@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TLK2_HUMAN: (2015-10-21 )
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPSSGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
Atome Classification :
(70 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.....--..460.......470.......480.-......490.---.......500.......510.......520.......530.....-..540.......550--.......560.......570.......580.......590.......600-.......610.......620.......630.....-..640.......650........660.......670.......680.......690....-...-700....--...--710.......720.......730..------.....740.......750.......760.......770
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
M
E
E
L
HSL
D
P
R
R
Q
E
L
L
E
A
R
FTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQ
N
D
Q
R
NRKRKAEPYETSQGKGTPRGH
K
I
S
D
Y
F
E
FAGGSAPGTSPGRSVPPVARSSPQHSLSNPL
P
R
R
V
EQPLYGLDG
S
A
A
K
E
A
T
E
E
Q
S
A
L
P
T
L
M
S
V
M
LAKPRL
D
T
E
Q
L
A
Q
RGA
G
L
C
F
T
F
V
SAQQNSPSSTGSGNTEHSCSSQ
K
Q
I
S
I
Q
HRQTQSDL
T
I
E
K
I
S
A
LENSKNSD
L
E
K
KE
G
R
I
D
D
L
L
RAN
C
D
L
R
R
Q
I
D
E
Q
Q
K
M
L
E
K
Y
K
E
R
L
N
R
C
V
T
M
S
K
K
L
L
I
E
KS
K
Q
E
K
M
A
CRDK
S
M
Q
D
R
L
RLG
H
F
T
T
VRHGA
S
F
T
E
QWTD
G
Y
A
F
Q
N
L
I
K
Q
Q
E
R
I
N
S
Q
R
E
E
I
E
R
Q
R
K
M
L
AKRKPPAMGQAPPAT
N
E
Q
K
Q
R
KSKTNGAENETPSSGNTELKDTAP
A
L
G
A
H
S
L
L
R
L
T
L
A
E
Y
H
E
Q
E
E
I
F
K
L
R
L
GHL
K
K
E
E
A
E
I
Q
A
E
L
E
R
L
E
R
V
R
N
L
H
I
R
E
L
K
R
I
HNEDNSQFKDHPT--LN
D
R
Y
L
L
L
H
L
LGRG
G
F
S
E
V
Y
K
A
FDLT-EQ
R
Y
V
A
V
K
-
I
---
H
QLNKNWR
D
E
K
K
E
N
Y
H
K
H
A
C
R
E
Y
R
I
H
KELDHP
R
I
V
K
L
Y
D
Y
FSLD
T
-
D
S
F
C
T
V
L
E
YCEGN
D
L
--
D
F
Y
L
K
Q
H
KLM
S
E
K
E
A
R
S
I
I
M
Q
I
V
N
A
L
K
Y
L
N
EIKP
P
I
I
H
Y
DLKPG
N
I
L
L
V
N-GTAC
G
E
I
K
I
TDF
G
L
S
K
IMDDDSYNSVDG
M
E
L
TSQG-A
G
T
Y
W
YL
P
P
E
C
F
V
-VGKEPPKISNKVD
V
W
S
V
G
V
I
F
Y
Q
C
L
YGRKPFGHN
Q
S
Q
Q
D
I
L
QENT
I
-
L
K
A
-TEVQFPP--KPV--VT
P
E
A
K
A
F
I
R
R
C
L
A
Y
RKEDRI
D
V
Q
Q
------LACD
P
Y
L
L
P
H
I
R
K
SVSTSSPA
G
A
A
I
ASTSGASNNSSSN
5
PsiBlast_PDB
80.82
31%
-102
- C1 -
3HX4
3
?
A:
[40-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
Q
H
S
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
---------
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
73
PsiBlast_CBE
79.74
31%
-112
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[14-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
--
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
---
A
K
-----------
N
-------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
-
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
--
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
--
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
G
-------
G
S
--------
V
L
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
--
V
-
L
A
Q
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
--
I
-
L
K
A
E
Y
E
F
D
S
P
Y
--
W
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
HPW
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------
76
PsiBlast_CBE
79.26
31%
-106
- C1 -
4FG9
1
KCC1A_HUMAN
A:
[10-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
--
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
---------
E
N
-------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
-
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
--
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
--
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
---------------------------
P
G
Y
V
A
P
E
--
V
-
L
A
Q
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
--
I
-
L
K
A
E
Y
E
F
D
S
P
Y
--
W
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
HPW
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
77
PsiBlast_CBE
79.03
31%
-109
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[9-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
W
K
Q
A
E
D
--
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
---
A
---------
S
M
E
N
-------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
-
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
--
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
--
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
G
L
S
K
M
E
D
P
G
-----------------
T
P
G
Y
V
A
P
E
--
V
-
L
A
Q
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
--
I
-
L
K
A
E
Y
E
F
D
S
P
Y
--
W
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
HPW
I
A
------------------------------------
74
PsiBlast_CBE
78.47
31%
-110
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[10-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
Q
A
E
D
--
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
---
A
K
E
----------
N
-------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
-
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
--
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
--
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
--------------------------
T
P
G
Y
V
A
P
E
--
V
-
L
A
Q
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
--
I
-
L
K
A
E
Y
E
F
D
S
P
Y
--
W
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
HPW
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
--------------
2
PsiBlast_PDB
78.44
31%
-90
- C1 -
3MWU
1
?
A:
[19-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
-
T
Q
Q
E
Y
A
V
K
-
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
-
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
--
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
------------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
-
A
-
F
D
L
P
Q
--
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
------
C
L
E
H
P
W
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
129
HHSearch
78.18
32%
-105
- C1 -
2RKU
6
PLK1_HUMAN
A:
[10-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
R
--
S
R
R
R
Y
V
R
G
R
F
L
G
K
G
G
F
A
K
C
F
E
I
S
D
A
D
-
T
K
E
V
F
A
G
K
-
I
---
V
P
K
S
L
L
L
K
P
H
----
Q
R
E
K
M
S
M
E
I
S
I
H
R
S
L
A
H
Q
H
V
V
G
F
H
G
F
F
E
-
D
N
-
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
N
--
R
V
I
H
R
D
L
K
L
G
N
L
F
L
N
E
----
D
L
E
V
K
I
G
D
F
G
L
A
T
K
V
E
Y
D
G
E
R
-------
K
K
V
L
-
C
G
T
P
N
Y
I
A
P
E
V
L
S
--
K
K
---
G
H
S
F
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
E
T
S
C
L
K
E
T
Y
L
R
-----
I
K
K
-
N
E
Y
S
I
P
----
K
H
--
I
N
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
P
T
I
N
E
------
L
L
N
D
E
F
F
T
S
G
Y
I
P
A
R
L
P
I
T
C
L
T
I
P
P
R
F
S
I
A
P
S
------
12
PsiBlast_PDB
77.41
31%
-85
- C1 -
4M84
1
?
A:
[21-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
75
PsiBlast_CBE
77.29
31%
-111
- C1 -
4FG9
1
KCC1A_HUMAN
B:
[14-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
--
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
-
T
Q
K
L
V
A
I
K
C
I
---
A
K
-------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
G
-
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
--
F
D
R
I
V
E
K
G
F
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
--
I
V
H
R
D
L
K
P
E
N
L
L
Y
Y
S
-
L
D
E
D
S
K
I
M
I
S
D
F
------------------
V
L
S
T
A
-
C
G
T
P
G
Y
V
A
P
E
--
V
-
L
A
Q
K
P
--
Y
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
-
Y
D
E
N
D
A
K
L
F
E
Q
--
I
-
L
K
A
E
Y
E
F
D
S
P
Y
--
W
D
D
--
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
HPW
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
K
S
K
W
K
Q
A
F
N
A
T
A
V
V
21
PsiBlast_CBE
76.91
34%
-106
- C1 -
3Q5I
1
?
A:
[29-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
E
G
K
--
I
G
E
S
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
N
-
G
H
S
E
K
A
I
K
-
V
I
K
K-------------
K
F
H
E
E
I
Y
N
E
I
S
L
L
K
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
-
D
K
-
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
-
E
Q
I
I
N
R
H
K
F
-
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
--
K
H
N
I
V
H
R
D
I
K
P
E
N
I
L
L
E
N
-
K
N
S
L
L
N
I
K
I
V
D
F
G
L
S
S
F
F
S
K
D
-
Y
K
L
R
D
R
L
--------
G
T
A
Y
Y
I
A
P
E
V
L
------
K
K
K
Y
N
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
-
G
Q
N
D
Q
D
I
I
K
K
V
E
K
-
G
K
Y
-
Y
-
F
D
F
N
D
--
W
K
N
--
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
E
E
------
A
L
N
S
R
W
I
K
K
Y
A
N
N
I
N
K
S
D
Q
K
T
L
C
G
A
L
S
N
M
R
K
F
E
G
S
Q
K
L
57
PsiBlast_CBE
75.81
31%
-101
- C1 -
3DBF
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
----
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
-----------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
------------
1
PsiBlast_PDB
75.39
31%
-89
- C1 -
3IGO
8
?
A:
[19-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
-
T
Q
Q
E
Y
A
V
K
-
V
-----
I
N
K
A
S
A
K
N
K
-
T
S
---
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
-
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
--
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
----------------
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
-
A
-
F
D
L
P
Q
--
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
------
C
L
E
H
P
W
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
3
PsiBlast_PDB
75.27
31%
-91
- C1 -
3NCG
1
?
A:
[19-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
-
T
Q
Q
E
Y
A
V
K
-
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
-
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
--
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
--------------
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
-
A
-
F
D
L
P
Q
--
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
------
C
L
E
H
P
W
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
24
PsiBlast_CBE
75.24
31%
-104
- C1 -
3DBD
1
?
A:
[38-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
----
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
-----------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
------------
14
PsiBlast_PDB
75.12
31%
-80
- C1 -
4WG5
1
?
A:
[21-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
17
PsiBlast_PDB
75.09
31%
-87
- C1 -
4MX9
1
?
A:
[21-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
13
PsiBlast_PDB
74.62
31%
-83
- C1 -
4ONA
1
?
A:
[20-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
56
PsiBlast_CBE
74.60
31%
-112
- C1 -
2YCR
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
K
P
Q
-------
47
PsiBlast_CBE
74.45
31%
-110
- C1 -
2CN8
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
---
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
--------------
53
PsiBlast_CBE
74.44
31%
-106
- C1 -
2YCS
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------
32
PsiBlast_CBE
74.37
31%
-109
- C1 -
4BDF
3
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
16
PsiBlast_PDB
74.01
31%
-85
- C1 -
4MXA
1
?
A:
[21-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
19
PsiBlast_PDB
73.77
32%
-97
- C1 -
2WEI
1
?
A:
[19-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
-
T
Q
Q
E
Y
A
V
K
-
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
-
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
--
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
K
--------
M
K
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
-
A
-
F
D
L
P
Q
--
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
------
C
L
E
H
P
W
I
Q
K
Y
S
S
E
-------------------------
33
PsiBlast_CBE
73.72
31%
-114
- C1 -
4BDE
5
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
54
PsiBlast_CBE
73.44
31%
-107
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------
6
PsiBlast_PDB
73.36
31%
-86
- C1 -
3KU2
1
?
A:
[44-322]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
45
PsiBlast_CBE
73.30
31%
-111
- C1 -
2WTD
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
31
PsiBlast_CBE
73.30
31%
-106
- C1 -
4BDG
2
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
4
PsiBlast_PDB
73.22
31%
-86
- C1 -
4Y5Q
1
?
A:
[19-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
F
A
E
R
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
-
T
Q
Q
E
Y
A
V
K
-
V
-----
I
N
K
A
S
A
K
N
K
D
T
S
---
T
I
L
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
-
D
S
-
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
--
F
D
E
I
I
K
R
K
R
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
E
S
-
K
E
K
D
C
D
I
K
I
I
D
F
G
L
S
T
C
F
Q
Q
N
T
-----------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
R
G
T
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
-
Y
G
K
N
E
Y
D
I
L
K
R
V
E
T
-
G
K
Y
-
A
-
F
D
L
P
Q
--
W
R
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
------
C
L
E
H
P
W
I
-----
Q
K
Y
S
S
E
T
P
T
I
S
D
L
P
S
L
E
S
A
M
T
N
I
R
Q
F
48
PsiBlast_CBE
73.20
31%
-107
- C1 -
2CN5
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
R
-------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-------------
51
PsiBlast_CBE
73.19
31%
-106
- C1 -
2YIR
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
--------
38
PsiBlast_CBE
73.18
31%
-109
- C1 -
4A9U
10
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
----------
D
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
35
PsiBlast_CBE
73.11
31%
-111
- C1 -
4BDC
2
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
55
PsiBlast_CBE
72.95
31%
-109
- C1 -
2W0J
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
T
A
L
P
Q
--------
97
PsiBlast_CBE
72.87
31%
-100
- C1 -
2WTW
1
AURKA_HUMAN
A:
[21-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
-
S
K
F
I
L
A
L
K
-
V
-----
L
F
K
A
--
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
-
D
A
-
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
--
Y
K
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
--
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
-
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
----------------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
------
T
Y
-
K
R
I
-
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
------
V
L
E
H
P
W
I
T
A
N
S
S
K
-------------------------
25
PsiBlast_CBE
72.76
31%
-102
- C1 -
3DBC
1
?
A:
[38-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
----
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
-----------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
------------
34
PsiBlast_CBE
72.72
31%
-114
- C1 -
4BDD
3
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
11
PsiBlast_PDB
72.61
31%
-87
- C1 -
3T3U
5
?
A:
[22-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
9
PsiBlast_PDB
72.56
31%
-84
- C1 -
3N51
3
?
A:
[22-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
27
PsiBlast_CBE
72.52
31%
-108
- C1 -
4BDK
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
26
PsiBlast_CBE
72.40
31%
-102
- C1 -
3DB8
1
?
A:
[38-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
M
S
T
----
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
-----------------------------------
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
------------
29
PsiBlast_CBE
72.34
31%
-104
- C1 -
4BDI
6
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
------------
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
Q
P
--
49
PsiBlast_CBE
72.26
31%
-103
- C1 -
2YCF
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------
61
PsiBlast_CBE
72.23
32%
-103
- C1 -
3HZT
9
?
A:
[3-264]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
R
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
-
T
G
A
E
R
A
I
K
-
I
-----
I
K
K
S
--
S
V
T
T
T
S
N
S
G
A
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
--
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
--
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
R
D
A
L
I
K
I
V
D
F
G
L
S
------
A
H
F
E
V
G
-----------
T
A
Y
Y
I
A
P
E
V
L
------
R
K
K
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
-
G
Q
T
D
Q
E
I
L
K
R
----
V
E
K
-
G
K
F
S
F
D
P
--
P
D
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
------
A
L
N
H
P
W
I
V
K
F
C
S
Q
V
G
K
H
A
L
T
G
A
L
G
N
M
K
K
F
Q
S
S
Q
K
L
A
Q
A
30
PsiBlast_CBE
72.16
31%
-113
- C1 -
4BDH
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
43
PsiBlast_CBE
72.07
31%
-109
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
42
PsiBlast_CBE
71.48
31%
-104
- C1 -
2XM9
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
58
PsiBlast_CBE
71.43
31%
-92
- C1 -
3DBE
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
----
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
-------
E
R
K
K
D
L
----
P
N
Y
I
A
P
E
V
L
C
-
K
K
G
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
------------
46
PsiBlast_CBE
71.28
31%
-108
- C1 -
2WTC
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
8
PsiBlast_PDB
71.01
31%
-85
- C1 -
3I7B
4
?
A:
[23-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
39
PsiBlast_CBE
70.86
31%
-103
- C1 -
4A9T
4
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
28
PsiBlast_CBE
70.56
31%
-110
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
44
PsiBlast_CBE
70.54
31%
-108
- C1 -
2WTI
3
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
37
PsiBlast_CBE
70.41
31%
-110
- C1 -
4BDA
8
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
--------------
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
-----
10
PsiBlast_PDB
70.08
31%
-84
- C1 -
3SXF
3
?
A:
[22-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AI
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
E
Q
I
S
V
D
V
P
S
L
D
N
A
I
L
N
I
R
Q
F
Q
G
T
Q
K
L
36
PsiBlast_CBE
70.05
31%
-110
- C1 -
4BDB
10
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-------------
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
-
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
52
PsiBlast_CBE
69.56
31%
-106
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
---------------
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
-------
103
PsiBlast_CBE
69.45
31%
-102
- C1 -
3QBN
1
AURKA_HUMAN
A:
[17-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
-
S
K
F
I
L
A
L
K
-
V
-----
L
F
K
A
--
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
-
D
A
-
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
--
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
--
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
-
G
E
L
K
I
A
D
-------------
T
L
----------
S
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
------
T
Y
-
K
R
I
-
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
------
V
L
E
H
P
W
I
T
A
N
S
S
--------------------------
78
PsiBlast_CBE
69.25
32%
-84
- C1 -
2V7O
3
KCC2G_HUMAN
A:
[29-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
T
D
D
Y
Q
L
F
E
E
L
G
K
G
-
F
S
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
-
I
---
N
T
K
K
L
S
A
R
D
H
Q
K
L
E
------
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
-
F
H
Y
-
L
V
F
D
L
V
T
G
G
E
L
--
F
E
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
--
H
D
I
V
H
R
D
L
K
P
E
N
L
L
L
A
S
-
K
C
K
G
A
A
V
K
L
A
D
F
G
L
A
I
--------
E
V
Q
G
E
Q
Q
A
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
--
V
-
L
R
K
D
P
--
Y
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
D
Q
H
K
L
Y
Q
Q
----
I
K
A
-
G
A
Y
D
F
P
S
PE
W
D
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
D
Q
------
A
L
K
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
R
Q
E
T
V
E
C
L
R
K
F
N
A
R
R
K
L
K
G
-
59
PsiBlast_CBE
69.24
31%
-95
- C1 -
3DB6
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
----
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
-------
E
R
K
K
D
L
-
C
G
T
P
N
Y
I
A
P
E
V
L
C
-
K
K
G
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
R
------------
41
PsiBlast_CBE
68.92
31%
-109
- C1 -
4A9R
2
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
G
E
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
96
PsiBlast_CBE
68.08
31%
-86
- C1 -
2J4Z
3
AURKA_HUMAN
A:
[42-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
-
S
K
F
I
L
A
L
K
-
V
-----
L
F
K
A
--
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
-
D
A
-
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
--
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
--
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
-
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
S
R
R
T
T
L
----------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
------
T
Y
-
K
R
I
-
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
------
V
L
E
H
P
W
I
T
A
N
S
S
K
-------------------------
60
PsiBlast_CBE
67.69
31%
-92
- C1 -
3D5X
1
?
A:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
--
T
M
K
R
Y
M
R
G
R
F
L
G
K
G
G
F
A
K
C
Y
E
I
T
D
M
D
-
T
K
E
V
F
A
G
K
-
V
---
V
P
K
S
M
L
L
K
P
H
Q
K
E
K
----
M
S
T
E
I
A
I
H
K
S
L
D
N
P
H
V
V
G
F
H
G
F
F
E
-
D
D
-
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
--
L
E
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
N
R
--
V
I
H
R
D
L
K
L
G
N
L
F
L
N
D
-
D
M
---
D
V
K
I
G
D
F
G
L
A
T
K
I
E
F
D
G
-------
E
R
K
K
D
--------
I
A
P
E
V
L
C
-
K
K
G
H
----
S
F
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
-----
E
T
S
C
L
K
E
T
Y
I
R
I
K
K
-
N
E
Y
S
V
P
R
--
H
----
I
N
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
P
S
V
A
E
------
L
L
T
D
E
F
F
T
S
G
Y
A
P
M
R
L
P
T
S
C
L
T
V
P
P
-------------
22
PsiBlast_CBE
67.34
33%
-89
- C1 -
3MA6
1
?
B:
[29-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
-
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
A
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
---------------------------
95
PsiBlast_CBE
66.90
31%
-86
- C1 -
2J4Z
2
AURKA_HUMAN
B:
[42-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
-
S
K
F
I
L
A
L
K
-
V
-----
L
F
K
A
--
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
-
D
A
-
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
--
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
--
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
-
G
E
L
K
I
A
D
F
G
W
S
V
H
A
P
S
S
R
R
T
T
L
----------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
------
T
Y
-
K
R
I
-
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
------
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
N
-------------------
40
PsiBlast_CBE
66.35
31%
-106
- C1 -
4A9S
1
CHK2_HUMAN
A:
[13-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
-
T
C
K
K
V
A
I
K
-
I
---
I
S
K
-----------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
--
D
A
-
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
--
F
D
K
V
V
G
N
K
R
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
--
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
-
Q
E
E
D
C
L
I
K
I
T
D
F
G
H
S
K
I
L
--
T
S
--------
L
M
R
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
V
S
L
K
D
Q
I
T
----
S
-
G
K
Y
N
F
I
P
--
E
V
W
AE
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
------
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
A
L
P
Q
V
L
A
----
23
PsiBlast_CBE
65.21
33%
-85
- C1 -
3MA6
1
?
A:
[29-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-
F
S
D
R
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
-
T
G
Q
E
C
A
V
K
-
V
-----
I
S
K
--
R
Q
V
K
Q
K
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
K
-
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
--
F
D
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
--
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
-
K
S
K
D
A
N
I
R
I
I
D
F
G
L
S
--------
T
H
F
E
-
S
K
K
M
K
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
-
N
G
A
N
E
Y
D
I
L
K
K
V
E
K
-
G
K
Y
-
T
-
F
E
L
P
Q
--
W
K
K
--
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
------
A
L
D
H
E
W
I
Q
T
Y
T
K
--------------------------
99
PsiBlast_CBE
65.00
31%
-97
- C1 -
1MUO
1
AURKA_HUMAN
A:
[33-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
-
S
K
F
I
L
A
L
K
-
V
-----
L
F
K
A
--
Q
L
E
K
A
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
-
D
A
-
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
--
Y
R
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
--
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
-
G
E
L
K
I
A
D
F
G
W
S
----------
L
----------
C
G
T
L
D
Y
L
P
P
E
M
I
-----
E
G
R
M
H
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
------
T
Y
-
K
R
I
-
S
R
V
E
F
T
F
--
P
D
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
------
V
L
E
H
P
W
I
T
A
N
S
S
--------------------------
91
PsiBlast_CBE
63.23
32%
-95
- C1 -
2R5T
1
SGK1_HUMAN
A:
[42-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
H
K
A
-
E
E
V
F
Y
A
V
K
-
V
-----
L
Q
K
K
A
I
L
-------------
V
L
L
-
K
N
V
K
H
P
F
L
V
G
L
H
--
F
S
F
Q
T
A
D
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
--
F
Y
H
L
Q
R
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
N
--
I
V
Y
R
D
L
K
P
E
N
I
L
L
----
D
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
--
E
N
I
E
H
N
S
T
-----
T
S
T
F
-
C
G
T
P
E
Y
L
A
P
E
--
V
-
L
H
K
Q
P
--
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
P
P
F
Y
S
R
N
T
A
E
--
M
Y
D
N
I
L
-
N
K
P
-
L
Q
L
------
K
P
N
--
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
A
K
D
------
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
----
70
PsiBlast_CBE
57.49
32%
-96
- C1 -
2YAA
1
DAPK2_MOUSE
A:
[64-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
-
D
-
V
V
L
I
L
E
L
V
S
G
G
E
L
--
F
D
F
L
A
Q
K
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
--
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
N
I
P
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
-------
D
G
V
E
F
K
N
I
--
F
G
T
P
E
F
V
A
P
E
--
I
-
V
N
Y
E
P
--
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
I
T
A
V
-
S
Y
D
-
F
D
E
E
F
F
S
--
Q
----
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
------
A
L
R
H
P
W
I
T
P
V
D
T
Q
Q
A
M
V
R
R
E
S
V
V
N
L
E
N
F
K
K
Q
Y
V
-----