@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK3_HUMAN: (2015-10-20 )
MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLESDLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDAMDAKKRRQQNF
Atome Classification :
(93 SA)
.........10.--.......20.---------.......30........40........50........60---.--.--...--..---.-70..-....-..80-........90--..------......100.......110-------.-------.-.....120.......130.......140........150.......160......------.170........180.......190.-----.-----..-...200.......210.......220..-...--..230----------........240..-------.....250.......260.......270......-.---280...-.-...290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEQPPA
P
K
S
K
L
K
--
K
L
S
E
D
SLTK
Q
---------
P
E
E
V
F
D
V
L
E
K
LGEGS
Y
G
S
V
F
K
A
I
H
KESG
Q
V
V
A
I
K
QVP
V
E
---
S
--
D
--
L
Q
E
--
I
I
---
K
-
E
I
S
I
-
M
Q
QC-DS
P
Y
-
V
V
K
Y
Y
G
S
YFK--NT------
D
L
W
I
V
M
EYCGAG
S
V
S
D
I
I
R
-------L-------R-NKT
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
-
R
K
I
H
R
D
IKAG
N
I
L
L
NTEGH
A
K
LADFGVA------
G
Q
L
-
T
D
T
M
AKRNTVIGT
P
F
WM
A
P
E
V
I
-----
Q
-----
E
I-G
Y
N
C
V
A
D
I
W
S
LGI
T
S
I
EMAEGKPPYADI-H
P
M
--
R
A
I
F
-----------
M
I
PTNPPPTFRKP-------ELW
S
D
D
F
T
D
F
V
K
K
C
L
VKNP
E
Q
R
A
T
A
T
Q
L
L
QHPFI-K---NA
K
P
V
S
-
I
-
L
R
D
L
I
T
E
A
M
E
I
K
A
K
R
H
E
E
Q
Q
R
E
L
E
EEEENS
D
E
D
ELDS
H
T
M
V
K
T
S
V
E
S
VGTMRAT
S
T
M
S
E
G
A
Q
T
M
I
EHN
S
T
M
L
ESDL
G
T
M
V
INSEDEEEEDGTMKRNATSPQVQR
P
S
F
M
D
Y
F
D
K
Q
DFKNKSHENCNQNMHEPFPMSKNVFPDNWKVPQDG
D
F
D
F
L
K
NL
S
L
E
E
L
Q
M
R
L
K
AL
D
P
M
M
E
R
E
I
E
E
L
R
Q
R
YTAKRQP
I
L
D
A
M
D
A
K
K
R
R
QQNF
43
PsiBlast_CBE
77.79
44%
-107
- C4 -
5AJQ
2
STK10_HUMAN
A:
[14-292]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
--------
E
EE
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
75.75
44%
-100
- C4 -
4AOT
1
STK10_HUMAN
B:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
---
S
--
E
E
E
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
------------
I
G
T
P
Y
W
M
A
P
E
V
V
M-------------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
75.64
43%
-105
- C4 -
4USF
1
?
B:
[14-291]
---------------------------------
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
---
S
--
E
E
E
L
E
D
--
Y
M
---
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
-
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
N
----------
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD-
S
N
K
P
I
-----
R
E
L
I
A
E
A
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
75.53
56%
-93
- C4 -
3A7I
1
STK24_HUMAN
A:
[15-291]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
EAE
D
--
E
--
I
E
D
--
I
Q
---
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
----------------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
--
E
-------
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
74.71
42%
-98
- C4 -
4ZJJ
1
PAK1_HUMAN
A:
[3-293]
-----
S
D
E
E
I
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
-----------
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.58
54%
-90
- C4 -
3A7I
1
STK24_HUMAN
A:
[15-298]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
74.49
39%
-98
- C4 -
4FIE
1
PAK4_HUMAN
A:
[153-418]
-------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
QQ
R
--
R
E
L
--
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.47
54%
-88
- C4 -
3A7H
1
STK24_HUMAN
A:
[15-298]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
74.12
43%
-107
- C4 -
4USF
1
?
A:
[14-291]
---------------------------------
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
---
S
--
E
E
E
L
E
D
--
Y
M
---
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
-
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
--------------
T
P
Y
W
M
A
P
E
V
V
M
C
E---------
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD-
S
N
K
P
I
-----
R
E
L
I
A
E
A
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
73.99
42%
-101
- C4 -
4ZJI
1
PAK1_HUMAN
A:
[8-296]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------------
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.94
54%
-91
- C4 -
3A7J
1
STK24_HUMAN
A:
[15-298]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
73.87
55%
-97
- C4 -
4FZD
1
STK26_HUMAN
B:
[6-282]
---------------------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
D
---------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
S
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.74
42%
-111
- C4 -
4OBQ
2
M4K4_HUMAN
A:
[17-312]
------------------
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----------------------
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
PPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
73.58
42%
-109
- C4 -
4ZK5
2
?
A:
[18-312]
-------------------
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---
E
--
D
--
E
E
E
--
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.57
44%
-103
- C4 -
4AOT
1
STK10_HUMAN
A:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
---
S
--
E
E
E
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
--------------
G
T
P
Y
W
M
A
P
E
V
V
M--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
73.48
42%
-104
- C4 -
4U43
1
M4K4_HUMAN
A:
[15-312]
----------------
D
L
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---
E
--
D
--
E
E
E
--
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
PPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
73.13
55%
-89
- C4 -
4O27
1
STK24_HUMAN
B:
[4-280]
---------------------------------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
72.92
44%
-108
- C4 -
4USD
1
?
B:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
---
S
--
E
E
E
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
----------------------
G
T
P
Y
W
M
A
P
E
V
V
MC-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
72.79
42%
-101
- C4 -
4ZJJ
1
PAK1_HUMAN
B:
[5-293]
-------
E
E
I
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------------
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
72.65
43%
-103
- C4 -
4RVT
2
M4K4_HUMAN
A:
[17-312]
----------------
D
L
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----------
E
--
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
------------------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
72.51
42%
-103
- C4 -
4ZJI
1
PAK1_HUMAN
B:
[8-294]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
------------
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
72.46
42%
-105
- C4 -
4OBP
2
M4K4_HUMAN
A:
[14-311]
---------------
I
D
L
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---
E
--
D
--
E
E
E
--
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
D
D
----
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.39
42%
-99
- C4 -
4ZY6
1
PAK1_HUMAN
B:
[8-295]
-----------
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---
Q
--
Q
--
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
---------------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
72.34
42%
-104
- C4 -
4U45
1
M4K4_HUMAN
A:
[13-312]
--------------
D
I
D
L
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---
E
--
D
--
E
E
E
--
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
PPD
D
--
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
72.29
42%
-103
- C4 -
4ZY4
2
PAK1_HUMAN
B:
[7-294]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---
Q
-----
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.14
42%
-103
- C4 -
4U44
2
M4K4_HUMAN
A:
[13-311]
--------------
D
I
D
L
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
---
E
--
D
--
E
E
E
--
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
HD
D
---
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
V
S
------
A
-----------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
72.07
55%
-97
- C4 -
3GGF
1
STK26_HUMAN
B:
[21-298]
---------------------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
-----------------
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
D
---------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
S
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
71.95
46%
-103
- C4 -
4OBO
2
M4K4_HUMAN
A:
[20-308]
----------------------
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----------
E
--
I
K
---
L
-
E
I
N
M
-
L
K
K
Y
S
H
H
R
N
-
I
A
T
Y
Y
G
A
F
I
K
K
S
D
D
------
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
-------
N
-------
T
K
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
-
S
-------
K
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
---
D
Q
P
N
E
R
-
Q
-
V
R
I
Q
L
K
D
H
I
D
R
T
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
71.89
55%
-96
- C4 -
3GGF
1
STK26_HUMAN
A:
[21-300]
---------------------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
D
---------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
S
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
F
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
71.88
41%
-94
- C4 -
3Q4Z
1
PAK1_HUMAN
A:
[7-299]
----------
L
E
--
K
L
R
I
I
V
S
V
G
D
---------
P
K
-----
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
Q
M
N
L
------------
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
N
N
H
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
71.79
41%
-101
- C4 -
4P90
1
PAK1_HUMAN
B:
[9-294]
---------------
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
----------------
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
------------------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.76
55%
-86
- C4 -
4FZF
1
?
B:
[6-282]
---------------------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
D
---------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
S
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
71.73
54%
-98
- C4 -
4NZW
1
STK25_HUMAN
B:
[18-286]
---------------------------------
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
I
T
R
Y
F
G
S
Y
L
K
--
S
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
K
-
P
G
P
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
---------------
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
---
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
-
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
S
P
P
T
L
E
G
Q
-------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
---
Y
T
K
K
T
S
-
F
-
L
T
E
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
71.70
55%
-89
- C4 -
4FZA
3
STK26_HUMAN
B:
[6-282]
---------------------------------
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
S
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
G
S
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
R
-
A
G
P
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
--
R
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
V
G
D
---------
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
S
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
71.49
41%
-93
- C4 -
4O0R
1
PAK1_HUMAN
A:
[6-293]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---
Q
--
Q
--
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
71.47
44%
-99
- C4 -
3FXZ
1
?
A:
[17-291]
-----------------------
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
N
L
Q
---
Q
QP
K
--
K
E
L
--
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
71.27
42%
-98
- C4 -
4ZY5
2
PAK1_HUMAN
B:
[8-295]
-----------
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---
Q
-----
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
71.11
44%
-95
- C4 -
2J7T
1
STK10_HUMAN
A:
[15-296]
----------------------
L
D
---------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----
E
--
E
--
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
----
I
G
T
P
Y
W
M
A
P
E
V
V
-----
M
C
E
T
M
K
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
70.76
42%
-107
- C4 -
4OBO
2
M4K4_HUMAN
A:
[17-311]
------------------
S
S
L
-
R
D
---------
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
--------------
E
I
---
K
L
E
I
N
M
-
L
K
K
Y
-
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
--
K
S
D
D
----
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
L
V
K
N
------
T
-------
K
-
G
N
T
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
-
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
------------------
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
-
T
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
--
R
A
L
F
-----------
L
I
P
R
N
P
P
P
R
L
K
S
K
-------
K
W
-
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
QP
N
E
R
Q
V
R
-
I
Q
L
K
D
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
70.56
42%
-91
- C4 -
4ZY6
1
PAK1_HUMAN
A:
[7-295]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----------
Q
--
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
----------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
70.34
39%
-93
- C4 -
2F57
1
PAK7_HUMAN
A:
[43-313]
---------------------------------
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
H
H
D
N
-
V
V
D
M
Y
S
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
R
I
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
-
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
Q
A
M
R
-----------
R
I
R
D
S
L
P
P
R
V
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
-
K
---
L
A
G
P
P
S
-
C
-
I
V
P
L
M
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.13
44%
-99
- C4 -
4EQU
2
STK10_HUMAN
A:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-----------
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
---------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
69.78
39%
-89
- C4 -
2F57
1
B:
[43-313]
---------------------------------
P
R
E
Y
L
A
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
H
H
D
N
-
V
V
D
M
Y
S
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
D
G
R
I
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
-
P
Y
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
Q
A
M
R
-----------
R
I
R
D
S
L
P
P
R
V
K
D
L
-------
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
L
-
K
---
L
A
G
P
P
S
-
C
-
I
V
P
L
M
R
Q
Y
R
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
69.73
44%
-97
- C4 -
4BC6
2
STK10_HUMAN
A:
[9-287]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
---
S
--
E
E
E
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
--------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
69.23
41%
-94
- C4 -
4O0T
1
PAK1_HUMAN
A:
[6-294]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
Q
---
Q
--
Q
--
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
68.99
44%
-98
- C4 -
4EQU
2
STK10_HUMAN
B:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------EE
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
--------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
68.74
44%
-99
- C4 -
4USE
1
?
B:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------EE
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
-------------
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
K
------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
68.54
42%
-89
- C4 -
4ZJI
1
?
C:
[4-295]
------
D
E
E
I
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
------------
K
K
EL
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
68.47
43%
-95
- C4 -
2UV2
6
SLK_HUMAN
A:
[35-312]
---------------------------------
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
---
S
--
E
E
E
L
E
D
--
Y
M
---
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
-
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
N
-
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD-
S
N
K
P
I
-----
R
E
L
I
A
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
68.32
44%
-97
- C4 -
4USE
1
?
A:
[17-295]
---------------------------------
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
---
S
--
E
EE
L
E
D
--
Y
I
---
V
-
E
I
E
I
-
L
A
T
C
-
D
H
P
Y
-
I
V
K
L
L
G
A
Y
Y
H
--
D
G
------
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
I
M
L
-------
E
-------
L
-
D
R
G
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
-
L
K
T
L
Q
-------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
D
P
P
T
L
L
T
P
-------
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
-
S
---
S
I
T
S
N
K
-
A
-
L
R
E
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
68.09
38%
-95
- C4 -
5D9H
1
?
A:
[18-308]
-----------------------------------
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
S
H
P
N
-
V
V
T
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
-------
Y
I
V
N
R
GEH
K
-
N
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
V
T
R
---
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
T
L
E
T
G
VKEMM--
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
---
K
A
K
N
R
E
Y
L
-
I
E
K
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
67.84
40%
-104
- C4 -
3EQC
2
MP2K1_HUMAN
A:
[33-331]
-----------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
A
--
I
--
R
N
Q
--
I
I
---
R
-
E
L
Q
V
-
L
H
E
C
-
N
S
P
Y
-
I
V
G
F
Y
G
A
F
Y
S
--
D
G
------
E
I
S
I
C
M
E
H
M
D
G
G
S
L
D
Q
V
L
K
-------
K
---------
A
G
R
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
------
G
Q
L
-
I
D
S
M
A
-----
V
G
T
R
S
Y
M
S
P
E
R
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-
D
A
K
E
L
E
L
M
F
GCPMA
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-------
G
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
-
K
---
R
S
D
A
E
E
-
V
-
D
F
A
G
W
L
C
S
T
I
G
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.83
42%
-93
- C4 -
4ZY4
1
PAK1_HUMAN
A:
[7-294]
----------
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
--
Q
--
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
------
A
Q
I
-
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
67.72
43%
-93
- C4 -
2J51
5
SLK_HUMAN
A:
[35-312]
---------------------------------
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
---
S
--
E
EE
L
E
D
--
Y
M
---
V
-
E
I
D
I
-
L
A
S
C
-
D
H
P
N
-
I
V
K
L
L
D
A
F
Y
Y
--
E
N
------
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
V
M
L
-------
E
-------
L
-
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
------
A
K
N
-
T
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
--
R
V
L
L
-----------
K
I
A
K
S
E
P
P
T
L
A
Q
P
-------
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
-
T
VD-
S
N
K
P
I
-----
R
E
L
I
A
E
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
67.01
39%
-94
- C4 -
2X4Z
3
A:
[22-282]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
66.96
42%
-93
- C4 -
4ZJJ
1
PAK1_HUMAN
C:
[5-296]
-------
E
E
I
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
Q
----------
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
----------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
--------------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
--------
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
66.95
36%
-87
- C4 -
4FIF
1
PAK4_HUMAN
A:
[51-332]
------------P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
DPGD
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.82
42%
-90
- C4 -
4ZJI
1
?
D:
[7-295]
---------
I
L
E
--
K
L
R
S
I
V
S
V
G
D
---------
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
------------
K
K
EL
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
-------
A
Q
I
-
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
66.43
36%
-92
- C4 -
4FIF
1
PAK4_HUMAN
B:
[52-332]
------------Q-
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
DPGD
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
HHSearch
66.12
39%
-92
* C4 *
4JDI
1
PAK4_HUMAN
A:
[73-340]
----------------------------------
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
QQ
R
--
R
E
L
--
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
66.08
38%
-98
- C4 -
5D9H
1
?
B:
[18-309]
-----------------------------------
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
S
H
P
N
-
V
V
T
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
-------
Y
IVNRGEH
K
-
N
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
-
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
------
A
F
L
A
T
G
G
D
V
T
R
N
---
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
T
L
E
T
G
VEDKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
-
Q
---
K
A
K
N
R
E
Y
L
-
I
E
K
L
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
HHSearch
66.07
40%
-94
- C4 -
4KS7
2
A:
[20-285]
-----------------------
D
---------
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
---
K
QQ
R
--
R
E
L
--
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
F
N
-
V
V
E
M
Y
K
S
Y
L
V
--
G
E
------
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
----------------
S
-
Q
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
I
-
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
-
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
-
S
P
V
--
Q
A
M
K
-----------
R
L
R
D
S
P
P
P
K
L
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
-
L
---
Q
T
G
L
P
E
-
C
-
L
V
P
L
I
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
65.95
36%
-95
- C4 -
4FIG
1
?
A:
[53-332]
--------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
DPGD
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.59
42%
-98
- C4 -
4ZJJ
1
PAK1_HUMAN
D:
[6-295]
--------
E
I
L
E
--
K
L
R
S
I
V
S
V
------------
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
Q
M
N
L
----------
P
K
K
E
L
I
I
---
N
-
E
I
L
V
-
M
R
E
N
-
K
N
P
N
-
I
V
N
Y
L
D
S
Y
----
G
D
------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
V
V
T
-----------------
E
T
C
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
F
C
-----------
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
-
A
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
--
R
A
L
Y
-----------
L
I
A
T
N
G
T
P
E
L
Q
N
P
-------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
-
K
---
I
A
K
P
L
S
-
S
-
L
T
P
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
65.27
39%
-91
- C4 -
4O0Y
1
A:
[19-279]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
65.25
36%
-91
- C4 -
4FIG
1
?
B:
[53-332]
--------------
R
V
S
H
E
Q
F
R
A
A
LQLVVDPGD
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
65.17
40%
-100
- C4 -
3DAK
1
OXSR1_HUMAN
A:
[12-290]
-------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
H
H
P
N
-
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
-------
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-------------
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
65.15
39%
-93
- C4 -
2CDZ
1
A:
[29-289]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
65.00
39%
-92
- C4 -
2J0I
4
A:
[29-289]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
64.91
40%
-101
- C4 -
3DAK
1
OXSR1_HUMAN
D:
[12-290]
-------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
H
H
P
N
-
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
-------
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
I
-
T
R
N
------
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
64.80
40%
-96
- C4 -
4KS8
1
A:
[21-276]
---------------------------------
P
R
L
L
L
D
S
Y
V
K
I
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
M
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
F
N
-
V
V
E
M
Y
K
S
Y
L
V
--
G
E
------
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
I
V
S
-----------------
Q
V
R
L
N
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
I
-
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
-
L
Y
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
-
S
P
V
--
Q
A
M
K
-----------
R
L
R
D
S
P
P
P
K
L
K
N
S
-------
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
L
-
L
---
Q
T
G
L
P
E
-
C
-
L
V
P
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
64.78
40%
-103
- C4 -
3DAK
1
OXSR1_HUMAN
C:
[12-290]
-------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
H
H
P
N
-
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
-------
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
64.47
40%
-100
- C4 -
3DAK
1
OXSR1_HUMAN
B:
[12-290]
-------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
H
H
P
N
-
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
-------
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---
K
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
64.39
39%
-90
- C4 -
2Q0N
7
A:
[27-287]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
64.22
39%
-92
- C4 -
4APP
2
A:
[22-282]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
T
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
64.08
39%
-91
- C4 -
4O0X
1
?
A:
[19-279]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
63.45
39%
-87
- C4 -
4NJD
1
A:
[22-282]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
63.42
39%
-103
- C4 -
2VWI
1
OXSR1_HUMAN
D:
[17-298]
-------------------------------------
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
H
H
P
N
-
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
-------
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
-----------
T
F
V
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
S
L
E
T
G
VQDKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
---
K
A
K
N
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
62.66
37%
-110
- C4 -
3FME
1
MP2K6_HUMAN
A:
[9-272]
-------------------------------------
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
--N
S
-
Q
--
E
--
Q
K
R
--
L
L
---
M
-
D
L
D
I
S
M
R
T
V
-
D
C
P
F
-
T
V
T
F
Y
G
A
L
F
R
--
E
G
------
D
V
W
I
C
M
E
L
M
D
-
T
S
L
D
K
F
Y
K
-------
Q
V
I
D
----
K
-
G
Q
T
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
-----------------------
A
G
C
K
P
Y
M
A
P
E
R
I
-----
N
PELN-
Q
---
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
W
G
T
P
F
--
Q
Q
L
K
-----------
Q
V
V
E
E
P
S
P
Q
L
-
P
A
-------
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
-
T
---
L
H
E
S
K
G
-
T
-
D
V
A
S
F
V
K
L
I
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
62.15
39%
-91
- C4 -
4O0V
1
A:
[19-279]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
E
L
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
61.37
39%
-101
- C4 -
2VWI
1
OXSR1_HUMAN
B:
[17-292]
-------------------------------------
Y
E
L
Q
E
V
I
G
S
---
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
KCQ
T
--
S
--
M
D
E
--
L
L
---
K
-
E
I
Q
A
-
M
S
Q
C
-
H
H
P
N
-
I
V
S
Y
Y
T
S
F
V
V
--
K
D
------
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
I
I
K
H
I
V
A
K
GE
H
-------
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
-
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
T
G
G
D
--------------
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
--
K
V
L
M
-----------
L
T
L
Q
N
D
P
P
S
L
E
T
G
ML-----
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.69
54%
-46
- C4 -
4QMW
2
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
59.29
54%
-47
- C4 -
4QMU
2
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.01
54%
-41
- C4 -
4QML
2
STK24_HUMAN
A:
[25-305]
----------------------
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
58.70
54%
-47
- C4 -
4QMN
1
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.23
54%
-46
- C4 -
4QMS
2
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.01
54%
-44
- C4 -
4QMO
4
STK24_HUMAN
A:
[22-304]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.01
54%
-43
- C4 -
4QMM
3
STK24_HUMAN
A:
[22-304]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
57.88
54%
-44
- C4 -
4QMP
2
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
57.73
54%
-46
- C4 -
4QMV
3
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.46
54%
-44
- C4 -
4QMQ
3
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.61
54%
-43
- C4 -
4QMT
2
STK24_HUMAN
A:
[22-305]
-------------------
N
L
K
A
D
---------
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
---
E
--
A
--
E
D
E
--
I
E
D
I
Q
Q
-
E
I
T
V
-
L
S
Q
C
-
D
S
P
Y
-
V
T
K
Y
Y
G
S
Y
L
K
--
D
T
------
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
---------
L
-------
E
-
P
G
P
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
-
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
------
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
--
K
V
L
F
-----------
L
I
P
K
N
N
P
P
T
L
E
G
N
---------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
---
N
A
K
K
T
S
-
Y
-
L
T
E
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
48.02
39%
-60
- C4 -
5BMS
1
A:
[19-279]
---------------------------------
P
R
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
---
K
--
Q
--
Q
R
R
EL
L
F
---
N
-
E
V
V
I
-
M
R
D
Y
-
Q
H
E
N
-
V
V
E
M
Y
N
S
Y
L
V
--
G
D
------
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
-----------------
H
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
------
A
Q
V
-
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
-
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
-
P
P
L
--
K
A
M
K
-----------
M
I
R
D
N
L
P
P
R
L
K
N
L
-------
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
-
A
---
K
A
G
P
P
A
-
S
-
I
V
P
L
M
R
Q
N
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------