@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TLK1_HUMAN: (2015-10-21 )
MSVQSSSGSLEGPPSWSQLSTSPTPGSAAAARSLLNHTPPSGRPREGAMDELHSLDPRRQELLEARFTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETPEKKQSESSRGRKRKAENQNESSQGKSIGGRGHKISDYFEYQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSPTALAFGDHPIVQPKQLSFKIIQTDLTMLKLAALESNKIQDLEKKEGRIDDLLRANCDLRRQIDEQQKLLEKYKERLNKCISMSKKLLIEKSTQEKLSSREKSMQDRLRLGHFTTVRHGASFTEQWTDGFAFQNLVKQQEWVNQQREDIERQRKLLAKRKPPTANNSQAPSTNSEPKQRKNKAVNGAENDPFVRPNLPQLLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRINNEDNSQFKDHPTLNERYLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYLLPHMRRSNSSGNLHMAGLTASPTPPSSSIITY
Atome Classification :
(64 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450-........460.......470.......480....---...490.......500.....---..510.......520.......530.......540....-...550.--------------------------------------......560.......570.......580.......590....-...600.......610.......620.......630.......640.-......650.......660.......670.......680.......-690.....--.--.700-........710.......720.......730....-----...740.......750.......760....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSVQSSSGSLEGPPSWSQLSTSPTPG
S
A
A
A
A
R
S
L
L
NHTPPSGRPREG
A
M
D
E
L
HSL
D
P
R
R
Q
E
L
L
E
A
R
FTGVASGSTGSTGSCSVGAKASTNNESSNHSFGSLGSLSDKESETP
E
K
KQ
S
E
S
SRGRKRKAENQNESSQGKSIGGRGHKIS
D
Y
F
E
YQGGNGSSPVRGIPPAIRSPQNSHSHSTPSSSVRPNSPSP
T
A
L
AFGDHPIVQPKQ
L
S
F
K
I
IQT
D
L
T
M
L
K
L
AALESNK
I
Q
D
L
E
K
KE
G
R
I
D
D
L
L
RAN
C
D
L
R
R
Q
I
D
E
Q
Q
K
L
L
E
K
Y
K
E
R
L
N
K
C
I
S
M
S
K
K
L
L
IEK
S
T
Q
E
K
L
S
S
R
E
K
S
M
Q
D
R
L
RLG
H
F
T
T
VRHGA
S
F
T
E
Q
WTD
G
F
A
F
Q
N
L
V
K
Q
Q
E
W
V
N
Q
Q
R
E
D
I
E
R
Q
R
K
L
L
AKRKPPTANNSQAPSTNS
E
P
K
Q
R
KNKAVNGAENDPFVRPN
L
P
Q
L
L
T
L
A
E
Y
H
E
Q
E
E
I
F
K
L
R
L
GHL
K
K
E
E
A
E
I
Q
A
E
L
E
R
L
E
R
V
R
N
L
H
I
R
E
L
K
R
INNEDNSQFKDHPT--L
N
E
R
Y
L
L
L
H
L
LGRG
G
F
S
E
V
Y
K
A
F
D
L
Y
E
Q
R
Y
A
A
V
K
I
---
H
Q
L
N
K
S
W
R
D
E
K
K
E
N
Y
H
K
H
A
C
R
---
E
Y
R
I
H
KELDHP
R
I
V
K
L
Y
D
Y
FSL
D
T
D
T
F
C
T
V
L
E
YCEGN
D
L
-
D
F
Y
L
K
Q
H
--------------------------------------
K
LM
S
E
K
E
A
R
S
I
V
M
Q
I
V
N
A
L
R
Y
L
N
EIKP
P
I
I
H
Y
DLKPG
N
I
L
L
V
D-GTACG
E
I
K
I
TDF
G
L
S
K
IMDDDSYGVDGMDLTSQGA
G
T
Y
W
YL
P
P
E
C
F
V
-VGKEPPKISNKVD
V
W
S
V
G
V
I
F
F
Q
C
L
YGRKPFGHN
Q
S
Q
Q
D
I
L
QENT
I
-
L
K
A
T
E
VQF--P--VKP--VV
S
S
E
A
K
A
F
I
R
R
C
L
A
Y
RKEDRF
D
V
H
Q
LANDPYLL
P
-----
H
M
RRSNSSG
N
L
H
M
AGLTASPTPPSSSIITY
7
PsiBlast_PDB
84.25
32%
-103
- C1 -
3Q5I
1
?
A:
[29-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
E
G
K
--
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
K-------------
K
F
H
E
E
I
Y
N
---
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
-
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
--------------------------------------
K
F
-
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
--
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
-
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
Y
K
L
R
D
R
L
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
K
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
-
G
Q
N
D
Q
D
I
I
K
K
V
E
K
-
G
K
Y
Y
-
F
D
F
--
N
--
D
W
K
--
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
A
L
N
S
R
W
I
K
K
-----
Y
A
N
N
I
N
K
S
D
Q
K
T
L
C
G
A
L
S
N
M
R
K
F
E
G
S
Q
K
L
A
69
PsiBlast_CBE
82.57
31%
-117
* C1 *
3LIJ
1
?
A:
[35-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
---
I
R
-----
K
-----
S
S
N
S
K
L
L
E
---
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
-
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
-
F
D
E
I
I
H
R
--------------------------------------
M
K
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
E
K
D
A
L
I
K
I
V
D
F
G
L
S
A
V
F
E
N
Q
K
K
-------
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
------
R
K
K
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
-
G
Q
T
D
Q
E
I
L
R
K
V
E
K
-
G
K
Y
T
-
F
D
S
--
P
--
E
W
K
--
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
Q
Q
A
L
E
H
P
W
I
K
E
-----
M
C
S
K
K
E
S
L
P
S
L
A
N
A
I
E
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
2
PsiBlast_PDB
80.67
32%
-98
- C1 -
3MWU
1
?
A:
[19-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
--------------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
----
D
R
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
A
-
F
D
L
--
P
--
Q
W
R
--
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
117
HHSearch
80.22
30%
-104
- C1 -
3HKO
2
?
A:
[23-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
L
Q
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
---
M
N
K
N
K
I
--
R
Q
---
K
D
V
E
R
I
K
T
---
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
-
D
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
-
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
--
G
I
C
H
R
D
I
K
P
E
N
F
L
F
S
T
--
N
K
S
F
E
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
N
N
G
----------
A
G
T
P
Y
F
V
A
P
E
V
L
N
-
T
T
--
N
E
S
Y
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
-
T
I
S
Q
--
V
-
L
N
-
K
K
L
C
F
EN
P
--
N
Y
N
--
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
-----
F
S
D
K
I
Y
K
M
S
---------------------
6
PsiBlast_PDB
79.21
32%
-98
- C1 -
2WEI
1
?
A:
[19-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
--------------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
M
K
D
R
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
A
-
F
D
L
--
P
--
Q
W
R
--
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
--------------------------
67
PsiBlast_CBE
78.44
32%
-108
- C1 -
2W0J
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
T
A
L
P
Q
---------
126
HHSearch
78.36
31%
-104
- C1 -
2RKU
6
PLK1_HUMAN
A:
[10-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
--
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
T
K
E
V
F
A
G
K
I
---
V
P
K
S
L
L
L
K
P
H
----
Q
R
E
K
M
S
M
---
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
-
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
--
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
----
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
------
K
K
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
S
--
K
K
---
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
-----
I
K
K
N
E
--
Y
--
S
--
I
P
K
--
H
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
L
L
N
D
E
F
F
T
S
-----
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
-------
1
PsiBlast_PDB
78.24
32%
-96
- C1 -
3IGO
8
?
A:
[19-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-----
I
N
K
A
S
A
K
N
K
-
T
S
---
T
I
L
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
--------------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
--------------
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
A
-
F
D
L
--
P
--
Q
W
R
--
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
65
PsiBlast_CBE
78.08
32%
-110
- C1 -
2YCR
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
--------
62
PsiBlast_CBE
77.71
32%
-104
- C1 -
2YIR
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-------------
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
---------
42
PsiBlast_CBE
77.65
32%
-107
- C1 -
4BDF
3
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
64
PsiBlast_CBE
77.36
32%
-105
- C1 -
2YCS
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
--------
75
PsiBlast_CBE
77.27
31%
-101
- C1 -
3DBF
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
-------------
57
PsiBlast_CBE
77.26
32%
-107
- C1 -
2CN8
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
---------------
53
PsiBlast_CBE
77.21
32%
-108
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
40
PsiBlast_CBE
77.13
32%
-112
- C1 -
4BDH
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
58
PsiBlast_CBE
77.12
32%
-106
- C1 -
2CN5
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
R
-------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
--------------
41
PsiBlast_CBE
77.05
32%
-105
- C1 -
4BDG
2
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
66
PsiBlast_CBE
76.94
32%
-105
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
--------
44
PsiBlast_CBE
76.81
32%
-112
- C1 -
4BDD
3
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
47
PsiBlast_CBE
76.79
32%
-108
- C1 -
4BDA
8
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
43
PsiBlast_CBE
76.29
32%
-112
- C1 -
4BDE
5
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
------------
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
4
PsiBlast_PDB
76.24
32%
-94
- C1 -
4Y5Q
1
?
A:
[19-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
--------------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
---
D
R
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
A
-
F
D
L
--
P
--
Q
W
R
--
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
55
PsiBlast_CBE
76.07
32%
-109
- C1 -
2WTD
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
37
PsiBlast_CBE
76.07
32%
-106
- C1 -
4BDK
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
------------
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
52
PsiBlast_CBE
76.02
32%
-102
- C1 -
2XM9
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
26
PsiBlast_CBE
75.90
33%
-86
- C1 -
4WG3
1
?
A:
[20-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
R
--------------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
T
-
F
E
L
--
P
--
Q
W
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
76
PsiBlast_CBE
75.51
31%
-98
- C1 -
3DBE
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
--
G
E
R
K
K
D
L
-------
P
N
Y
I
A
P
E
V
L
C
-
K
K
G
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
-------------
49
PsiBlast_CBE
75.49
32%
-103
- C1 -
4A9T
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
68
PsiBlast_CBE
75.39
32%
-101
- C1 -
2YCF
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
--------
3
PsiBlast_PDB
75.13
32%
-97
- C1 -
3NCG
1
?
A:
[19-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
---
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
-
F
D
E
I
I
K
R
--------------------------------------
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
-----
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
A
-
F
D
L
--
P
--
Q
W
R
--
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
-----
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
Q
A
E
K
K
L
63
PsiBlast_CBE
74.63
32%
-104
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
---------------
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
--------
72
PsiBlast_CBE
74.54
31%
-106
- C1 -
3DBD
1
?
A:
[38-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
-------------
48
PsiBlast_CBE
74.49
32%
-107
- C1 -
4A9U
10
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
----------
D
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
54
PsiBlast_CBE
74.48
32%
-107
- C1 -
2WTI
3
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
56
PsiBlast_CBE
74.23
32%
-107
- C1 -
2WTC
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
------
73
PsiBlast_CBE
73.51
31%
-104
- C1 -
3DBC
1
?
A:
[38-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
-------------
51
PsiBlast_CBE
72.93
32%
-108
- C1 -
4A9R
2
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
74
PsiBlast_CBE
72.68
31%
-104
- C1 -
3DB8
1
?
A:
[38-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
---------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
-------------
46
PsiBlast_CBE
72.68
32%
-108
- C1 -
4BDB
10
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-------------
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
38
PsiBlast_CBE
72.44
32%
-108
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
--------------
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
25
PsiBlast_CBE
72.20
33%
-85
- C1 -
4WG4
1
?
A:
[20-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
R
--------------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
T
-
F
E
L
--
P
--
Q
W
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
13
PsiBlast_PDB
71.98
33%
-89
- C1 -
4IFG
1
?
A:
[44-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
R
--------------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
T
-
F
E
L
--
P
--
Q
W
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
A
Q
A
A
L
L
77
PsiBlast_CBE
71.60
31%
-101
- C1 -
3DB6
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
--
G
E
R
K
K
D
L
----
C
G
T
P
N
Y
I
A
P
E
V
L
C
-
K
K
G
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
-------------
70
PsiBlast_CBE
71.35
33%
-94
- C1 -
3MA6
1
?
B:
[29-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
R
Q
V
K
Q
-
T
D
K
E
S
L
L
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
R
--------------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
A
S
K
K
M
K
D
K
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
T
-
F
E
L
--
P
--
Q
W
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
----------------------------
78
PsiBlast_CBE
71.09
31%
-97
- C1 -
3D5X
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
T
K
E
V
F
A
G
K
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
-------
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
-
L
E
L
H
K
R
R
--------------------------------------
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
--
G
E
R
K
K
D
-----------
I
A
P
E
V
L
C
-
K
K
G
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
N
E
Y
S
V
--
P
RH
I
N
P
--
V
----
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
L
L
T
D
E
F
F
T
S
-----
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
--------------
50
PsiBlast_CBE
69.58
32%
-104
- C1 -
4A9S
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
---
I
S
K
-----------
P
A
L
N
V
E
T
---
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
-
F
D
K
V
V
G
N
--------------------------------------
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
-------
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
S
-
G
K
Y
N
F
I
P
---
E
--
V
W
A
--
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
-----
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
-----
71
PsiBlast_CBE
69.24
33%
-89
- C1 -
3MA6
1
?
A:
[29-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
-------
I
S
K
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
---
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
-
F
D
E
I
I
S
R
--------------------------------------
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
T
H
F
E
-
S
K
K
M
K
D
K
I
-------
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
T
-
F
E
L
--
P
--
Q
W
K
--
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
-----
Y
T
K
---------------------------
103
PsiBlast_CBE
68.52
31%
-102
- C1 -
3DFC
1
DAPK1_HUMAN
B:
[63-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
8
PsiBlast_PDB
68.45
30%
-88
- C1 -
4MVF
2
CDPK2_PLAFK
A:
[55-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
V
T
N
Q
L
Y
A
I
K
-------------
E
E
K
K
D
R
L
K
N
I
N
R
F
F
Q
E
I
E
I
M
K
K
L
D
H
P
N
I
V
K
L
Y
E
T
Y
E
N
D
N
Y
I
Y
-
L
I
M
E
L
C
S
G
R
E
L
-
F
D
S
I
I
E
N
--------------------------------------
G
S
F
T
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
--
I
V
H
R
D
L
K
P
E
N
F
L
F
Q
S
-
E
N
K
D
S
L
L
K
I
I
D
F
G
L
S
K
-------
N
L
-----------------------------
K
Y
D
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
G
Y
P
P
F
-
Y
--------------------
C
F
--
Y
--
E
N
D
WG
S
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
C
T
I
E
E
A
L
N
H
P
W
I
T
Q
-----
M
T
K
S
H
V
E
L
S
S
T
L
L
K
N
L
K
N
F
K
K
E
N
E
L
K
K
I
A
L
88
PsiBlast_CBE
67.27
31%
-98
- C1 -
3GU7
1
DAPK1_HUMAN
A:
[63-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
97
PsiBlast_CBE
66.66
31%
-99
- C1 -
3EHA
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
---------------------------------------
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
81
PsiBlast_CBE
66.51
31%
-85
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[64-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
K
--------------------------------------
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---
G
V
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
-
S
Y
D
F
D
E
E
F
--
F
--
S
Q
----
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
VD
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----------
95
PsiBlast_CBE
66.29
31%
-97
- C1 -
4YO4
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
Q
F
E
K
--------------------------
89
PsiBlast_CBE
66.14
31%
-100
- C1 -
3GU6
1
DAPK1_HUMAN
A:
[63-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
100
PsiBlast_CBE
65.59
31%
-97
- C1 -
1JKL
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
98
PsiBlast_CBE
65.44
31%
-100
- C1 -
3EH9
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
---------------------------------------
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
90
PsiBlast_CBE
65.02
31%
-96
- C1 -
3GU5
1
DAPK1_HUMAN
A:
[63-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
102
PsiBlast_CBE
64.59
31%
-100
- C1 -
1IG1
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
91
PsiBlast_CBE
64.32
31%
-97
- C1 -
3GU4
1
DAPK1_HUMAN
A:
[63-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
101
PsiBlast_CBE
63.97
31%
-99
- C1 -
1JKK
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
F
-----------------------------
80
PsiBlast_CBE
63.91
31%
-86
- C1 -
2YAA
1
DAPK2_MOUSE
B:
[64-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
-
V
L
I
L
E
L
V
S
G
G
E
L
-
F
D
F
L
A
Q
K
--------------------------------------
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
---
G
V
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
-
S
Y
D
F
D
E
E
F
--
F
--
S
Q
----
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
H
P
W
I
T
P
VD
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----------
87
PsiBlast_CBE
62.18
31%
-92
- C1 -
3F5U
1
DAPK1_HUMAN
A:
[63-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
L
A
E
K
--------------------------------------
E
S
L
T
E
E
E
A
T
E
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
K
P
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
P
Q
F
E
--------------------------
99
PsiBlast_CBE
61.47
31%
-94
- C1 -
1P4F
1
DAPK1_HUMAN
A:
[62-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
---
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
-
I
L
E
L
V
A
G
G
E
L
-
F
D
F
---------------------------------------------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
R
N
V
P
--
R
I
K
I
I
D
F
G
L
A
H
K
I
D
---
F
G
N
E
F
K
N
I
----
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
-
N
Y
E
F
E
D
E
Y
--
F
--
S
N
----
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
-----
Q
F
----------------------------