@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TAOK1_HUMAN: (2015-10-20 )
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
Atome Classification :
(91 SA)
.........10........20........30........40........50........60........70........80........90.......------..100......-.-110...--.------....120--------.......--..130.......140.......150.......-160.......170...----.....----180----.----........190....--...---200.-........210.......220.......-230...-..--.----.240...-..-.--------.-250..----.....260.......270.......280.....-----.-.290-.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSTNRAGSLKD
P
E
I
A
E
L
F
F
KE
D
P
E
K
L
F
T
D
L
R
E
IGHGSF
G
A
V
Y
F
A
RDVRTN
E
V
V
A
I
K
K
MSYSGKQS
T
E
K
W
Q
D
I
I
K
E
V
K
F
L
Q
R
IKHPNSIE-YK
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-L-G-
S
A
S
D
--
L
------
L
E
V
H
K
----------K
P
L
Q
E
V
E
--
I
A
A
I
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
T
M
I
H
R
DIKAG
N
I
L
L-TEPG
Q
V
K
L
ADFG-SAS----MASP
A
----
N
------S----FVGTPYWMA
P
E
V
I
L
A
--MDE---G--Q-YDG
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
ERKPPLF
N
M
N
-
A
M
S
A
L
Y
-
H
I
--A----QNESPTL-QS-N--------
E
-
W
S
D
Y
F
----
R
N
F
V
D
S
C
L
Q
KIPQDRP
T
S
E
E
L
L
K
H
I
F
V
L
RERP
E
-----
T
-
V
L
I
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
L
L
F
Q
EAHNGPAVEA
Q
E
E
E
E
E
Q
DHGVGRTGTVNSVGSNQSIP
S
M
S
I
SASSQSSSVNSLPDVSD
D
K
S
E
L
D
MMEGD
H
T
VMSNS
S
V
I
H
LKPEEENYREEGDPRTRASDPQSP
P
Q
V
S
R
H
K
S
H
YRN
R
E
H
F
A
T
I
R
T
A
S
L
V
T
R
Q
M
Q
E
H
E
Q
D
S
E
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Q
H
Q
K
Q
L
M
T
L
E
N
K
L
K
A
E
M
D
E
H
R
L
RLDK
D
L
E
T
Q
RN
N
F
A
A
E
M
E
K
L
I
K
K
H
Q
A
A
M
E
K
E
A
K
V
MS
N
E
E
K
K
F
Q
Q
H
I
Q
A
Q
Q
K
K
E
L
N
S
F
L
E
S
Q
K
R
E
Y
K
L
R
K
E
Q
L
K
E
E
L
NENQST
P
K
K
E
K
Q
E
W
L
S
K
Q
K
E
N
I
Q
H
F
Q
A
E
E
E
A
N
L
L
R
R
Q
R
Q
Y
L
E
L
E
C
R
R
F
K
R
R
M
L
LGRH
N
L
E
Q
D
L
V
R
E
E
L
N
K
R
Q
T
Q
K
D
L
E
H
A
M
L
L
R
Q
H
E
S
M
Q
E
L
E
F
R
H
L
N
T
I
Q
K
M
R
C
E
L
I
R
L
Q
H
Q
T
E
L
T
N
Q
L
E
Y
N
K
R
R
E
R
E
L
R
R
K
H
V
M
E
V
R
QQ
P
K
SL
K
S
K
E
L
Q
I
K
K
Q
F
Q
D
T
C
K
I
Q
T
R
Q
Y
K
A
L
R
N
H
L
LETTP
K
S
E
H
K
A
V
L
K
R
L
K
E
E
Q
T
R
K
L
A
I
L
A
E
Q
Y
D
H
S
I
N
E
M
L
S
T
Q
A
LRLDEA
Q
E
A
E
C
Q
V
L
K
M
Q
L
Q
Q
E
L
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
A
E
A
Q
H
D
R
E
L
R
E
L
E
Q
R
V
S
L
R
R
A
L
L
E
Q
K
I
E
E
E
M
L
A
L
Q
N
E
R
T
E
R
I
R
S
L
L
E
R
Q
A
R
E
I
E
AFDSE
S
M
RLG
F
S
N
M
V
L
SNL
S
P
E
A
FSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNS
P
Q
A
L
R
R
TASGGRTEQGMSRST
S
V
T
SQISNGSHMSYT
2
PsiBlast_PDB
98.23
88%
-85
- C1 -
1U5R
1
TAOK2_RAT
A:
[40-348]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
-
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
------
L
E
V
H
K
----------
K
P
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
-
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
S
----
I
M
A
P
A
----
N
------
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
--
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
-
A
M
S
A
L
Y
-
H
I
--
A
----
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
-
W
S
E
Y
F
----
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.13
88%
-86
- C1 -
1U5R
1
TAOK2_RAT
B:
[40-348]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
-
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
------
L
E
V
H
K
----------
K
P
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
-
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
S
----
I
M
A
P
A
----
N
------
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
--
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
-
A
M
S
A
L
Y
-
H
I
--
A
----
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
-
W
S
E
Y
F
----
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
97.51
88%
-88
- C1 -
2GCD
1
TAOK2_RAT
B:
[1-309]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
-
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
------
L
E
V
H
K
----------
K
P
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
-
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
S
----
I
M
A
P
A
----
N
------
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
--
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
-
A
M
S
A
L
Y
-
H
I
--
A
----
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
-
W
S
E
Y
F
----
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.96
88%
-85
- C1 -
2GCD
1
TAOK2_RAT
A:
[1-309]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
-
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
S
D
--
L
------
L
E
V
H
K
----------
K
P
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
-
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
S
----
I
M
A
P
A
----
N
------
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
--
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
-
A
M
S
A
L
Y
-
H
I
--
A
----
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
-
W
S
E
Y
F
----
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
E
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.19
41%
-76
- C1 -
4U44
2
M4K4_HUMAN
A:
[13-311]
-----------
D
I
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
A
--------------------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.09
41%
-71
- C1 -
4U45
1
M4K4_HUMAN
A:
[13-312]
-----------
D
I
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
A
-------------
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.96
41%
-74
- C1 -
4ZK5
2
?
A:
[18-312]
----------------
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
A
-------------
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
72.94
41%
-75
- C1 -
4U43
1
M4K4_HUMAN
A:
[15-312]
-------------
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
---------------
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
71.53
41%
-76
- C1 -
4OBP
2
M4K4_HUMAN
A:
[14-311]
------------
I
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
A
-------------
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
71.11
40%
-78
- C1 -
4RVT
2
M4K4_HUMAN
A:
[17-312]
-------------
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
----
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
---------------
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
70.66
41%
-78
- C1 -
4OBQ
2
M4K4_HUMAN
A:
[17-312]
---------------
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
-
V
---------------
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
70.07
42%
-64
- C1 -
4ZY6
1
PAK1_HUMAN
B:
[18-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
----------------------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
69.79
41%
-83
- C1 -
4OBO
2
M4K4_HUMAN
A:
[17-311]
---------------
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
T
D
--
L
------
V
K
N
T
K
G---------
N
T
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
-
T
E
N
A
E
V
K
L
V
D
F
G
------------
R
----
N
------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
--
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
-
P
M
R
A
L
F
-
L
I
--
P
----
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
-
W
S
K
K
F
----
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
D
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
69.71
43%
-74
- C1 -
4ZJI
1
PAK1_HUMAN
B:
[19-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
-----
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
-------------T---
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
69.44
43%
-75
- C1 -
4ZJJ
1
PAK1_HUMAN
A:
[19-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
--------------T---
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
69.32
42%
-66
- C1 -
4ZY5
2
PAK1_HUMAN
B:
[18-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
E
----
Q
------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.83
47%
-63
- C1 -
3A7I
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
68.30
42%
-67
- C1 -
4O0T
1
PAK1_HUMAN
A:
[17-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
E
----
Q
------
S
KRSE
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
67.52
42%
-66
- C1 -
4O0R
1
PAK1_HUMAN
A:
[17-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
E
----
Q
------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
67.47
42%
-69
- C1 -
4ZY4
2
PAK1_HUMAN
B:
[18-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
E
----
Q
------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.89
47%
-60
- C1 -
3A7H
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
66.13
43%
-77
- C1 -
4ZJJ
1
PAK1_HUMAN
B:
[19-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
--------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
--------------T---
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
66.12
42%
-68
- C1 -
4ZY4
1
PAK1_HUMAN
A:
[18-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
E
----
Q
------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.87
47%
-59
- C1 -
3A7J
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.77
42%
-65
- C1 -
4ZY6
1
PAK1_HUMAN
A:
[18-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
I
T
P
E
----
Q
------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
65.64
42%
-65
- C1 -
4P90
1
PAK1_HUMAN
B:
[17-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------------
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
--------------------------
S
KR
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
64.90
47%
-62
- C1 -
4O27
1
STK24_HUMAN
B:
[3-276]
----------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QI
K
R
N
------
E
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
62.06
43%
-72
- C1 -
4ZJJ
1
PAK1_HUMAN
C:
[19-296]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
---
Q
---
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
------------
E
----
Q
------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-------
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
61.96
43%
-68
- C1 -
4ZJI
1
?
C:
[19-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
A
----
Q
---------------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
61.11
43%
-70
- C1 -
4ZJI
1
?
D:
[19-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
-
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
T
D
--
V
--------
V
T
E
----------
T
C
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
-
G
M
D
G
S
V
K
L
T
D
F
G
-
F
-
A
----
Q
I
T
-------------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
--
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
-
P
L
R
A
L
Y
-
L
I
--
A
----
T
N
G
T
P
E
L
-
Q
N
-
P
--------
E
K
L
S
A
I
F
----
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
A
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.10
38%
-63
- C1 -
4USD
1
?
B:
[16-299]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
-----------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
-------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.83
41%
-63
- C1 -
4USF
1
?
B:
[13-276]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
-
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
-
G
-
G
A
V
D
A
V
M
------
L
E
L
-
E
----------
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
A
----
K
N
-------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
---
R
--
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
-
W
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
-----
P
-
I
R
E
L
-
I
A
E
A
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.55
41%
-62
- C1 -
4USF
1
?
A:
[13-276]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
-
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
-
G
-
G
A
V
D
A
V
M
------
L
E
L
-
E
----------
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
A
----
K
-----------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E-------
R
--
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
-
W
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
-----
P
-
I
R
E
L
-
I
A
E
A
K
A
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
59.51
46%
-52
- C1 -
4NZW
1
STK25_HUMAN
B:
[17-290]
----------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
I
T
R
-
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
------
D
L
L
K
P
----------
G
P
L
E
E
T
Y
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
G
----------------------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
--------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
-
P
M
R
V
L
F
-
L
I
--
P
----
K
N
S
P
P
T
L
-
E
G
-
Q
--------
H
--
S
K
P
F
----
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
K
K
-----
T
S
F
L
T
E
-
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
59.39
38%
-62
- C1 -
4AOT
1
STK10_HUMAN
B:
[16-299]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K-------------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
------------
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.31
44%
-48
- C1 -
4FZA
3
STK26_HUMAN
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
------
D
L
L
R
A
----------
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
-
P
M
R
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
--
V
-
G
--------
D
-
F
T
K
S
F
----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
58.52
38%
-59
- C1 -
4AOT
1
STK10_HUMAN
A:
[16-299]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
---------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
58.40
44%
-51
- C1 -
4FZD
1
STK26_HUMAN
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
------
D
L
L
R
A
----------
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
G
----
Q
L
T
------
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
-
P
M
R
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
--
V
-
G
--------
D
-
F
T
K
S
F
----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
57.65
44%
-49
- C1 -
4FZF
1
?
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
------
D
L
L
R
A
----------
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
-
P
M
R
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
--
V
-
G
--------
D
-
F
T
K
S
F
----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
56.06
38%
-64
- C1 -
4EQU
2
STK10_HUMAN
B:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
KNL----------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
55.76
44%
-51
- C1 -
3GGF
1
STK26_HUMAN
A:
[20-293]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
------
D
L
L
R
A
----------
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
-
V
A
----------R---
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
-
P
M
R
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
--
V
-
G
--------
D
-
F
T
K
S
F
----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
55.56
44%
-50
- C1 -
3GGF
1
STK26_HUMAN
B:
[20-293]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
S
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
-
G
-
G
G
S
A
--
L
------
D
L
L
R
A
----------
G
P
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
Q
G
D
V
K
L
A
D
F
G
-
V
A
--------------
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
-
P
M
R
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
--
V
-
G
--------
D
-
F
T
K
S
F
----
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
55.32
39%
-68
- C1 -
5AJQ
2
STK10_HUMAN
A:
[13-276]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
N
L
K
T
--------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
53.54
38%
-61
- C1 -
2J7T
1
STK10_HUMAN
A:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
N
L
K
T
L
Q
K
------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
52.59
41%
-57
- C1 -
2J51
5
SLK_HUMAN
A:
[34-297]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
-
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
-
G
-
G
A
V
D
A
V
M
------
L
E
L
-
E
----------
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
A
----
K
N
T
R
T
I
Q
R
R
D
------
S
----
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
---
R
--
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
-
W
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
-----
P
-
I
R
E
L
-
I
A
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
52.55
41%
-55
- C1 -
2UV2
6
SLK_HUMAN
A:
[34-297]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
-
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
-
G
-
G
A
V
D
A
V
M
------
L
E
L
-
E
----------
R
P
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
-
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
A
----
K
N
T
R
T
I
Q
R
R
D
------
S
----
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
---
R
--
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
-
W
S
S
N
F
----
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
D
S
N
K
-----
P
-
I
R
E
L
-
I
A
E
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
51.87
38%
-53
- C1 -
4USE
1
?
A:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
N
LK
T
L
Q
---------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
51.69
38%
-55
- C1 -
4BC6
2
STK10_HUMAN
A:
[8-293]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
N
L
K
T
L
Q
----------------------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
51.66
38%
-61
- C1 -
4EQU
2
STK10_HUMAN
A:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
KNL-----------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
50.17
37%
-59
- C1 -
5D9H
1
?
B:
[26-309]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
M
------
L
D
I
I
K
YIVNRGEHKN
G
V
L
E
E
A
I
--
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
----
D
VTRN---------
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-------
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
T
L
-
E
T
-
G
VEDKEMMK
K
-
Y
G
K
S
F
----
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
-----
E
-
Y
L
I
E
K
L
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
49.73
38%
-58
- C1 -
4USE
1
?
B:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
-
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
V
D
A
I
M
------
L
E
L
D
R
----------
G
-
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
-
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
A
K
N
L
K
T
L
Q
K
--------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
--
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
-
P
M
R
V
L
L
-
K
I
--
A
----
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
-
W
S
V
E
F
----
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
I
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
48.22
37%
-58
- C1 -
5D9H
1
?
A:
[26-308]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
M
------
L
D
I
I
K
Y
I
V
N
R
GEHKN
G
V
L
E
E
A
I
--
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
----
D
VTR---------
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-------
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
T
L
-
E
T
-
G
VKEMMK--
K
-
Y
G
K
S
F
----
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
A
K
N
R
-----
E
-
Y
L
I
E
K
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
47.79
47%
-27
- C1 -
4QMT
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
47.66
37%
-61
- C1 -
2VWI
1
OXSR1_HUMAN
D:
[23-290]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
V
------
L
D
I
I
K
H
I
V
A
K
GEHKS
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
-----------
T
----
F
V
G
T
P
C
W
M
A
P
E
V
-----
M
E
Q
---
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
-
Y
G
K
S
F
----
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
N
K
-----
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.81
47%
-27
- C1 -
4QMN
1
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
46.44
31%
-57
- C1 -
4BID
1
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
----------------EE--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
FKV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
46.27
47%
-23
- C1 -
4QMQ
3
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
46.25
47%
-28
- C1 -
4W8E
1
STK24_HUMAN
A:
[8-284]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
46.18
47%
-23
- C1 -
4QMO
4
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.99
47%
-22
- C1 -
4QML
2
STK24_HUMAN
A:
[25-299]
---------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
45.98
37%
-52
- C1 -
3DAK
1
OXSR1_HUMAN
C:
[18-285]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
V
------
L
D
I
I
K
H
I
V
A
K
GEHKS
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
----
D
------
T
----
F
V
G
T
P
C
W
M
A
P
E
V
-----
M
E
Q
---
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
-
Y
G
K
S
F
----
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
45.77
47%
-27
- C1 -
4QMW
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
45.75
31%
-59
- C1 -
4BIC
2
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
G
-------------E---
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
FKV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
45.28
37%
-51
- C1 -
3DAK
1
OXSR1_HUMAN
A:
[18-285]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
V
------
L
D
I
I
K
H
I
V
A
K
GEHKS
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
-----------------
V
G
T
P
C
W
M
A
P
E
V
-----
M
E
Q
---
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
-
Y
G
K
S
F
----
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
45.27
47%
-26
- C1 -
4QMU
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
45.24
37%
-61
- C1 -
2VWI
1
OXSR1_HUMAN
C:
[23-290]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
V
------
L
D
I
I
K
H
I
V
A
K
GEHKS
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
----
D
ITRNKV-------
G
T
P
C
W
M
A
P
E
V
-----
M
E
Q
---
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
S
L
-
E
T
--K-------
K
-
Y
G
K
S
F
----
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.08
47%
-23
- C1 -
4QMM
3
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
44.83
33%
-65
- C1 -
2WQN
1
NEK7_HUMAN
A:
[38-283]
-------------------------------
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
-
Y
Y
A
S
F
I
E
------
D
N
E
L
N
I
V
L
E
---
L
-
A
-
D
A
G
D
--
L
S
R
M
I
K
H
F
K
K
Q
K
----------
R
L
I
P
E
R
T
--
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
-
T
A
T
G
V
V
K
L
G
D
L
---------------------------------
T
P
Y
Y
M
S
P
E
R
I
-----
H
E
---
N
--
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
-
M
N
-
L
Y
S
L
C
K
-
K
I
--
E
----
Q
C
D
Y
P
P
L
-
P
S
-
D
--------
H
-
Y
S
E
E
L
----
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
44.58
37%
-53
- C1 -
3DAK
1
OXSR1_HUMAN
D:
[18-285]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
V
------
L
D
I
I
K
H
I
V
A
K
GEHKS
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
----
D
ITRN-------
F
V
G
T
P
C
W
M
A
P
E
V
-----
M
E
Q
---
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
-
Y
G
K
S
F
----
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
44.47
31%
-56
- C1 -
4BIE
2
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
G
-------------E---
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
FKV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
44.44
47%
-23
- C1 -
4QMV
3
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
44.32
47%
-25
- C1 -
4QMS
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
44.31
47%
-22
- C1 -
4QMP
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
-
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
L
D
--
L
------
L
E
--
P
----------
G
P
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
-
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
G
----
Q
L
T
D
T
QIKR
N
------
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
--
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
-
P
M
K
V
L
F
-
L
I
--
P
----
K
N
N
P
P
T
L
-
E
G
-
N
----------
Y
S
K
P
L
----
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
44.17
37%
-53
- C1 -
3DAK
1
OXSR1_HUMAN
B:
[18-285]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
P
N
I
V
S
-
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
---
L
-
L
-
S
G
G
S
--
V
------
L
D
I
I
K
H
I
V
A
K
GEHKS
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
-
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
----
L
A
T
G
G
----
D
--------------
T
P
C
W
M
A
P
E
V
-----
M
E
Q
---
V
--
R
G
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
-
P
M
K
V
L
M
-
L
T
--
L
----
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
-
Y
G
K
S
F
----
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
43.37
31%
-53
- C1 -
4BHN
2
B:
[43-295]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
43.04
31%
-55
- C1 -
4BIB
3
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
--------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
----------------EE--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
FKV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
43.02
31%
-55
- C1 -
4BID
1
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
-------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
42.54
31%
-58
- C1 -
4BIC
2
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
-------------------
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
42.27
31%
-59
* C1 *
2CLQ
1
B:
[30-282]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
42.23
31%
-58
- C1 -
4BIB
1
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
-------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
PsiBlast_CBE
42.12
31%
-58
- C1 -
2J4Z
3
AURKA_HUMAN
A:
[40-286]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
-
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
Y
R
--
E
------
L
Q
K
L
S
----------
K
F
D
E
Q
R
T
--
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
A
D
F
G
--
W
S
----
V
H
A
P
S
----
S
RRT---
T
----
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
---
G
--
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
-
T
Y
Q
E
T
Y
-
K
R
--
I
----
S
R
V
E
F
T
F
--
P
-
D
--------
F
-
V
T
E
G
A
----
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
42.01
31%
-54
- C1 -
4BIE
2
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-------
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
41.36
31%
-55
- C1 -
4BF2
1
B:
[43-295]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
---------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
-------------------
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
F
KV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
41.28
31%
-57
- C1 -
2CLQ
1
M3K5_HUMAN
A:
[30-282]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
G
------E-----
T
----
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
FKV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
41.00
31%
-68
- C1 -
3EFW
1
AURKA_HUMAN
A:
[137-383]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
-
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
Y
R
--
E
------
L
Q
K
L
S
----------
K
F
D
E
Q
R
T
--
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
A
D
F
----------------------------------
L
D
Y
L
P
P
E
M
I
------
E
-----------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
-
T
Y
Q
E
T
Y
K
R
I
--
S
----
R
V
E
F
----------------
T
-
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
40.40
31%
-57
- C1 -
4BF2
2
M3K5_HUMAN
A:
[43-295]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
----------
E
E
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
-
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
-
G
G
S
L
S
A
--
L
------
L
R
S
K
W
----------
G
P
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
-
T
S
K
----
R
L
A
--------------EE--
F
T
G
T
L
Q
Y
M
A
P
E
I
I
-----
D
K
---
G
PR
G
-
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
--
G
M
FKV
H
P
E
I
P
E
S
-
M
S
-
A
--------
E
-
A
--------
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
PsiBlast_CBE
40.37
31%
-61
- C1 -
1MUO
1
AURKA_HUMAN
A:
[31-277]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
-
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
Y
R
--
E
------
L
Q
K
L
S
----------
K
F
D
E
Q
R
T
--
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
A
D
F
G
--
W
S
-------------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
---
G
--
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
-
T
Y
Q
E
T
Y
-
K
R
--
I
----
S
R
V
E
F
T
F
--
P
-
D
--------
F
-
V
T
E
G
A
----
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
PsiBlast_CBE
39.81
31%
-59
- C1 -
2J4Z
2
AURKA_HUMAN
B:
[40-286]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
-
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
Y
R
--
E
------
L
Q
K
L
S
----------
K
F
D
E
Q
R
T
--
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
A
D
F
G
--
W
S
----
V
H
A
P
S
----
S
RRT---
T
----
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
---
G
--
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
-
T
Y
Q
E
T
Y
-
K
R
--
I
----
S
R
V
E
F
T
F
--
P
-
D
--------
F
-
V
T
E
G
A
----
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-----
P
-
S
N
C
Q
-
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
39.64
31%
-62
- C1 -
3EFW
1
AURKA_HUMAN
B:
[137-383]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
-
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
Y
R
--
E
------
L
Q
K
L
S
----------
K
F
D
E
Q
R
T
--
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
-
G
S
A
G
E
L
K
I
A
D
F
----------------------------------
L
D
Y
L
P
P
E
M
I
------
E
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
-
T
Y
Q
E
T
Y
K
R
I
--
S
----
R
V
E
F
----------------
T
-
F
P
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
PsiBlast_CBE
36.49
31%
-50
- C1 -
4YUR
1
PLK4_HUMAN
A:
[21-269]
---------------------------------
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
-
L
Y
N
Y
F
E
D
------
S
N
Y
V
Y
L
V
L
E
M
C
-
H
N
G
-
E
M
N
R
--
Y
------
L
K
N
R
V
----------
K
P
F
S
E
N
E
--
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
-
T
R
N
M
N
I
K
I
A
D
F
-----------------------------------------------------
G
--
L
----
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
-
V
K
N
T
L
N
-
K
V
V
L
A
----
D
Y
E
M
P
S
F
-
L
S
-
I
--------
E
-
A
K
D
--------
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
35.18
31%
-46
- C1 -
3COK
1
PLK4_HUMAN
A:
[19-267]
---------------------------------
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
-
L
Y
N
Y
F
E
D
------
S
N
Y
V
Y
L
V
L
E
M
C
-
H
N
G
-
E
M
N
R
--
Y
------
L
K
N
R
V
----------
K
P
F
S
E
N
E
--
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
-
T
R
N
M
N
I
K
I
A
D
F
G
-
L
A
T
Q
---
L
K
--------------------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
-
V
K
------
V
VL
A
----
D
Y
E
M
P
S
F
-
L
S
-
I
--------
E
-
A
K
D
--------
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------