@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TAOK3_HUMAN: (2015-10-20 )
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
Atome Classification :
(80 SA)
.........10........20........30........40........50........60........70........80-........90......------..100..-.-.-..-.110---.------...---------..-..-.120.......130.......140-.......150.......160.....-..-----170--.....----.----.----.-.180.......190--...---..-..200.......210.......220.....-..230.....--.--.240..--.--------.-....250.......260....------...270....-..---.-280.....-...-.290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRKGVLKDP
E
I
A
D
L
FYKD
D
P
E
E
L
F
I
G
L
H
E
IGHGS
F
G
A
V
Y
F
A
TNAHT
S
E
V
V
A
I
K
KMSYSGKQ
T
H
E
K
W
Q
D
I
L
K
E
V
K
F
L
R
QLKH-PNTIEYK
G
C
Y
L
K
E
H
T
A
------
W
L
V
M
E
Y
C
-L-G-
S
A
-
S
D
-----
L
------
L
E
V
---------
H
K
-K
P
-
L
Q
E
V
E
I
A
A
I
T
H
G
A
L
H
G
L
A
Y
L
H
S
H
A
-
L
I
H
R
DIKAG
N
I
L
LTEPG
Q
V
K
L
ADFG-SA-----S----MASP
A
----
N
----S----F-VGTPYWMA
P
E
V
I
L
A
--MDE---GQ-YDG
K
V
D
I
W
S
L
G
I
T
C
I
E
L
A
ERKPPLFN
M
N
A
M
-
S
A
L
Y
H
I
AQND--S--PTL-QS--N--------E-
W
T
D
S
F
R
R
F
V
D
Y
C
L
Q
KIPQERP------
T
S
A
E
L
L
R
H
D
F
-VR---R-D--R
P
L
R
V
-
L
I
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
ETRNGPLNESQEDEEDSEHGT
S
L
N
R
E
M
D
SLGSNHSIP
S
M
S
VSTGSQSS
S
V
N
S
M
Q
E
V
M
DESSS
E
L
V
M
M
HDDESTINSSS
S
V
V
HKK
D
H
V
F
I
RDEAGHGDPRPEPR
P
T
Q
S
V
Q
S
Q
A
L
H
Y
R
N
R
E
R
F
A
T
I
K
S
A
S
L
V
T
R
Q
I
H
E
H
E
Q
E
N
E
L
R
E
Q
M
S
G
Y
K
R
M
R
R
Q
H
Q
K
Q
L
I
A
L
E
N
K
L
K
A
E
M
D
E
H
R
L
K
L
Q
K
E
V
E
THANNSS
I
E
L
E
K
L
A
K
K
Q
V
A
I
IEKEAKVAAA
D
E
K
K
F
Q
Q
Q
I
L
A
Q
Q
K
K
D
L
T
T
F
L
E
S
Q
K
K
Q
Y
K
I
C
K
E
K
I
K
E
E
M
NEDHST
P
K
K
E
K
Q
E
R
I
S
K
H
K
E
N
L
QH
T
Q
A
E
E
E
A
H
L
L
T
Q
Q
R
L
Y
YDKN
C
R
F
F
K
R
K
I
M
I
K
RH
E
V
E
Q
Q
N
I
R
E
E
L
N
K
K
R
T
Q
K
E
M
E
H
A
M
L
I
RHDEST
R
E
L
E
Y
R
Q
L
H
T
L
Q
K
L
R
M
D
L
I
R
L
Q
H
Q
T
E
L
E
N
Q
L
E
Y
N
K
R
R
E
R
E
L
H
R
K
H
V
M
E
L
R
QQPKN
L
K
A
M
E
M
Q
I
K
K
Q
F
Q
D
T
C
K
V
Q
T
K
Q
Y
K
A
LKN
H
Q
L
E
VTPKN
E
H
K
T
I
L
K
T
L
K
D
E
Q
T
R
K
L
A
I
L
A
E
Q
Y
E
Q
S
I
N
E
M
M
A
S
Q
A
LRLDEAQE
A
E
C
Q
A
L
R
L
Q
L
Q
Q
E
M
E
L
L
N
A
Y
Q
S
K
I
K
M
Q
T
E
A
Q
H
E
R
E
L
Q
K
L
E
Q
R
V
S
L
R
R
A
H
L
E
Q
K
I
E
E
E
L
A
A
L
Q
K
E
R
S
E
R
I
K
N
L
L
E
R
Q
E
R
E
I
E
T
F
D
M
E
S
L
R
MGFG
N
L
V
T
L
DFPKEDYR
23
PsiBlast_CBE
97.83
81%
-91
- C3 -
2GCD
1
TAOK2_RAT
B:
[1-309]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
-
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
------
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
-
S
D
-----
L
------
L
E
V
---------
H
K
-
K
P
-
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
-
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
-----
S
----
I
M
A
P
A
----
N
----
S
----
F
-
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
-
S
A
L
Y
H
I
A
Q
N
E
--
S
--
P
A
L
-
Q
S
--
G
--------
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
------
T
S
E
V
L
L
K
H
R
F
-
V
L
---
R
-
E
--
R
P
P
T
V
-
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
97.27
81%
-87
- C3 -
1U5R
1
TAOK2_RAT
A:
[40-348]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
-
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
------
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
-
S
D
-----
L
------
L
E
V
---------
H
K
-
K
P
-
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
-
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
-----
S
----
I
M
A
P
A
----
N
----
S
----
F
-
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
-
S
A
L
Y
H
I
A
Q
N
E
--
S
--
P
A
L
-
Q
S
--
G
--------
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
------
T
S
E
V
L
L
K
H
R
F
-
V
L
---
R
-
E
--
R
P
P
T
V
-
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
96.68
81%
-88
- C3 -
1U5R
1
TAOK2_RAT
B:
[40-348]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
-
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
------
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
-
S
D
-----
L
------
L
E
V
---------
H
K
-
K
P
-
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
-
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
-----
S
----
I
M
A
P
A
----
N
----
S
----
F
-
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
-
S
A
L
Y
H
I
A
Q
N
E
--
S
--
P
A
L
-
Q
S
--
G
--------
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
------
T
S
E
V
L
L
K
H
R
F
-
V
L
---
R
-
E
--
R
P
P
T
V
-
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.96
81%
-86
- C3 -
2GCD
1
TAOK2_RAT
A:
[1-309]
-------
D
P
D
V
A
E
L
F
F
K
D
D
P
E
K
L
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
-
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
------
W
L
V
M
E
Y
C
-
L
-
G
-
S
A
-
S
D
-----
L
------
L
E
V
---------
H
K
-
K
P
-
L
Q
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
-
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
P
G
L
V
K
L
G
D
F
G
-
S
A
-----
S
----
I
M
A
P
A
----
N
----
S
----
F
-
V
G
T
P
Y
W
M
A
P
E
V
I
L
A
--
M
D
E
---
G
Q
-
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
-
S
A
L
Y
H
I
A
Q
N
E
--
S
--
P
A
L
-
Q
S
--
G
--------
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
------
T
S
E
V
L
L
K
H
R
F
-
V
L
---
R
-
E
--
R
P
P
T
V
-
I
M
D
-
L
I
Q
R
T
K
D
A
V
R
E
L
D
N
L
Q
Y
R
K
M
K
K
I
L
F
Q
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
75.11
40%
-82
- C3 -
4U44
2
M4K4_HUMAN
A:
[15-311]
------------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
--HD
D
Q
L
-
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
-----
A
------------------
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
72.67
40%
-84
- C3 -
4OBP
2
M4K4_HUMAN
A:
[15-311]
------------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
--D
D
Q
L
--
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
-----
A
-------------
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
71.72
40%
-78
- C3 -
4U45
1
M4K4_HUMAN
A:
[15-312]
------------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
D
D
Q
L
--
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
-----
A
-------------
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
71.60
40%
-80
- C3 -
4ZK5
2
?
A:
[18-312]
---------------
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
S
-----
A
-------------
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
70.89
40%
-84
- C3 -
4U43
1
M4K4_HUMAN
A:
[15-312]
------------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
E
D
E
E
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
--------------------
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.62
46%
-69
- C3 -
3A7I
1
STK24_HUMAN
A:
[17-292]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
69.61
40%
-89
- C3 -
4OBO
2
M4K4_HUMAN
A:
[17-311]
--------------
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
-----
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
--D
D
Q
L
--
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-----------------
R
----
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
68.56
40%
-81
- C3 -
4RVT
2
M4K4_HUMAN
A:
[17-312]
------------
D
L
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
----
T
----
E
E
I
K
L
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
--------------------
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
68.37
40%
-85
- C3 -
4OBQ
2
M4K4_HUMAN
A:
[17-312]
--------------
S
S
L
R
D
P
A
G
I
F
E
L
V
E
V
V
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
V
M
D
V
--------------
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
K
K
S
P
P
G
H
D
D
Q
L
W
L
V
M
E
F
C
G
A
-
G
-
S
I
-
T
D
-----
L
------
V
K
N
---------
T
K
G
N
T
-
L
K
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
-
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
N
A
E
V
K
L
V
D
F
G
-
V
--------------------
N
----
T
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
I
-
A
--
C
D
E
NPD
A
T
-
Y
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
-
R
A
L
F
L
I
P
R
N
P
--
P
--
P
R
L
-
K
S
--
K
--------
K
-
W
S
K
K
F
F
S
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
------
S
T
E
Q
L
L
K
H
P
F
-
I
R
D
QP
N
-
E
--
R
Q
V
R
I
Q
L
K
D
-
H
I
D
R
T
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.66
41%
-72
- C3 -
4ZY6
1
PAK1_HUMAN
B:
[18-295]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
-------------------------
S
KRST
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
67.56
41%
-73
- C3 -
4O0T
1
PAK1_HUMAN
A:
[17-294]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
E
----
Q
----
S
KRSE
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.89
46%
-67
- C3 -
3A7H
1
STK24_HUMAN
A:
[17-292]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
66.88
41%
-71
- C3 -
4O0R
1
PAK1_HUMAN
A:
[17-293]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
E
----
Q
----
S
K
R
S
E
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
66.79
41%
-80
- C3 -
4ZJI
1
PAK1_HUMAN
B:
[19-294]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
-----
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
-----------T---
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
66.76
40%
-70
- C3 -
4USF
1
?
B:
[13-288]
------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
------
W
I
L
I
E
F
C
-
A
-
G
-
G
A
-
V
D
A
V
---
M
------
L
E
L
----------
E
-
R
P
-
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
-----
A
----
K
N
-----------------
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
---
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
E
--
P
--
P
T
L
A
Q
P
--
S
--------
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
------
T
T
S
Q
L
L
Q
H
P
F
-
V
T
---
V
-
D
SN
K
P
I
R
E
-
L
I
A
-
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
66.64
41%
-73
- C3 -
4ZY5
2
PAK1_HUMAN
B:
[18-295]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
E
----
Q
----
S
KRST
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
66.57
41%
-82
- C3 -
4ZJJ
1
PAK1_HUMAN
A:
[19-293]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
----
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
------------T---
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
66.39
41%
-72
- C3 -
4ZY6
1
PAK1_HUMAN
A:
[18-295]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---------
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
E
----
Q
----
S
K
R
S
T
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
66.00
46%
-71
- C3 -
4O27
1
STK24_HUMAN
B:
[3-276]
------------------
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QI
K
R
N
----
E
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
65.80
41%
-75
- C3 -
4ZY4
2
PAK1_HUMAN
B:
[18-294]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
---
Q
Q
-
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
E
----
Q
----
S
KRST
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
65.66
40%
-70
- C3 -
4USF
1
?
A:
[13-288]
------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
------
W
I
L
I
E
F
C
-
A
-
G
-
G
A
-
V
D
A
V
---
M
------
L
E
L
----------
E
-
R
P
-
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
-----
A
----
K
----------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E-------
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
E
--
P
--
P
T
L
A
Q
P
--
S
--------
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
------
T
T
S
Q
L
L
Q
H
P
F
-
V
T
---
V
-
D
SN
K
P
I
R
E
-
L
I
A
-
E
A
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.42
46%
-66
- C3 -
3A7J
1
STK24_HUMAN
A:
[17-292]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
65.38
41%
-83
- C3 -
4ZJJ
1
PAK1_HUMAN
B:
[19-293]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
--------
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
------------T---
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
64.96
41%
-74
- C3 -
4ZY4
1
PAK1_HUMAN
A:
[18-294]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
I
T
P
E
----
Q
----
S
K
R
S
T
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
64.63
38%
-73
- C3 -
4USD
1
?
B:
[16-299]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
--
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
---------------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
C
-----------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
63.99
41%
-80
- C3 -
4ZJJ
1
PAK1_HUMAN
C:
[19-296]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
Q
M
N
L
---
Q
---
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
--
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-----------------
E
----
Q
----
S
KRST
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
63.86
38%
-76
- C3 -
5AJQ
2
STK10_HUMAN
A:
[13-293]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
------
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
K
N
L
K
T
------------------
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
62.92
46%
-59
- C3 -
4NZW
1
STK25_HUMAN
B:
[17-290]
------------------
D
P
E
E
L
F
T
K
L
D
R
I
G
K
G
S
F
G
E
V
Y
K
G
I
D
N
H
T
K
E
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
I
T
R
Y
F
G
S
Y
L
K
S
T
K
L
------
W
I
I
M
E
Y
--
L
-
G
-
G
G
-
S
A
-----
L
------
D
L
L
---------
K
P
-
G
P
-
L
E
E
T
Y
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
R
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
-----
G
---------------------------
T
P
F
W
M
A
P
E
V
I
-----
K
Q
------
Y
D
F
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
L
H
P
M
-
R
V
L
F
L
I
P
K
N
S
--
P
--
P
T
L
-
E
G
--
Q
--------
H
--
S
K
P
F
K
E
F
V
E
A
C
L
N
K
D
P
R
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
T
---
R
Y
T
--
K
K
T
S
F
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
62.90
38%
-70
- C3 -
4AOT
1
STK10_HUMAN
B:
[16-299]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
K------------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
----------
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
62.78
41%
-72
- C3 -
4P90
1
PAK1_HUMAN
B:
[17-294]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
L
------------
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
-----------------------------
S
KR
S
E
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
62.47
41%
-76
- C3 -
4ZJI
1
?
C:
[19-295]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
C
-----
A
----
Q
-------------
S
KRST
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
61.67
41%
-78
- C3 -
4ZJI
1
?
D:
[19-295]
------------------
D
P
K
K
K
Y
T
R
F
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
N
--------
K
K
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
-
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
------
W
V
V
M
E
Y
L
-
A
-
G
G
S
L
-
T
D
-----
V
--------
V
---------
T
E
-
T
C
-
M
D
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
-
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
D
G
S
V
K
L
T
D
F
G
-
F
------
A
----
Q
I
T
-----------
S
KRST
M
-
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
R
---
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
-
R
A
L
Y
L
I
A
T
N
G
--
T
--
P
E
L
-
Q
N
--
P
--------
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
------
S
A
K
E
L
L
Q
H
Q
F
-
L
K
---
I
-
A
--
K
P
L
S
S
-
L
T
P
-
L
I
A
A
A
K
E
A
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
61.39
38%
-68
- C3 -
4AOT
1
STK10_HUMAN
A:
[16-299]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
--------------------------
G
T
P
Y
W
M
A
P
E
V
V
M
------------
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
60.94
45%
-54
- C3 -
4FZA
3
STK26_HUMAN
B:
[5-278]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
------
W
I
I
M
E
Y
--
L
-
G
-
G
G
-
S
A
-----
L
------
D
L
L
---------
R
A
-
G
P
-
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
--
V
--
G
--------
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
-
S
--
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
59.68
40%
-66
- C3 -
2UV2
6
SLK_HUMAN
A:
[34-309]
------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
------
W
I
L
I
E
F
C
-
A
-
G
-
G
A
-
V
D
A
V
---
M
------
L
E
L
----------
E
-
R
P
-
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
-----
A
----
K
N
T
R
T
I
Q
R
R
D
----
S
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
---
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
E
--
P
--
P
T
L
A
Q
P
--
S
--------
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
------
T
T
S
Q
L
L
Q
H
P
F
-
V
T
---
V
-
D
SN
K
P
I
R
E
-
L
I
A
-
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
58.99
45%
-57
- C3 -
4FZD
1
STK26_HUMAN
B:
[5-278]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
------
W
I
I
M
E
Y
--
L
-
G
-
G
G
-
S
A
-----
L
------
D
L
L
---------
R
A
-
G
P
-
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
-----
G
----
Q
L
T
------
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
--
V
--
G
--------
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
-
S
--
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
58.75
38%
-72
- C3 -
4EQU
2
STK10_HUMAN
B:
[16-301]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
KNL--------------------
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
58.41
45%
-54
- C3 -
4FZF
1
?
B:
[5-278]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
------
W
I
I
M
E
Y
--
L
-
G
-
G
G
-
S
A
-----
L
------
D
L
L
---------
R
A
-
G
P
-
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
--
V
--
G
--------
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
-
S
--
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
57.82
38%
-70
- C3 -
2J7T
1
STK10_HUMAN
A:
[16-301]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
K
N
L
K
T
L
Q
K
-----------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
57.57
45%
-55
- C3 -
3GGF
1
STK26_HUMAN
B:
[20-293]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
------
W
I
I
M
E
Y
--
L
-
G
-
G
G
-
S
A
-----
L
------
D
L
L
---------
R
A
-
G
P
-
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
-
V
A
-------------------
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
--
V
--
G
--------
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
-
S
--
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.53
38%
-64
- C3 -
4BC6
2
STK10_HUMAN
A:
[8-293]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
K
N
L
K
T
L
Q
---------------------
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
57.44
40%
-66
- C3 -
2J51
5
SLK_HUMAN
A:
[34-309]
------------------
N
P
E
D
F
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
---
T
K
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
A
S
C
D
H
-
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
------
W
I
L
I
E
F
C
-
A
-
G
-
G
A
-
V
D
A
V
---
M
------
L
E
L
----------
E
-
R
P
-
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
-
V
S
-----
A
----
K
N
T
R
T
I
Q
R
R
D
----
S
----
F
-
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
ET
S
K
D
---
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
E
--
P
--
P
T
L
A
Q
P
--
S
--------
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
------
T
T
S
Q
L
L
Q
H
P
F
-
V
T
---
V
-
D
SN
K
P
I
R
E
-
L
I
A
-
E
A
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
57.18
45%
-56
- C3 -
3GGF
1
STK26_HUMAN
A:
[20-293]
------------------
D
P
E
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
------
W
I
I
M
E
Y
--
L
-
G
-
G
G
-
S
A
-----
L
------
D
L
L
---------
R
A
-
G
P
-
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
D
F
G
-
V
A
---------------R---
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
-
R
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
--
V
--
G
--------
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
I
V
K
---
N
-
S
--
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
F
K
R
W
K
A
E
G
H
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
56.25
38%
-62
- C3 -
4USE
1
?
A:
[16-301]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---
T
K
S
E
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
K
N
LK
T
L
Q
--------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
56.10
38%
-68
- C3 -
4USE
1
?
B:
[16-301]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
-------
E
E
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
-----------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
K
N
L
K
T
L
Q
K
-------------------
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
55.16
38%
-69
- C3 -
4EQU
2
STK10_HUMAN
A:
[16-301]
------------------
D
P
N
E
V
W
E
I
V
G
E
L
G
-----
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
---------
L
E
D
Y
I
V
E
I
E
I
L
A
T
C
D
H
-
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
------
W
I
M
I
E
F
C
-
P
-
G
-
G
A
-
V
D
A
I
---
M
------
L
E
L
---------
D
R
-
G
--
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
-
V
S
-----
A
KNL----------------------
I
G
T
P
Y
W
M
A
P
E
V
V
M
C
E
T
M
K
D
---
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
-
R
V
L
L
K
I
A
K
S
D
--
P
--
P
T
L
-
L
T
P-
S
--------
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
------
S
A
A
Q
L
L
E
H
P
F
-
V
S
---
S
-
I
--
T
S
N
K
A
-
L
R
E
-
L
V
A
E
A
K
A
E
V
M
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
54.25
39%
-68
- C3 -
5D9H
1
?
B:
[26-309]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
-
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
M
------
L
D
I
IKYIVNRGE
H
K
-
N
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
-
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
----
D
VTRN--------
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
T
L
-
E
T
--
G
VEDKEMMK
K
-
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
------
T
A
A
E
L
L
K
C
K
F
-
F
Q
---
K
-
A
--
K
N
R
E
Y
-
L
I
E
K
L
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
54.03
40%
-67
- C3 -
2VWI
1
OXSR1_HUMAN
D:
[23-295]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
-
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
V
------
L
D
I
I
K
H
I
V
A
K
GE
H
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
-
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
---------
T
----
F
-
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
S
L
-
E
T
--
G
VQDKEMLK
K
-
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
------
T
A
A
E
L
L
R
H
K
F
-
F
Q
---
K
-
A
--
K
N
K
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
54.02
40%
-64
- C3 -
3DAK
1
OXSR1_HUMAN
A:
[18-290]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
-
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
V
------
L
D
I
I
K
H
I
V
A
K
GE
H
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
-
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
----------------
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
S
L
-
E
T
--
G
VQDKEMLK
K
-
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
------
T
A
A
E
L
L
R
H
K
F
-
F
Q
---
K
-
A
--
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
53.28
40%
-65
- C3 -
3DAK
1
OXSR1_HUMAN
D:
[18-290]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
-
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
V
------
L
D
I
I
K
H
I
V
A
K
GE
H
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
-
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
----
D
ITRN-----
F
-
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
S
L
-
E
T
--
G
VQDKEMLK
K
-
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
------
T
A
A
E
L
L
R
H
K
F
-
F
Q
---
K
-
A
--
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
53.16
39%
-68
- C3 -
5D9H
1
?
A:
[26-308]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
-
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
M
------
L
D
I
I
K
Y
I
V
N
R
GE
H
K
-
N
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
-
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
----
D
VTR--------
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
T
L
-
E
T
--
G
VKEMMK--
K
-
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
------
T
A
A
E
L
L
K
C
K
F
-
F
Q
---
K
-
A
--
K
N
R
E
Y
-
L
I
E
K
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
52.92
40%
-64
- C3 -
3DAK
1
OXSR1_HUMAN
C:
[18-290]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
-
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
V
------
L
D
I
I
K
H
I
V
A
K
GE
H
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
-
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
----
D
----
T
----
F
-
V
G
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
S
L
-
E
T
--
G
VQDKEMLK
K
-
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
------
T
A
A
E
L
L
R
H
K
F
-
F
Q
---
K
-
A
--
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
52.62
40%
-64
- C3 -
3DAK
1
OXSR1_HUMAN
B:
[18-290]
-----------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
L
E
K
C
Q
T
S
M
--
D
E
L
L
K
E
I
Q
A
M
S
Q
C
H
H
-
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
------
W
L
V
M
K
---
L
-
L
-
S
G
-
G
S
-----
V
------
L
D
I
I
K
H
I
V
A
K
GE
H
K
-
S
G
V
L
D
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
-
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
-----
F
----
L
A
T
G
G
----
D
-------------
T
P
C
W
M
A
P
E
V
M
E
Q
--
V
R
-----
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
-
K
V
L
M
L
T
L
Q
N
D
--
P
--
P
S
L
-
E
T
--
G
VQDKEMLK
K
-
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
------
T
A
A
E
L
L
R
H
K
F
-
F
Q
---
K
-
A
--
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.26
46%
-28
- C3 -
4W8D
1
STK24_HUMAN
A:
[9-284]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
49.99
46%
-28
- C3 -
4W8E
1
STK24_HUMAN
A:
[9-284]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
49.75
34%
-68
- C3 -
2WQN
1
NEK7_HUMAN
A:
[39-283]
----------------------------
K
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
-
P
N
V
I
K
Y
Y
A
S
F
I
E
D
N
E
L
------
N
I
V
L
E
---
L
-
A
-
D
A
-
G
D
-----
L
S
R
M
I
K
H
F
K
K
---------
Q
K
-
R
L
-
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
-
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
T
G
V
V
K
L
G
D
L
-------------------------------------
T
P
Y
Y
M
S
P
E
R
I
-----
H
E
---
N
G
-
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
-
M
N
L
Y
-
S
L
C
K
K
I
E
Q
C
D
--
Y
--
P
P
L
-
P
S
--
D
--------
H
-
Y
S
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
P
------
D
V
T
Y
V
Y
D
V
A
K
-
R
M
---
H
-
A
--
C
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
49.44
31%
-78
- C3 -
3EFW
1
AURKA_HUMAN
A:
[131-383]
--------------------
E
D
F
E
I
G
-
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
------
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
-
Y
R
-----
E
------
L
Q
K
---------
L
S
-
K
--
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
--------------------------------------
L
D
Y
L
P
P
E
M
I
------
E
---------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
T
Y
-
Q
E
T
Y
K
R
I
S
R
V
--
E
--
F
T
F
--
P
--
D
--------
F
-
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
------
M
L
R
E
V
L
E
H
P
W
-
I
T
---
A
-
N
--
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
49.27
46%
-25
- C3 -
4QML
2
STK24_HUMAN
A:
[25-299]
-----------------
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
49.15
46%
-27
- C3 -
4QMN
1
STK24_HUMAN
A:
[24-299]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
48.78
46%
-25
- C3 -
4QMO
3
STK24_HUMAN
A:
[24-299]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
48.73
31%
-76
- C3 -
3EFW
1
AURKA_HUMAN
B:
[131-383]
--------------------
E
D
F
E
I
G
-
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
------
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
-
Y
R
-----
E
------
L
Q
K
---------
L
S
-
K
--
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
--------------------------------------
L
D
Y
L
P
P
E
M
I
------
E
--------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
T
Y
-
Q
E
T
Y
K
R
I
S
R
V
--
E
--
F
T
F
--
P
--
D
--------
F
-
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
------
M
L
R
E
V
L
E
H
P
W
-
I
T
---
A
-
N
--
S
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
48.65
46%
-26
- C3 -
4QMQ
3
STK24_HUMAN
A:
[24-299]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
47.98
46%
-29
- C3 -
4U8Z
1
STK24_HUMAN
A:
[9-284]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
47.82
46%
-26
- C3 -
4QMS
2
STK24_HUMAN
A:
[24-299]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
47.31
46%
-25
- C3 -
4QMP
2
STK24_HUMAN
A:
[24-299]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
46.49
46%
-26
- C3 -
4QMM
3
STK24_HUMAN
A:
[24-299]
----------------
K
A
D
P
E
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
D
E
I
E
D
I
Q
--
Q
E
I
T
V
L
S
Q
C
D
S
-
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
------
W
I
I
M
E
Y
L
-
G
-
G
G
S
A
-
L
D
-----
L
------
L
E
-----------
P
-
G
P
-
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
-
V
A
-----
G
----
Q
L
T
D
T
QIKR
N
----
T
----
F
-
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
Q
---
S
A
-
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
-
K
V
L
F
L
I
P
K
N
N
--
P
--
P
T
L
-
E
G
--
N
----------
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
------
T
A
K
E
L
L
K
H
K
F
-
I
L
---
R
-
N
A-
K
K
T
S
Y
-
L
T
E
-
L
I
D
R
Y
K
R
W
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
46.09
31%
-61
- C3 -
3OMV
1
B:
[44-304]
-----------------------------
I
G
S
G
S
F
G
T
V
Y
-
K
G
K
W
H
G
D
V
A
V
K
I
L
K
V
V
---
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
-
V
N
I
L
L
F
M
G
Y
M
T
K
D
N
L
A
-------
I
V
T
Q
W
C
-
E
-
G
-
S
S
L
Y
K
-----
H
------
L
H
V
---------
Q
E
-
T
K
-
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
-
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
-
L
A
-----
T
----
V
-------------------P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
--
Q
D
N
---
N
P
-
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
S
H
I
N
N
R
-
D
Q
I
I
F
M
V
G
R
G
YA
S
--
P
D
L
-
S
K
LY
K
--------
N
-
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
LFPQIL
S
S
I
E
L
L
Q
H
S
L
-
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
45.51
31%
-61
- C3 -
3OMV
1
RAF1_HUMAN
A:
[44-304]
-----------------------------
I
G
S
G
S
F
G
T
V
Y
-
K
G
K
W
H
G
D
V
A
V
K
I
L
K
V
V
---
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
-
V
N
I
L
L
F
M
G
Y
M
T
K
D
N
L
A
-------
I
V
T
Q
W
C
-
E
-
G
-
S
S
L
Y
K
-----
H
------
L
H
V
---------
Q
E
-
T
K
-
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
-
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
V
K
I
G
D
F
G
-
L
A
-----
T
----
V
-------------------P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
--
Q
D
N
---
N
P
-
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
S
H
I
N
N
R
-
D
Q
I
I
F
M
V
G
R
G
YA
S
--
P
D
L
-
S
K
LY
K
--------
N
-
C
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
-
P
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
45.20
31%
-67
- C3 -
1MUO
1
AURKA_HUMAN
A:
[25-277]
--------------------
E
D
F
E
I
G
-
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
------
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
-
Y
R
-----
E
------
L
Q
K
---------
L
S
-
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
--
W
-----
S
-----------------------
L
-
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
---
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
T
Y
-
Q
E
T
Y
K
R
I
S
R
V
--
E
--
F
T
F
--
P
--
D
--------
F
-
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
------
M
L
R
E
V
L
E
H
P
W
-
I
T
---
A
-
N
--
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
43.67
31%
-61
* C3 *
2W1G
1
AURKA_HUMAN
A:
[19-263]
-----------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
-
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
------
Y
L
I
L
E
Y
A
P
L
-
G
-
T
V
-
Y
R
-----
E
------
L
Q
K
---------
L
S
-
K
F
-
D
E
Q
R
T
A
T
Y
I
T
E
L
A
-
N
A
L
S
Y
C
H
S
K
R
-
V
I
H
R
D
I
K
P
E
N
L
L
L
G
S
A
G
E
L
K
I
A
D
F
G
-
W
S
-----
V
----
H
A
--------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
---
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
E
A
N
T
Y
-
Q
E
T
Y
K
R
I
S
R
V
--
E
--
F
T
F
-
P
D
--
F
--------
V
--
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
------
M
L
R
E
V
L
E
H
P
W
-
I
T
---
A
-
N
--
S
S
K
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
39.72
31%
-46
- C3 -
4YUR
1
PLK4_HUMAN
A:
[21-269]
-----------------------------
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
------
Y
L
V
L
E
M
C
-
H
N
G
-
E
M
-
N
R
-----
Y
------
L
K
N
---------
R
V
-
K
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
---------------------------------------------------------
G
L
----
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
V
K
-
N
T
L
N
K
V
V
L
A
D
--
Y
E
M
P
S
F
-
L
S
--
I
--------
E
-
A
K
D
L
I
H
Q
L
----
L
R
R
N
P
A
D
R
L
------
S
L
S
S
V
L
D
H
P
F
-
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
38.42
31%
-55
- C3 -
3ALN
1
MP2K4_HUMAN
B:
[27-289]
--------------------------
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
-
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
------
W
I
C
M
E
L
--
M
-
S
-
T
S
-
F
D
K
F
Y
K
Y
V
------
Y
S
V
---------
L
D
-
D
V
-
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
-
I
S
GQL-----------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
---------------
D
--
P
--
P
Q
L
-
S
N
--
S
EER-----
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
------
K
Y
K
E
L
L
K
H
P
F
-
I
L
---
M
-
Y
--
E
E
R
A
V
-
E
V
A
-
C
Y
V
C
K
I
L
D
Q
M
P
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
38.20
31%
-47
- C3 -
3COK
1
PLK4_HUMAN
A:
[19-267]
-----------------------------
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
------
Y
L
V
L
E
M
C
-
H
N
G
-
E
M
-
N
R
-----
Y
------
L
K
N
---------
R
V
-
K
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
G
-
L
A
-----
T
Q
---
L
K
-----------------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
------
V
V
L
A
D
--
Y
EM
P
S
F
-
L
S
--
I
--------
E
-
A
K
D
L
I
H
Q
L
----
L
R
R
N
P
A
D
R
L
------
S
L
S
S
V
L
D
H
P
F
-
M
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
37.25
31%
-55
- C3 -
3ALN
1
MP2K4_HUMAN
A:
[27-289]
--------------------------
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
-
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
------
W
I
C
M
E
L
--
M
-
S
-
T
S
-
F
D
K
F
Y
K
Y
V
------
Y
S
V
---------
L
D
-
D
V
-
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
-
I
S
GQ------------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
-------
T
Q
V
V
K
G
D
--
P
--
P
Q
L
-
S
N
--
S
EER-----
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
------
K
Y
K
E
L
L
K
H
P
F
-
I
L
---
M
-
Y
--
E
E
R
A
V
-
E
V
A
-
C
Y
V
C
K
I
L
D
Q
M
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
37.18
31%
-50
- C3 -
4JXF
2
PLK4_HUMAN
A:
[15-264]
-----------------------------
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
K
A
G
M
V
Q
R
V
Q
N
E
V
K
I
H
C
Q
L
K
H
-
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
------
Y
L
V
L
E
M
C
-
H
N
G
-
E
M
-
N
R
-----
Y
------
L
K
N
---------
R
V
-
K
P
-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
-
I
L
H
R
D
L
T
L
S
N
L
L
L
T
R
N
M
N
I
K
I
A
D
F
G
-
L
A
-----
T
Q---
L
K
M
P
H
----
E
----------------------------------------
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
-
N
T
L
N
K
V
V
L
A
D
--
Y
E
M
P
S
F
-
L
S
--
I
--------
E
-
A
K
D
L
I
H
Q
L
----
L
R
R
N
P
A
D
R
L
------
S
L
S
S
V
L
D
H
P
F
-
M
S
---
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
35.34
31%
-57
- C3 -
3ALO
1
MP2K4_HUMAN
A:
[27-289]
--------------------------
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
-
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
------
W
I
C
M
E
L
--
M
-
S
-
T
S
-
F
D
K
F
Y
K
Y
V
------
Y
S
V
---------
L
D
-
D
V
-
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
-
I
S
G
Q
L
V
D
S
----
I
A
K
T
R
----
D
----
A
-------
G
C
R
P
Y
M
A
P
E
R
I
D
P
-----------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
S
V
F
D
Q
L
T
Q
V
V
K
G
D
--
P
--
P
Q
L
-
S
N
--
S
EE
R
-----
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
------
K
Y
K
E
L
L
K
H
P
F
-
I
L
---
M
-
Y
--
E
E
R
A
V
-
E
V
A
-
C
Y
V
C
K
I
L
D
Q
M
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------