S
-
S
D
C
P
-
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
---
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
----------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
----------------------------
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
Y
-
E
E
R
----
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
53.40
35%
-99
- C2 -
4EQU
2
STK10_HUMAN
A:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
-------
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
-
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
53.13
32%
-92
- C2 -
4BIB
3
M3K5_HUMAN
A:
[26-280]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---------
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
----------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
52.73
32%
-99
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[29-284]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
D
S
----
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
--------
E
T
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
52.29
32%
-95
- C2 -
4BIE
2
M3K5_HUMAN
A:
[26-281]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---------
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
51.83
32%
-98
- C2 -
4BF2
2
M3K5_HUMAN
A:
[42-296]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
-----------
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
--------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
51.75
35%
-84
- C2 -
2J51
5
SLK_HUMAN
A:
[37-303]
------------------------------------------------------------
D
F
W
E
I
I
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
-
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
-
D
H
-
P
-
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
-
V
D
A
V
M
L
E
L
E
R
P
------
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
---
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
T
R
T
--
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CET
S
----
K
----
D
-
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
-
S
N
K
----
P
I
R
E
L
I
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
51.54
32%
-96
- C2 -
4BIC
2
M3K5_HUMAN
A:
[26-281]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
------
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
A
-----
G
---------
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
51.29
33%
-96
- C2 -
3ALO
1
MP2K4_HUMAN
A:
[30-295]
--------------------------------------------------------------------
I
G
R
G
--
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
-
Q
K
Q
L
L
M
D
L
D
V
-
V
M
R
S
-
S
D
C
P
-
Y
I
V
Q
F
Y
G
A
L
F
R
E
------
G
D
C
W
I
C
M
E
L
M
S
T
-
S
F
D
K
F
Y
K
Y
V
Y
S
V
---
L
D
D
V
I
P
--
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
-
N
-
L
K
I
I
H
R
D
I
K
P
S
N
I
L
---
L
D
R
-
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
V
D
S
I
A
K
T
R
--
D
-------
A
G
C
R
P
Y
M
A
P
E
R
I
----
D
P----------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
D
Q
-
L
T
Q
------------
V
V
K
G
D
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
-
I
L
M
Y
-
E
E
R
----
A
V
E
V
A
C
Y
V
C
K
I
L
D
Q
M
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
51.08
32%
-94
- C2 -
4BID
1
B:
[26-281]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
R
-----
S
Q
P
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
L
-----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
50.95
35%
-87
- C2 -
2UV2
6
SLK_HUMAN
A:
[37-303]
------------------------------------------------------------
D
F
W
E
I
I
G
E
L
G
D
----
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
-
K
S
E
E
E
-
L
E
D
Y
M
V
E
I
D
I
-
L
A
S
C
-
D
H
-
P
-
N
I
V
K
L
L
D
A
F
Y
Y
E
------
N
N
L
W
I
L
I
E
F
C
A
G
G
A
-
V
D
A
V
M
L
E
L
E
R
P
------
L
T
--
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
-
K
I
I
-
H
R
D
L
K
A
G
N
I
L
---
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
-----
K
N
T
R
T
--
I
Q
R
-
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CET
S
----
K
----
D
-
R
P
----
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
D
-
S
N
K
----
P
I
R
E
L
I
A
E
A
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
50.85
32%
-97
- C2 -
4BID
1
M3K5_HUMAN
A:
[26-280]
-------------------------------------------------------------------
V
L
G
K
G
--
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
-
E
---------
L
H
E
E
I
A
L
-
H
K
H
L
-
K
H
-
K
-
N
I
V
Q
Y
L
G
S
F
S
E
N
------
G
F
I
K
I
F
M
E
Q
V
P
G
G
S
L
S
A
L
L
R
-------
S
K
W
G
P
L
K
DN
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
-
N
-
Q
I
V
-
H
R
D
I
K
G
D
N
V
L
---
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
R
----------------
E
E
F
T
G
T
L
Q
Y
M
A
P
E
I
I
----
D
----
K
----
G
P
R
G
----
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
-
Q
A
-
A
M
F
------------
K
V
G
----
M
F
K
V
H
P
E
I
P
E
S
M
S
A
E
A
K
A
F
---
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
-
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
50.72
35%
-90
- C2 -
4USE
1
?
A:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
--
L
Q
--------
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
-
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
49.46
35%
-93
- C2 -
4BC6
2
STK10_HUMAN
A:
[11-282]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-
T
K
S
E
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
H
D
------
G
K
L
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
--
L
Q
---------
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
-
K
D
TP--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
48.49
35%
-90
- C2 -
4USE
1
?
B:
[19-290]
------------------------------------------------------------
E
V
W
E
I
V
G
E
L
G
D
G
--
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
E
-
L
E
D
Y
I
V
E
I
E
I
-
L
A
T
C
-
D
H
-
P
-
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
P
G
G
A
-
V
D
A
I
M
L
E
L
D
R
G
------
L
T
--
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
-
K
-
R
I
I
-
H
R
D
L
K
A
G
N
V
L
---
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
-----
K
N
L
K
T
--
L
Q
K
-------
T
P
Y
W
M
A
P
E
V
V
M
C
--
E
----
T
----
M
-
K
D
T
P
--
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
-
L
L
K
------------
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
S
S
I
-
T
S
N
----
K
A
L
R
E
L
V
A
E
A
K
A
E
V
M
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
46.80
31%
-100
- C2 -
4FG8
1
KCC1A_HUMAN
A:
[17-272]
-----------------------------------------------------------
R
D
I
Y
D
F
R
D
V
L
G
T
G
--
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------
N
E
I
A
V
-
L
H
K
I
-
K
H
-
P
-
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--------
E
K
G
F
Y
T
--
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
-
G
I
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
-
D
S
K
I
M
I
S
D
F
--------------------------
T
P
G
Y
V
A
P
E
V
L
----
A
----
Q
------
K
P
----
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
-
K
L
-
F
E
Q
------------
I
L
K
A
E
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A
G
D
-
T
A
L
----
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
46.40
31%
-96
- C2 -
4FG8
1
KCC1A_HUMAN
B:
[17-272]
-----------------------------------------------------------
R
D
I
Y
D
F
R
D
V
L
G
T
G
--
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------
N
E
I
A
V
-
L
H
K
I
-
K
H
-
P
-
N
I
V
A
L
D
D
I
Y
E
S
G
------
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
--------
E
K
G
F
Y
T
--
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
-
G
I
V
-
H
R
D
L
K
P
E
N
L
L
YYS
L
D
E
-
D
S
K
I
M
I
S
D
F
G
-------
G
S
--------
V
-
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
----
A
----
Q
------
K
P
----
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
-
K
L
-
F
E
Q
------------
I
L
K
A
E
Y
E
F
------
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
-
I
A
G
D
-
T
A
L
----
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
38.62
46%
-51
- C2 -
4QML
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
36.23
46%
-52
- C2 -
4QMO
3
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
36.07
46%
-54
- C2 -
4QMS
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
35.88
46%
-52
- C2 -
4QMN
1
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
35.50
46%
-52
- C2 -
4QMX
1
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
35.49
46%
-53
- C2 -
4QMZ
1
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
35.32
46%
-55
- C2 -
4QMQ
3
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
35.12
46%
-54
- C2 -
4QMW
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
34.44
46%
-51
- C2 -
4QMV
3
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
33.72
46%
-51
- C2 -
4QMY
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
33.62
46%
-52
- C2 -
4QMU
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
33.43
46%
-51
- C2 -
4QMP
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
33.05
46%
-50
- C2 -
4QMM
3
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
32.96
46%
-52
- C2 -
4QMT
2
STK24_HUMAN
A:
[35-293]
------------------------------------------------------------------
E
K
I
G
K
G
--
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
-
I
E
D
I
Q
Q
E
I
T
V
-
L
S
Q
C
-
D
S
-
P
-
Y
V
T
K
Y
Y
G
S
Y
L
K
D
------
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
E
---------
P
G
P
L
D
--
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
-
E
-
K
K
I
-
H
R
D
I
K
A
A
N
V
L
---
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
T
D
--
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
----
K
----
Q
------
S
A
----
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
-
L
F
L
------------
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
-
K
K
T
----
S
Y
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------