@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TYK2_HUMAN: (2015-10-21 )
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
Atome Classification :
(94 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910....-...920.......930.......940.......950.......960.......970.......980.......990--...--.....1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110.-.....1120......1130......1140......1150......1160......1170......1180....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPLRHWGMARGSKPVGDGA
Q
P
M
A
A
MGG
L
K
V
L
L
H
WAGPGGGEP
W
V
T
FSESSL
T
A
E
E
V
C
I
H
I
A
H
KVGIT
P
P
C
F
N
L
F
A
L
FDAQ
A
Q
V
WLP
P
N
H
I
LEIPRDA
S
L
M
L
Y
F
R
I
R
F
Y
F
RNWHGMNPREP
A
V
Y
RCGPPGTEASSDQTAQGMQLLDP
A
S
F
E
Y
L
F
E
QG
K
H
E
F
V
N
D
V
A
S
L
WELS
T
E
E
E
I
H
H
FKNE
S
L
G
M
A
F
L
H
L
C
H
L
A
L
RHGI
P
L
E
E
V
A
K
KT
S
F
K
D
C
I
P
R
S
F
R
R
H
I
R
Q
H
S
A
L
T
R
L
R
L
R
N
V
F
R
R
F
L
R
DFQPG
R
L
S
Q
Q
M
V
M
V
K
Y
L
A
T
L
E
R
L
A
P
RFGTERV
P
V
C
H
L
R
L
L
A
QAEGE
P
C
Y
I
RDSGVAPTDPGPESAAGPPT
H
E
V
L
V
TGTGG
I
Q
WWPV
E
E
EVNKEEGSSGSSGRNP
Q
A
S
L
FGK
K
A
K
A
H
KAVGQPADRPRE
P
L
W
A
Y
F
CD
F
R
D
I
T
H
V
V
L
K
E
H
C
V
S
I
HRQDN
K
C
L
E
LSLP
S
R
A
A
A
L
S
F
V
S
L
VDG
Y
F
R
LTADSSH
Y
L
C
HEVAP
P
R
L
V
M
S
I
RDGIHG
P
L
L
E
P
F
V
Q
AKLRPED
G
L
Y
L
I
H
WSTSH
P
Y
R
L
I
L
T
V
A
Q
RSQAP
D
G
M
Q
S
L
RLRKFPIEQQDG
A
F
V
L
E
GWGRSF
P
S
V
R
E
L
G
A
A
L
Q
G
C
L
L
RAG
D
D
C
F
S
L
R
R
CCLPQPGETS
N
L
I
I
M
RGARASPRTL
N
L
S
Q
L
S
FHRV
D
Q
K
E
I
T
Q
L
S
HLGQGTRTNVYE
G
R
L
R
VEGSGDPEEGKMDDEDPLVPGRDR
G
Q
E
L
R
V
V
L
K
VLDPSHHD
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
VSH
T
H
L
A
F
V
H
G
V
CVRGPE
N
I
M
V
T
E
Y
VEHGP
L
D
V
W
L
RRERGHV
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
LENKNLVHGNVCG
R
N
I
L
L
A
RLGLAEGTS
P
F
I
K
LSDPGVGLGAL
S
R
E
E
R
V
E
RIPWLAPECLPGGA
N
S
L
S
T
A
M
D
KWG
F
G
A
T
L
L
E
I
CFDGEAPLQSRSP
S
E
K
E
H
F
Y
Q
R
Q
HRLPEPSC
P
Q
L
A
T
L
T
S
Q
CLTYEPTQRP
S
F
R
T
I
L
R
D
L
T
RLQPHNLA
D
V
L
T
VNPDSPASD
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
LGEGHF
G
K
V
S
L
Y
C
Y-DPTNDGTG
E
M
V
A
V
K
A
L
KADCGPQHRS
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
YKGCCEDQ
G
E
K
S
L
Q
L
V
M
E
YVPL
G
S
L
R
D
Y
L
P---RHS--I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
AR
N
V
LLDND
R
L
V
K
IGDF
G
L
A
KAVPEGH
E
Y
Y
R
V
REDGDS
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
HCDSSQS
P
P
T
K
F
L
E
L
I
GI-AQG
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
ERLPRPDKC
P
C
E
V
Y
H
L
M
K
N
C
W
ETEASFR
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
YQGQAPSVFSVC
1
PsiBlast_PDB
87.72
98%
-108
- C1 -
4OLI
2
TYK2_HUMAN
A:
[37-635]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
V
-------------------------
E
L
R
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P
G
----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
S
C
P
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
P
-----------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-------
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
--
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
------
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
----------
8
PsiBlast_PDB
59.45
98%
-118
- C1 -
4GFO
4
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
-----------
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
------
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
6
PsiBlast_PDB
58.90
99%
-112
- C1 -
3NZ0
1
A:
[7-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
C
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
G
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
-------
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
18
PsiBlast_PDB
58.09
91%
-109
- C1 -
4E1Z
1
A:
[1-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
---
K
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
C
--
V
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
H
-
T
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
----------
11
PsiBlast_PDB
57.70
97%
-110
- C1 -
3LXP
1
A:
[24-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
--
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
---
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
15
PsiBlast_PDB
57.49
97%
-104
- C1 -
4GJ2
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
10
PsiBlast_PDB
57.03
97%
-108
- C1 -
3LXN
1
A:
[24-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
---
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
16
PsiBlast_PDB
56.83
97%
-104
- C1 -
4GJ3
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
17
PsiBlast_PDB
56.65
97%
-105
- C1 -
4GIH
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
----------
19
PsiBlast_PDB
56.15
91%
-114
- C1 -
4E20
1
A:
[1-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
E
G
C
G
P
Q
L
R
S
G
W
Q
R
E
I
E
I
L
R
T
L
Y
H
E
H
I
V
K
Y
K
G
C
C
E
D
----
S
V
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
C
--
V
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
A
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
C
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
Y
C
D
S
N
Q
S
P
H
T
K
F
T
E
L
I
G
-----
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
R
C
P
C
E
I
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
Q
N
L
V
P
I
L
Q
T
A
Q
E
K
Y
Q
----------
14
PsiBlast_PDB
55.83
97%
-104
- C1 -
4GII
1
A:
[9-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
7
PsiBlast_PDB
55.44
98%
-112
- C1 -
3NYX
3
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
--
G
E
M
V
A
V
K
A
L
K
A
D
C
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
Q
-
E
K
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
N
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
C
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
13
PsiBlast_PDB
55.25
97%
-104
- C1 -
4GVJ
1
A:
[8-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
A
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
R
H
---------
12
PsiBlast_PDB
55.02
97%
-102
- C1 -
4PY1
1
A:
[25-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
V
F
H
K
R
Y
L
K
K
I
R
D
L
G
E
G
H
F
G
K
V
S
L
Y
C
Y
-
D
P
T
N
D
G
T
G
E
M
V
A
V
K
A
L
K
A
D
A
G
P
Q
H
R
S
G
W
K
Q
E
I
D
I
L
R
T
L
Y
H
E
H
I
I
K
Y
K
G
C
C
E
D
A
G
A
A
S
L
Q
L
V
M
E
Y
V
P
L
G
S
L
R
D
Y
L
P
---
R
H
S
--
I
G
L
A
Q
L
L
L
F
A
Q
Q
I
C
E
G
M
A
Y
L
H
S
Q
H
Y
I
H
R
D
L
A
A
R
N
V
L
L
D
N
D
R
L
V
K
I
G
D
F
G
L
A
K
A
V
P
E
G
H
E
Y
Y
R
V
R
E
D
G
D
S
P
V
F
W
Y
A
P
E
C
L
K
E
Y
K
F
Y
Y
A
S
D
V
W
S
F
G
V
T
L
Y
E
L
L
T
H
C
D
S
S
Q
S
P
P
T
K
F
L
E
L
I
G
I
-
A
Q
G
Q
M
T
V
L
R
L
T
E
L
L
E
R
G
E
R
L
P
R
P
D
K
C
P
A
E
V
Y
H
L
M
K
N
C
W
E
T
E
A
S
F
R
P
T
F
E
N
L
I
P
I
L
K
T
V
H
E
K
Y
Q
G
---------
21
PsiBlast_CBE
52.40
100%
-85
- C1 -
5C03
6
?
B:
[51-341]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
H
R
V
D
Q
K
E
I
T
Q
L
S
H
L
G
Q
G
T
R
T
N
V
Y
E
G
R
L
R
--------------------------
E
L
R
V
V
L
K
V
L
D
P
S
H
H
D
I
A
L
A
F
Y
E
T
A
S
L
M
S
Q
V
S
H
T
H
L
A
F
V
H
G
V
C
V
R
G
P
E
N
I
M
V
T
E
Y
V
E
H
G
P
L
D
V
W
L
R
R
E
R
G
H
V
P
M
A
W
K
M
V
V
A
Q
Q
L
A
S
A
L
S
Y
L
E
N
K
N
L
V
H
G
N
V
C
G
R
N
I
L
L
A
R
L
G
L
A
E
G
T
S
P
F
I
K
L
S
D
P
G
V
G
L
G
A
L
S
R
E
E
R
V
E
R
I
P
W
L
A
P
E
C
L
P
-----
L
S
T
A
M
D
K
W
G
F
G
A
T
L
L
E
I
C
F
D
G
E
A
P
L
Q
S
R
S
P
S
E
K
E
H
F
Y
Q
R
Q
H
R
L
P
E
P
S
C
P
Q
L
A
T
L
T
S
Q
C
L
T
Y
E
P
T
Q
R
P
S
F
R
T
I
L
R
D
L
T
R
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
51.21
50%
-105
- C1 -
4E4M
1
JAK2_HUMAN
B:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
93
PsiBlast_CBE
50.63
50%
-103
- C1 -
4JIA
2
A:
[8-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
70
PsiBlast_CBE
50.58
50%
-105
- C1 -
4E4M
1
JAK2_HUMAN
D:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
68
PsiBlast_CBE
50.55
50%
-100
- C1 -
4F08
1
JAK2_HUMAN
A:
[13-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
76
PsiBlast_CBE
50.46
50%
-103
* C1 *
3Q32
1
JAK2_HUMAN
A:
[3-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
58
PsiBlast_CBE
50.34
50%
-103
- C1 -
3KRR
1
A:
[2-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
72
PsiBlast_CBE
50.16
50%
-102
- C1 -
4E4M
1
JAK2_HUMAN
A:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
59
PsiBlast_CBE
50.15
50%
-105
- C1 -
2W1I
1
JAK2_HUMAN
A:
[37-326]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
---------
49
PsiBlast_CBE
50.06
50%
-101
- C1 -
4BBF
1
D:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
95
PsiBlast_CBE
50.02
50%
-102
- C1 -
4JI9
1
JAK2_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
69
PsiBlast_CBE
49.60
50%
-102
- C1 -
4E4M
1
E:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
75
PsiBlast_CBE
49.38
50%
-102
- C1 -
3Q32
1
B:
[3-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
--------
63
PsiBlast_CBE
49.27
50%
-102
- C1 -
3TJC
1
JAK2_HUMAN
A:
[9-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
86
PsiBlast_CBE
49.25
50%
-103
- C1 -
4D0X
2
A:
[6-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
47
PsiBlast_CBE
49.24
59%
-97
- C1 -
3EYH
1
A:
[2-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
E
---
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
D
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
98
PsiBlast_CBE
49.16
50%
-101
- C1 -
4HGE
1
JAK2_HUMAN
A:
[11-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
20
PsiBlast_PDB
49.13
57%
-100
- C1 -
4E4L
1
JAK1_HUMAN
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
92
PsiBlast_CBE
49.03
50%
-99
- C1 -
4AQC
1
JAK2_HUMAN
A:
[11-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
57
PsiBlast_CBE
49.02
50%
-101
- C1 -
3LPB
1
JAK2_HUMAN
A:
[5-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
-----
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
46
PsiBlast_CBE
49.01
57%
-100
- C1 -
4E4L
1
JAK1_HUMAN
B:
[12-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
-----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
96
PsiBlast_CBE
48.91
50%
-102
- C1 -
4IVA
1
A:
[9-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
94
PsiBlast_CBE
48.83
50%
-105
- C1 -
4JI9
1
B:
[8-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
44
PsiBlast_CBE
48.75
57%
-101
- C1 -
4E4L
1
E:
[12-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
67
PsiBlast_CBE
48.70
50%
-100
- C1 -
4F08
1
B:
[13-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
66
PsiBlast_CBE
48.63
50%
-101
- C1 -
4F09
1
A:
[13-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
61
PsiBlast_CBE
48.58
50%
-101
- C1 -
3TJD
1
JAK2_HUMAN
A:
[9-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
35
PsiBlast_CBE
48.57
57%
-101
- C1 -
4FK6
1
JAK1_HUMAN
A:
[11-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
--
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
E
---
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
D
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
52
PsiBlast_CBE
48.39
50%
-101
- C1 -
4BBF
2
JAK2_HUMAN
A:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
97
PsiBlast_CBE
48.29
50%
-104
- C1 -
4HGE
1
B:
[8-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
45
PsiBlast_CBE
48.21
57%
-94
- C1 -
4E4L
1
JAK1_HUMAN
D:
[12-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
--
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
26
PsiBlast_CBE
48.19
57%
-103
- C1 -
4K6Z
1
A:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
41
PsiBlast_CBE
48.15
57%
-98
- C1 -
4EHZ
6
JAK1_HUMAN
A:
[6-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
D
G
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
64
PsiBlast_CBE
48.13
50%
-103
- C1 -
4GMY
1
A:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
65
PsiBlast_CBE
48.06
50%
-106
- C1 -
4GFM
1
A:
[10-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
-----------
62
PsiBlast_CBE
47.92
50%
-103
- C1 -
3TJC
1
B:
[6-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
31
PsiBlast_CBE
47.82
57%
-99
- C1 -
4IVB
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
36
PsiBlast_CBE
47.73
57%
-99
- C1 -
4EI4
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
34
PsiBlast_CBE
47.68
57%
-98
- C1 -
4FK6
1
B:
[12-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
E
---
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
--
G
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
28
PsiBlast_CBE
47.67
57%
-100
- C1 -
4IVD
1
JAK1_HUMAN
A:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
25
PsiBlast_CBE
47.63
57%
-100
- C1 -
4K77
1
JAK1_HUMAN
A:
[12-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
---
G
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
38
PsiBlast_CBE
47.48
57%
-101
- C1 -
4EHZ
5
D:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
91
PsiBlast_CBE
47.43
50%
-99
- C1 -
4AQC
1
B:
[9-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
32
PsiBlast_CBE
47.42
57%
-97
- C1 -
4IVB
1
JAK1_HUMAN
A:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
33
PsiBlast_CBE
47.38
57%
-100
- C1 -
4I5C
5
B:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
37
PsiBlast_CBE
47.15
57%
-101
- C1 -
4EI4
1
JAK1_HUMAN
A:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
------
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
87
PsiBlast_CBE
47.14
50%
-100
- C1 -
4D0W
2
A:
[6-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
-
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
-----------
42
PsiBlast_CBE
47.04
57%
-100
- C1 -
4E4N
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
29
PsiBlast_CBE
47.01
57%
-98
- C1 -
4IVC
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
39
PsiBlast_CBE
46.97
57%
-101
- C1 -
4EHZ
5
JAK1_HUMAN
C:
[14-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
-----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
40
PsiBlast_CBE
46.95
57%
-101
- C1 -
4EHZ
2
JAK1_HUMAN
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
60
PsiBlast_CBE
46.90
50%
-102
- C1 -
3TJD
1
B:
[6-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
30
PsiBlast_CBE
46.64
57%
-95
- C1 -
4IVC
1
JAK1_HUMAN
A:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
27
PsiBlast_CBE
46.64
57%
-99
- C1 -
4IVD
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
51
PsiBlast_CBE
46.62
50%
-101
- C1 -
4BBF
2
JAK2_HUMAN
B:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
50
PsiBlast_CBE
46.46
50%
-103
- C1 -
4BBF
1
JAK2_HUMAN
C:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
56
PsiBlast_CBE
46.09
50%
-102
- C1 -
4BBE
2
JAK2_HUMAN
A:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
88
PsiBlast_CBE
45.83
52%
-100
- C1 -
3E64
1
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
43
PsiBlast_CBE
45.82
57%
-100
- C1 -
4E4N
1
JAK1_HUMAN
A:
[1-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
I
V
S
E
K
K
P
A
T
E
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
-----
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
E
----
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
54
PsiBlast_CBE
45.68
50%
-97
- C1 -
4BBE
1
JAK2_HUMAN
C:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
53
PsiBlast_CBE
45.64
50%
-100
- C1 -
4BBE
1
D:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
55
PsiBlast_CBE
45.63
50%
-97
- C1 -
4BBE
2
JAK2_HUMAN
B:
[5-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
N
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
-------------
24
PsiBlast_CBE
45.16
57%
-97
- C1 -
4K77
1
B:
[13-294]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
P
T
H
F
E
K
R
F
L
K
R
I
R
D
L
G
E
G
H
F
G
K
V
E
L
C
R
Y
-
D
P
E
G
D
N
T
G
E
Q
V
A
V
K
S
L
K
P
----
N
H
I
A
D
L
K
K
E
I
E
I
L
R
N
L
Y
H
E
N
I
V
K
Y
K
G
I
C
T
----
N
G
I
K
L
I
M
E
F
L
P
S
G
S
L
K
E
Y
L
P
---
K
N
K
NK
I
N
L
K
Q
Q
L
K
Y
A
V
Q
I
C
K
G
M
D
Y
L
G
S
R
Q
Y
V
H
R
D
L
A
A
R
N
V
L
V
E
S
E
H
Q
V
K
I
G
D
F
G
L
T
K
A
I
E
T
D
K
E
Y
Y
T
V
K
D
D
R
D
S
P
V
F
W
Y
A
P
E
C
L
M
Q
S
K
F
Y
I
A
S
D
V
W
S
F
G
V
T
L
H
E
L
L
T
Y
C
D
S
D
S
S
P
M
A
L
F
L
K
M
I
G
P
-
T
H
G
Q
M
T
V
T
R
L
V
N
T
L
K
E
G
K
R
L
P
C
P
P
N
C
P
D
E
V
Y
Q
L
M
R
K
C
W
E
F
Q
P
S
N
R
T
S
F
Q
N
L
I
E
G
F
E
A
L
L
K
-------------
48
PsiBlast_CBE
44.99
50%
-95
- C1 -
3UGC
1
A:
[6-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
-------------
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
------------
89
PsiBlast_CBE
44.92
52%
-98
- C1 -
3E63
1
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
90
PsiBlast_CBE
44.13
52%
-99
- C1 -
3E62
1
A:
[2-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
103
Fugue
34.20
38%
-82
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
-------
N
K
V
A
V
K
C
I
K
-----
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V
--
E
E
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
S
V
--
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
---
G
R
V
P
Y
-----------
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
-
E
L
---------
77
PsiBlast_CBE
25.39
50%
-54
- C1 -
5CF6
1
?
B:
[21-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
----
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
--------
99
PsiBlast_CBE
25.35
50%
-52
- C1 -
4P7E
1
B:
[1-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
--
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
---------
81
PsiBlast_CBE
25.19
50%
-52
- C1 -
5CF4
1
?
B:
[22-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
-
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
100
PsiBlast_CBE
24.99
50%
-52
- C1 -
4P7E
1
JAK2_HUMAN
A:
[4-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
---
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
Q
M
A
G
---------
78
PsiBlast_CBE
24.66
50%
-56
- C1 -
5CF6
1
?
A:
[25-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
83
PsiBlast_CBE
24.57
50%
-52
- C1 -
4ZIM
1
B:
[20-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
---------
73
PsiBlast_CBE
24.34
50%
-53
- C1 -
5CF8
1
?
B:
[3-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
--------
84
PsiBlast_CBE
24.28
50%
-55
- C1 -
4ZIM
1
JAK2_HUMAN
A:
[25-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
80
PsiBlast_CBE
23.56
50%
-55
- C1 -
5CF5
1
?
A:
[25-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
--------
79
PsiBlast_CBE
23.41
50%
-50
- C1 -
5CF5
1
?
B:
[21-315]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
A
G
R
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
--------
85
PsiBlast_CBE
23.39
50%
-49
- C1 -
5AEP
1
A:
[6-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
S
---
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
82
PsiBlast_CBE
22.51
50%
-54
- C1 -
5CF4
1
?
A:
[26-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
----
R
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
----------
74
PsiBlast_CBE
22.35
50%
-55
- C1 -
5CF8
1
?
A:
[5-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
F
E
E
R
H
L
K
F
L
Q
Q
L
G
K
G
N
F
G
S
V
E
M
C
R
Y
-
D
P
L
Q
D
N
T
G
E
V
V
A
V
K
K
L
Q
H
S
T
-
E
E
H
L
R
D
F
E
R
E
I
E
I
L
K
S
L
Q
H
D
N
I
V
K
Y
K
G
V
C
Y
-----
N
L
K
L
I
M
E
Y
L
P
Y
G
S
L
R
D
Y
L
Q
---
K
H
K
ER
I
D
H
I
K
L
L
Q
Y
T
S
Q
I
C
K
G
M
E
Y
L
G
T
K
R
Y
I
H
R
D
L
A
T
R
N
I
L
V
E
N
E
N
R
V
K
I
G
D
F
G
L
T
K
V
L
P
Q
D
K
E
Y
Y
K
V
K
E
P
G
E
S
P
I
F
W
Y
A
P
E
S
L
T
E
S
K
F
S
V
A
S
D
V
W
S
F
G
V
V
L
Y
E
L
F
T
Y
I
E
K
S
K
S
P
P
A
E
F
M
R
M
I
G
N
D
K
Q
G
Q
M
I
V
F
H
L
I
E
L
L
K
N
N
G
R
L
P
R
P
D
G
C
P
D
E
I
Y
M
I
M
T
E
C
W
N
N
N
V
N
Q
R
P
S
F
R
D
L
A
L
R
V
D
Q
I
R
D
N
M
A
G
H
--------