@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TNI3K_HUMAN: (2015-10-21 )
MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480..--..--..----..490.......500...------....510....-...520.......530.......540.......550.-.--.-..---------------..--560.......570.......580.......590.......600----.......----.610----........620...-..---..630...--.-...640-........650.......660........670..-.....680....----..-----..690-..------..------....700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGNYKSRPTQT
C
T
D
E
W
K
K
KVSE
S
Y
V
I
T
I
ERLE
D
D
L
Q
I
K
E
K
E
L
T
E
L
R
N
I
FGSDEA
F
S
K
V
N
L
N
Y
RTEN
G
L
S
L
L
H
L
C
C
ICGG
K
K
S
H
I
R
T
L
M
L
KGLRPSRLTRNG
F
T
A
L
H
L
A
V
YKD
N
A
E
L
I
T
S
L
L
HSGAD
I
Q
QVGYGG
L
T
A
L
H
I
A
T
I
AG
H
L
E
A
A
D
V
L
L
QHGANVNIQ
D
A
V
F
F
T
P
L
H
I
A
A
YY
G
H
E
Q
V
T
R
L
L
L
KFGAD
V
N
VSGEVGDRP
L
H
L
A
S
A
K
G
F
L
N
I
A
K
L
L
M
EEGSKADVNAQDNEDHV
P
L
H
F
C
S
RFG
H
H
D
I
V
K
Y
L
L
QSDLEVQP
H
V
V
N
I
YGDT
P
L
H
L
A
C
YN
G
K
F
E
V
A
K
E
I
I
QISGTES
L
T
K
E
NIF
S
E
T
A
F
H
S
ACTYGK
S
I
D
L
V
K
F
L
L
DQ
N
V
I
NINHQGRDGH
T
G
L
H
S
A
C
Y
H
G
H
I
R
L
V
Q
F
L
LDNGAD
M
N
L
V
A
CDPSRSSGE
K
D
E
Q
T
C
L
M
W
A
YEKG
H
D
A
I
V
T
L
L
K
H
YKRPQDELPCNEYSQPGGDG
S
Y
V
SVPS
P
L
G
K
I
K
S
M
T
KEKA
D
I
L
L
L
RAGLP
S
H
F
H
L
Q
LSE
I
E
F
H
E
IIGSGSFG
K
V
YKGR-CR--N
K
--
I
V
----
A
I
K
R
YRANTYCSK
S
D
V
D
M
------
F
C
R
E
V
S
I
L
C
QL-N
H
P
C
V
I
Q
F
V
G
A
CLNDPS
Q
F
A
I
V
T
QYISG
G
S
L
F
S
L
L
H
E
-
Q
--
K
-
R
I
---------------
L
D
--
L
QS
K
L
I
I
A
V
D
V
A
K
G
M
E
Y
L
H
N
L
T
Q
P
I
I
H
RDLNSH
N
I
L
L
YEDGH-----
A
V
V
A
DF
G
----
E
S
R
-----
F
L
Q
S
LDEDNMTKQP-GN---
L
R
W
M
A
P
E
V
--
F
-
T
Q
C
TR--
Y
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T-GEIP
F
A
HLKPA
A
A
A
-
A
D
M
A
Y
HH-IRPP----IG-----YSIP--K
P
------
I
S
------
S
L
L
I
R
GWNACPEGRP
E
F
S
E
V
V
M
K
L
E
E
C
LCN
I
E
LMSPASSNSSGSLSPSSSS
D
C
L
VNRGGPG
R
S
H
V
A
A
L
R
S
R
F
E
L
E
Y
A
LNA
R
S
Y
A
A
L
S
Q
SAGQYSSQGL
S
L
E
E
M
K
R
SLQYTPIDKYGYVSD
P
M
S
S
M
H
F
HSCRNSSSFEDSS
11
PsiBlast_PDB
79.04
34%
-122
- C2 -
3P86
1
CTR1_ARATH
A:
[38-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
-
W
H
--
G
S
--
D
V
----
A
V
K
I
L
M
E
Q
D
F
H
A
E
R
-
V
N
E
------
F
L
R
E
V
A
I
M
K
R
L
-
R
H
P
N
I
V
L
F
M
G
A
-
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
-
S
G
A
R
-
E
Q
---------------
L
D
--
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
T
-----
V
K
V
C
D
F
----------------------------
G
T
---
P
E
W
M
A
P
E
V
--
L
-
R
D
E
P
S
--
N
E
-
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
Q
V
V
-
A
A
V
G
F
K
C
-
K
R
L
E
----
I
P
-----
R
N
L
N
--
P
Q
------
V
A
------
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
-
T
I
M
D
L
L
R
P
L
I
K
--------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
77.75
35%
-131
- C2 -
4CSV
1
?
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-
W
R
--
N
Y
N
I
E
V
----
A
V
K
T
L
K
E
G
T
M
----
S
V
E
E
------
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
-
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C----------------------
V
N
--
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
--
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
-----
V
K
V
A
D
F
G
-----------------------------FP-
I
K
W
T
A
P
E
A
--
I
-
S
Y
-
N
R
--
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
----
P
G
M
S
G
-
S
E
V
I
E
Q
V
-
E
R
-------
G
-----
Y
R
M
P
--
R
P
QGCP
E
E
I
Y
------
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
---------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
77.33
32%
-124
- C2 -
4RFM
1
A:
[7-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
----------------------FP-
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
--------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.78
35%
-104
- C2 -
3PPZ
1
CTR1_ARATH
A:
[38-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
N
I
K
E
K
I
G
A
G
S
F
G
T
V
H
R
A
E
-
W
H
--
G
S
--
D
V
----
A
V
K
I
L
M
E
----
A
E
R
-
V
N
E
------
F
L
R
E
V
A
I
M
K
R
L
-
R
H
P
N
I
V
L
F
M
G
A
-
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
K
-
S
GA
R
-
E
Q
---------------
L
D
--
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
T
-----
V
K
V
C
D
F
G
----
L
S
R
L
K
AST
F
L
S
S
------
K
S
A
A
-
G
T
---
P
E
W
M
A
P
E
V
--
L
-
R
D
E
P
S
--
N
E
-
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
-
L
Q
Q
P
W
G
N
L
N
P
A
Q
V
V
-
A
A
V
G
F
K
C
-
K
R
L
E
----
I
P
-----
R
N
L
N
--
P
Q
------
V
A
------
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
-
T
I
M
D
L
L
R
P
L
I
K
--------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
76.75
35%
-103
- C2 -
4YZM
1
B:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
--
D
K
S-
V
V
----
A
I
K
S
L
I
L
G
------
E
T
E
M
I
E
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
P
R
---
M
V
M
E
L
V
P
C
G
D
L
Y
H
R
L
L
D
-
K
--
A
-
H
P
---------------
I
K
--
W
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
P
I
V
H
R
D
L
R
S
P
N
I
L
L
Q
S
L
D
E
NAPVC
A
K
V
A
D
F
G
----
L
S
Q
-----------------
L
L
-
G
N
---
F
Q
W
M
A
P
E
T
--
I
G
A
--
E
S
--
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
E
G
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
E
G
L
R
P
T
----
I
P
-----
E
D
C
P
--
P
R
------
L
R
------
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
76.72
31%
-127
- C2 -
4KIO
2
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
-------
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
76.65
32%
-126
- C2 -
4MF1
1
ITK_HUMAN
A:
[7-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
---
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
76.63
31%
-128
- C2 -
3QGY
1
ITK_HUMAN
A:
[21-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
K
E
G
S
M
S
E
----
D
D
------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.21
35%
-121
- C2 -
4UEU
1
?
A:
[6-265]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
-
W
R
--
N
Y
N
I
E
V
----
A
V
K
T
L
K
E
G
T
M
----
S
V
E
E
------
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
-
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
--
G
-
H
T
---------------
V
N
--
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
--
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
-----
V
K
V
A
D
F
G
----
L
A
R
-----
L
---
I
-----------
A
KFP
I
K
W
T
A
P
E
A
--
I
-
S
Y
-
N
R
--
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
----
P
G
M
S
G
-
S
E
V
I
E
Q
V
-
E
R
-------
G
-----
Y
R
M
P
--
R
P
QGCP
E
E
I
Y
------
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
75.94
31%
-126
- C2 -
3QGW
1
ITK_HUMAN
A:
[24-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
K
E
G
S
M
S
E
----
D
D
------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------FP-
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
75.93
32%
-129
- C2 -
1SM2
1
B:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
------------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.84
32%
-106
- C2 -
3L8P
1
A:
[12-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
W
N
D
I
K
F
Q
D
V
I
G
E
G
N
F
G
Q
V
L
K
A
R
-
I
K
--
K
D
--
G
L
R
M
D
A
A
I
K
R
M
-------------------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
--
R
-
V
L
ETD
P
A
F
A
I
A
N
STAST
L
S
--
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
--
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
-----
A
K
I
A
D
F
G
----
L
S
R
-----
G
Q
E
V
Y
V
K
K
-----
P
------
V
R
W
M
A
I
E
S
--
L
-
N
Y
S
V
---
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
--------
P
----
Q
G
-----
Y
R
L
E
--
K
P
------
L
N
CD
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
---------------------------------------------------------------------------------------
61
PsiBlast_CBE
75.64
32%
-125
- C2 -
3V5L
1
D:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
--
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
------------------------FP-
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.62
35%
-96
- C2 -
4YZN
1
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
--
D
K
S
-
V
V
----
A
I
K
S
L
I
L
-------
E
T
E
M
I
E
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
P
R
---
M
V
M
E
L
V
P
C
G
D
L
Y
H
R
L
L
D
-
K
--
A
-
H
P
---------------
I
K
--
W
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
P
I
V
H
R
D
L
R
S
P
N
I
L
L
Q
S
L
D
E
NAPVC
A
K
V
A
D
F
G
----
L
S
Q
-------
Q
S
V
--
H
S
V
S
G
L
L
-
G
N
---
F
Q
W
M
A
P
E
T
--
I
G
A
E
E
E
S
--
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
E
G
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
E
G
L
R
P
T
----
I
P
-----
E
D
C
P
--
P
R
------
L
R
------
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
75.36
32%
-124
- C2 -
1SM2
1
ITK_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
75.27
35%
-105
- C2 -
4YZM
1
ROCO4_DICDI
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
--
D
K
S
-
V
V
----
A
I
K
S
L
I
L
--------
T
E
M
IEK
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
P
R
---
M
V
M
E
L
V
P
C
G
D
L
Y
H
R
L
L
D
-
K
--
A
-
H
P
---------------
I
K
--
W
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
P
I
V
H
R
D
L
R
S
P
N
I
L
L
Q
S
L
D
E
NAPVC
A
K
V
A
D
F
G
----
L
S
Q
-------
Q
----------
L
-
G
N
---
F
Q
W
M
A
P
E
T
--
I
G
A
E
E
----
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
E
G
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
E
G
L
R
P
T
----
I
P
-----
E
D
C
P
--
P
R
------
L
R
------
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
75.26
33%
-118
- C2 -
3T9T
3
A:
[8-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
75.17
31%
-120
- C2 -
3QGY
1
B:
[22-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
K
E
G
S
M
S
E
----
D
D
------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
-----------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.04
31%
-108
- C2 -
3OMV
1
RAF1_HUMAN
A:
[30-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
I
L
K
V
-
V
D
P
T
P
E
Q
F
Q
A
------
F
R
N
E
V
A
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
D
--
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
-
Q
--
E
-
T
K
---------------
F
Q
--
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
-----
V
K
I
G
D
F
G
----
L
A
T
-----
V
------------
P
T
G
S
---
V
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
N
NP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
A
S
P
DLSK
L
Y
-----
K
N
C
P
--
K
A
------
M
K
------
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-----------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
74.78
31%
-129
- C2 -
4KIO
2
ITK_HUMAN
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
--------
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
74.74
32%
-127
- C2 -
1SNU
1
B:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
------------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
74.56
31%
-120
- C2 -
4PP9
1
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.54
35%
-96
- C2 -
4F1O
1
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
--
D
K
S
-
V
V
----
A
I
K
S
L
I
L
G
D
--
S
E
G
E
T
E
M
IEK
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
P
R
---
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
D
-
K
--
A
-
H
P
---------------
I
K
--
W
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
L
D
E
NAPVC
A
K
V
A
D
F
G
----
T
S
Q
-------
Q
S
V
--
H
S
V
S
G
L
L
-
G
N
---
F
Q
W
M
A
P
E
T
--
I
G
A
E
E
E
S
--
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
E
G
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
E
G
L
R
P
T
----
I
P
-----
E
D
C
P
--
P
R
------
L
R
------
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.51
35%
-94
- C2 -
4F1M
2
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
--
D
K
S
-
V
V
----
A
I
K
S
L
I
L
G
D
--
S
E
G
E
T
E
M
I
E
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
P
R
---
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
D
-
K
--
A
-
H
P
---------------
I
K
--
W
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
L
D
E
NAPVC
A
K
V
A
D
F
S
----
L
S
Q
-------
Q
S
V
--
H
S
V
S
G
L
L
-
G
N
---
F
Q
W
M
A
P
E
T
--
I
G
A
E
E
E
S
--
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
E
G
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
E
G
L
R
P
T
----
I
P
-----
E
D
C
P
--
P
R
------
L
R
------
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
74.42
32%
-121
- C2 -
1SNU
1
ITK_HUMAN
A:
[5-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
74.42
32%
-126
- C2 -
3V5J
1
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
-
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
---
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
------
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
74.42
31%
-135
- C2 -
4PPC
2
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
--------------------
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
-----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
74.35
31%
-121
- C2 -
4KIO
3
ITK_HUMAN
C:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
---------------------
F
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
74.17
32%
-125
- C2 -
3V8W
1
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
---
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
74.09
31%
-123
- C2 -
4L7S
1
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
74.04
32%
-123
- C2 -
3V5L
1
ITK_HUMAN
C:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
-----------------------FP-
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
74.00
32%
-121
- C2 -
3V5L
1
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
----
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
-----------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
73.79
31%
-110
- C2 -
5C9C
1
?
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
---
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LAT-------------------------
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
--------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
73.76
31%
-124
- C2 -
3QGW
1
B:
[24-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
P
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
K
E
G
S
M
S
E
----
D
D
------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
------------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
----------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.69
31%
-123
- C2 -
4L7S
1
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLASTH
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
73.54
32%
-122
- C2 -
4MF1
1
B:
[7-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
---
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
----------------------FP-
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
A
A
S
G
-------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
73.52
32%
-126
- C2 -
3V5J
1
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
----
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
------------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
L
------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.52
35%
-93
- C2 -
4F0F
1
A:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
I
E
Y
E
K
Q
I
G
K
G
G
F
G
L
V
H
K
G
R
L
V
K
--
D
K
S-
V
V
----
A
I
K
S
L
I
L
G
D
--
S
E
G
E
T
E
M
IE
K
F
Q
E
F
Q
R
E
V
F
I
M
S
N
L
-
N
H
P
N
I
V
K
L
Y
G
L
M
H
N
P
P
R
---
M
V
M
E
F
V
P
C
G
D
L
Y
H
R
L
L
D
-
K
--
A
-
H
P
---------------
I
K
--
W
S
V
K
L
R
L
M
L
D
I
A
L
G
I
E
Y
M
Q
N
Q
N
P
P
I
V
H
R
D
L
R
S
P
N
I
F
L
Q
S
L
D
E
NAPVC
A
K
V
A
D
F
G
----
L
S
Q
-------
Q
S
V
--
H
S
V
S
G
L
L
-
G
N
---
F
Q
W
M
A
P
E
T
--
I
G
A
E
E
E
S
--
Y
T
E
K
A
D
T
Y
S
F
A
M
I
L
Y
T
I
L
T
-
G
E
G
P
F
D
E
Y
S
Y
G
K
I
K
F
I
N
M
I
R
E
E
G
L
R
P
T
----
I
P
-----
E
D
C
P
--
P
R
------
L
R
------
N
V
I
E
L
C
W
S
G
D
P
K
K
R
P
H
F
S
Y
I
V
K
E
L
S
E
L
-----------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
73.50
32%
-110
- C2 -
4M14
2
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
73.39
31%
-130
- C2 -
4PPC
2
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
--------------------
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
---
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
-----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
73.32
31%
-110
- C2 -
4MBJ
1
BRAF_HUMAN
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----
W
S
-------
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
73.30
31%
-122
- C2 -
4PP9
1
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
-----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
103
Fugue
73.24
30%
-120
- C2 -
1BYG
1
CSK_HUMAN
A:
[15-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
-
Y
R
G--
N
--
K
V
----
A
V
K
C
I
K
-------
N
D
A
Q
A
------
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
--
G
R
S
V
---------------
L
G
--
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
--
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
-----
A
K
V
S
D
F
G
-----------------------------LLP
V
K
W
T
A
P
E
A
--
L
-
R
E
-
K
K
--
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
D
V
-
V
P
R
V
E
K
G
-
Y
K
M
D
----
A
P
-----
D
G
C
P
--
P
A
------
V
Y
------
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
73.04
32%
-112
- C2 -
4M13
1
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
73.04
32%
-122
- C2 -
3V8T
1
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
---
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
-----------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
73.02
31%
-131
- C2 -
4QD6
2
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
-------
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
72.93
31%
-101
- C2 -
4EHE
1
BRAF_HUMAN
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
---------------
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
72.74
32%
-110
- C2 -
3MJ2
1
A:
[7-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
72.64
31%
-106
- C2 -
4EHG
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
---------------------
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
72.59
32%
-108
- C2 -
4M15
2
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
---------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
72.49
32%
-107
- C2 -
4M0Y
2
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
72.48
32%
-110
- C2 -
4HCU
1
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
72.45
32%
-109
- C2 -
4M12
1
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
72.32
32%
-127
- C2 -
3V8W
1
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
-
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
72.32
31%
-106
- C2 -
3OMV
1
B:
[30-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
I
L
K
V
-
V
D
P
T
P
E
Q
F
Q
A
------
F
R
N
E
V
A
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
Y
M
T
K
D
--
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
-
Q
--
E
-
T
K
---------------
F
Q
--
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
-----
V
K
I
G
D
F
G
----
L
A
T
-----
V
------------
P
T
G
S
---
V
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
N
NP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
-
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
A
S
P
DLSK
L
Y
-----
K
N
C
P
--
K
A
------
M
K
------
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-----------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
72.20
31%
-105
- C2 -
4PP7
1
BRAF_HUMAN
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----
W
S
-------
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.18
32%
-112
- C2 -
4HCT
1
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.03
32%
-124
- C2 -
3MJ1
1
A:
[7-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
---------------------
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
------------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
72.02
32%
-112
- C2 -
4M0Z
2
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.86
31%
-131
- C2 -
4PPA
2
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
--------
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.81
31%
-128
- C2 -
4PPB
2
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
--------
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLASTH
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
71.58
32%
-111
- C2 -
4HCV
1
A:
[10-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
R
-----
F
V
--
L
D
-
D
Q
Y
T
S
S
T
-
G
T
KFP
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
71.58
31%
-100
- C2 -
2WQB
1
A:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
W
N
D
I
K
F
Q
D
V
I
G
E
G
--
G
Q
V
L
K
A
R
-
I
K
--
K
D
--
G
L
R
M
D
A
A
I
K
R
M
K
---------------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
--
R
-
V
L
ETD
P
A
F
A
I
A
N
STAST
L
S
--
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
--
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
-----
A
K
I
A
D
F
G
----
L
S
R
-----
G
Q
E
V
Y
V
K
K
T
-
G
R
L
P
------
V
R
W
M
A
I
E
S
--
L
-
N
Y
S
V
---
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
--------
P
----
Q
G
-----
Y
R
L
E
--
K
P
------
L
N
CD
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
----------------------------------------------------------------------------------------
92
PsiBlast_CBE
71.50
31%
-101
- C2 -
4MBJ
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----
W
S
G
S
H
Q
F
E
Q
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
71.47
31%
-131
- C2 -
4PPA
2
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D-
K
V
----
A
I
K
T
I
--------
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLASTH
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
71.30
31%
-100
- C2 -
4G9R
1
BRAF_HUMAN
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LATE
K
S
---------------------
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
71.22
31%
-96
- C2 -
4G9R
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LATE
K
----------------------
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.22
30%
-103
- C2 -
4CQE
1
?
A:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
---------------------------
G
S
---
I
L
W
M
A
P
E
V
IR
M
-
Q
--
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
--------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
71.12
31%
-123
- C2 -
4MF0
2
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
----
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
T
----------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
71.12
31%
-127
- C2 -
4MF0
2
B:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
----
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
-----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
71.09
31%
-108
- C2 -
4EHG
1
BRAF_HUMAN
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LATE-----------------------
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
71.04
31%
-104
- C2 -
4G9C
1
BRAF_HUMAN
A:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LATV
K
----------------
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
71.02
32%
-122
- C2 -
3V8T
1
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
---
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----
M
------------------------P--
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
--------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
70.88
32%
-121
- C2 -
4PQN
2
A:
[7-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
--
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
R
E
G
A
M
-
S
E
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
-----------------------------FP-
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
A
I
-----------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
70.66
31%
-104
- C2 -
4G9C
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LATV-----------------
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
70.64
31%
-126
- C2 -
4PPB
2
ITK_HUMAN
A:
[7-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
L
T
F
V
Q
E
I
G
S
G
Q
F
G
L
V
H
L
G
Y
-
W
L
--
N
K
D
-
K
V
----
A
I
K
T
I
--------
E
D
---------
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
-
E
Q
A
P
I
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
R
T
-
Q
--
R
-
G
L
---------------
F
A
--
A
E
T
L
L
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
-----
I
K
V
S
D
F
G
----------------------------
P
---
V
K
W
A
S
P
E
V
--
F
-
S
-
F
S
R
--
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
-
E
D
I
S
------------
T
G
-----
F
R
L
Y
--
K
P
RLAS
T
H
V
Y
------
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
S
R
L
L
R
Q
L
A
E
I
A
E
S
G
-------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
70.53
32%
-113
- C2 -
2OSC
1
A:
[30-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
R
-
I
---------M
D
A
-
A
I
K
R
M
K
------
K
D
D
H
R
D
------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
-
E
H
----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
--
R
-
V
L
ETD
P
A
F
A
I
A
N
STAST
L
S
--
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
--
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
-----
A
K
I
A
D
F
G
----
L
----------------
M
G
R
L
P
------
V
R
W
M
A
I
E
S
--
L
-
N
Y
S
V
---
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
--------
P
----
Q
G
-----
Y
R
L
E
--
K
P
------
L
N
CD
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
--------------------------------------------------------------------------------------------
31
PsiBlast_CBE
70.46
31%
-95
- C2 -
3C4C
1
BRAF_HUMAN
A:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
----------------------
S
----
G
S
---
I
L
W
M
A
P
E
V
I
R
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
70.46
31%
-104
- C2 -
4JVG
1
BRAF_HUMAN
A:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
LATV
K
S
----------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------
134
HHSearch
70.39
32%
-115
- C2 -
4C8B
2
RIPK2_HUMAN
A:
[33-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
-
H
A
DW
R
V
--
Q
V
----
A
V
K
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
-
P
E
F
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
-
K
--
T
-
E
Y
---------------
P
D
VA
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
N
M
T
P
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
-----
V
K
I
A
D
F
----------------------------
G
T
---
I
I
Y
M
P
P
E
N
--
Y
---------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
K
Q
P
F
E
D
V
T
N
P
L
Q
I
-
M
Y
S
V
S
Q
G
-
H
R
P
V
----
I
N
EESLP
Y
D
I
P
H
R
A
R
------
M
I
------
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
------------------------------------------------------------------------------------------
100
PsiBlast_CBE
70.38
31%
-100
- C2 -
4E4X
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
LATV
K
S
R
-----
W
S
G
S
H
Q
F
E
Q
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
70.07
31%
-98
- C2 -
4EHE
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----
W
S
G
S
H
Q
F
E
Q
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-----------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
69.64
31%
-105
- C2 -
3C4C
1
B:
[13-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
-----------------------
S
----
G
S
---
I
L
W
M
A
P
E
V
IR
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
69.43
31%
-99
- C2 -
4FK3
1
BRAF_HUMAN
A:
[25-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
----------------------
S
----
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
D
LSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
----------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
69.33
31%
-102
- C2 -
4JVG
1
BRAF_HUMAN
B:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
LAT-------------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
69.26
31%
-107
- C2 -
3OG7
1
BRAF_HUMAN
A:
[25-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
---------------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
---------------------------
G
S
---
I
L
W
M
A
P
E
V
IR-----
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
--------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
69.25
31%
-104
- C2 -
4JVG
1
D:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
LATV
K
S
----------------------
S
---
I
L
W
M
A
P
E
V
IR
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
69.21
31%
-106
- C2 -
4WO5
1
B:
[33-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
LAT------------------------
G
S
---
I
L
W
M
A
P
E
V
I
R
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
-------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
69.05
31%
-98
- C2 -
4PP7
1
B:
[37-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
-
I
--
E
-
T
K
---------------
F
E
--
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----
W
S
G
S
H
Q
F
E
Q
L
S
----
G
S
---
I
L
W
M
A
P
E
V
--
I
-
R
M
Q
D
K
NP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
F
M
V
G
R
G
-
Y
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
A
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
-------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
68.77
31%
-106
- C2 -
4WO5
1
BRAF_HUMAN
A:
[33-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
--
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----
W
S
----
F
E
Q
L
S
----
G
S
---
I
L
W
M
A
P
E
V
I
R
M
----
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
-------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.39
31%
-102
- C2 -
4JVG
1
BRAF_HUMAN
C:
[17-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
-
W
H
--
G
D
---
V
----
A
V
K
M
L
N
V
-
T
A
P
T
P
Q
Q
L
Q
A
------
F
K
N
E
V
G
V
L
R
K
T
-
R
H
V
N
I
L
L
F
M
G
--
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
-
S
--
E
-
T
K
---------------
F
E
--
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
--
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
N
T
-----
V
K
I
G
D
F
G
LA--------------------------
S
---
I
L
W
M
A
P
E
V
I
R
M
-
Q
D
S
N
P
--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
-
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
-
I
E
M
V
G
R
G
-
S
L
S
P
DLSK
V
R
-----
S
N
C
P
--
K
R
------
M
K
------
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
68.21
31%
-119
- C2 -
4X3J
1
A:
[37-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
A
------------RM
D
A
A
I
K
------------------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
---------
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
-
S
--
R
-
V
L
ETD
P
A
F
A
I
A
N
STAST
L
S
--
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
--
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
-----
A
K
I
A
D
F
G
------------------------
L
P
------
V
R
W
M
A
I
E
S
--
L
-
N
Y
S
V
---
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
-
E
K
L
--------
P
----
Q
G
-----
Y
R
L
E
--
K
P
------
L
N
CD
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
-------------------------------------------------------------------------------------------