@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UFO_HUMAN: (2015-10-21 )
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Atome Classification :
(107 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530-......--.--.540........550..-.-.---.-----..-560-........570.......580.......590-.......600...--....610.......620.......630--....-.--.----------.640....-..--.650..-.....660.......670.......680--........690.......-700--.--.--.....710.......720.......730.......740.......750...-....760.......770.......780.......790......----.800.......810.....-..820.......830.......840.......850.......860.......870.......880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAWRCPRMGR
V
P
L
A
W
C
L
A
L
CGWACMAPRGTQAEESPFVGNPGNITGARGL
T
G
T
L
R
C
Q
L
Q
VQGEPP
E
V
H
WLRDG
Q
I
L
E
LADSTQTQVPLGEDEQD
D
W
I
V
V
S
Q
L
R
I
T
S
L
Q
LSDTG
Q
Y
Q
C
L
V
F
LG
H
Q
T
F
VSQPGYVGLEGL
P
Y
F
LEEPED
R
T
VAANTP
F
N
L
S
CQAQGPPEP
V
D
L
L
W
LQDAVPLATAPGHGPQRSLHVPGLNKTS
S
F
S
C
EAHNAKG
V
T
TS
R
T
A
T
I
T
VLPQQPR
N
L
H
L
VSRQP
T
E
L
E
V
A
WTPGLSGI
Y
P
L
T
H
C
T
L
Q
A
V
L
SNDGMGIQAGEPDPPEEPLTSQASV
P
P
H
Q
L
R
LGSLHPHT
P
Y
H
I
R
V
A
C
TSSQGPSSW
T
H
W
L
PVETPEGVPLGPPENISATRNG
S
Q
A
F
V
H
WQEPRAPLQG
T
L
L
G
Y
R
L
A
YQGQD
T
P
E
V
L
M
D
IGLR
Q
E
V
T
L
E
L
QGDGSV
S
N
L
T
V
C
V
A
A
Y
TAAGDGPWSLPV
P
L
EAWRPGQ
A
Q
P
V
H
Q
L
V
KEPSTPAFS
W
P
W
W
Y
V
L
L
G
A
V
V
A
A
A
C
V
L
I
L
A
L
F
L
V
H
RRKKETRYGEVFEPTVERG
E
L
V
V
R
Y
R
V
R
K
S
YSRRT
T
E
A
T
L
N
SLGI
S
E
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
--L--GK-TLGEGEF
G
A
VMEGQ-L-N---Q-----D
D
-
S
I
--
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
EF-DH
P
N
V
M
R
L
I
G
V
CF--QGSERESFPA
P
V
V
I
L
P
FMKHG
D
L
H
S
F
L
--
L
Y
S
R-L--G----------DQPVY
L
P
T
-
Q
M
--
L
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
RNCMLN---ENM
S
V
C
VADFGLS
K
K
IYN-G
D
Y
--Y--R--QGRIAKM
P
V
K
W
I
A
I
E
S
L
A
D
R
VYTSKSDV
W
S
FG
V
T
M
W
E
I
ATRGQTPYPGVE
N
-
S
E
I
Y
D
Y
L
R
QGNRLK
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
CWELNPQDRP
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
ALPPAQEPD-
E
I
L
Y
V
NMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCL
T
A
AEVHPA
G
R
Y
V
L
CPSTTPSPAQPADRGSPAAPGQEDGA
28
PsiBlast_CBE
95.78
69%
-129
- C3 -
2P0C
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
---
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
----------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.54
69%
-126
- C3 -
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
--
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
-----------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
----------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
27
PsiBlast_CBE
94.66
69%
-127
- C3 -
3BPR
1
MERTK_HUMAN
B:
[25-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
-
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
--------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------
26
PsiBlast_CBE
94.39
69%
-124
- C3 -
3BPR
1
D:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------
2
PsiBlast_PDB
94.35
69%
-124
- C3 -
3BPR
1
MERTK_HUMAN
A:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
94.03
69%
-128
- C3 -
3TCP
1
MERTK_HUMAN
A:
[26-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
-----
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------
25
PsiBlast_CBE
93.36
69%
-121
- C3 -
3BRB
2
B:
[24-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
D
-----------------------------------------------------------------------------------
23
PsiBlast_CBE
93.22
69%
-128
- C3 -
4M3Q
1
B:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
-----
S
V
M
E
G
N
-
L
-
K
-------------
S
--
L
K
V
A
V
K
T
M
------------
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
-----------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
24
PsiBlast_CBE
91.01
69%
-118
- C3 -
3TCP
1
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
---
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
116
HHSearch
90.23
62%
-128
- C3 -
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
--
P
---
F
T
--
L
--
G
R
-
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
-
L
------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
L
--
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
---------------
P
F
N
L
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
D
F
G
L
------------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.91
61%
-128
- C3 -
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
--
P
---
F
T
--
L
--
G
R
-
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
-
L
------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
L
--
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
---------------
P
F
N
L
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
D
F
G
L
------------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.76
69%
-114
- C3 -
4MHA
1
B:
[26-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
--
L
--
G
K
-
I
L
G
E
G
E
F
G
S
V
M
E
G
N
-
L
-
K
---
Q
-----
E
D
G
T
S
--
L
K
V
A
V
K
T
M
K
--------------------
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-
L
--
E
----------
T
G
P
K
H
I
P
L
-
Q
T
--
L
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
-
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.10
61%
-122
- C3 -
4FEQ
1
A:
[22-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
--
L
--
G
R
-
M
L
G
K
G
---
S
V
R
E
A
Q
-
L
-
K
----------
D
G
S
F
--
V
K
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
-------------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
-------------------
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
D
F
G
---------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
L
-------------------------------------------------------------------------------------
122
HHSearch
81.56
41%
-113
- C3 -
3PLS
1
A:
[3-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
--
P
H
E
R
V
V
--
T
HS
D
R
-
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
-
Y
-
I
---
D
Q----
A
Q
-
N
R
--
I
Q
C
A
I
K
S
L
S
R
-
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
-
N
H
P
N
V
L
A
L
I
G
I
M
L
--
P
P
E
---
G
--
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
--
R
S
P
------------------
Q
R
N
P
T
V
-
K
D
--
L
I
S
F
G
L
-
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
-
R
E
Y
--
Y
--
S
VQ
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
-
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
----
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
-
L
P
---------------------------------------------------------------------------
132
HHSearch
80.90
35%
-102
- C3 -
4FL3
1
KSYK_HUMAN
A:
[362-633]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Y
L
--
D
R
K
L
L
T
--
L
--
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
-
Y
-
Q
---
M
-----
K
K
-
V
V
--
K
T
V
A
V
K
I
L
K
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
--
A
----
E
---
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
--
Q
Q
N
-------------------
R
H
V
K
D
-
K
N
--
I
I
E
L
V
H
-
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
---
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
-------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
----
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
-----------------------------------------------------------------------------------
92
PsiBlast_CBE
79.24
40%
-110
- C3 -
3PLS
1
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
--
P
H
E
R
V
V
--
T
HS
D
R
-
V
I
G
K
G
H
F
G
V
V
Y
H
G
E
Y
I
-
D
---
Q
-----
A
Q
-
N
R
--
I
Q
C
A
I
K
S
L
S
-
R
I
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
-
N
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
-------
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
---------------------
R
S
P
Q
R
N
P
T
V
K
D
--
L
I
S
F
G
L
-
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
-
R
E
Y
--
Y
SV
Q
--
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
I
D
P
-
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
----
L
V
G
E
V
E
Q
I
V
S
A
L
L
G
D
H
Y
V
Q
-
L
P
---------------------------------------------------------------------------
121
HHSearch
78.63
42%
-117
- C3 -
3C1X
1
A:
[71-359]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
--
G
P
S
S
L
I
V
H
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
-
L
---
D
N----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
S
E
-----
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
--
R
N
E
------------------
T
H
N
P
T
V
-
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
37
PsiBlast_CBE
77.05
45%
-113
- C3 -
3U6I
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
130
HHSearch
76.73
41%
-98
- C3 -
4CKJ
16
A:
[20-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
P
R
K
N
L
V
--
L
--
G
K
-
T
L
G
E
G
E
F
G
K
V
V
K
A
T
-
A
-
F
---
H
LKG--
R
A
-
G
Y
--
T
T
V
A
V
K
M
L
K
E
-
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
------
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
-
K
--
V
-------------
R
A
L
T
M
-
G
D
--
L
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
-
E
D
S
--
Y
--
V
--
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
-
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
V
K
R
R
------------------------------------------------------------------------------------
120
HHSearch
76.17
35%
-105
- C3 -
4FYO
1
A:
[11-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
--
D
R
K
L
L
T
--
L
--
E
D
K
E
L
G
S
G
N
F
G
T
V
K
K
G
Y
-
Y
-
Q
---
M
-----
K
K
-
V
V
--
K
T
V
A
V
K
I
L
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
-
D
N
P
Y
I
V
R
M
I
G
I
C
E
--
A
----
E
---
S
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
--
Q
Q
N
-------------------
R
H
V
K
D
-
K
N
--
I
I
E
L
V
H
-
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
---
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
--
Y
--
K
--
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
G
-
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
----
V
E
L
R
L
R
N
Y
Y
Y
D
V
V
N
E
G
H
H
-------------------------------------------------------------------------------
42
PsiBlast_CBE
75.99
45%
-114
- C3 -
3EFK
1
MET_HUMAN
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
41
PsiBlast_CBE
75.81
45%
-117
- C3 -
3EFK
1
B:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
38
PsiBlast_CBE
75.78
45%
-113
- C3 -
3U6H
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
15
PsiBlast_PDB
75.66
45%
-119
- C3 -
4EEV
1
A:
[49-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
------------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
129
HHSearch
75.59
41%
-107
- C3 -
4CLJ
1
A:
[27-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
--
L
--
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-
S
-------------
P
--
L
Q
V
A
V
K
T
L
P
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
------
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P
R
--
P
----------
S
Q
P
S
S
L
A
M
-
L
D
--
L
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
-
P
I
E
Y
G
------------------------------------------------------------------------
9
PsiBlast_PDB
75.50
43%
-108
- C3 -
3VW8
1
A:
[32-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
GP
S
S
L
I
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
----------------------------------------------------------------------------
68
PsiBlast_CBE
75.46
41%
-97
- C3 -
3LW0
2
IGF1R_HUMAN
A:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P--------------------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
49
PsiBlast_CBE
75.45
45%
-119
- C3 -
2RFN
1
MET_HUMAN
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
----
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
93
PsiBlast_CBE
75.33
42%
-102
- C3 -
4XEY
1
ABL1_HUMAN
B:
[122-389]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
------
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
---------------------------------------------------------------------------------
65
PsiBlast_CBE
75.22
41%
-96
- C3 -
3LW0
2
D:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P--------------------
P
P
-
S
L
SK
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
131
HHSearch
75.13
37%
-106
* C3 *
4AOJ
1
NTRK1_HUMAN
A:
[38-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
K
R
R
D
I
V
--
L
--
K
W
-
E
L
G
E
G
A
F
G
K
V
F
L
A
E
-
C
-
H
---
N
LLP------
K
--
M
L
V
A
V
K
A
L
K
E
A
--
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
G
------
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
--
R
S
H
G
-
P
D--------------
P
G
P
L
G
L
-
G
Q
--
L
L
A
V
A
S
-
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-----------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
-
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
----
V
H
A
R
L
Q
A
L
A
Q
A
P
P
------------------------------------------------------------------------------------
67
PsiBlast_CBE
75.12
41%
-97
- C3 -
3LW0
3
IGF1R_HUMAN
B:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P--------------------
P
P
-
S
L
SK
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
117
HHSearch
74.80
38%
-102
- C3 -
3CBL
3
A:
[109-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
L
--
N
H
E
D
L
V
--
L
--
G
E
-
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
-
L
-
R
---
A
-----
D
N
-----
T
L
V
A
V
K
S
C
R
E
T
-
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
--
Q
K
------
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
--
R
T
E
------------------
G
A
R
L
R
V
-
K
T
--
L
L
Q
M
V
G
-
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
-
G
V
Y
--
A
--
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
-
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
----
I
Y
Q
E
L
Q
S
I
R
K
R
H
-------------------------------------------------------------------------------------
82
PsiBlast_CBE
74.76
41%
-98
- C3 -
3NW5
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
--
E
----------
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
66
PsiBlast_CBE
74.54
41%
-96
- C3 -
3LW0
3
IGF1R_HUMAN
C:
[12-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P--------------------
P
P
-
S
L
SK
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
17
PsiBlast_PDB
74.51
45%
-109
- C3 -
2WD1
3
A:
[24-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
125
HHSearch
74.46
41%
-103
- C3 -
3L9P
4
A:
[68-346]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
--
L
--
I
R
-
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
-
S
---
G
--------
S
P
--
L
Q
V
A
V
K
T
L
P
E
-
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
------
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
-
P
R-
P
----------
S
Q
P
S
S
L
A
M
-
L
D
--
L
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
-
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
T
Q
D
P
D
V
I
N
T
A
L
-
P
I
E
--------------------------------------------------------------------------
44
PsiBlast_CBE
74.46
45%
-112
- C3 -
3EFJ
1
MET_HUMAN
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
48
PsiBlast_CBE
74.28
45%
-118
- C3 -
2RFN
1
B:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
----
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
63
PsiBlast_CBE
74.10
42%
-101
- C3 -
3DKF
1
A:
[33-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
--------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
--------------------------------------------------------------------
102
PsiBlast_CBE
74.01
44%
-99
- C3 -
3QRJ
1
ABL1_HUMAN
B:
[15-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
136
HHSearch
73.94
41%
-96
- C3 -
3TT0
1
FGFR1_HUMAN
A:
[65-355]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
--
P
R
D
R
L
V
--
L
--
G
K
-
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
-
A
-
I
---
G
LDKDK
P
N
-
R
V
--
T
K
V
A
V
K
M
L
K
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
G
------
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-
P
--
P
GLEYSYNPSH
N
P
E
E
Q
L
S
S
-
K
D
--
L
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
-
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
-
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
---------------------------------------------------------------------------------
100
PsiBlast_CBE
73.92
42%
-95
- C3 -
1OPK
3
ABL1_MOUSE
A:
[217-490]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
G
K
------------------------------------------------------------------------
43
PsiBlast_CBE
73.88
45%
-114
- C3 -
3EFJ
1
B:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
------------------------------------------------------------------------------
61
PsiBlast_CBE
73.73
45%
-109
- C3 -
4KNB
2
MET_HUMAN
C:
[19-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
------------------
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
---------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
19
PsiBlast_PDB
73.62
45%
-107
- C3 -
4R1V
4
A:
[24-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.54
44%
-112
- C3 -
3F82
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L--------------
K
--
I
H
C
A
V
K
S
L
N
-
R
----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
------------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
35
PsiBlast_CBE
73.54
45%
-110
- C3 -
4DEH
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
---------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-------
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
59
PsiBlast_CBE
73.50
45%
-110
- C3 -
2WGJ
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
33
PsiBlast_CBE
73.46
45%
-107
- C3 -
4XMO
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
---------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.44
45%
-106
- C3 -
3RHK
1
MET_HUMAN
A:
[50-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
46
PsiBlast_CBE
73.42
45%
-113
- C3 -
3CCN
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
---------------
K
--
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
---
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
133
HHSearch
73.41
36%
-96
- C3 -
1T46
1
?
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
--
P
R
N
R
L
S
--
F
--
G
K
-
T
L
G
A
G
A
F
G
K
V
V
E
A
T
-
A
-
Y
GLI
K
-----
S
D
-
A
A
--
M
T
V
A
V
K
M
L
K
P
S
A
-
H
L
T
E
R
E
A
L
M
S
E
L
K
V
L
S
Y
L
G
N
H
M
N
I
V
N
L
L
G
A
C
T
--
I
G
G
------
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
--
R
R
K
R
-
D
SF--------------
L
A
L
D
L
-
E
D
--
L
L
S
F
S
Y
-
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
T
---
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
-
D
S
N
--
Y
--
V
--
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
Y
K
M
I
K
E
G
F
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
----
I
V
Q
L
I
E
K
Q
I
S
E
S
T
N
-----------------------------------------------------------------------------------
45
PsiBlast_CBE
73.39
45%
-112
- C3 -
3CD8
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
---------------
K
--
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
------------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
---
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
97
PsiBlast_CBE
73.34
42%
-96
- C3 -
2Z60
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
G
-------------------------------------------------------------------------
40
PsiBlast_CBE
73.25
45%
-109
- C3 -
3F66
4
MET_HUMAN
A:
[27-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L--------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
--------------------------------------------------------------------------------
80
PsiBlast_CBE
73.21
41%
-98
- C3 -
3NW7
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
--
E
----------
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
---
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
81
PsiBlast_CBE
73.12
41%
-95
- C3 -
3NW6
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
--
E
----------
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
50
PsiBlast_CBE
73.09
45%
-104
- C3 -
3LQ8
1
A:
[30-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
-
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
79
PsiBlast_CBE
73.05
41%
-101
- C3 -
1JQH
1
IGF1R_HUMAN
B:
[16-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
----------------------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
--------
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
70
PsiBlast_CBE
73.04
42%
-100
- C3 -
3I81
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
E
----------
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
-------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
K
---------------------------------------------------------------------------
95
PsiBlast_CBE
72.99
42%
-98
- C3 -
3IK3
1
ABL1_MOUSE
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
G
K
R
-----------------------------------------------------------------------
36
PsiBlast_CBE
72.95
45%
-112
- C3 -
4DEG
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
---------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
96
PsiBlast_CBE
72.88
42%
-99
- C3 -
3IK3
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
--------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
G
K
R
-----------------------------------------------------------------------
90
PsiBlast_CBE
72.85
42%
-100
- C3 -
4D2R
1
A:
[10-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
--
E
----------
N
N
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
K
---------------------------------------------------------------------------
20
PsiBlast_PDB
72.68
45%
-112
- C3 -
3I5N
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
-------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
99
PsiBlast_CBE
72.65
42%
-95
- C3 -
3OY3
1
ABL1_MOUSE
A:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
G
-------------------------------------------------------------------------
83
PsiBlast_CBE
72.64
41%
-96
- C3 -
2OJ9
1
A:
[15-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------------------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
-
Y
S
E
E
N
K
-----------------------------------------------------------------------
72
PsiBlast_CBE
72.51
44%
-114
- C3 -
3QTI
1
MET_HUMAN
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
-------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
31
PsiBlast_CBE
72.43
45%
-107
- C3 -
3RHK
1
B:
[50-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.38
42%
-96
- C3 -
3QQU
1
IGF1R_HUMAN
B:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
------------------------
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
K
---------------------------------------------------------------------------
47
PsiBlast_CBE
72.38
45%
-110
- C3 -
2RFS
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
---------------
K
--
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
71
PsiBlast_CBE
72.37
44%
-116
- C3 -
3QTI
1
B:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
54
PsiBlast_CBE
72.28
45%
-107
- C3 -
3ZXZ
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
94
PsiBlast_CBE
72.25
42%
-101
- C3 -
4XEY
1
ABL1_HUMAN
A:
[122-388]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
----
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
101
PsiBlast_CBE
72.20
44%
-101
- C3 -
4TWP
1
ABL1_HUMAN
B:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
N
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
53
PsiBlast_CBE
72.20
45%
-104
- C3 -
3ZZE
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
34
PsiBlast_CBE
72.18
45%
-111
- C3 -
4DEI
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
-------------
K
--
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
103
PsiBlast_CBE
72.17
42%
-101
- C3 -
3MS9
2
ABL1_MOUSE
B:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
73
PsiBlast_CBE
72.17
44%
-111
- C3 -
3L8V
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
104
PsiBlast_CBE
72.14
42%
-97
- C3 -
3MS9
2
ABL1_MOUSE
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
---
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.12
45%
-107
- C3 -
4AOI
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------
78
PsiBlast_CBE
72.08
44%
-111
- C3 -
3A4P
3
A:
[37-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
--------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
18
PsiBlast_PDB
72.07
45%
-111
- C3 -
4R1Y
3
A:
[24-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-----------------
I
H
C
A
V
K
S
L
N
---------
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
77
PsiBlast_CBE
72.02
44%
-115
- C3 -
3CE3
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
84
PsiBlast_CBE
71.98
42%
-96
- C3 -
3QQU
1
D:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
-----------------
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
----------------------------------------------------------------------------
58
PsiBlast_CBE
71.94
45%
-105
- C3 -
2WKM
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
51
PsiBlast_CBE
71.90
45%
-107
- C3 -
4AP7
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
91
PsiBlast_CBE
71.86
42%
-112
- C3 -
3LVP
2
IGF1R_HUMAN
A:
[44-321]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
--
E
------------
P
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--------------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
K
---------------------------------------------------------------------------
57
PsiBlast_CBE
71.85
45%
-104
- C3 -
3ZBX
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
32
PsiBlast_CBE
71.78
45%
-108
- C3 -
4XYF
1
A:
[31-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L--------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S
V
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
87
PsiBlast_CBE
71.67
42%
-99
- C3 -
3QQU
1
IGF1R_HUMAN
A:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-----------------------
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
----------------------------------------------------------------------------
76
PsiBlast_CBE
71.59
44%
-115
- C3 -
3CTH
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
39
PsiBlast_CBE
71.57
45%
-110
- C3 -
3F66
3
B:
[27-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
--------------------------------------------------------------------------------
89
PsiBlast_CBE
71.49
44%
-114
- C3 -
1R0P
1
A:
[30-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
-------------
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
DS
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
6
PsiBlast_PDB
71.41
61%
-108
- C3 -
4FF8
1
A:
[80-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
-
D
H
P
H
V
A
K
L
V
-------------------
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-
I
-------------------
P
L
-
Q
T
--
L
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
------------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
I
E
N
-
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
----------------------------------------------------------------------------------------
64
PsiBlast_CBE
71.34
42%
-90
- C3 -
3DKC
1
A:
[33-317]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
F
D
S
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
G
-------------------------------------------------------------------
12
PsiBlast_PDB
71.31
45%
-103
- C3 -
4MXC
1
A:
[51-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
56
PsiBlast_CBE
71.17
45%
-104
- C3 -
3ZC5
1
A:
[29-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L-------------
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
------------------------------------------------------------------------------------
98
PsiBlast_CBE
71.16
42%
-94
- C3 -
3OY3
1
ABL1_MOUSE
B:
[10-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
--
M
--
K
H
-
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
-
W
-
K
---
K
-----
Y
S
-----
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-
C
--
N
----------
R
Q
E
V
---
S
-
A
V
--
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
L
-
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
G
-------------------------------------------------------------------------
62
PsiBlast_CBE
70.89
45%
-113
- C3 -
4KNB
3
MET_HUMAN
A:
[19-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L--------------
K
--
I
H
C
A
V
K
S
L
----
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------
75
PsiBlast_CBE
70.74
44%
-118
- C3 -
3CTJ
1
A:
[32-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
-
V
N
A
T
Y
V
N
V
K
--------------------------------------------------------------------
85
PsiBlast_CBE
70.57
42%
-96
- C3 -
3QQU
1
IGF1R_HUMAN
C:
[9-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
--
M
--
S
R
-
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
-
A
-
K
GVV
K
-----
D
E
-
P
E
--
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
M
----------------
V
L
A
P
P
-
S
L
S
K
M
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
-
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
-
N
----------------------------------------------------------------------------
60
PsiBlast_CBE
69.94
45%
-112
- C3 -
4KNB
1
D:
[19-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
----------
G
-
K
K
--
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
--
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
----------------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
---------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
---
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
-----------------------------------------------------------------------------------
11
PsiBlast_PDB
69.68
45%
-104
- C3 -
4GG7
1
A:
[51-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------
134
HHSearch
69.32
33%
-96
- C3 -
4OTW
1
A:
[10-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
K
E
T
E
L
R
--
K
--
L
K
-
V
L
G
S
G
V
F
G
T
V
H
K
G
V
-
W
-
I
---
P
-----
E
G
-
E
S
I
K
I
P
V
C
I
K
V
I
E
D
K
-
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
-
D
H
A
H
I
V
R
L
L
G
L
C
P
--
G
S
-------
S
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
--
R
Q
H
R
------------------
G
A
L
G
P
-
Q
L
--
L
L
N
W
G
V
-
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
---
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
-
D
---------------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
L
-
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
----
L
A
N
E
F
T
R
M
A
R
D
P
P
R
Y
L
V
I
K
------------------------------------------------------------------------------
10
PsiBlast_PDB
68.55
45%
-105
- C3 -
4GG5
1
A:
[51-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
--
F
--
N
E
-
V
I
G
R
G
H
F
G
C
V
Y
H
G
T
-
L
L
D
---
N
-----
D
G
-
K
K
--
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---------------------
R
N
E
T
H
N
P
T
V
K
D
--
L
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
-
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
-
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------