@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TESK1_HUMAN: (2015-10-20 )
MAGERPPLRGPGPGPGEVPGEGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDDFHCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCLVRREDRGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAPLTRTALTHNQGSVARGGPSATLPRPDPRLSRSRSDLFLPPSPESPPNWGDNLTRVNPFSLREDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVTTPETLVQPGTPARRCRSLPSSPELPRRMETALPGPGPPAVGPSAEEKMECEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWAGEPWNRAQHSLPRAAALERTEPSPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS
Atome Classification :
(29 SA)
.........10........20........30........40........50........60........70........----------------80......--...90--.---------......-..100.....-..110.......120-------.......130.......-140------..--.----.--...-.150.......160---........170.........180.....--..190.......200--.........210........220---.......230--.---......240.......250.......260.......270.-.-.----------..--------------.---------.-280.......290.......300.......310..---.....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MA
G
ERPPLRGPGPGP
G
EVP
G
EGPPGPGGTGGGPGRGRPSSYRALRSAVSSLARVDD
F
HC
A
EKIGAGFF
S
EVYKV
R
HRQS----------------G-QVMVLK--MNKL---P---------SNRGNT-L
R
EVQLMNRL-
R
HPNILRFMGVC
V
HQ-------GQ
L
HAL
T
EYMNGGT
L
EQ-LL-------SS--
P
----E--PLS-WPVR
L
HLALDIAR----GLRY
L
HSKG--V
F
HRDLTSKNCLVR
R
ED--RGFTAVVGDFGL
A
----EKIPVY
R
EGAR-
K
EPLAVVGSPY---WMA
P
EVLR
G
E--L---Y
D
EKADVFAFGIVL
C
ELIARVPADPDYLPR
T
EDFGLDVPA-F-R----------TL--------------V---------G-DDCPLPFLLLA
I
HCCN
L
EPSTRAPF
T
EIT
Q
H
L
EWI---
L
EQL
P
EPAPLTRTAL
T
HNQGSVARGGPSATLPRPDPRLSRSRSDLFLPPS
P
ESPPNWGDNLTRVNPFSL
R
EDLRGGKIKLLDTPSKPVLPLVPPSPFPSTQLPLVTT
P
ETLVQPGTPARRCRSLPSS
P
ELPRR
M
ETALPGPGPPAVGPS
A
E
EK
M
E
C
EGSS
P
E
P
EPPGPAPQLPLAVATDNFISTCSSASQPWSPRSGPVLNNNPPAVVVNSPQGWA
G
EPWNRA
Q
HSLPRAAA
L
ER
T
EPSPPPSAP
R
EP
D
EGLPCPGCCLGPFSFGFLSMCPRPTPAVARYRNLN
C
EAGSLL
C
HR
G
H
HAKPPTPSLQLPGARS
69
HHSearch
89.72
46%
-137
- C1 -
3S95
8
LIMK1_HUMAN
A:
[8-285]
----------------------------------------------------
R
P
S
D
L
I
H
G
E
V
L
G
K
G
C
F
G
Q
A
I
K
V
T
H
R
E
T
----------------
G
-
E
V
M
V
M
K
--
E
L
I
R
---
F
D
E
-------
E
T
Q
R
T
F
-
L
K
E
V
K
V
M
R
C
L
-
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
-------
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
-
I
I
-------
K
S
M-
D
----
S
--
Q
Y
P
-
W
S
Q
R
V
S
F
A
K
D
I
A
S
----
G
M
A
Y
L
H
S
M
N
--
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
-----
N
K
N
V
V
V
A
D
F
G
L
A
----
R
L
M
V
-----------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
I
N
G
R
--
S
---
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
G
R
V
N
A
D
P
D
Y
L
P
R
T
M
D
F
G
L
N
V
R
G
-
F
-
L
----------
D
R
Y-------------
C
---------
P
-
P
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
---
R
M
H
L
A
G
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.50
42%
-144
- C1 -
4TPT
1
B:
[1-296]
-------------------------------------------------------
D
L
I
H
G
E
V
L
G
K
G
F
F
G
Q
A
I
K
V
T
H
K
A
T
----------------
G
-
K
V
M
V
M
K
E
L
I
R
C
D
---
E
---------
E
T
Q
K
T
F
-
L
T
E
V
K
V
M
R
S
L
-
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
-------
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
-
F
L
-------
R
S
--
M
----
D
--
P
F
P
-
W
Q
Q
K
V
R
F
A
K
G
I
A
S
----
G
M
A
Y
L
H
S
M
C
--
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
-----
T
V
V
V
A
D
F
G
L
S
----
R
L
I
V
-----------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
L
N
G
K
--
S
---
Y
D
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
G
Q
V
Y
A
D
P
D
C
L
P
R
T
L
D
F
G
L
N
V
K
L
-
F
W
E
----------
K
F
--------------
V
---------
P
-
T
D
C
P
P
A
F
F
P
L
A
A
I
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
I
P
L
P
A
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
86.36
43%
-138
- C1 -
3S95
6
B:
[6-290]
--------------------------------------------------
I
F
R
P
S
D
L
I
H
G
E
V
L
G
K
G
C
F
G
Q
A
I
K
V
T
H
R
E
T
----------------
G
-
E
V
M
V
M
K
E-
L
I
R
F
---
D
---------
E
E
T
Q
R
T
F
L
K
E
V
K
V
M
R
C
L
-
E
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
-------
K
R
L
N
F
I
T
E
Y
I
K
G
G
T
L
R
G
-
I
I
-------
K
S
--
M
----
D
--
S
Q
Y
P
W
S
Q
R
V
S
F
A
K
D
I
A
S
----
G
M
A
Y
L
H
S
M
N
--
I
I
H
R
D
L
N
S
H
N
C
L
V
R
E
N
K
-----
N
V
V
V
A
D
F
G
L
A
RLMV---------------
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
I
N
G
R
--
S
---
Y
D
E
K
V
D
V
F
S
F
G
I
V
L
C
E
I
I
G
R
V
N
A
D
P
D
Y
L
P
R
T
M
D
F
G
L
N
V
R
G
-
F
-
L
----------
D
R
--------------
Y
---------
C
P
P
N
C
P
P
S
F
F
P
I
T
V
R
C
C
D
L
D
P
E
K
R
P
S
F
V
K
L
E
H
W
L
E
T
L
---
R
M
H
L
A
G
H
L
P
L
G
P
Q
L
E
Q
L
D
R
G
F
W
E
T
Y
R
R
G
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.33
42%
-136
- C1 -
4TPT
1
LIMK2_HUMAN
A:
[1-296]
-------------------------------------------------------
D
L
I
H
G
E
V
L
G
K
G
F
F
G
Q
A
I
K
V
T
H
K
A
T
----------------
G
-
K
V
M
V
M
K
E
L
I
R
C
D
---
E
---------
E
T
Q
K
T
F
-
L
T
E
V
K
V
M
R
S
L
-
D
H
P
N
V
L
K
F
I
G
V
L
Y
K
D
-------
K
K
L
N
L
L
T
E
Y
I
E
G
G
T
L
K
D
-
F
L
-------
R
S
--
M
----
D
--
P
F
P
-
W
Q
Q
K
V
R
F
A
K
G
I
A
S
----
G
M
A
Y
L
H
S
M
C
--
I
I
H
R
D
L
N
S
H
N
C
L
I
K
L
D
K
-----
T
V
V
V
A
D
F
G
L
S
----
R
L
I
V
--------
K
K
R
Y
T
V
V
G
N
P
Y
---
W
M
A
P
E
M
L
N
G
K
--
S
---
Y
D
E
T
V
D
I
F
S
F
G
I
V
L
C
E
I
I
G
Q
V
Y
A
D
P
D
C
L
P
R
T
L
D
F
G
L
N
V
K
L
-
F
W
E
----------
K
F
--------------
V
---------
P
-
T
D
C
P
P
A
F
F
P
L
A
A
I
C
C
R
L
E
P
E
S
R
P
A
F
S
K
L
E
D
S
F
E
A
L
S
L
Y
L
G
E
L
G
I
P
L
P
A
E
L
E
E
L
D
H
T
V
S
M
Q
Y
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
HHSearch
58.48
33%
-111
- C1 -
4BKJ
10
DDR1_HUMAN
A:
[11-308]
-------------------------------------------------------
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
P
QDLVSLDFPLNVRKG
H
P
-
L
L
V
A
V
K
--
I
L
R
P
---
D
AT
K
------
N
A
R
N
D
F
-
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
-------
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
-
F
L
-------
S
A
--
H
QLED
P
--
T
I
S
-
Y
P
M
L
L
H
V
A
A
Q
I
A
S
----
G
M
R
Y
L
A
T
L
N
--
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
F
T
I
K
I
A
D
F
G
M
S
----
R
N
L
Y
A
G
D
Y
--
Y
-----
R
A
V
L
P
I
R
---
W
M
A
W
E
C
I
L
M
G
--
K
---
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
-------
Q
L
T
D
E
Q
V
I
-
E
----------
N
A
G
E
F
F
R
DQGRQVYLS
R
---------
P
-
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
---
A
L
N
T
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
58.13
31%
-107
- C1 -
4EHG
1
BRAF_HUMAN
A:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
E
-----------------
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
RGYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
56.49
31%
-105
- C1 -
4MNF
1
B:
[52-313]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
QTAQ
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
E
------------------
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
VGRGYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
56.09
31%
-114
- C1 -
5C9C
1
?
A:
[40-301]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
--APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
-------------------
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
56.01
31%
-107
- C1 -
4G9R
1
B:
[40-302]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
E
K
----------------
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
55.81
31%
-110
- C1 -
4MBJ
1
BRAF_HUMAN
A:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
--------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
55.76
30%
-108
- C1 -
4F0F
1
A:
[18-286]
-----------------------------------------------------
D
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
D
----------------
K
-
S
V
V
A
I
K
--
S
L
I
L
---
G
DSEGETEMI
E
K
F
Q
E
F
-
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
-------
P
--
R
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
-------
D
K
--
A
----
H
--
P
I
K
-
W
S
V
K
L
R
L
M
L
D
I
A
L
----
G
I
E
Y
M
Q
N
Q
N
PP
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
L
D
EN
A
P
V
C
A
K
V
A
D
F
G
L
S
----
Q
Q
S
V
H
--------
S
V
S
G
L
L
G
N
F
Q
---
W
M
A
P
E
T
I
G
A
E
EE
S
---
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
G
E
G
------
P
F
D
-
E
Y
S
Y
G
K
I
K
-
F
-
I
----------
N
M
--------------
I
R
EEGLRPTI
P
-
E
D
C
P
P
R
L
R
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
55.70
31%
-106
- C1 -
4G9C
1
B:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
-------------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
55.51
31%
-104
- C1 -
4EHE
1
B:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
G
S
H
Q
-
F
E
Q
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
55.42
31%
-113
- C1 -
3IDP
1
B:
[32-293]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
---------------------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
55.38
30%
-108
- C1 -
2A19
1
E2AK2_HUMAN
B:
[11-273]
------------------------------------------------------
M
D
F
K
E
I
E
L
I
G
S
G
G
F
G
Q
V
F
K
A
K
H
R
I
D
----------------
G
-
K
T
Y
V
I
K
--
R
V
K
--------------
Y
N
N
E
K
A
-
E
R
E
V
K
A
L
A
K
L
-
D
H
V
N
I
V
H
Y
N
G
C
W
D
G
F
D
YDRSK
T
K
C
L
F
I
Q
M
E
F
C
D
K
G
T
L
E
Q
-
W
I
-------
E
K
R
R
G
----
E
--
K
L
D
-
K
V
L
A
L
E
L
F
E
Q
I
T
K
----
G
V
D
Y
I
H
S
K
K
--
L
I
N
R
D
L
K
P
S
N
I
F
L
V
D
T
-----
K
Q
V
K
I
G
D
F
G
L
V
----
T
S
L
K
N
D
G
------
K
R
T
R
S
K
G
T
L
R
---
Y
M
S
P
E
Q
I
S
S
Q
--
D
---
Y
G
K
E
V
D
L
Y
A
L
G
L
I
L
A
E
L
L
H
V
C
--
D
T
A
F
----
E
----
T
S
K
F
-
F
-
T
----------
D
L
R
DGI----------
I
---------
S
-
D
I
F
D
K
K
E
K
T
L
L
Q
K
L
L
S
K
K
P
E
D
R
P
N
T
S
E
I
L
R
T
L
T
V
W
---
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
55.35
31%
-108
- C1 -
3IDP
1
BRAF_HUMAN
A:
[32-293]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
------------------
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
---NP-
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
55.21
31%
-111
- C1 -
4EHG
1
B:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
---------------------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.99
31%
-119
- C1 -
4CSV
1
?
A:
[18-269]
-------------------------------------------------------------
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
----------------
N
I
E
V
A
V
K
T
--
L
K
E
G
---
T
---------
M
S
V
E
E
F
-
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-------
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
-
Y
L
-------
R
D
--
C
--------
V
N
-
A
Q
A
L
L
D
M
A
A
Q
V
A
S
----
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
-----
V
V
K
V
A
D
F
G
----------------------------
F
PIK
W
T
A
P
E
A
I
S
Y
N
--
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
-
Y
-
R
----------
M
P
--------------
R
---------
P
-
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
---
F
--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
54.55
31%
-102
- C1 -
4MNF
1
BRAF_HUMAN
A:
[52-313]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
E
------------------
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
54.34
31%
-108
- C1 -
4E4X
1
BRAF_HUMAN
A:
[40-302]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
--------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
54.27
31%
-114
- C1 -
4PP7
1
BRAF_HUMAN
A:
[40-302]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
--------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
53.97
31%
-102
- C1 -
4MBJ
1
B:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
G
S
H
Q
-
F
E
Q
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.68
31%
-110
- C1 -
4UEU
1
?
A:
[18-268]
-------------------------------------------------------------
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
----------------
N
I
E
V
A
V
K
T
--
L
K
E
G
---
T
---------
M
S
V
E
E
F
-
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
-------
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
-
Y
L
-------
R
D
--
C
----
E
GH
T
V
N
-
A
Q
A
L
L
D
M
A
A
Q
V
A
S
----
G
M
A
Y
L
E
S
Q
N
--
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
-----
V
V
K
V
A
D
F
G
L
A
----
R
L
I
-----------------
A
K
F
PIK
W
T
A
P
E
A
I
S
Y
N
--
R
---
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
G
-
Y
-
R
----------
M
P
--------------
R
---------
P
-
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
---
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
53.01
31%
-105
- C1 -
4EHE
1
BRAF_HUMAN
A:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
-----------
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
52.74
31%
-104
- C1 -
4G9C
1
BRAF_HUMAN
A:
[40-304]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
------------
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
52.65
31%
-98
- C1 -
4E4X
1
B:
[40-302]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
G
S
H
Q
-
F
E
Q
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
52.29
31%
-103
- C1 -
4PP7
1
B:
[40-302]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
V
K
S
R
W
S
G
S
H
Q
-
F
E
Q
L
S
--
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
51.92
31%
-106
- C1 -
4G9R
1
BRAF_HUMAN
A:
[40-302]
----------------------------------------------------------
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
--
G
K
W
H
----------------
G
-
D
V
A
V
K
M
--
L
N
V
T
APT
P
---------
Q
Q
L
Q
A
F
-
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
-------
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
-
H
L
-------
H
I
--
I
----
E
--
T
K
F
-
E
M
I
K
L
---
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
-----
L
T
V
K
I
G
D
F
G
L
A
----
T
E
K
S
---------------
G
S
I
L
---
W
M
A
P
E
V
I
R
M
Q
--
D
KNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
------
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
-
F
-
M
V
G
R
GYLSPDL
S
K
--------------
V
---------
R
-
S
N
C
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
---
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
50.91
31%
-116
- C1 -
4XCU
1
A:
[54-290]
--------------------------------------------------------------------------------------------------
V
K
M
L
K
--
D
N
A
S
---
D
---------
K
D
L
A
D
L
-
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
-------
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
-
F
L
R
A
R
RPPG
S
S
--
E
----
G
--
P
L
S
-
F
P
V
L
V
S
C
A
Y
Q
V
A
R
----
G
M
Q
Y
L
E
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
-----
V
M
K
I
A
D
F
G
L
A
RGV-
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
---------
W
M
A
P
E
A
L
F
D
R
--
V
---
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
G
-
H
-
R
----------
M
D
--------------
R
---------
P
-
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
---
L
L
A
V
S
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------