@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TYRO3_HUMAN: (2015-10-21 )
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Atome Classification :
(59 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510....------...--520..-.......530.......--540-.----.--.......550.......560.......570...-.-...580.......590.......600.......610.......--620----------..-.---....--.630.......640.......650.......660..-----.....670.......680-...--.--.--..690.......700.......710.......720.......730......-.740.......750.......760.......770.......----780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
L
R
R
SMGRPGLPPLPLPPPP
R
L
G
L
L
L
A
A
L
A
S
LLLPESAAAG
L
K
LMGA
P
V
K
L
T
VSQGQ
P
V
K
L
N
C
SVEGMEEPD
I
Q
W
VKD
G
A
V
V
Q
N
L
D
Q
LYIPVSEQ
H
W
I
G
F
L
S
L
K
S
VERSDA
G
R
Y
W
C
QVEDGGETEISQ
P
V
W
L
T
VEG
V
P
F
F
T
VEPKDLAVPPNA
P
F
Q
L
S
CEAVGPPE
P
V
T
I
V
W
WRGTTKIGGPAPSP
S
V
L
N
V
TGVTQ
S
T
M
F
S
CEAHNLKGLASS
R
T
A
T
V
H
L
QALPAAP
F
N
I
T
V
T
K
LSSSNA
S
V
A
W
MPGA
D
G
R
A
L
L
Q
SC
T
V
Q
V
T
QAPGG
W
E
V
L
A
V
V
VPVP
P
F
T
C
L
L
R
D
LVPATN
Y
S
L
R
V
R
C
ANALGPSPYADWVPFQTKGLAPASAPQ
N
L
H
A
I
RTDS
G
L
I
L
E
W
E
E
VIPEAPLEGPLGP
Y
K
L
S
W
V
QDNGTQD
E
L
T
V
EGTRANLTGWDP
Q
K
D
L
I
V
R
V
C
V
SNAVGCGPWSQ
P
L
V
V
SSHDRAGQQGPPHSRT
S
W
V
P
V
V
L
G
V
L
T
A
L
V
T
A
A
A
L
A
L
I
L
L
R
K
R
RKETR
F
G
Q
A
F
D
S
V
M
ARGEP
A
V
H
F
R
A
A
R
SFNRE
R
P
E
R
I
E
A
T
L
D
SLGI
S
D
E
L
K
E
K
L
E
D
VLIP
E
Q
------
Q
F
T
--
L
--
G
R
-MLGKGEFGS
V
R
E
A
Q
LKQ--E---D----G--
S
F
V
K
V
A
V
K
M
L
K
A
D
IIA
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
EF-D-H
P
H
V
A
K
L
V
G
V
S
L
R
SRAKGRLP
I
P
M
V
I
L
P
F
MKHG
D
L
H
A
F
L
L
A
S
R
--I-G----------EN-P---FN
L
P
--
L
Q
T
L
I
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
SR
N
F
I
H
R
D
L
A
ARNC
M
L
A
-----
E
D
M
T
V
C
V
A
DFGLS
R
K
IYS-G
D
Y
--
Y
--R--QGCASKLP
V
K
W
L
A
L
E
S
LADN
L
Y
T
V
QS
D
V
W
A
F
G
V
T
M
W
E
I
M
TRGQTPYAGIEN-
A
E
I
Y
N
Y
L
IGGNRLKQ
P
P
E
C
M
E
D
V
Y
D
L
M
Y
Q
C
WSADPKQRPS
F
----
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
VLSASQD
P
L
Y
I
N
I
ERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSD
C
R
Y
I
LTPGGLAEQPGQAEHQPES
P
L
N
E
T
Q
R
L
L
L
L
Q
QGLLPHSSC
115
HHSearch
91.19
98%
-153
- C3 -
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---------
F
T
--
L
--
G
R
-
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
-
H
P
H
V
A
K
L
V
G
V
S
L
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
--
I
---------------
P
---
F
N
L
P
--
L
Q
T
L
V
R
F
M
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-----
E
D
M
T
V
C
V
A
D
F
G
L
------------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------------------
120
HHSearch
75.15
44%
-119
- C3 -
3PLS
1
A:
[3-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
------
R
V
V
--
T
HS
D
R
-
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
D
--
Q
---
A
----
Q
--
N
R
I
Q
C
A
I
K
S
L
S
R
I
-
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
-
N
-
H
P
N
V
L
A
L
I
G
I
M
L
P
P
--
E
G
---
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
------------------
P
-
Q
---
R
N
P
T
--
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
-
R
E
Y
--
Y
--
S
VQ
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
-
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
----
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
L
P
----------------------------------------------------------------------------------------
72
PsiBlast_CBE
74.34
40%
-132
- C3 -
1R0P
1
A:
[5-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
---------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
DS
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
62
PsiBlast_CBE
74.34
41%
-120
- C3 -
3PLS
1
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
------
R
V
V
--
T
HS
D
R
-
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
D
--
Q
---
A
----
Q
--
N
R
I
Q
C
A
I
K
S
L
-
S
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
-
N
-
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
-----
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
P
Q
---------------
R
N
-
P
------
T
--
V
K
D
L
I
S
F
G
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
-
R
E
Y
--
Y
SV
Q
--
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
-
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
----
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
L
P
----------------------------------------------------------------------------------------
58
PsiBlast_CBE
74.07
42%
-133
- C3 -
4KNB
2
MET_HUMAN
C:
[2-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
------------------
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------------------
56
PsiBlast_CBE
73.58
42%
-127
- C3 -
4R1V
4
A:
[7-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
73.07
41%
-127
- C3 -
3F66
4
MET_HUMAN
A:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
--------------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.32
39%
-136
- C3 -
3DKG
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
------
C
V
Y
H
G
T
L
L
D
--------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
-------------------------------------------------------------------------------------
65
PsiBlast_CBE
72.06
40%
-134
- C3 -
3DKF
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
----------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
--------------------------------------------------------------------------------
68
PsiBlast_CBE
71.13
40%
-131
- C3 -
3F82
1
A:
[9-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
N
R
-----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
------------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
60
PsiBlast_CBE
70.83
42%
-136
- C3 -
4KNB
3
MET_HUMAN
A:
[5-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
L
----
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
70.49
38%
-106
- C3 -
3LW0
4
IGF1R_HUMAN
B:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
66
PsiBlast_CBE
70.36
40%
-116
- C3 -
3DKC
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
D
S
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
G
-------------------------------------------------------------------------------
78
PsiBlast_CBE
69.79
38%
-104
- C3 -
3LW0
3
D:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
57
PsiBlast_CBE
69.57
42%
-132
- C3 -
4KNB
1
D:
[5-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
-----------
G
--
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
----------------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
---------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
---
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------------------
79
PsiBlast_CBE
69.35
38%
-104
- C3 -
3LW0
4
IGF1R_HUMAN
C:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
67
PsiBlast_CBE
69.35
40%
-124
- C3 -
3L8V
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
70
PsiBlast_CBE
69.33
40%
-126
- C3 -
3CTH
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
63
PsiBlast_CBE
69.19
40%
-137
- C3 -
3QTI
2
B:
[12-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
---------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
81
PsiBlast_CBE
69.12
38%
-106
- C3 -
3LW0
3
IGF1R_HUMAN
A:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
118
HHSearch
68.73
42%
-131
- C3 -
3C1X
1
A:
[70-358]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
--
G
---
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
R
------------------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
90
PsiBlast_CBE
68.70
38%
-104
- C3 -
4D2R
1
A:
[1-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-
E
----------
N
N
-
P
---
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
102
PsiBlast_CBE
68.65
41%
-119
- C3 -
2Z60
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
---
S
---------
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------
N
-
R
---
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
--------------------------------------------------------------------------------------
85
PsiBlast_CBE
68.37
38%
-104
- C3 -
3NW6
1
A:
[7-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-
E
----------
N
N
-
P
---
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
103
PsiBlast_CBE
68.31
41%
-118
- C3 -
1OPK
3
ABL1_MOUSE
A:
[223-482]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
---
S
---------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------
N
-
R
---
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
-------------------------------------------------------------------------------------
77
PsiBlast_CBE
68.14
38%
-104
- C3 -
3I81
1
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE--
E
----------
N
N
-
P
---
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
-------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
116
HHSearch
68.10
36%
-111
- C3 -
3CBL
3
A:
[109-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
L
N
H
E
------
D
L
V
--
L
--
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
--------------
D
N
T
L
V
A
V
K
S
C
R
E
T
-
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
Q
K
------
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
-------------------
G
---
A
R
L
R
--
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-
G
V
Y
--
A
--
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
-
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
----
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
67.91
38%
-104
- C3 -
3NW7
1
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-
E
----------
N
N
-
P
---
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
101
PsiBlast_CBE
67.67
41%
-117
- C3 -
3IK3
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
---
S
---------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------
N
-
R
---
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
------------------------------------------------------------------------------------
61
PsiBlast_CBE
67.66
40%
-129
- C3 -
3C1X
1
A:
[66-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
71
PsiBlast_CBE
67.62
40%
-130
- C3 -
3CE3
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
59
PsiBlast_CBE
67.55
42%
-135
- C3 -
4KNB
2
MET_HUMAN
B:
[8-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
----------------
K
I
H
C
A
V
K
S
-------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
-----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV---------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------------------
100
PsiBlast_CBE
67.20
41%
-117
- C3 -
3IK3
1
ABL1_MOUSE
B:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
--
Y
---
S
---------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------
N
-
R
---
Q
E
V
S
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
K
E
L
G
K
R
------------------------------------------------------------------------------------
126
HHSearch
67.07
36%
-115
* C3 *
4AOJ
1
NTRK1_HUMAN
A:
[37-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
------
D
I
V
--
L
--
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
LL
P
------------
K
M
L
V
A
V
K
A
L
K
E
A
--
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
------
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
--
P
D--------------
P
---
G
P
L
G
--
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
----
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
67.06
38%
-107
- C3 -
1JQH
1
IGF1R_HUMAN
B:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
--------
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
86
PsiBlast_CBE
67.02
38%
-102
- C3 -
3NW5
1
A:
[6-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-
E
----------
N
N
-
P
---
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
127
HHSearch
66.95
41%
-111
- C3 -
4CKJ
16
A:
[18-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
K
------
N
L
V
--
L
--
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
--
L
---
K
----
G
RA
G
Y
T
T
V
A
V
K
M
L
K
E
-
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
---
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
--
K
V------------------
R
A
L
T
--
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
-
E
D
S
--
Y
--
V
--
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
-
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------------------------------------------------
125
HHSearch
66.73
38%
-117
- C3 -
3L9P
4
A:
[67-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
------
N
I
T
--
L
--
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
G
--------------
S
P
L
Q
V
A
V
K
T
L
P
E
V
-
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
---
L
---
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
--
P
R
P
----------
S
Q
-
P
---
S
S
L
A
--
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
---------------------------------------------------------------------------------------
122
HHSearch
66.62
32%
-118
- C3 -
4FYO
1
A:
[11-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
------
L
L
T
--
L
--
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
Q
M
------
K
----
K
--
V
V
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
-
N
P
Y
I
V
R
M
I
G
I
C
E
A
-------
E
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
--------------------
N
---
R
H
V
K
--
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
-----
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
--
Y
--
K
--
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
----
A
A
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
E
G
H
H
-------------------------------------------------------------------------------------------
64
PsiBlast_CBE
66.56
40%
-129
- C3 -
3A4P
3
A:
[22-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
--------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
93
PsiBlast_CBE
66.45
38%
-98
- C3 -
3QQU
1
IGF1R_HUMAN
B:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
--------------------------PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
95
PsiBlast_CBE
65.91
38%
-112
- C3 -
3LVP
2
IGF1R_HUMAN
A:
[39-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-
E
-------------
P
---
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--------------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
87
PsiBlast_CBE
65.86
38%
-101
- C3 -
2OJ9
1
A:
[6-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE-----------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
129
HHSearch
65.49
38%
-120
- C3 -
4CLJ
1
A:
[27-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
V
S
----------------
P
L
Q
V
A
V
K
T
L
P
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
------
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
--
P
R
P
----------
S
Q
-
P
---
S
S
L
A
--
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
P
I
E
Y
G
-------------------------------------------------------------------------------------
91
PsiBlast_CBE
64.91
38%
-100
- C3 -
3QQU
1
D:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
--------------------
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.91
40%
-128
- C3 -
3CTJ
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
L
L
D
--
N
---
D
----
G
--
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-------
I
-
R
----------
N
E
-
T
---
H
N
P
T
--
V
K
D
L
I
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
-----
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
---------------------------------------------------------------------------------
133
HHSearch
64.82
40%
-106
- C3 -
3TT0
1
FGFR1_HUMAN
A:
[64-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
------
R
L
V
--
L
--
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
--
L
---
D
KDKP
N
--
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
---
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--
P
-
P
GLEYSYNPSH
N
P
-
E
---
E
Q
L
S
--
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
-----
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
-
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------------------
99
PsiBlast_CBE
64.60
41%
-117
- C3 -
4XEY
1
ABL1_HUMAN
A:
[128-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
-
K
L
G
G
----
E
V
Y
E
G
V
W
K
K
--
Y
---
S
---------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------
N
-
R
---
Q
E
V
N
--
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
-----
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------------------
135
HHSearch
64.44
39%
-103
- C3 -
2XIR
1
A:
[21-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
F
P
R
D
------
R
L
K
--
L
--
G
K
-
P
L
G
R
G
A
F
G
Q
V
I
E
A
D
A
F
G
ID
K
---
T
----
A
--
T
C
R
T
V
A
V
K
M
L
K
E
G
-
A
T
H
S
E
H
R
A
L
M
S
E
L
K
I
L
I
H
I
-
G
H
H
L
N
V
V
N
L
L
G
A
C
T
K
P
G
--
G
---
P
L
M
V
I
V
E
F
C
K
F
G
N
L
S
T
Y
L
R
S
K
R
--
N
-
E
----------
F
V
-
P
YYK
D
F
L
T
--
L
E
H
L
I
C
Y
S
F
Q
V
A
K
G
M
E
F
L
A
S
R
K
C
I
H
R
D
L
A
A
R
N
I
L
L
S
-----
E
K
N
V
V
K
I
C
D
F
G
L
A
R
D
I
Y
K
-
D
P
D
--
Y
--
V
--
R
K
G
D
A
R
L
P
L
K
W
M
A
P
E
T
I
F
D
R
V
Y
T
I
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
S
L
G
A
S
P
Y
P
G
V
K
I
D
E
E
F
C
R
R
L
K
E
G
T
R
M
R
A
P
D
Y
T
T
P
E
M
Y
Q
T
M
L
D
C
W
H
G
E
P
S
Q
R
P
T
F
----
S
E
L
V
E
H
L
G
N
L
L
Q
A
N
A
------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
63.95
38%
-101
- C3 -
3QQU
1
IGF1R_HUMAN
C:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE
M
-------------------
V
L
A
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
94
PsiBlast_CBE
63.04
38%
-100
- C3 -
3QQU
1
IGF1R_HUMAN
A:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
VV
K
---
D
----
E
--
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------------------
P
PS
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
98
PsiBlast_CBE
62.62
40%
-115
- C3 -
3EKK
1
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
-------------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
---------------------------------------------------------------------------------
97
PsiBlast_CBE
62.42
40%
-104
- C3 -
3EKN
1
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------
134
HHSearch
62.41
42%
-115
- C3 -
3ZBF
1
A:
[30-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
E
------
K
L
T
--
L
--
R
L
-
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
--
I
LGV
G
----
S
--
G
E
I
K
V
A
V
K
T
L
K
K
G
S
T
-
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
------
P
Q
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
--
M
-
A
----------
T
F
Y
G
---
P
L
L
T
--
L
V
D
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
VKDYT
S
P
R
I
V
K
I
G
D
F
G
L
A
R
D
I
Y
-------------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
H
S
N
-
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
----
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
R
-----------------------------------------------------------------------------------------
96
PsiBlast_CBE
62.06
40%
-111
- C3 -
1I44
1
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
-----------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------
88
PsiBlast_CBE
61.03
40%
-104
- C3 -
4IBM
1
?
B:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
---
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------
75
PsiBlast_CBE
60.61
41%
-98
- C3 -
3ETA
1
INSR_HUMAN
A:
[13-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------
89
PsiBlast_CBE
60.44
40%
-101
- C3 -
4IBM
1
?
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
---------------------------------------------------------------------------------
74
PsiBlast_CBE
57.97
41%
-96
- C3 -
3ETA
1
B:
[13-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
II
K
---
G
----
E
--
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE
A
-
E
----------
N
N
-
P
---
G
R
P
P
PT
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------