@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TIE1_HUMAN: (2015-10-20 )
MVWRVPPFLLPILFLASHVGAAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWGPPLLLEKDDRIVRTPPGPPLRLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQTDVIWKSNGSYFYTLDWHEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRKPDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSENVTLMNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLEGWHVEGTDRLRVSWSLPLVPGPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCTLLGPASPPAHVLLPPSGPPAPRHLHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGAGDPLWIDVDRPEETSTIIRGLNASTRYLFRMRASIQGLGDWSNTVEESTLGNGLQAEGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Atome Classification :
(101 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820....-----...830...---..----..840.-......850....----.---.-----.---860---.--.-----.---.---..----...870.......880.......890.......900.....-..-910.......920.......930..--.--.....940.......950.......960.......970.......980.......990.......1000---.---.---.....1010.......1020......1030......1040......1050...-...-1060-......1070......1080......1090......1100......1110........1120......1130.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVWRV
P
P
F
L
L
P
I
L
F
L
A
S
H
VGA
A
V
D
L
T
L
L
ANLRLTDP
Q
R
F
F
L
T
C
VSGEAGAGRGSDAWGPP
L
L
LEKDD
R
I
V
RTPPGPP
L
R
L
ARNGS
H
Q
V
T
L
RGFS
K
P
S
D
L
V
G
V
F
S
CVGGAGA
R
R
T
R
V
I
Y
V
HNSPGAHLLP
D
K
V
T
H
TVNKGD
T
A
V
L
S
A
R
VHKEKQT
D
V
I
W
KSNG
S
Y
F
Y
T
L
D
WHEAQD
G
R
F
L
L
QLPNVQPPSSG
I
Y
S
A
T
Y
LEASP
L
G
S
A
F
F
R
L
I
V
R
GCGAGRWGPGC
T
K
ECPGCLHGGVCHDHDG
E
C
VCPPGF
T
G
T
R
C
E
Q
A
C
REGRFG
Q
S
C
Q
E
QCPGISGCR
G
L
T
F
CLPDPYGCSCGSGWRG
S
Q
C
Q
E
ACAPGHFGAD
C
R
L
Q
C
Q
CQNGGT
C
D
RFSGCVCPSGWHGVHCEKSDR
I
P
Q
I
L
N
M
A
S
E
L
E
FNLETMPRINCAAAGNPFPVRG
S
I
E
L
RKPD
G
T
V
L
L
S
T
K
A
IVEPEKTTAEFEV
P
R
L
V
L
ADSG
F
W
E
C
R
V
STSGGQD
S
R
R
F
K
V
N
V
KVPPVPLA
A
P
R
L
L
T
K
QS
R
Q
L
V
V
S
P
L
V
SFSGDGP
I
S
T
V
R
L
H
Y
RPQDSTM
D
W
S
T
I
V
VDPSE
N
V
T
L
M
N
LRPKT
G
Y
S
V
R
V
Q
L
SRPGEGGEGAWGPPTLMTTDC
P
E
P
L
L
Q
P
W
L
EGWHVEGT
D
R
L
R
V
S
W
SLPLVPGPLVGD
G
F
L
L
R
LWDGTR
G
Q
E
R
R
ENVSSP
Q
A
R
T
A
L
LTGLTPG
T
H
Y
Q
L
D
V
Q
L
Y
H
C
T
LLGPASPP
A
H
V
L
LPPSGPPAPR
H
L
H
A
QALSDS
E
I
Q
L
T
WKHPEALPGP
I
S
K
Y
V
V
E
V
Q
V
AGGAGD
P
L
W
I
DVDRP
E
E
T
S
T
I
I
RGLNA
S
T
R
Y
L
F
R
M
R
A
S
IQGLGDWSNT
V
E
E
STLGNGLQAEGPV
Q
E
S
R
A
A
E
EGL
D
Q
Q
L
I
L
A
V
V
G
S
V
S
A
T
C
L
T
I
L
A
A
L
L
T
L
V
C
I
R
R
S
C
L
H
RRR
T
F
T
YQSGSGE
E
T
I
L
Q
FSS
G
T
L
T
L
TRRPKLQP-----EPLSYPVLE---WE----DI
T
F
E
D
-LIGEG
N
F
G
Q
V
I
R
A
----
M
---
I
-----
K
---K-----D--G-----L---
K
---
M
N
----
A
A
I
K
M
L
K
E
Y
ASENDH
R
D
F
A
G
E
L
E
V
L
C
KLGHHP
N
I
I
N
L
L
G
AC-KN-R
G
Y
L
Y
I
A
I
EYAPY
G
N
L
L
D
F
L
R
K-SR--V--LETD
P
A
F
A
R
EHGTAS
T
L
S
S
R
Q
L
L
R
F
A
S
D
A
A
N
G
M
Q
Y
L
S
E
K
Q
F
I
H
R
D
L
A
ARNVLV
G
E
N
L
A
S
K
I
A
D
FGLSR----G---
E
---
E
V
Y
V
K
K
-TMGRL
P
V
R
W
M
A
I
ESL
N
Y
S
V
Y
T
TK
S
D
V
W
S
F
G
V
L
L
W
E
I
V
SLGGTPYCG-
M
T
C
-
A
E
L
Y
-
E
KLPQGYRMEQPRNC
D
D
E
V
Y
E
L
M
R
Q
C
W
RDRPYERP
P
F
A
Q
I
A
L
Q
L
G
R
M
--
L
E
A
R
K
A
Y
V
N
M
S
L
F
EN
F
T
YAGIDATAEEA
4
PsiBlast_PDB
86.59
81%
-101
- C2 -
3L8P
1
A:
[7-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
Y
P
V
L
D
---
W
N
----
D
I
K
F
Q
D
-
V
I
G
E
G
N
F
G
Q
V
L
K
A
----
R
---
I
-----
K
---
K
-----
D
--
G
-----
L
---
R
---
M
D
----
A
A
I
K
R
M
-----------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
-
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
R
--
V
--
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
----
G
---
Q
---
E
V
Y
V
K
K
------
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
-
M
T
C
-
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
--
1
PsiBlast_PDB
82.60
79%
-98
- C2 -
2WQB
1
A:
[16-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
V
L
D
---
W
N
----
D
I
K
F
Q
D
-
V
I
G
E
G
--
G
Q
V
L
K
A
----
R
---
I
-----
K
---
K
-----
D
--
G
-----
L
---
R
---
M
D
----
A
A
I
K
R
M
K
-------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
-
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
R
--
V
--
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
----
G
---
Q
---
E
V
Y
V
K
K
-
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
-
M
T
C
-
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
---
21
PsiBlast_CBE
79.91
80%
-103
- C2 -
4X3J
1
A:
[37-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
-------------------------------------
R
---
M
D
----
A
A
I
K
----------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
----------
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
R
--
V
--
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
--------------------------
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
-
M
T
C
-
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
------
3
PsiBlast_PDB
78.79
81%
-100
- C2 -
2OSC
1
A:
[30-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
----
R
---
I
--------------------------------
M
D
----
A
A
I
K
R
M
K
----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
-----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
R
--
V
--
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
----------------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
-
M
T
C
-
A
E
L
Y
-
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
-------
86
PsiBlast_CBE
71.52
47%
-91
- C2 -
4R6V
1
A:
[43-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
----
E
---
A
F
GMD--------------------
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
------------------------
58
PsiBlast_CBE
71.34
46%
-95
- C2 -
3RI1
1
?
A:
[24-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
-------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
-----------------------
57
PsiBlast_CBE
70.63
46%
-93
- C2 -
3RI1
1
FGFR2_HUMAN
B:
[24-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
------------------
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
-------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
N
----------------------
71
PsiBlast_CBE
69.68
46%
-94
- C2 -
3B2T
1
B:
[22-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
L
T
L
G
K
-
P
L
----
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
------------
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
--------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
85
PsiBlast_CBE
69.45
47%
-96
- C2 -
4QQC
1
A:
[43-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
----
E
---
A
F
GMD--------------------
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
------------------------
77
PsiBlast_CBE
69.26
46%
-93
- C2 -
2PY3
1
B:
[35-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
L
T
L
G
K
-
P
L
G
----
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
-----------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
N
----------------------
81
PsiBlast_CBE
69.22
47%
-95
- C2 -
4TYJ
2
A:
[31-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
--
G
Q
V
V
R
A
----
E
---
A
F
GMDP
A
---
R
-----
P
--
D
-----
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
---------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
S
E
E
---------------------
87
PsiBlast_CBE
69.14
47%
-90
- C2 -
4QQ5
1
A:
[43-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
----
E
---
A
F
GMD--------------------
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
------------------------
28
PsiBlast_CBE
68.93
48%
-97
- C2 -
1FGI
1
B:
[29-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
67
PsiBlast_CBE
68.75
47%
-88
- C2 -
4J99
1
?
D:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
AVG
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
EA-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
T
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
78
PsiBlast_CBE
68.72
46%
-93
- C2 -
2PY3
1
FGFR2_HUMAN
A:
[35-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
L
T
L
G
K
-
P
L
----
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
---------------
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
N
----------------------
134
HHSearch
68.70
43%
-86
- C2 -
1T46
1
?
A:
[23-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----
R
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
----
T
---
A
-----
Y
GLI
K
-----
S
--
D
-----
A
---
A
---
M
T
----
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
-
T
I
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
--
D
SF--------------
L
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
----
D
IKN
D
---
S
N
Y
V
V
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
-
M
P
V
D
S
K
F
Y
-
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
Q
--
I
S
E
S
T
N
----------------------
72
PsiBlast_CBE
68.70
46%
-94
- C2 -
3B2T
1
FGFR2_HUMAN
A:
[22-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
K
L
T
L
G
K
-
P
L
G
E
G
C
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
------------------
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
--------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
N
Q
E
--------------------
53
PsiBlast_CBE
68.61
48%
-89
- C2 -
3C4F
1
FGFR1_HUMAN
A:
[21-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
125
HHSearch
68.42
46%
-89
- C2 -
2PVF
1
A:
[34-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
----
K
L
T
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
---
A
-----
V
---
G
IDKDK
P
----------------
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
M
E
Y
S
Y
--------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
-----------------------
104
PsiBlast_CBE
68.40
42%
-99
- C2 -
3IK3
1
ABL1_MOUSE
A:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
--
R
--
Q
E
--------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
--------------
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------
47
PsiBlast_CBE
68.34
48%
-92
- C2 -
4WUN
1
FGFR1_HUMAN
A:
[30-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
82
PsiBlast_CBE
68.33
47%
-88
- C2 -
4TYI
1
A:
[31-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
R
A
----
E
---
A
FGMDP
A
---
R
-----
P
--
D
-----
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
--------------
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
G
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
------------------------
66
PsiBlast_CBE
68.32
47%
-89
- C2 -
4J95
1
FGFR2_HUMAN
A:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
-----------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DI-----------
Y
Y
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
46
PsiBlast_CBE
68.23
48%
-100
- C2 -
4WUN
1
B:
[30-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
------------------
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
--------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
-----------------------
15
PsiBlast_PDB
68.23
48%
-91
- C2 -
4V05
4
FGFR1_HUMAN
A:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
-----------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--------
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
29
PsiBlast_CBE
68.19
48%
-94
- C2 -
1AGW
1
B:
[29-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
63
PsiBlast_CBE
68.15
47%
-94
- C2 -
4J95
2
?
D:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DI-------------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
44
PsiBlast_CBE
68.08
48%
-88
- C2 -
4ZSA
1
FGFR1_HUMAN
A:
[27-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
35
PsiBlast_CBE
67.77
48%
-93
- C2 -
4NK9
2
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
--------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
102
PsiBlast_CBE
67.74
39%
-86
- C2 -
4AGC
1
A:
[33-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
I
V
M
D
P
D
E
L
P
-------
L
P
Y
D
A
S
K
---
W
E
FPRD
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
----
D
A
F
G
I
-----
D
---
K
-----
T
--
A
-----
T
---
C
---
R
T
----
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
--
N
--
E
F
V
P
Y
-------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
IYK
D
---
P
D
Y
V
R
K
-
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
-
V
K
I
-
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
--
L
Q
A
N
A
Q
----------------------
14
PsiBlast_PDB
67.51
48%
-91
- C2 -
4NK9
5
FGFR1_HUMAN
A:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--------
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
-----------
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
27
PsiBlast_CBE
67.50
48%
-90
- C2 -
2FGI
1
B:
[29-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
40
PsiBlast_CBE
67.49
48%
-88
- C2 -
4RWJ
1
B:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
-------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
----------------
Y
K
K
T
-
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
----------------------
48
PsiBlast_CBE
67.42
48%
-90
- C2 -
3RHX
2
B:
[25-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
108
PsiBlast_CBE
67.31
42%
-91
- C2 -
3QRJ
1
ABL1_HUMAN
B:
[15-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
--
R
--
Q
E
V
N
A
V
V
--------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
---------------------------
12
PsiBlast_PDB
67.26
48%
-89
- C2 -
1FGI
1
FGFR1_HUMAN
A:
[29-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
-----------------------
52
PsiBlast_CBE
67.24
48%
-85
- C2 -
3C4F
1
B:
[21-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
RVTK
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
9
PsiBlast_PDB
67.22
44%
-87
- C2 -
2IVS
5
RET_HUMAN
A:
[14-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
DPK
W
E
FPRK
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
----
T
A
F
H
L
-----
K
---
G
-----
R
--
A
-----
G
---
Y
---
T
T
----
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
-
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
R
------
K
V
G
P
G
Y
L
------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
----
D
VYE
E
---
D
S
Y
V
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
-
I
P
P
-
E
R
L
F
-
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
--
M
V
K
R
------------------------
50
PsiBlast_CBE
67.21
48%
-89
- C2 -
4RWK
1
B:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
----------I--
D
Y
Y
K
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
----------------------
36
PsiBlast_CBE
67.16
48%
-92
- C2 -
4F65
4
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
----------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
-----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
---------H--
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
----------------------
129
HHSearch
67.15
46%
-89
- C2 -
2I1M
1
A:
[45-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
----
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
----
T
---
A
-----
F
---
G
-----
L
--
G
-----
K
---
E
DAV
L
K
----
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
-
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
R
--
V
--
L
E
T
D
-------
S
---
T
A
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
----
D
IMN
D
---
S
N
Y
I
V
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
-
I
L
V
N
S
K
F
Y
-
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
--
A
Q
E
D
R
R
E
R
--------------------
64
PsiBlast_CBE
67.15
47%
-86
- C2 -
4J95
1
?
C:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--------------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
103
PsiBlast_CBE
67.09
42%
-95
- C2 -
3IK3
1
ABL1_MOUSE
B:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
--
R
--
Q
E
--------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
-----------
73
PsiBlast_CBE
67.08
47%
-86
- C2 -
2PWL
1
FGFR2_HUMAN
B:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
-----------------------
65
PsiBlast_CBE
67.00
47%
-86
- C2 -
4J95
1
?
B:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
-----------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
N
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
49
PsiBlast_CBE
67.00
48%
-91
- C2 -
3RHX
5
FGFR1_HUMAN
A:
[25-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
---------------------
34
PsiBlast_CBE
66.94
48%
-93
- C2 -
4NKA
2
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
---------HH-
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
30
PsiBlast_CBE
66.92
48%
-92
- C2 -
4V04
5
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
------------
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
127
HHSearch
66.88
48%
-91
- C2 -
4CKJ
16
A:
[22-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
----
N
L
V
L
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
----
T
---
A
-----
F
---
H
-----
L
--
K
-----
G
RA
G
Y
---
T
T
----
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
-
S
Q
-
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
R
--
K
--
V
-------------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
DVY-
E
---
E
---
D
S
Y
V
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
-
I
P
P
-
E
R
L
F
-
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
--
M
V
K
R
R
-----------------------
59
PsiBlast_CBE
66.82
47%
-89
- C2 -
1OEC
1
A:
[35-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
M
A
----
E
A
VG
I
------------------
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
-------------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
-----------------------
42
PsiBlast_CBE
66.78
48%
-82
- C2 -
3JS2
1
B:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
-----------------------
37
PsiBlast_CBE
66.71
48%
-92
- C2 -
4F64
3
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
RVTK
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
38
PsiBlast_CBE
66.65
48%
-92
- C2 -
4F63
3
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
-
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
136
HHSearch
66.51
45%
-93
- C2 -
1OPK
3
ABL1_MOUSE
A:
[219-477]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
---
T
---------
V
A
V
K
T
L
K
E
--
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
------------------
R
Q
E
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
------------
89
PsiBlast_CBE
66.48
48%
-84
- C2 -
4XCU
1
A:
[25-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
R
A
----
E
---
A
F
GMDP
A
---
R
-----
P
--
D
-----
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
---------
P
P
G
S
S
E
----
G
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
G
---
V
HHI
D
Y
Y
K
K
T
-
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
S
H
----------------------
69
PsiBlast_CBE
66.47
47%
-84
- C2 -
4J99
1
B:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
M
E
Y
S
Y
D
-------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
T
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
16
PsiBlast_PDB
66.43
48%
-85
- C2 -
4UWB
4
?
A:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
--
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
HH-
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
70
PsiBlast_CBE
66.40
47%
-88
- C2 -
4J99
1
FGFR2_HUMAN
A:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
-----------------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN---------
D
Y
Y
K
T
---
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
39
PsiBlast_CBE
66.34
48%
-90
- C2 -
4RWL
1
B:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
----------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
----------
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
---------------------
61
PsiBlast_CBE
66.26
47%
-85
- C2 -
4J98
1
FGFR2_HUMAN
B:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
AVG
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
EA-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
Q
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
54
PsiBlast_CBE
66.18
48%
-93
- C2 -
4K33
1
A:
[44-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
I
G
I
-----
D
---
K
-----
D
RA
A
-----
K
---
P
---
V
T
----
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
G
L
D
Y
S
F
D
T
S
----
E
Q
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
DVH-
N
---
L
---
D
Y
Y
K
E
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
--
L
T
V
T
------------------------
18
PsiBlast_PDB
66.10
48%
-83
- C2 -
3JS2
1
FGFR1_HUMAN
A:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
-------
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
105
PsiBlast_CBE
65.92
42%
-93
- C2 -
2Z60
1
ABL1_MOUSE
A:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
--
R
--
Q
E
--------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------
80
PsiBlast_CBE
65.88
47%
-86
- C2 -
4UXQ
1
A:
[29-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
R
A
----
E
---
A
F
GMDP
A
---
R
-----
P
--
D
-----
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
G
P
-------------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
G
---
V
HHI
D
Y
Y
K
K
T
-
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
------------------------
45
PsiBlast_CBE
65.88
48%
-88
- C2 -
5A4C
7
?
B:
[26-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
----------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
107
PsiBlast_CBE
65.82
42%
-90
- C2 -
3OY3
1
ABL1_MOUSE
A:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
--
R
--
Q
E
--------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------
100
PsiBlast_CBE
65.82
39%
-84
- C2 -
4ASD
1
A:
[39-348]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
D
E
L
P
LDEHC
E
R
L
P
Y
D
A
S
K
---
W
E
FPRD
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
----
D
A
F
G
I
-----
D
---
K
-----
T
--
A
-----
T
---
C
---
R
T
----
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
--
N
--
E
F
V
P
Y
-------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
IYK
D
---
P
D
Y
V
R
K
-
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
-
V
K
I
-
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
--
L
Q
A
N
A
-----------------------
31
PsiBlast_CBE
65.70
48%
-85
- C2 -
4UWC
9
?
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
Y
---
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
---------------------
13
PsiBlast_PDB
65.62
48%
-96
- C2 -
4F65
5
FGFR1_HUMAN
A:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-----------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-----------------
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
33
PsiBlast_CBE
65.52
48%
-92
- C2 -
4NKS
1
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
-
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
----------------------
P
N
RVTK
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
D
Y
Y
K
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
25
PsiBlast_CBE
65.48
48%
-92
- C2 -
3TT0
4
B:
[77-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--------------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
----------------------
98
PsiBlast_CBE
65.42
42%
-91
- C2 -
4HVS
1
A:
[48-329]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
Q
G
L
---
I
-----
K
---
S
-----
D
--
A
---------
A
---
M
T
----
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
E
N
I
V
N
L
L
G
A
C
-
T
H
-
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
DS
F
--
H
S
S
D
T
S
P
A
S
M
E
D
D
E
N
A
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
DIK-
N
---
D
---
S
N
Y
V
D
K
-
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
-
M
P
V
D
S
K
F
Y
-
K
M
I
K
E
G
F
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
Q
--
I
S
E
S
------------------------
74
PsiBlast_CBE
65.40
47%
-84
- C2 -
2PWL
1
FGFR2_HUMAN
A:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
----------------
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
68
PsiBlast_CBE
65.29
47%
-86
- C2 -
4J99
1
?
C:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
M
E
Y
S
Y
D
-------
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
T
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
------------------------
24
PsiBlast_CBE
65.24
47%
-85
- C2 -
3GQL
1
FGFR1_HUMAN
B:
[36-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-----------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
----------------------
20
PsiBlast_PDB
65.19
48%
-83
- C2 -
4RWJ
1
FGFR1_HUMAN
A:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
IHH
I
---
D
Y
Y
K
K
T
--
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
---------------------
128
HHSearch
65.01
47%
-84
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[66-353]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
---
R
D
----
R
L
V
L
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
----
E
---
A
-----
I
---
G
-----
L
--
D
KDKPN
R
---
V
---
T
K
----
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
I
H
H
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
32
PsiBlast_CBE
65.00
48%
-84
- C2 -
4UWB
3
?
B:
[28-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-------------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
Y
---
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----H--
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
92
PsiBlast_CBE
64.95
41%
-94
- C2 -
2I0V
1
A:
[31-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
L
P
Y
N
E
K--
W
E
FPRN
N
L
Q
F
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
----
T
A
F
G
L
-----
G
---
K
-----
E
--
D
-----
A
---
V
---
L
K
----
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
-
T
H
-
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
-
K
R
--------------------
Q
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
DIM-
N
---
D
---
S
N
Y
I
V
K
-
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
G
L
N
P
Y
P
G
I
L
V
N
-
S
K
F
Y
-
K
L
V
K
D
G
Y
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
--
A
Q
E
-------------------------
75
PsiBlast_CBE
64.93
47%
-82
- C2 -
4J96
1
FGFR2_HUMAN
B:
[43-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
----
E
A
V
G
I
-----
D
---
K
-----
D
--
K
-----
P
---
K
E
A
-
V
T
----
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-
R
R
--
P
--
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
DIN-
N
---
I
---
D
Y
Y
K
M
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
L
T
L
T
T
N
----------------------
26
PsiBlast_CBE
64.85
48%
-93
- C2 -
5AM6
1
B:
[29-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---------------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
-----------------------
43
PsiBlast_CBE
64.81
48%
-87
- C2 -
4ZSA
1
B:
[27-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
----------
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
------------------------
23
PsiBlast_CBE
64.72
47%
-88
- C2 -
3GQL
1
C:
[36-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
---------------------
122
HHSearch
64.69
41%
-90
- C2 -
3CBL
3
A:
[111-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
---
H
E
----
D
L
V
L
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
----
R
---
L
-----
R
---
A
-----
D
--
N
-----
T
---
L
---------
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
-
T
Q
-
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-
E
G
-------------------
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--
A
---
D
---
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
-
L
S
N
-
Q
Q
T
R
-
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
--
R
K
R
H
------------------------
51
PsiBlast_CBE
64.66
48%
-81
- C2 -
4RWK
1
FGFR1_HUMAN
A:
[36-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
---
I
HHI
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
---------------------
79
PsiBlast_CBE
64.55
47%
-88
- C2 -
4QRC
1
A:
[43-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
R
A
----
E
---
A
F
GMDP
A
---
R
-----
P
--
D
-----
Q
---
A
---
S
T
----
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
-
T
Q
-
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-
R
R
--
P
--
P
G
P
D
L
S
P
D
G
P
R
S
S
E
G
P
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
G
---
V
HHI
D
Y
Y
K
K
T
-
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
I
P
V
-
E
E
L
F
-
S
L
L
R
E
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
--
L
L
A
V
------------------------
106
PsiBlast_CBE
64.41
42%
-91
- C2 -
3OY3
1
ABL1_MOUSE
B:
[10-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
--
R
--
Q
E
--------------
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
--
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
-------------
130
HHSearch
64.39
42%
-84
- C2 -
2XIR
1
A:
[27-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
----
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
----
D
---
A
-----
F
---
G
IDK--
T
--
A
-----
T
---
C
---
R
T
----
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
-
T
K
P
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
--
N
--
E
F
V
P
Y
-------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
IYK
D
---
P
D
Y
V
R
K
-
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
-
V
K
I
D
E
E
F
C
-
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
--
L
Q
A
N
A
-----------------------
101
PsiBlast_CBE
63.93
39%
-85
- C2 -
4AGD
1
A:
[34-348]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
I
V
M
D
P
D
E
L
P
-------
L
P
Y
D
A
S
K
---
W
E
FPRD
R
L
K
L
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
----
D
A
F
G
I
-----
D
---
K
-----
T
--
A
-----
T
---
C
---
R
T
----
V
A
V
K
M
L
K
E
G
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
-
G
G
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
-
K
R
--
N
--
E
F
V
P
Y
-------
Y
K
D
F
L
T
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
E
K
N
V
V
K
I
C
D
F
G
L
A
R
----
D
IYK
D
---
P
D
Y
V
R
K
-
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
-
V
K
I
-
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
S
E
L
V
E
H
L
G
N
L
--
L
Q
A
N
A
Q
----------------------
138
HHSearch
63.69
40%
-97
* C2 *
4AOJ
1
NTRK1_HUMAN
A:
[38-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
---
R
R
----
D
I
V
L
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
----
E
---
C
-----
H
---
N
LLP---------------
K
---
M
L
----
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
-
T
E
-
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
-
H
G
--
P
--
D
------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
------------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
-
L
S
N
-
T
E
A
I
-
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
--
A
Q
A
P
P
-----------------------
137
HHSearch
63.62
37%
-92
- C2 -
4FYO
1
A:
[13-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
---
R
K
----
L
L
T
L
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
----
Y
---
Y
-----
Q
---
M
-----
K
--
K
-----
V
---
V
---
K
T
----
V
A
V
K
I
L
-----
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
R
--------------------
H
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
---
E
---
N
Y
Y
K
A
-----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
-
M
K
G
-
S
E
V
T
-
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
--
Y
Y
D
V
V
N
E
G
H
H
------------------
90
PsiBlast_CBE
63.49
45%
-86
- C2 -
4XLI
1
?
B:
[5-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
----
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
-------------
S
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
S
------------------------
11
PsiBlast_PDB
63.39
48%
-81
- C2 -
3TT0
1
FGFR1_HUMAN
A:
[77-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
D
I
H
H
I
---
D
Y
Y
K
K
T
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
A
L
T
S
N
Q
E
--------------------
10
PsiBlast_PDB
63.22
47%
-86
- C2 -
3GQL
1
FGFR1_HUMAN
A:
[36-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
---
A
---
I
-----
G
---
L
-----
D
--
K
-----
D
---
K
---
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
-
T
Q
-
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-
R
R
--
P
--
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--------------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
-
V
P
V
-
E
E
L
F
-
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
S
M
P
L
D
-------------
91
PsiBlast_CBE
63.18
45%
-90
- C2 -
4XLI
1
?
A:
[5-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
----
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
-------------
S
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
S
------------------------
96
PsiBlast_CBE
62.81
45%
-86
- C2 -
2XYN
4
ABL2_HUMAN
B:
[29-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
--
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
N
-------------
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
-------------------------
94
PsiBlast_CBE
62.74
45%
-91
- C2 -
3GVU
2
ABL2_HUMAN
A:
[29-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
N
-------------
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
--------
G
---
D
T
Y
T
-----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
S
------------------------
93
PsiBlast_CBE
61.72
45%
-90
- C2 -
3HMI
1
ABL2_HUMAN
A:
[29-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
E
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
N
-------------
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
L
M
--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
S
------------------------
97
PsiBlast_CBE
60.93
45%
-88
- C2 -
2XYN
2
ABL2_HUMAN
A:
[29-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
--
D
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
N
-------------
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
D
-------------------------
95
PsiBlast_CBE
60.06
45%
-84
- C2 -
2XYN
4
ABL2_HUMAN
C:
[29-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
---
R
T
----
D
I
T
M
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
----
V
---
W
-----
K
---
K
-----
Y
--
S
-----
L
--------
T
----
V
A
V
K
T
L
K
--
T
M
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
L
-
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
-
C
N
-------------
R
E
E
V
T
A
V
V
L
-----
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
LM--
T
---
G
---
D
T
Y
T
A
H
-
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
-
I
D
L
-
S
Q
V
Y
-
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
--
F
H
--------------------------
133
HHSearch
58.80
32%
-89
- C2 -
4OTW
1
A:
[10-283]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
---
E
T
----
E
L
R
K
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
----
V
---
W
-----
I
---
P
-----
E
--
G
-----
E
---
S
I
K
-
I
P
----
V
C
I
K
V
I
E
D
K
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
C
-
P
G
--
S
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
R
-------------------
G
A
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
----
L
LPP
D
-------------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
-
L
R
L
-
A
E
V
P
-
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
--
A
R
D
P
P
R
Y
L
V
I
K
-----------------