@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TSSK2_HUMAN: (2015-10-21 )
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
Atome Classification :
(30 SA)
.........10........20........30........40........-50---........60........70........80.-.......90........100..---------------.--------------..---------..110.......120.......130.......140.---.---.---..--.----.150.......--160.......170.......180.......190..--.......200.......210...-.---...220.-...-....-230...--...--.240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MD
D
A
T
V
L
RKK
G
Y
I
V
G
I
NLGKG
S
Y
A
K
V
K
S
A
Y
S
ER
L
K
F
N
V
A
V
K
I
I
DRKKT
P
-
T
D
---
F
V
E
R
FLPRE
M
D
I
L
A
T
VNHG
S
I
I
K
T
Y
E
I
F
ETS-D
G
R
I
Y
I
I
M
ELGVQ
G
D
L
L
E
F
I
K
C---------------Q--------------G
A
---------
L
H
E
D
V
A
R
K
M
F
R
Q
L
S
S
A
V
K
Y
C
H
D
L
D
I
V
H
R
DLKCE
N
L
L---L---D---KD--F----
N
I
K
LSDFGF
S
K
--
R
C
LRDSN
G
R
I
I
L
SKTFCGS
A
A
Y
A
A
P
E
V
L
Q
SI--PY--QPK
V
Y
D
I
W
S
L
G
V
I
L
Y
I
M
V
CGSMP-Y---
D
D
S
D
I
-
R
-
K
M
L
-
R
I
Q
K
-
E
HRVDF--PRS--KNLT
C
E
C
K
D
L
I
Y
R
M
LQP
D
V
S
QRL
H
I
D
E
I
L
S
H
SWLQPPKPKATSSASFKREGEG
K
Y
R
A
E
C
K
LDTKTGLRPDHRPDHKLGAKT
Q
H
R
L
L
V
VPENE
N
R
M
E
D
R
L
A
E
TSRAKDHHISGAEVGKAST
123
HHSearch
87.72
32%
-109
- C1 -
3HKO
2
?
A:
[26-337]
---------
K
K
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-
K
---
D
V
E
R
I
-
K
T
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
E
--
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
K
T
QICPC
P
E
C
N
E
E
A
I
N
G
S
IF
R
E
S
L
D
F
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
---
F
---
S
---
T
N
KS
F
----
E
I
K
L
V
D
F
G
L
S
K
--
E
F
Y
K
L
N
N
G
--------
A
G
T
P
Y
F
V
A
P
E
V
L
N
T
T
NE
S
Y
--
G
P
K
-
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
-
F
---
P
G
V
N
D
-
A
-
D
T
I
-
S
Q
V
L
-
N
K
K
L
C
F
EN
P
N
Y
--
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
---------------------------------------------------------------------------
135
HHSearch
81.62
33%
-116
- C1 -
2ZV2
1
KKCC2_HUMAN
A:
[12-297]
--------
L
N
Q
Y
T
L
K
D
E
I
G
K
--
Y
G
V
V
K
L
A
Y
N
E
N
D
N
T
Y
Y
A
M
K
V
L
S
K
K
-----------
E
Q
V
-
Y
Q
E
I
A
I
L
K
K
L
D
H
P
N
V
V
K
L
V
E
V
L
D
D
P
N
E
D
H
L
Y
M
V
F
E
L
V
N
Q
G
P
V
M
E
V
P
-
T
---------------
L
--------------
K
P
---------
L
S
E
D
Q
A
R
F
Y
F
Q
D
L
I
K
G
I
E
Y
L
H
Y
Q
K
I
I
H
R
D
I
K
P
S
N
L
L
---
V
---
G
---
E
D
--
G
----
H
I
K
I
A
D
F
G
V
S
N
--
E
F
K
G
S
D
----
A
L
L
S
N
T
V
G
T
P
A
F
M
A
P
E
S
L
S
E
T
--
R
K
I
F
S
G
K
A
L
D
V
W
A
M
G
V
T
L
Y
C
F
V
F
G
Q
C
P
-
F
---
M
D
E
R
I
-
M
-
C
L
H
-
S
K
I
K
-
S
Q
A
L
E
F
--
P
D
Q
--
P
D
I
A
E
D
L
K
D
L
I
T
R
M
L
D
K
N
P
E
S
R
I
V
V
P
E
I
K
L
H
P
W
V
T
R
------------------------------------------------------------------------------------
128
HHSearch
79.28
30%
-113
- C1 -
2Y0A
1
DAPK1_HUMAN
A:
[12-278]
----------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
K
-
S
S
RRG
V
S
R
E
D
I
E
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
--
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
---------------
K
--------------
E
S
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
---
L
---
L
---
D
R
--
N
VP
K
P
R
I
K
I
I
D
F
G
L
A
H
--
K
I
D
F
G
N
E
-----
F
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
N
Y
E
--
P
L
--
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
-
F
---
L
G
D
T
K
-
Q
-
E
T
L
-
A
N
V
S
-
A
V
N
Y
E
F
--
E
D
E
YF
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-----------------------------------------------------------
51
PsiBlast_CBE
76.78
38%
-144
- C1 -
4FG8
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
E
--------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
-
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
F
---------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
--
S
----
K
I
M
I
S
D
F
------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
-
K
-
L
F
E
-
Q
I
L
K
A
E
Y
E
F
D
S
--
P
Y
W
--
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------------------------------------------------------------
50
PsiBlast_CBE
76.21
38%
-137
- C1 -
4FG8
1
KCC1A_HUMAN
B:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
K
---------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
-
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
F
---------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
--
S
----
K
I
M
I
S
D
F
G
------------
G
S
V
L
--
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
--
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
-
K
-
L
F
E
-
Q
I
L
K
A
E
Y
E
F
D
S
--
P
Y
W
--
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
G
D
T
A
L
D
K
N
I
H
Q
S
V
S
E
Q
I
K
K
N
F
A
---------------------------------------------------------------
52
PsiBlast_CBE
76.17
38%
-129
- C1 -
4FG7
1
KCC1A_HUMAN
A:
[26-276]
-----------------
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
--
A
-------------
S
M
E
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
-
S
-
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
---------------
K
--------------
G
F
---------
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
---
E
D
--
S
----
K
I
M
I
S
D
F
G
L
S
K
-----
M
E
D
P
G
----------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
------
S
-
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
Y
---
D
E
N
D
A
-
K
-
L
F
E
-
Q
I
L
K
A
E
Y
E
F
D
S
--
P
Y
W
--
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
E
Q
A
L
Q
H
P
W
I
A
-------------------------------------------------------------------------------------
103
PsiBlast_CBE
75.84
35%
-123
- C1 -
2WEI
1
?
A:
[24-281]
-----------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
S
A
K
-
N
K
---
D
T
S
T
I
L
-
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
-
S
S
-
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
---------------
R
--------------
K
R
---------
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
ESK
E
---
K
D
--
C
----
D
I
K
I
I
D
F
G
L
S
T
---
C
F
Q
Q
N
T
K
M
----
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
---
T
Y
--
D
E
K
C
-
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
-
F
YGK
N
E
Y
D
I
-
L
-
K
R
V
-
E
T
G
K
--
Y
A
F
D
L
--
P
Q
W
--
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
T
Q
C
L
E
H
P
W
I
Q
K
Y
S
S
E
--------------------------------------------------------------------------------
75
PsiBlast_CBE
75.59
31%
-125
- C1 -
2WTW
1
AURKA_HUMAN
A:
[15-265]
-----------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
---------------
L
--------------
S
K
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
---
E
A
N
T
Y
-
Q
-
E
T
Y
-
K
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
--------------------------------------------------------------------------------
23
PsiBlast_CBE
72.45
35%
-118
- C1 -
4CZT
3
CIPKN_ARATH
C:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------
108
PsiBlast_CBE
72.23
31%
-110
- C1 -
2J4Z
3
AURKA_HUMAN
A:
[36-286]
-----------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
K
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
S
S
R
R
T
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
---
E
A
N
T
Y
-
Q
-
E
T
Y
-
K
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
--------------------------------------------------------------------------------
22
PsiBlast_CBE
72.09
35%
-109
- C1 -
4CZT
4
CIPKN_ARATH
D:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
----------------------------------------------------
61
PsiBlast_CBE
72.06
31%
-122
- C1 -
3DJ6
1
AURKA_MOUSE
A:
[16-269]
-------------
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
R
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
N
--
G
----
E
L
K
I
A
D
F
G
W
-------------
T
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
---
E
A
H
T
Y
-
Q
-
E
T
Y
-
R
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
---------------------------------------------------------------------------------
100
PsiBlast_CBE
71.67
35%
-123
- C1 -
3MA6
1
?
B:
[40-292]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
----
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
-
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
R
---------
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
--
A
----
N
I
R
I
I
D
F
G
L
S
T
--
H
F
--
E
A
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
---
T
Y
--
D
E
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
-
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
--
P
Q
W
--
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
----------------------------------------------------------------------------------
63
PsiBlast_CBE
70.88
31%
-111
- C1 -
3D2I
1
AURKA_MOUSE
A:
[16-269]
-------------
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
R
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
---
E
A
H
T
Y
-
Q
-
E
T
Y
-
R
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
---------------------------------------------------------------------------------
65
PsiBlast_CBE
70.86
31%
-110
- C1 -
3D14
1
AURKA_MOUSE
A:
[16-269]
-------------
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
R
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
---
E
A
H
T
Y
-
Q
-
E
T
Y
-
R
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
---------------------------------------------------------------------------------
28
PsiBlast_CBE
70.21
36%
-111
- C1 -
3AQV
1
AAPK2_HUMAN
A:
[13-270]
-----------
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
-
S
L
---
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
-
T
D
-
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
---------------
H
--------------
G
R
---------
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
---
A
H
--
M
----
N
A
K
I
A
D
F
G
L
S
N
--
M
M
---
S
D
G
E
F
L
--------
P
N
Y
A
A
P
E
V
I
S
G
R
--
L
Y
--
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
-
F
---
D
D
E
H
V
-
P
-
T
L
F
-
K
K
I
R
-
G
G
V
F
Y
I
--
P
E
Y
--
L
N
R
S
V
A
T
--
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
H
E
W
F
K
Q
D
L
P
S
Y
L
F
P
E
---------------------------------------------------------------------------
9
PsiBlast_PDB
70.10
35%
-110
- C1 -
4CZT
3
CIPKN_ARATH
A:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
V
S
L
D
D
V
D
A
I
F
D
D
S
G
E
S
-----------------------------------------------------------
101
PsiBlast_CBE
69.57
35%
-121
- C1 -
3MA6
1
?
A:
[40-292]
-----------------
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
Q
V
K
-
Q
K
---
T
D
K
E
S
L
L
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
-
D
-
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
---------------
R
--------------
K
R
---------
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
SKS
K
D
--
A
----
N
I
R
I
I
D
F
G
L
S
T
--
H
F
--
E
-
S
K
K
M
---
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
---
T
Y
--
D
E
K
C
-
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
-
F
---
N
G
A
N
E
-
Y
-
D
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
--
P
Q
W
--
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
R
D
A
L
D
H
E
W
I
Q
T
Y
T
K
---------------------------------------------------------------------------------
62
PsiBlast_CBE
69.55
31%
-123
- C1 -
3DJ5
1
AURKA_MOUSE
A:
[16-269]
-------------
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
R
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
N
--
G
----
E
L
K
I
A
D
F
G
W
-------------
T
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
---
E
A
H
T
Y
-
Q
-
E
T
Y
-
R
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
---------------------------------------------------------------------------------
60
PsiBlast_CBE
69.54
31%
-109
- C1 -
3DJ7
1
AURKA_MOUSE
A:
[16-269]
-------------
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
R
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
---
E
A
H
T
Y
-
Q
-
E
T
Y
-
R
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
---------------------------------------------------------------------------------
64
PsiBlast_CBE
68.58
31%
-107
- C1 -
3D15
1
AURKA_MOUSE
A:
[16-269]
-------------
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
R
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
N
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
S
-----------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
-
F
---
E
A
H
T
Y
-
Q
-
E
T
Y
-
R
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
T
L
A
E
V
L
E
H
P
W
I
K
A
N
S
S
---------------------------------------------------------------------------------
107
PsiBlast_CBE
68.39
31%
-109
- C1 -
2J4Z
2
AURKA_HUMAN
B:
[36-286]
-----------
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
E
-
K
A
---
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
-
T
-
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
---------------
L
--------------
S
K
---------
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
---
S
A
--
G
----
E
L
K
I
A
D
F
G
W
S
V
--
H
A
--
P
S
S
R
R
T
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
--
M
H
--
D
E
K
V
-
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
-
F
---
E
A
N
T
Y
-
Q
-
E
T
Y
-
K
--
R
-
I
S
R
V
E
F
--
T
F
P
--
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
N
--------------------------------------------------------------------------
26
PsiBlast_CBE
68.18
35%
-119
- C1 -
4CZU
3
CIPKN_ARATH
C:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
---
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
D
A
I
F
D
D
S
-----------------------------------------------------------------
24
PsiBlast_CBE
67.79
35%
-113
- C1 -
4CZT
2
CIPKN_ARATH
B:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
----
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------
10
PsiBlast_PDB
67.74
35%
-107
- C1 -
4CZU
3
CIPKN_ARATH
A:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
---
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
D
D
V
D
A
I
F
D
D
S
G
E
S
K
N
L
V
V
---------------------------------------------------------
25
PsiBlast_CBE
66.49
35%
-106
- C1 -
4CZU
3
CIPKN_ARATH
D:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
---
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
N
A
D
V
S
L
D
D
V
D
A
I
F
D
D
S
N
L
V
V
E
R
R
E
----------------------------------------------------
27
PsiBlast_CBE
66.30
35%
-110
- C1 -
4CZU
3
CIPKN_ARATH
B:
[13-269]
-----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
-
K
N
---
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
-
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
---------------
N
--------------
G
R
---------
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
---
A
N
--
G
----
A
L
K
V
S
D
F
G
L
S
A
LP
Q
Q
V
R
E
D
G
---
L
L
H
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
--
G
Y
--
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
-
F
---
E
D
S
N
L
-
T
-
S
L
Y
-
K
--
K
-
I
F
K
A
E
F
--
T
C
P
--
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
N
E
W
F
K
K
G
Y
K
A
P
K
F
E
D
D
V
D
A
I
F
D
D
S
G
-----------------------------------------------------------------
66
PsiBlast_CBE
65.74
34%
-110
- C1 -
2JAM
3
KCC1G_HUMAN
B:
[8-265]
--------
R
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
--
K
K
S
-----------
S
L
E
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
-
S
-
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
---------------
R
--------------
G
V
---------
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
LTP
E
---
E
N
--
S
----
K
I
M
I
T
D
F
G
L
S
K
-----
M
E
Q
N
G
---
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--
P
Y
--
S
-
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
-
F
---
Y
E
E
T
E
-
S
-
K
L
F
-
E
K
I
K
-
E
G
Y
Y
E
F
ES
P
F
W
--
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
--------------------------------------------------------------
134
HHSearch
64.16
31%
-107
- C1 -
3TKI
1
CHK1_HUMAN
A:
[7-269]
---------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
--
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
---------------
D
--------------
I
G
---------
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
--
D
----
N
L
K
I
S
D
F
G
L
A
T
--
V
F
R
Y
N
N
--
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
--
E
F
--
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
---
D
Q
P
S
D
S
C
-
Q
E
Y
-
S
D
W
K
-
E
K
K
T
Y
L
--
N
P
W
--
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
T
S
-----------------------------------------------------------------------
124
HHSearch
63.89
30%
-100
- C1 -
2YEX
8
CHK1_HUMAN
A:
[7-268]
---------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
V
-
D
----
C
P
E
N
-
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
--
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
---------------
D
--------------
I
G
---------
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
---
E
R
--
D
----
N
L
K
I
S
D
F
G
L
A
T
--
V
F
R
Y
N
N
--
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
--
E
F
--
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
-
W
---
D
Q
P
S
D
-
S
C
Q
E
Y
-
S
D
W
K
-
E
K
K
T
Y
L
--
N
P
W
--
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
---------------------------------------------------------------------------------