@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TSSK1_HUMAN: (2015-10-21 )
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
Atome Classification :
(43 SA)
.........10........20........30........40........-50.......-----.60........70........80.-.-.......90........100..---------------.--------------..---------..110.......120.......130.......140.---.---...--..150.......-----160.......170.......180.....--..190..--.......200.......210.......220-....--..-.230....--...-.240.......250.......260.......270...-....280.......290.......300.......310.......320.......330.......340.......350.......360.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDDAAVLKRRGYLLGINL
G
EGSYAKVKSAY
S
ERLKFNVAIKIIDRKKAP-ADF
L
EKFLP-----
R
E
I
EILAML
N
HCSIIKT
Y
EI
F
E-T-
S
-HGKVYIV
M
ELAVQGDL
L
ELIKT---------------R--------------GA---------
L
H
E
D
EARKK
F
HQLSLAIKY
C
HDLDV
V
HRDLKCDNLL---L---DKD--FNIKLSDFSFSK-----RCLRDDSGRMALSKTFCGSPAYAA
P
EVL--QGI--PY--QPKVYDIWSLGVILYIMVCGSMPYDDSNIK-KMLR--IQ-
K
E
H-RVNF--PRS-
K
HLT
G
ECKDLI
Y
HMLQPDVNRR
L
HI
D
EIL
S
HCWMQPK-ARGSPSVAIN
K
E
G
ESSRG
T
EPLWT
P
EPGSDKKSATK
L
E
P
E
G
EAQPQAQ
P
ETK
P
EGTAMQMSRQ
S
EILGFPSKPST
M
E
T
E
EGPPQQP
P
ETRAQ
133
HHSearch
78.53
35%
-107
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[12-297]
--------
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
--------
E
Q
V
-
Y
-----
Q
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
-
D
-
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
P
-
T
---------------
L
--------------
K
P
---------
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
---
G
E
D
--
G
H
I
K
I
A
D
F
G
V
S
N
-----
E
F
K
G
S
D
----
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
--
S
E
T
--
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
F
M
D
E
R
I
M
-
C
L
H
S
--
K
I
-
K
S
Q
-
A
L
E
F
--
P
D
Q
-
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
T
R
----------------------------------------------------------------------------------------------
122
HHSearch
77.45
31%
-105
- C1 -
3HKO
2
?
A:
[26-336]
---------
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-
K
D
V
E
R
I
-
K
-----
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
-
D
-
E
--
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
S
IF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
---
F
---
S
T
N
KS
F
E
I
K
L
V
D
F
G
L
S
K
-----
E
F
Y
K
L
N
N
G
--------
A
G
T
P
Y
F
V
A
P
E
V
L
--
N
T
T
NE
S
Y
--
G
P
K
-
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
-
D
T
I
S
--
Q
V
-
L
N
K
-
K
L
C
F
EN
P
N
Y
-
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
-
S
D
K
I
Y
K
M
S
------------------------------------------------------------------------------------
30
PsiBlast_CBE
77.24
37%
-124
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[13-266]
-----------
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-
S
L
D
V
V
G
K
I
K
-----
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
-
T
-
P
--
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
---------------
H
--------------
G
R
---------
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
H
--
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
G
E
F
L
----------------
P
N
Y
A
A
P
E
V
I
--
S
G
R
--
L
Y
--
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
-
T
L
F
K
--
K
I
-
R
G
G
-
V
F
Y
I
--
P
---
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
-
L
P
S
Y
L
F
P
E
------------------------------------------------------------------------------------
64
PsiBlast_CBE
72.73
32%
-111
- C1 -
4BDI
6
CHK2_HUMAN
A:
[15-313]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
A
Q
P
-----------------------------------------------------------------
58
PsiBlast_CBE
71.25
32%
-105
- C1 -
2YCR
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
K
P
Q
----------------------------------------------------------------------
62
PsiBlast_CBE
69.76
32%
-107
- C1 -
4BDK
4
CHK2_HUMAN
A:
[15-311]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
A
-------------------------------------------------------------------
89
PsiBlast_CBE
69.70
32%
-109
- C1 -
2W0J
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
-
T
--
A
L
P
Q
----------------------------------------------------------------------
63
PsiBlast_CBE
69.15
32%
-115
- C1 -
4BDJ
1
CHK2_HUMAN
A:
[15-311]
--------
R
D
E
Y
I
M
S
K
T
L
G
-----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
A
-------------------------------------------------------------------
84
PsiBlast_CBE
68.86
32%
-107
- C1 -
2YIT
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------LN
V
E
-
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
67
PsiBlast_CBE
68.20
32%
-109
- C1 -
4BDF
3
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
87
PsiBlast_CBE
67.59
32%
-109
- C1 -
2YCS
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------NV
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
86
PsiBlast_CBE
67.18
32%
-105
- C1 -
2YIQ
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
70
PsiBlast_CBE
67.17
32%
-112
- C1 -
4BDC
2
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
79
PsiBlast_CBE
67.15
32%
-110
- C1 -
2WTI
3
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
10
PsiBlast_PDB
67.05
37%
-108
- C1 -
4CZT
3
CIPKN_ARATH
A:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
--------------------------------------------------------------------
85
PsiBlast_CBE
66.76
32%
-111
- C1 -
2YIR
1
CHK2_HUMAN
A:
[9-301]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------LN
V
E
-
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
-----------------------------------------------------------------------
37
PsiBlast_CBE
66.76
36%
-134
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
---
S
-
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
F
---------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
--
S
K
I
M
I
S
D
F
G
---------------
G
--
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
--
P
Y
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
-
K
L
F
E
Q
I
L
K
-
A
E
Y
-
E
F
D
S
--
P
Y
W
-
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
-
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
------------------------------------------------------------------------
80
PsiBlast_CBE
66.53
32%
-112
- C1 -
2WTD
4
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
90
PsiBlast_CBE
66.52
32%
-102
- C1 -
2YCF
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
38
PsiBlast_CBE
66.44
36%
-143
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
---
S
-
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
F
---------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
--
S
K
I
M
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
--
P
Y
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
-
K
L
F
E
Q
I
L
K
-
A
E
Y
-
E
F
D
S
--
P
Y
W
-
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
-
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
------------------------------------------------------------------------
11
PsiBlast_PDB
66.29
37%
-108
- C1 -
4CZU
3
CIPKN_ARATH
A:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
------------------------------------------------------------------
69
PsiBlast_CBE
66.27
32%
-113
- C1 -
4BDD
3
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
77
PsiBlast_CBE
65.97
32%
-106
- C1 -
2XM9
1
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
83
PsiBlast_CBE
65.95
32%
-109
- C1 -
2CN5
1
CHK2_HUMAN
A:
[15-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
R
-------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
------------------------------------------------------------------------------
36
PsiBlast_CBE
65.69
36%
-130
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
------------
S
M
E
-----
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
---
S
-
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
F
---------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
D
--
S
K
I
M
I
S
D
F
G
L
S
K
--------
M
E
D
P
G
----------
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
------
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
D
E
N
D
A
-
K
L
F
E
Q
I
L
K
-
A
E
Y
-
E
F
D
S
--
P
Y
W
-
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-----------------------------------------------------------------------------------------------
88
PsiBlast_CBE
65.65
32%
-107
- C1 -
2YCQ
1
CHK2_HUMAN
A:
[9-302]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
----------------------------------------------------------------------
24
PsiBlast_CBE
65.38
37%
-108
- C1 -
4CZT
4
CIPKN_ARATH
D:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
-------------------------------------------------------------
78
PsiBlast_CBE
65.35
32%
-108
- C1 -
2WTJ
5
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
66
PsiBlast_CBE
65.15
32%
-108
- C1 -
4BDG
2
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-----
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
29
PsiBlast_CBE
64.94
37%
-108
- C1 -
4CZU
3
CIPKN_ARATH
B:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
--------------------------------------------------------------------------
72
PsiBlast_CBE
64.91
32%
-109
- C1 -
4BDA
8
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
------
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
25
PsiBlast_CBE
64.87
37%
-114
- C1 -
4CZT
3
CIPKN_ARATH
C:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
--------------------------------------------------------------------
27
PsiBlast_CBE
64.51
37%
-107
- C1 -
4CZU
3
CIPKN_ARATH
D:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
-------------------------------------------------------------
81
PsiBlast_CBE
63.09
32%
-107
- C1 -
2WTC
1
CHK2_HUMAN
A:
[15-310]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
-------------
P
A
L
N
V
E
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-------
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
R
T
Q
-
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
E
S
T
--
A
L
P
Q
V
L
--------------------------------------------------------------------
96
PsiBlast_CBE
62.42
33%
-127
- C1 -
3COK
1
PLK4_HUMAN
A:
[15-266]
-------------
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-
K
A
G
M
V
Q
R
V
Q
-----
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
-
D
-
S
--
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
---------------
R
--------------
V
K
P--------
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
--
M
N
I
K
I
A
D
F
G
L
A
T
-----
Q
L
------
K
--------------------------------
E
S
-
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
D
T
D
T
V
K
-----------
V
V
-
L
A
D
Y
--
E
M
P
-
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
-----------------------------------------------------------------------------------------------
26
PsiBlast_CBE
62.24
37%
-108
- C1 -
4CZT
2
CIPKN_ARATH
B:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
--------------------------------------------------------------------------
28
PsiBlast_CBE
60.66
37%
-116
- C1 -
4CZU
3
CIPKN_ARATH
C:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
K
M
I
A
Q
I
K
-----
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
--
A
-
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
N
--
G
A
L
K
V
S
D
F
G
L
S
A
LP---
Q
Q
V
R
E
D
----
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
-
S
L
Y
K
-----
K
I
F
-
K
A
E
F
--
T
C
P
-
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
-
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
--------------------------------------------------------------------------
95
PsiBlast_CBE
60.25
33%
-125
- C1 -
4YUR
1
PLK4_HUMAN
A:
[17-268]
-------------
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-
K
A
G
M
V
Q
R
V
Q
-----
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
-
D
-
S
-
N
-
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
---------------
R
V-------------
K
P
---------
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
--
M
N
I
K
I
A
D
F
------------------------------------------------
G
L
E
S
-
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---
T
V
K
-
N
T
L
----
N
-
K
V
V
-
L
A
D
Y
--
E
M
P
-
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
-----------------------------------------------------------------------------------------------
82
PsiBlast_CBE
59.59
32%
-114
- C1 -
2CN8
1
CHK2_HUMAN
A:
[15-301]
--------
R
D
E
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------N
V
E
--
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
-
E
-
D
--
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
---------------
N
--------------
K
R
---------
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
---
L
SSQ
E
E
D
--
C
L
I
K
I
T
D
F
G
H
S
K
-----
I
L
-------
T
S
L
M
R
T
L
C
--
P
T
Y
L
A
P
E
V
L
V
S
V
G
T
--
A
G
--
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
E
H
----
V
S
L
K
--
D
Q
I
T
S
G
-
K
Y
N
F
I-
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
L
Q
D
E
D
M
K
R
K
F
Q
D
L
L
S
E
E
N
-------------------------------------------------------------------------------
56
PsiBlast_CBE
59.24
35%
-115
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[8-265]
--------
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
S
--------
S
L
E
-----
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
-
T
-
H
--
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
--------------
G
V
---------
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
E
N
--
S
K
I
M
I
T
D
F
G
L
S
K
--------
M
E
Q
N
G
I
M
S
---
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
--
P
Y
--
S
-
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
-
K
L
F
E
--
K
I
-
K
E
G
-
Y
Y
E
F
ES
P
F
W
-
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
-
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
-----------------------------------------------------------------------
126
HHSearch
57.99
30%
-105
- C1 -
2W5A
5
NEK2_HUMAN
A:
[5-276]
--------
A
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
A
E
K
Q
M
-
L
V
-----
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
-
D
R
T
-
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
-----------
R
--------------
Q
Y
---------
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
---
L
---
D
G
K
--
Q
N
V
K
L
G
D
F
G
L
A
R
-----
I
L
---
T
----
S
F
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
M
--
N
R
M
---
Y
--
N
E
K
-
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
-
E
L
A
G
--
K
I
-
R
E
G
K
F
R
R
I
--
P
---
Y
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
-
H
H
H
H
H
---------------------------------------------------------------------------------------
124
HHSearch
57.20
31%
-94
- C1 -
2YEX
8
CHK1_HUMAN
A:
[7-267]
---------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
--
D
C
P
E
N
-
I
K
-----
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
-
E
-
G
--
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
---------------
D
--------------
I
G
---------
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
R
--
D
N
L
K
I
S
D
F
G
L
A
T
-----
V
F
R
Y
N
N
--
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
--
E
F
--
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
--
D
W
-
K
E
K
-
K
T
Y
L
--
N
P
W
-
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
-
L
K
------------------------------------------------------------------------------------------
99
PsiBlast_CBE
56.63
33%
-121
- C1 -
4JXF
2
PLK4_HUMAN
A:
[11-262]
-------------
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
K
A
M
Y
-
K
A
G
M
V
Q
R
V
Q
-----
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
-
D
-
S
--
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
---------------
R
--------------
V
K
P--------
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
N
--
M
N
I
K
I
A
D
F
G
L
A
T
-----
Q
L
------
K
M
P
H
E
-----------------------------
S
-
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----
V
K
-
N
T
L
----
N
-
K
V
V
-
L
A
D
Y
--
E
M
P
-
S
F
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
S
S
V
L
D
H
P
F
M
S
R
----------------------------------------------------------------------------------------------