@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TAOK2_HUMAN: (2015-10-20 )
MPAGGRAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPVLQSGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRKMKKILFQEAPNGPGAEAPEEEEEAEPYMHRAGTLTSLESSHSVPSMSISASSQSSSVNSLADASDNEEEEEEEEEEEEEEEGPEAREMAMMQEGEHTVTSHSSIIHRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTSTTSSARRRAYCRNRDHFATIRTASLVSRQIQEHEQDSALREQLSGYKRMRRQHQKQLLALESRLRGEREEHSARLQRELEAQRAGFGAEAEKLARRHQAIGEKEARAAQAEERKFQQHILGQQKKELAALLEAQKRTYKLRKEQLKEELQENPSTPKREKAEWLLRQKEQLQQCQAEEEAGLLRRQRQYFELQCRQYKRKMLLARHSLDQDLLREDLNKKQTQKDLECALLLRQHEATRELELRQLQAVQRTRAELTRLQHQTELGNQLEYNKRREQELRQKHAAQVRQQPKSLKVRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSPGQEAVLDQRMLGEEEEAVGERRILGKEGATLEPKQQRILGEESGAPSPSPQKHGSLVDEEVWGLPEEIEELRVPSLVPQERSIVGQEEAGTWSLWGKEDESLLDEEFELGWVQGPALTPVPEEEEEEEEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPCPASQLPGLLSHGLLAGLSFAVGSSSGLLPLLLLLLLPLLAAQGGGGLQAALLALEVGLVGLGASYLLLCTALHLPSSLFLLLAQGTALGAVLGLSWRRGLMGVPLGLGAAWLLAWPGLALPLVAMAAGGRWVRQQGPRVRRGISRLWLRVLLRLSPMAFRALQGCGAVGDRGLFALYPKTNKDGFRSRLPVPGPRRRNPRTTQHPLALLARVWVLCKGWNWRLARASQGLASHLPPWAIHTLASWGLLRGERPTRIPRLLPRSQRQLGPPASRQPLPGTLAGRRSRTRQSRALPPWR
Atome Classification :
(84 SA)
.........10........20........30........40........50........60........70........80..-......90......------..100......-.110...--.------..------.------.120-.-.....--..130.......140.......150.......160........170..----.....------180-.----........190...--.--...---200........210.......220......-.230...-....240...-..-.--------.250.......260.......270.......280.-.--...-----.-.290-.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPAGGRAGSLKDP
D
V
A
E
L
F
FKD
D
P
E
K
L
F
S
D
L
R
E
IGHGSF
G
A
V
Y
F
A
RDVRNS
E
V
V
A
I
K
K
MSYSGKQS
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L-RHP
N
T
I
Q
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-LG-
S
A
S
D
--
L
------
L
E
------
V
------
H
K-K-
P
-
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
SH
N
M
I
H
RDVKAG
N
I
L
LSE-P
G
L
V
K
LGDFGSAS----IMAP
A
------
N
---S----FVGTPYWMA
P
E
V
I
L
--
A
--MDE---GQ-YDG
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
ERKPPLF
N
M
-
N
A
M
S
A
L
Y
-
H
I
AQNESPVL-QS-G--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
KIPQDR
P
T
S
E
V
L
L
K
H
R
F
V
LR-E--R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
QEAPNGPGAEAPE
E
E
E
E
AE
P
Y
M
HRAGTLTSLESSHSVP
S
M
S
I
SASSQSSSVNSLADASDNE
E
E
E
E
E
E
E
E
E
E
E
E
EEG
P
E
A
R
E
M
A
M
M
QEGEHTVT
S
H
S
S
I
I
HRLPGSDNLYDDPYQPEITPSPLQPPAAPAPTS
T
T
S
S
A
R
R
R
A
Y
CRNRD
H
F
A
T
I
R
T
A
S
L
V
S
R
Q
I
Q
E
H
E
Q
D
S
A
L
R
E
Q
L
S
G
Y
K
R
M
R
R
Q
H
Q
K
Q
L
L
A
L
E
S
R
LRG
E
R
E
E
H
S
A
R
L
Q
R
E
L
E
A
Q
RAGF
G
A
E
A
E
K
L
A
R
R
H
Q
AI
G
E
K
E
A
R
A
A
Q
A
E
E
R
K
F
Q
Q
H
I
L
G
Q
Q
K
K
E
L
A
A
L
L
E
A
Q
K
R
T
Y
K
L
R
K
E
Q
L
K
E
E
L
QENPSTP
K
R
E
K
A
E
W
L
L
R
Q
K
E
Q
L
Q
Q
C
Q
A
E
E
E
A
G
L
L
R
R
Q
R
Q
Y
F
E
L
Q
C
R
Q
Y
K
R
K
M
L
L
A
RHSL
D
Q
D
L
L
R
E
D
L
N
K
K
Q
T
Q
K
D
L
E
C
A
L
L
L
R
Q
H
E
A
T
R
E
L
E
L
R
Q
L
Q
A
V
Q
R
T
R
A
E
L
T
R
L
Q
H
Q
T
ELGNQ
L
E
Y
N
K
R
R
E
Q
E
L
R
Q
K
H
A
A
Q
V
R
QQPKS
L
K
VRAGQRPPGLPLPIPGALGPPNTGTPIEQQPCSP
G
Q
E
A
V
L
D
Q
R
MLG
E
E
E
E
A
VGERRILGKEGATLE
P
K
Q
Q
R
ILGEESGAPSPSPQKHGS
L
V
D
E
E
VWG
L
P
E
E
I
E
E
LRVPSLVP
Q
E
R
SIVGQEEAG
T
W
SLWGKE
D
E
S
L
L
D
E
E
FE
L
G
WVQGPALTPVPEE
E
E
E
E
EEGAPIGTPRDPGDGCPSPDIPPEPPPTHLRPC
P
A
S
Q
L
P
G
L
L
S
H
G
L
L
A
G
L
S
FAVGSSS
G
L
L
P
L
L
L
L
L
L
L
P
L
L
AAQGG
G
G
L
Q
A
A
L
L
A
L
E
V
G
L
V
G
L
G
A
S
Y
L
L
L
C
T
A
L
HL
P
S
S
L
F
L
L
LAQGT
A
L
G
A
V
L
G
L
S
W
RRGLMGVP
L
G
L
G
A
A
W
L
L
AWPG
L
A
L
P
L
V
A
MAAGGR
W
V
R
QQG
P
R
V
R
R
G
I
S
R
L
W
L
R
V
L
L
RLS
P
M
A
F
R
A
L
Q
GCGAVGDR
G
L
F
A
LYPKTNKD
G
F
RSRLPVPGPRRRNPRTTQ
H
P
L
A
L
L
A
R
V
W
V
LCKGWN
W
R
L
A
R
ASQ
G
L
A
SHL
P
P
W
A
I
H
T
L
A
S
WGLLRGERPTRI
P
R
LLPRSQRQLGPPASRQPLP
G
T
L
AGRRSRTRQSRALPPWR
2
PsiBlast_PDB
98.70
99%
-86
- C2 -
1U5R
1
TAOK2_RAT
A:
[40-348]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
G
-
S
A
S
D
--
L
------
L
E
------
V
------
H
K
-
K
-
P
-
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
-
P
G
L
V
K
L
G
D
F
G
S
A
S
----
I
M
A
P
A
------
N
---
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-
N
A
M
S
A
L
Y
-
H
I
A
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
-
E
--
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.30
99%
-88
- C2 -
1U5R
1
TAOK2_RAT
B:
[40-348]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
G
-
S
A
S
D
--
L
------
L
E
------
V
------
H
K
-
K
-
P
-
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
-
P
G
L
V
K
L
G
D
F
G
S
A
S
----
I
M
A
P
A
------
N
---
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-
N
A
M
S
A
L
Y
-
H
I
A
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
-
E
--
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
97.74
99%
-87
- C2 -
2GCD
1
TAOK2_RAT
B:
[1-309]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
G
-
S
A
S
D
--
L
------
L
E
------
V
------
H
K
-
K
-
P
-
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
-
P
G
L
V
K
L
G
D
F
G
S
A
S
----
I
M
A
P
A
------
N
---
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-
N
A
M
S
A
L
Y
-
H
I
A
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
-
E
--
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.51
99%
-87
- C2 -
2GCD
1
TAOK2_RAT
A:
[1-309]
-----------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
------
E
H
T
A
W
L
V
M
E
Y
C
-
L
G
-
S
A
S
D
--
L
------
L
E
------
V
------
H
K
-
K
-
P
-
L
Q
E
V
E
--
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
-
P
G
L
V
K
L
G
D
F
G
S
A
S
----
I
M
A
P
A
------
N
---
S
----
F
V
G
T
P
Y
W
M
A
P
E
V
I
L
--
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
-
N
A
M
S
A
L
Y
-
H
I
A
Q
N
E
S
P
A
L
-
Q
S
-
G
--------
H
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
R
-
E
--
R
P
P
-----
T
-
V
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
71.14
40%
-71
- C2 -
4U44
2
M4K4_HUMAN
A:
[13-311]
-----------
D
I
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
SH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
-------------------
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
70.50
40%
-68
* C2 *
4U45
1
M4K4_HUMAN
A:
[13-312]
-----------
D
I
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
69.60
40%
-70
- C2 -
4ZK5
2
?
A:
[18-312]
----------------
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.08
40%
-71
- C2 -
4OBP
2
M4K4_HUMAN
A:
[14-311]
------------
I
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KS----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
S
A
---------------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
68.94
40%
-72
- C2 -
4U43
1
M4K4_HUMAN
A:
[15-312]
-------------
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
E
D
E
E
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
67.33
44%
-60
- C2 -
3A7I
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
66.65
40%
-80
- C2 -
4OBO
2
M4K4_HUMAN
A:
[17-311]
---------------
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
-----
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S----
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
-----------
R
------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
66.59
40%
-73
- C2 -
4RVT
2
M4K4_HUMAN
A:
[17-312]
-------------
D
L
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
T
----
E
E
----
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
PG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
66.34
40%
-75
- C2 -
4OBQ
2
M4K4_HUMAN
A:
[17-312]
---------------
S
S
L
---
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
KSPPG
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
-
S
I
T
D
--
L
------
V
K
------
N
------
T
K
G
N
-
T
-
L
K
E
D
W
--
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
-
N
A
E
V
K
L
V
D
F
G
V
-----------------
N
---
T
----
F
I
G
T
P
Y
W
M
A
P
E
V
I
---
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
-
H
P
M
R
A
L
F
-
L
I
P
R
N
P
P
P
R
L
-
K
S
-
K
--------
K
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
I
-
R
-
D
--
Q
P
N
E
R
Q
V
R
I
-
Q
L
K
D
-
H
I
D
R
T
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
65.30
40%
-63
- C2 -
4O0R
1
PAK1_HUMAN
A:
[17-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
E
------
Q
---
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
64.85
40%
-69
- C2 -
4ZY4
2
PAK1_HUMAN
B:
[18-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
E
------
Q
---
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
64.79
40%
-66
- C2 -
4ZY5
2
PAK1_HUMAN
B:
[18-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
E
------
Q
---
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
64.67
44%
-57
- C2 -
3A7H
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
64.59
40%
-66
- C2 -
4O0T
1
PAK1_HUMAN
A:
[17-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
E
------
Q
---
S
KRSE
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.43
44%
-57
- C2 -
3A7J
1
STK24_HUMAN
A:
[16-292]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
63.99
40%
-75
- C2 -
4ZJJ
1
PAK1_HUMAN
A:
[19-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
-------------T---
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
63.66
39%
-61
- C2 -
4USF
1
?
B:
[13-294]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
G
-
G
A
V
D
A
V
M
------
L
E
------
L
-------
E
-
R
-
P
-
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
KN----------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
--
S
K
D
---
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
SN
K
P
---------
I
R
E
-
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.52
40%
-62
- C2 -
4ZY6
1
PAK1_HUMAN
B:
[18-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
---------------------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
63.30
40%
-74
- C2 -
4ZJI
1
PAK1_HUMAN
B:
[19-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
-----
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
------------T---
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
63.14
39%
-61
- C2 -
4USF
1
?
A:
[13-294]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
G
-
G
A
V
D
A
V
M
------
L
E
------
L
-------
E
-
R
-
P
-
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
K--------------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E---------
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
SN
K
P
---------
I
R
E
-
L
I
A
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.11
40%
-63
- C2 -
4ZY6
1
PAK1_HUMAN
A:
[18-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
E
------
Q
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
63.11
44%
-58
- C2 -
4O27
1
STK24_HUMAN
B:
[3-276]
----------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QI
K
R
--
N
---
E
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
63.01
40%
-76
- C2 -
4ZJJ
1
PAK1_HUMAN
B:
[19-293]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
--------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
-------------T---
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
62.56
40%
-66
- C2 -
4ZY4
1
PAK1_HUMAN
A:
[18-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
I
T
P
E
------
Q
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
60.96
40%
-62
- C2 -
4P90
1
PAK1_HUMAN
B:
[17-294]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------------
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
------------------------
S
KR
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
60.31
40%
-70
- C2 -
4ZJJ
1
PAK1_HUMAN
C:
[19-296]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
---
Q
---
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
--------
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
-----------
E
------
Q
---
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
-----
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
60.01
40%
-67
- C2 -
4ZJI
1
?
C:
[19-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
C
A
----
Q
--------------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.41
43%
-52
- C2 -
4NZW
1
STK25_HUMAN
B:
[17-290]
----------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
I
T
R
Y
F
G
S
Y
L
K
------
S
T
K
L
W
I
I
M
E
Y
--
L
G
-
G
G
S
A
--
L
------
D
L
------
L
------
K
P
-
G
-
P
-
L
E
E
T
Y
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
---------------------------
T
P
F
W
M
A
P
E
V
I
-------
K
Q
------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
-
H
P
M
R
V
L
F
-
L
I
P
K
N
S
P
P
T
L
-
E
G
-
Q
--------
H
-
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
T
A
K
E
L
L
K
H
K
F
I
T
R
Y
T
--
K
K
T
-----
S
-
F
L
T
E
-
L
I
D
R
Y
K
R
W
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
59.29
40%
-71
- C2 -
4ZJI
1
?
D:
[19-295]
----------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
------
G
D
E
L
W
V
V
M
E
Y
L
-
A
G
G
S
L
T
D
--
V
--------------
V
------
T
E
-
T
-
C
-
M
D
E
G
Q
--
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
-
D
G
S
V
K
L
T
D
F
G
F
-
A
----
Q
I
T
------------
S
KRST
M
V
G
T
P
Y
W
M
A
P
E
V
V
-------
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
-
N
P
L
R
A
L
Y
-
L
I
A
T
N
G
T
P
E
L
-
Q
N
P
E
--------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
K
I
-
A
--
K
P
L
-----
S
-
S
L
T
P
-
L
I
A
A
A
K
E
A
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.13
42%
-47
- C2 -
4FZF
1
?
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
G
-
G
G
S
A
--
L
------
D
L
------
L
------
R
A
-
G
-
P
-
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
R
V
L
F
-
L
I
P
K
N
N
P
P
T
L
--
V
-
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
--
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
56.87
42%
-45
- C2 -
4FZA
3
STK26_HUMAN
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
G
-
G
G
S
A
--
L
------
D
L
------
L
------
R
A
-
G
-
P
-
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
R
V
L
F
-
L
I
P
K
N
N
P
P
T
L
--
V
-
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
--
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
56.61
42%
-51
- C2 -
4FZD
1
STK26_HUMAN
B:
[5-278]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
G
-
G
G
S
A
--
L
------
D
L
------
L
------
R
A
-
G
-
P
-
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
A
F
G
V
A
G
----
Q
L
T
--------
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
R
V
L
F
-
L
I
P
K
N
N
P
P
T
L
--
V
-
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
--
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
55.51
39%
-57
- C2 -
2UV2
6
SLK_HUMAN
A:
[34-313]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
G
-
G
A
V
D
A
V
M
------
L
E
------
L
-------
E
-
R
-
P
-
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
KN
T
R
T
I
Q
R
R
------
D
---
S
----
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
--
S
K
D
---
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
SN
K
P
---------
I
R
E
-
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.94
39%
-58
- C2 -
2J51
5
SLK_HUMAN
A:
[34-313]
----------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
------
E
N
N
L
W
I
L
I
E
F
C
-
A
G
-
G
A
V
D
A
V
M
------
L
E
------
L
-------
E
-
R
-
P
-
L
T
E
S
Q
--
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
-
D
G
D
I
K
L
A
D
F
G
V
S
A
KN
T
R
T
I
Q
R
R
------
D
---
S
----
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
CE
T
--
S
K
D
---
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
E
P
P
T
L
A
Q
P
-
S
--------
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
T
V
-
D
SN
K
P
---------
I
R
E
-
L
I
A
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
53.51
43%
-51
- C2 -
3GGF
1
STK26_HUMAN
A:
[20-293]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
G
-
G
G
S
A
--
L
------
D
L
------
L
------
R
A
-
G
-
P
-
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
----------R-----
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
R
V
L
F
-
L
I
P
K
N
N
P
P
T
L
--
V
-
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
--
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
G
H
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
53.45
43%
-49
- C2 -
3GGF
1
STK26_HUMAN
B:
[20-293]
----------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
------
G
S
K
L
W
I
I
M
E
Y
--
L
G
-
G
G
S
A
--
L
------
D
L
------
L
------
R
A
-
G
-
P
-
F
D
E
F
Q
--
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
Q
G
D
V
K
L
A
D
F
G
V
A
----------------
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
-
H
P
M
R
V
L
F
-
L
I
P
K
N
N
P
P
T
L
--
V
-
G
--------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
-
N
--
S
K
K
-----
T
S
Y
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
52.74
37%
-54
- C2 -
4AOT
1
STK10_HUMAN
B:
[16-299]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K------------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
------------
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
52.05
37%
-54
- C2 -
4USD
1
?
B:
[16-299]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
----------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--
C
-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
51.96
37%
-52
- C2 -
4AOT
1
STK10_HUMAN
A:
[16-299]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
--------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
--------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
50.15
35%
-63
- C2 -
5D9H
1
?
B:
[26-309]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
M
L
D
--
I
------
I
K
------
Y
IVNRGE
H
K
-
N
G
V
-
L
E
E
A
I
--
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
GDVTRN-----------
G
T
P
C
W
M
A
P
E
V
-------
M
E
Q
---
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
T
L
-
E
T
-
G
VEDKEMMK
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
-
A
--
K
N
R
-----
E
-
Y
L
I
E
K
L
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
49.86
36%
-61
- C2 -
3DAK
1
OXSR1_HUMAN
A:
[18-290]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
V
L
D
--
I
------
I
K
H
I
V
A
K
G
E
------
H
K
-
S
-
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
G---------------
V
G
T
P
C
W
M
A
P
E
V
M
E
--
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
49.03
36%
-62
- C2 -
3DAK
1
OXSR1_HUMAN
D:
[18-290]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
V
L
D
--
I
------
I
K
H
I
V
A
K
G
E
------
H
K
-
S
-
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
GDITRN---------
F
V
G
T
P
C
W
M
A
P
E
V
M
E
--
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
49.02
35%
-63
- C2 -
5D9H
1
?
A:
[26-308]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
M
L
D
--
I
------
I
K
------
Y
I
V
N
R
GE
H
K
-
N
G
V
-
L
E
E
A
I
--
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
GDVTR-----------
V
G
T
P
C
W
M
A
P
E
V
-------
M
E
Q
---
V
R
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
T
L
-
E
T
-
G
VKEMMK--
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
Q
K
-
A
--
K
N
R
-----
E
-
Y
L
I
E
K
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
48.69
36%
-62
- C2 -
3DAK
1
OXSR1_HUMAN
B:
[18-290]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
V
L
D
--
I
------
I
K
H
I
V
A
K
G
E
------
H
K
-
S
-
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
GD----------------
T
P
C
W
M
A
P
E
V
M
E
--
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
48.54
38%
-59
- C2 -
5AJQ
2
STK10_HUMAN
A:
[13-276]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
--
C
ET
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
48.35
37%
-58
- C2 -
4EQU
2
STK10_HUMAN
B:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
KNL---------------------
F
I
G
T
P
Y
W
M
A
P
E
V
V
M
--
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
47.48
37%
-50
- C2 -
4BC6
2
STK10_HUMAN
A:
[8-293]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
---------------------
P
Y
W
M
A
P
E
V
V
M
--
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
47.41
36%
-61
- C2 -
2VWI
1
OXSR1_HUMAN
D:
[23-295]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
V
L
D
--
I
------
I
K
H
I
V
A
K
G
E
------
H
K
-
S
-
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
G---------
T
----
F
V
G
T
P
C
W
M
A
P
E
V
M
E
--
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
--
K
N
K
-----
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
47.21
37%
-47
- C2 -
4USE
1
?
A:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
LK
T
L
Q
--------------------
T
P
Y
W
M
A
P
E
V
V
M
--
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
47.15
31%
-65
- C2 -
4BIC
2
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
-----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
A
G
-----------
E
----
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
46.93
44%
-30
- C2 -
4QMT
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
46.90
31%
-63
- C2 -
2CLQ
1
M3K5_HUMAN
A:
[30-282]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
D
S
---
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
A
G
--------E--
T
----
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
PsiBlast_CBE
46.83
31%
-65
- C2 -
3EFW
1
AURKA_HUMAN
B:
[133-383]
---------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
-
T
V
Y
R
--
E
------
L
Q
------
K
------
L
S
-
K
---
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
E
L
K
I
A
D
F
--------------------------------
L
D
Y
L
P
P
E
M
I
--------
E
--------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
-
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
---
P
-
D
--------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
-
N
--
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.33
44%
-29
- C2 -
4QMN
1
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
46.20
44%
-29
- C2 -
4QMW
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
46.05
31%
-65
- C2 -
4BIE
2
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
-------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
A
-----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
45.97
36%
-61
- C2 -
3DAK
1
OXSR1_HUMAN
C:
[18-290]
---------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
--
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
------
K
D
E
L
W
L
V
M
K
L
L
-
S
G
G
S
V
L
D
--
I
------
I
K
H
I
V
A
K
G
E
------
H
K
-
S
-
G
V
L
D
E
S
T
--
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
-
D
G
S
V
Q
I
A
D
F
G
V
S
A
----
F
L
A
T
G
GD--------
T
----
F
V
G
T
P
C
W
M
A
P
E
V
M
E
--
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
-
P
P
M
K
V
L
M
-
L
T
L
Q
N
D
P
P
S
L
-
E
T
-
G
VQDKEMLK
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
Q
K
-
A
--
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
45.88
37%
-51
- C2 -
2J7T
1
STK10_HUMAN
A:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
-----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
--
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
45.87
44%
-27
- C2 -
4QML
2
STK24_HUMAN
A:
[25-299]
---------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
45.79
31%
-60
- C2 -
2J4Z
3
AURKA_HUMAN
A:
[40-286]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
-
T
V
Y
R
--
E
------
L
Q
------
K
------
L
S
-
K
---
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
E
L
K
I
A
D
F
G
-
W
S
----
V
H
A
P
S
------
S
RRT
T
----
L
C
G
T
L
D
Y
L
P
P
E
M
I
--------
E
---
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
-
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
---
P
-
D
--------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
-
N
--
S
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
45.79
31%
-69
- C2 -
3EFW
1
AURKA_HUMAN
A:
[133-383]
---------------------------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
-
T
V
Y
R
--
E
------
L
Q
------
K
------
L
S
-
K
---
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
E
L
K
I
A
D
F
--------------------------------
L
D
Y
L
P
P
E
M
I
--------
E
---------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
-
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
---
P
-
D
--------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
-
N
--
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
45.67
31%
-63
- C2 -
4BID
1
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
-----------E--
E
----
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
45.39
37%
-51
- C2 -
4USE
1
?
B:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
----
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
-------------------
T
P
Y
W
M
A
P
E
V
V
M
--
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
45.26
31%
-66
- C2 -
4BIB
1
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
PsiBlast_CBE
45.25
31%
-59
- C2 -
4BIB
3
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
-----------E--
E
----
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
45.06
31%
-63
- C2 -
4BID
1
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
------------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
44.98
31%
-66
- C2 -
2CLQ
1
B:
[30-282]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
A
-----------------
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
44.93
44%
-24
- C2 -
4QMQ
3
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
44.88
31%
-66
- C2 -
4BIC
2
B:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
R
----
S
Q
P
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
A
------------------
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
-
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
44.79
31%
-63
- C2 -
4BIE
2
M3K5_HUMAN
A:
[27-279]
---------------------------------
L
G
K
G
T
Y
G
I
V
Y
A
G
R
D
L
S
N
Q
V
R
I
A
I
K
E
I
P
---
E
--------
L
H
E
E
I
A
L
H
K
H
L
-
K
H
K
N
I
V
Q
Y
L
G
S
F
S
E
------
N
G
F
I
K
I
F
M
E
Q
V
-
P
G
G
S
L
S
A
--
L
------
L
R
------
S
------
K
W
-
G
-
P
-
L
K
D
N
E
Q
T
I
G
F
Y
T
K
Q
I
L
E
G
L
K
Y
L
H
D
N
Q
I
V
H
R
D
I
K
G
D
N
V
L
I
N
T
Y
S
G
V
L
K
I
S
D
F
G
T
S
K
----
R
L
A
G
-----------
E
----
F
T
G
T
L
Q
Y
M
A
P
E
I
I
D
--
K
--
G
P
R
---
G
--
Y
G
K
A
A
D
I
W
S
L
G
C
T
I
I
E
M
A
T
G
K
P
P
F
Y
E
L
G
E
P
Q
A
A
M
F
-
K
V
G
M
F
K
V
H
P
E
-
I
P
-
E
--------
S
M
S
A
E
A
K
A
F
I
L
K
C
F
E
P
D
P
D
K
R
A
C
A
N
D
L
L
V
D
E
F
L
K
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
44.78
44%
-28
- C2 -
4QMU
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
44.72
44%
-24
- C2 -
4QMP
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
44.48
31%
-62
- C2 -
2J4Z
2
AURKA_HUMAN
B:
[40-286]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
-
T
V
Y
R
--
E
------
L
Q
------
K
------
L
S
-
K
---
F
D
E
Q
R
--
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
E
L
K
I
A
D
F
G
-
W
S
----
V
H
A
P
S
------
S
RRT
T
----
L
C
G
T
L
D
Y
L
P
P
E
M
I
--------
E
---
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
-
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
---
P
-
D
--------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
-
N
--
S
S
K
-----
P
-
S
N
C
Q
-
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
44.20
44%
-24
- C2 -
4QMV
3
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
44.20
44%
-24
- C2 -
4QMO
4
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
43.95
37%
-55
- C2 -
4EQU
2
STK10_HUMAN
A:
[16-301]
----------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
---
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
------
D
G
K
L
W
I
M
I
E
F
C
-
P
G
-
G
A
V
D
A
I
M
------
L
E
------
L
------
D
R
-
G
---
L
T
E
P
Q
--
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
-
E
G
D
I
R
L
A
D
F
G
V
S
A
KNL----------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
--
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
-
N
P
M
R
V
L
L
-
K
I
A
K
S
D
P
P
T
L
-
L
T
P
S
--------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
S
S
-
I
--
T
S
N
-----
K
-
A
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
43.82
33%
-62
- C2 -
2WQN
1
NEK7_HUMAN
A:
[38-283]
-------------------------------
K
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
-
N
H
P
N
V
I
K
Y
Y
A
S
F
I
E
------
D
N
E
L
N
I
V
L
E
---
L
A
-
D
A
G
D
--
L
S
R
M
I
K
H
F
K
------
K
------
Q
K
-
R
-
L
-
I
P
E
R
T
--
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
-
T
G
V
V
K
L
G
D
L
-------------------------------
T
P
Y
Y
M
S
P
E
R
I
-------
H
E
---
N
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
-
M
-
N
L
Y
S
L
C
K
-
K
I
E
Q
C
D
Y
P
P
L
-
P
S
-
D
--------
H
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
-
A
--
C
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
43.71
44%
-28
- C2 -
4QMS
2
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
42.34
44%
-23
- C2 -
4QMM
3
STK24_HUMAN
A:
[23-299]
-------------------
L
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
------
D
T
K
L
W
I
I
M
E
Y
L
-
G
G
G
S
A
L
D
--
L
------
L
E
--------------
P
-
G
-
P
-
L
D
E
T
Q
--
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
-
H
G
E
V
K
L
A
D
F
G
V
A
G
----
Q
L
T
D
T
QIKR--
N
---
T
----
F
V
G
T
P
F
W
M
A
P
E
V
I
-------
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
-
H
P
M
K
V
L
F
-
L
I
P
K
N
N
P
P
T
L
-
E
--
G
--------
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
-
N
A-
K
K
T
-----
S
-
Y
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
PsiBlast_CBE
37.60
31%
-56
- C2 -
1MUO
1
AURKA_HUMAN
A:
[31-277]
-------------------------------
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
-
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
------
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
-
T
V
Y
R
--
E
------
L
Q
------
K
------
L
S
-
K
-
F
-
D
E
Q
R
T
--
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
-
A
G
E
L
K
I
A
D
F
G
-
W
S
------------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
--------
E
---
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
-
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
E
F
T
F
---
P
-
D
--------
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
-
N
--
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------