@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ULK3_HUMAN: (2015-10-22 )
MAGPGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVKKDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIVSSSNQALLRQGTSARDLLREMARDKPRLLAALEVASAAMAKEEAAGGEQDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESRWEADTLDKEGLSESVRSSCTLQ
Atome Classification :
(99 SA)
.........10..---......20........30........40........50--..---.----.....60-........70........80..--......90........100....--------------------------------------.----..110.......120.......130.......140..-...----..--150---.......160......---.-170...---.....180.....--..190........200.......210.......220......------------------.-230...--..-----------...240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGPGWGPPRLD
G
---
F
I
L
T
E
RLGSG
T
Y
A
T
V
Y
K
A
Y
AKKDT
R
E
V
V
A
I
K
C
V
A
K
KSL--
N
K
---
A
----
S
V
E
N
L
L
T
-
E
I
E
I
L
K
GIRHP
H
I
V
Q
L
K
D
F
QWD--SD
N
I
Y
L
I
M
E
F
CAG
G
D
L
S
R
F
I
H
T
R
--------------------------------------R----I
L
P
E
K
V
A
R
V
F
M
Q
Q
L
A
S
A
L
Q
F
L
H
ERNISHLDL
K
P
Q
N
I
L
-
L
S
S
----LE--KPH---
L
K
LADF
G
F
AQHMSPWD---E-K-HVLR---GSPLYM
A
P
E
M
V
C
Q
--
R
Q
Y-DAR
V
D
L
W
S
M
G
V
I
L
Y
E
A
L
FGQPPFASR
S
F
S
E
L
E
E
K
I
RSN------------------
R
-
V
-
I
ELP--
L
R
-----------
P
L
L
S
R
D
C
R
D
L
L
Q
R
L
L
ERDPSRRI
S
F
Q
D
F
FAHPWVDLEHMPS
G
E
S
L
G
R
A
T
A
L
V
V
Q
A
V
K
KDQEGD
S
A
A
A
L
S
L
Y
C
K
A
L
D
F
F
V
P
A
L
H
Y
EV
D
A
Q
R
K
E
A
I
K
A
K
V
G
Q
Y
V
S
R
A
E
E
L
K
A
I
V
SSS
N
Q
A
L
L
RQGT
S
A
R
D
L
L
R
E
M
ARDK
P
R
L
L
A
A
L
E
V
A
S
A
A
M
A
K
E
EAAGGE
Q
D
A
L
D
L
Y
Q
H
S
L
G
E
L
L
L
L
L
AAEPP
G
R
R
R
E
L
L
H
T
E
V
Q
N
L
M
A
R
A
E
Y
L
K
E
Q
V
K
M
R
E
SRWEADTL
D
K
E
G
L
S
E
S
V
R
S
SCTLQ
7
PsiBlast_PDB
81.25
35%
-125
- C2 -
4CEG
3
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
A
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
80.53
35%
-143
- C2 -
2X81
1
AURKA_HUMAN
A:
[11-264]
----------
L
E
D
---
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.41
35%
-134
- C2 -
3COH
1
AURKA_HUMAN
B:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
--------------------
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.24
35%
-133
- C2 -
3COH
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
--------------------
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
80.15
35%
-128
- C2 -
3UO5
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
80.14
35%
-130
- C2 -
4DEA
4
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
PsiBlast_CBE
80.05
35%
-139
- C2 -
3LAU
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.00
35%
-142
- C2 -
3EFW
1
AURKA_HUMAN
B:
[130-383]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
--------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
79.88
35%
-131
- C2 -
3FDN
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
-------------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.88
35%
-137
- C2 -
5AAD
1
?
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
79.85
35%
-137
- C2 -
3O50
1
AURKA_HUMAN
A:
[6-259]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
-----
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
79.82
35%
-128
- C2 -
4DHF
1
AURKA_HUMAN
A:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
79.68
35%
-138
- C2 -
3P9J
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
79.62
35%
-130
- C2 -
3UP2
3
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.49
35%
-133
- C2 -
3MYG
2
AURKA_HUMAN
A:
[11-264]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
--------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
79.35
35%
-139
- C2 -
4UZH
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
79.29
32%
-122
- C2 -
3HKO
2
?
A:
[26-335]
-----------
K
K
---
Y
H
L
K
G
A
I
G
Q
G
S
Y
G
V
V
R
V
A
I
E
N
-
Q
T
R
A
I
R
A
I
K
I
M
N
K
N
K
I
R
Q-----
K
----
D
V
E
R
I
K
T
-
E
V
R
L
M
K
K
L
H
H
P
N
I
A
R
L
Y
E
V
Y
E
D
--
E
Q
Y
I
C
L
V
M
E
L
C
H
G
G
H
L
L
D
K
L
N
V
F
I
DDSTG
K
C
A
M
D
V
V
KTQICPC
P
E
C
N
E
E
A
I
N
G
SIF
R
E
S
L
D
F
----
V
Q
R
E
K
L
I
S
N
I
M
R
Q
I
F
S
A
L
H
Y
L
H
N
Q
G
I
C
H
R
D
I
K
P
E
N
F
L
-
F
S
T
----
N
K
--
S
F
E
---
I
K
L
V
D
F
G
L
S
K
E
F
Y
K
L
N
NG--------
A
---
G
T
P
Y
F
V
A
P
E
V
L
N
T
TN
E
S
Y
-
G
P
K
C
D
A
W
S
A
G
V
L
L
H
L
L
L
M
G
A
V
P
F
P
G
V
N
D
A
D
T
I
S
Q
V
L
N
K
------------------
K
L
C
-
F
E
N
P
--
N
Y
-----------
N
V
L
S
P
L
A
R
D
L
L
S
N
L
L
N
R
N
V
D
E
R
F
D
A
M
R
A
L
Q
H
P
W
I
S
Q
F
S
D
K
I
Y
K
M
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
79.22
35%
-146
- C2 -
3EFW
1
AURKA_HUMAN
A:
[130-383]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
---------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.07
35%
-135
- C2 -
2X6E
1
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
--------------------
T
L
D
Y
L
P
P
E
M
I
E
-----
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
79.04
35%
-127
- C2 -
3W10
1
AURKA_HUMAN
A:
[5-258]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
A
A
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.95
35%
-133
- C2 -
5AAF
1
?
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
78.87
35%
-138
- C2 -
3W16
1
AURKA_HUMAN
A:
[5-258]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
78.64
35%
-127
- C2 -
4DEB
3
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
78.63
35%
-137
- C2 -
2C6E
1
AURKA_HUMAN
B:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
78.58
35%
-125
- C2 -
4DHF
1
AURKA_HUMAN
B:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
78.57
35%
-134
- C2 -
2XNG
1
AURKA_HUMAN
A:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
78.51
35%
-126
- C2 -
3UOD
3
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.49
35%
-133
- C2 -
4BYI
1
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
78.34
35%
-133
- C2 -
3H0Z
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.27
36%
-133
- C2 -
4B8L
1
AUKBA_XENLA
A:
[14-267]
----------
I
D
D
---
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
N
-
K
F
I
M
A
L
K
V
L
F
K
S
Q
L
--
E
K
---
E
----
G
V
E
H
Q
L
R
R
E
I
E
I
Q
S
H
L
R
H
P
N
I
L
R
M
Y
N
Y
F
H
D
--
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
--------------------------------------
G
----
R
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
R
K
V
I
H
R
D
I
K
P
E
N
L
L
-
M
G
Y
--------
K
G
E
---
L
K
I
A
D
F
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
K
T
H
-
D
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
D
S
P
S
H
T
E
T
H
R
R
I
V
N
-----------------------
V
D
L
K
--
F
P
-----------
P
F
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
P
L
K
G
V
M
E
H
P
W
V
K
A
N
S
R
R
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
78.19
35%
-135
- C2 -
4JBQ
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
---------------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
78.10
35%
-127
- C2 -
4JAJ
1
AURKA_HUMAN
A:
[18-271]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
78.05
35%
-134
- C2 -
2XRU
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
----------------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
78.02
35%
-134
- C2 -
4JAI
1
AURKA_HUMAN
A:
[18-271]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
77.86
35%
-130
- C2 -
2W1D
1
AURKA_HUMAN
A:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.85
35%
-128
- C2 -
5AAE
1
?
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
77.75
35%
-123
- C2 -
3H10
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
A
A
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
77.74
35%
-126
- C2 -
4UZD
1
AURKA_HUMAN
B:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
-----------
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
77.72
35%
-135
- C2 -
3H0Z
1
AURKA_HUMAN
C:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
77.53
35%
-126
- C2 -
4DEE
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
77.49
35%
-125
- C2 -
4DED
4
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
77.25
35%
-127
- C2 -
4UZD
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
------------
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
77.16
35%
-130
- C2 -
2W1E
1
AURKA_HUMAN
A:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
77.06
35%
-124
- C2 -
3UP7
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.03
35%
-135
- C2 -
5AAG
1
?
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
76.92
35%
-135
- C2 -
3H0Y
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.89
35%
-129
- C2 -
2J4Z
2
AURKA_HUMAN
B:
[33-286]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.86
34%
-132
- C2 -
2WTW
1
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
-----------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
76.80
35%
-132
- C2 -
3H0Z
1
AURKA_HUMAN
B:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
------
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
76.54
35%
-125
- C2 -
4UTD
1
?
A:
[9-262]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
76.50
35%
-123
- C2 -
4JBO
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
D
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.50
35%
-129
- C2 -
2X6D
1
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
-----------
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.49
35%
-123
- C2 -
2J4Z
3
AURKA_HUMAN
A:
[33-286]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
76.11
35%
-132
- C2 -
3O50
1
AURKA_HUMAN
B:
[6-259]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
-----------------
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
-------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
76.10
35%
-130
- C2 -
3UOH
3
AURKA_HUMAN
B:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.02
35%
-130
- C2 -
4PRJ
1
AURKA_HUMAN
A:
[3-261]
--
K
R
Q
W
A
---
L
E
D
---
F
E
I
G
R
P
L
G
K
G
---
N
V
Y
L
A
-
R
E
K
N
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
K
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
----------------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
D
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
75.98
35%
-131
- C2 -
3K5U
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
---------------
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
N
C
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.94
35%
-128
- C2 -
4O0S
1
AURKA_HUMAN
A:
[9-262]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
--
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
75.84
35%
-126
- C2 -
3UOL
6
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
75.70
35%
-134
- C2 -
4BYJ
1
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
75.62
35%
-131
- C2 -
3NRM
1
AURKA_HUMAN
A:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
A
A
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
75.53
35%
-127
- C2 -
3UO4
4
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
75.42
35%
-133
- C2 -
4C3P
1
AURKA_HUMAN
D:
[9-262]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
-----------
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
75.41
35%
-122
- C2 -
3H10
1
AURKA_HUMAN
B:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
A
A
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
75.24
35%
-130
- C2 -
3UOH
4
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
75.18
35%
-126
- C2 -
3UOL
8
AURKA_HUMAN
B:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
75.06
35%
-128
- C2 -
1MQ4
1
AURKA_HUMAN
A:
[11-264]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
----
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.04
35%
-134
- C2 -
2J50
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
-------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
74.77
35%
-125
- C2 -
3UNZ
3
AURKA_HUMAN
B:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
74.76
35%
-133
- C2 -
2J50
1
AURKA_HUMAN
B:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
--------------
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
-------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
74.73
35%
-121
- C2 -
3UOK
1
AURKA_HUMAN
B:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
74.65
35%
-133
- C2 -
3W18
1
AURKA_HUMAN
A:
[5-258]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
-----------R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
74.57
35%
-122
- C2 -
3UOK
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
74.51
35%
-137
- C2 -
4B0G
1
AURKA_HUMAN
A:
[10-263]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
-------------
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
---------------------
T
L
D
Y
L
P
P
E
M
I
E
-----
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
74.45
35%
-134
- C2 -
2C6E
1
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
---------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
74.36
35%
-124
- C2 -
3UO6
3
AURKA_HUMAN
B:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
74.34
35%
-122
- C2 -
3UOJ
1
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
74.33
35%
-125
- C2 -
3UNZ
3
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
74.25
35%
-123
- C2 -
3UO6
3
AURKA_HUMAN
A:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
74.09
35%
-138
- C2 -
4UYN
1
AURKA_HUMAN
A:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---------
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
-------------------------
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
73.80
35%
-130
- C2 -
3H10
1
AURKA_HUMAN
D:
[7-260]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
----------------
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
73.80
35%
-122
- C2 -
3UOJ
1
AURKA_HUMAN
B:
[8-261]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
D
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
73.13
34%
-121
- C2 -
2WTV
4
AURKA_HUMAN
A:
[12-265]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.11
34%
-133
- C2 -
1OL6
1
AURKA_HUMAN
A:
[9-262]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
-
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
------
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
N
F
G
W
S
V
H
--------------------
T
L
D
Y
L
P
P
E
M
I
E
G
---
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
72.48
33%
-125
- C2 -
3QBN
1
AURKA_HUMAN
A:
[8-266]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
-------------------
T
L
S
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
72.44
35%
-131
- C2 -
3W18
1
AURKA_HUMAN
B:
[5-258]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
------------------
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
------
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
71.17
35%
-138
- C2 -
3O51
1
AURKA_HUMAN
A:
[6-259]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
--------------------------
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
71.10
35%
-126
- C2 -
4C3P
1
AURKA_HUMAN
A:
[9-262]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
-
R
-
T
T
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
71.01
35%
-126
- C2 -
1MUO
1
AURKA_HUMAN
A:
[24-277]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
----------------
L
C
---
G
T
L
D
Y
L
P
P
E
M
I
E
G
--
R
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
-----------------------
V
E
F
T
--
F
P
-----------
D
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
M
L
R
E
V
L
E
H
P
W
I
T
A
N
S
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
70.66
31%
-115
- C2 -
2W5A
5
NEK2_HUMAN
A:
[3-277]
--------
S
R
A
E
D
---
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
-
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
--
T
E
---
A
----
E
K
Q
M
L
V
S
-
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
I
D
RT
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
E
R----------------------------------
Q
----
Y
L
D
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-
L
H
R
D
L
K
P
A
N
V
F
-
L
D
G
----
K
----
Q
N
---
V
K
L
G
D
F
G
L
A
R
I
L
---
T
---
S
F
A
-
K
T
F
V
---
G
T
P
Y
Y
M
S
P
E
Q
M
N
R
--
M
-
Y
-
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
E
G
------------------
K
-
F
-
R
R
I
P
--
Y
-------------
R
Y
S
D
E
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
67.97
33%
-115
- C2 -
2Y0A
1
DAPK1_HUMAN
A:
[3-276]
----
V
F
R
Q
E
N
V
D
D
Y
--
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
-
T
G
L
Q
Y
A
A
K
F
I
K
K
R
R
T
--
K
S
---
S
RRGV
S
R
E
D
I
E
R
-
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
--
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--------------------------------------
E
----
S
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
-
L
L
D
----
R
N
VP
K
P
R
---
I
K
I
I
D
F
G
L
A
H
K
I
D
F
G
N
---
E
-
F
-
K
N
I
F
---
G
T
P
E
F
V
A
P
E
I
V
N
Y
--
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
N
V
S
A
V
------------------
N
-
Y
--
E
F
E
DE
Y
F
-----------
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
Q
D
S
L
Q
H
P
W
I
K
P
K
D
T
Q
Q
A
L
S
R
K
A
S
A
V
N
M
E
K
F
K
K
F
A
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
66.02
37%
-111
- C2 -
2JAM
3
KCC1G_HUMAN
A:
[11-266]
----------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
-
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
----------
S
----
S
L
E
N
----
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
--
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--------------------------------------
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
----
E
E
--
N
S
K
---
I
M
I
T
D
F
G
----
L
S
K
M
E
---
Q
-
N
-
G
I
M
S
TAC
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
------------------
Y
-
Y
E
F
E
S
P
--
F
W
-----------
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
65.09
30%
-117
- C2 -
4BGQ
3
CDKL5_HUMAN
A:
[11-299]
----------
M
N
K
---
F
E
I
L
G
V
V
G
E
G
A
Y
G
V
V
L
K
C
R
H
K
E
-
T
H
E
I
V
A
I
K
K
F
K
----------------
V
K
E
T
T
L
R
-
E
L
K
M
L
R
T
L
K
Q
E
N
I
V
E
L
K
E
A
F
R
R
--
R
G
K
L
Y
L
V
F
E
Y
V
E
K
N
M
L
E
L
L
E
E
M
P
--------------------------------------
N
----
G
V
P
P
E
K
V
K
S
Y
I
Y
Q
L
I
K
A
I
H
W
C
H
K
N
D
I
V
H
R
D
I
K
P
E
N
L
L
-
I
S
H
----
N
----
D
V
---
L
K
L
C
D
F
G
F
A
R
N
L
S
E
-----------------
T
R
W
Y
R
S
P
E
L
L
L
G
--
A
P
Y
-
G
K
S
V
D
M
W
S
V
G
C
I
L
G
E
L
S
D
G
Q
P
L
F
P
G
E
S
E
I
D
Q
L
F
T
I
Q
K
V
LGPLP
S
E
Q
M
K
L
F
Y
S
NPRF
H
-
G
-
L
R
F
P
--
A
V
N
H
P
Q
S
L
E
R
R
Y
L
G
I
L
N
S
V
L
L
D
L
M
K
N
L
L
K
L
D
P
A
D
R
Y
L
T
E
Q
C
L
N
H
P
T
F
Q
T
Q
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
64.99
37%
-109
- C2 -
2JAM
3
KCC1G_HUMAN
B:
[11-266]
----------------
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
-
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
----------
S
----
S
L
E
N
----
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
--
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--------------------------------------
G
----
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
L
T
P
----
E
E
--
N
S
K
---
I
M
I
T
D
F
G
----
L
S
K
M
E
---
Q
-
N
-
G
I
M
S
TAC
G
T
P
G
Y
V
A
P
E
V
L
A
Q
--
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
E
E
T
E
S
K
L
F
E
K
I
K
E
G
------------------
Y
-
Y
E
F
E
S
P
--
F
W
-----------
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
E
K
A
L
S
H
P
W
I
D
G
N
T
A
L
H
R
D
I
Y
P
S
V
S
L
Q
I
Q
K
N
F
A
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
62.09
31%
-103
- C2 -
2YEX
8
CHK1_HUMAN
A:
[2-267]
------
A
V
P
F
V
E
D
---
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
-
T
E
E
A
V
A
V
K
I
V
D
M
K
R
A
--
V
----
D
----
C
P
E
N
I
K
K
-
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
--------------------------------------
I
----
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
-
L
D
E
----
R
----
D
N
---
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
N
N
R
E
R
L
-
L
-
N
K
M
C
---
G
T
L
P
Y
V
A
P
E
L
L
K
R
--
R
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
Y
S
D
W
K
E
------------------
K
-
K
-
T
Y
L
N
--
P
W
-----------
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
D
R
W
Y
N
K
P
L
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
62.03
33%
-116
- C2 -
3C0I
1
CSKP_HUMAN
A:
[24-291]
-----------
D
V
---
Y
E
L
C
E
V
I
G
K
G
P
F
S
V
V
R
R
C
I
N
R
E
-
T
G
Q
Q
F
A
V
K
I
V
D
V
A
K
F
--
T
S
SPG
L
----
S
T
E
D
L
K
R
-
E
A
S
I
C
H
M
L
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
--
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
E
I
V
K
R
--------------------------------------
A
D
A
G
F
V
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
L
-
L
A
S
----
K
E
N-
S
A
P
---
V
K
L
G
G
F
G
V
A
I
Q
L
G
E
S
G
---
L
-
V
A
G
G
R
V
---
G
T
P
H
F
M
A
P
E
V
V
K
R
--
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
Y
G
T
K
-
E
R
L
F
E
G
I
I
K
G
------------------
K
-
Y
K
M
N
P
R
--
Q
W
-----------
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
Y
E
A
L
N
H
P
W
L
K
E
R
D
R
Y
A
Y
K
I
H
L
P
E
T
V
E
Q
L
R
K
F
N
A
R
R
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
59.91
39%
-77
- C2 -
4WNO
1
ULK1_HUMAN
A:
[12-283]
--------
T
E
T
V
G
K
F
E
F
S
R
K
D
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
--
A
K
---
S
----
Q
T
L
-
L
G
K
-
E
I
K
I
L
K
E
L
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
--
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
H
A
M
--------------------------------------
R
----
T
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
-
L
S
N
PAGR
R
A
--
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
Y
L
Q
S
N
M
---
M
-
A
-
A
T
L
C
---
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
-
D
G
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
P
Q
D
L
R
L
F
Y
E
K
N
------------------
K
-
T
-
L
V
P
T
--
I
P
-----------
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
D
F
D
E
F
F
H
H
P
F
L
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
56.66
39%
-74
- C2 -
4WNP
3
ULK1_HUMAN
A:
[11-283]
-------
G
T
E
T
V
G
K
F
E
F
S
R
K
D
L
I
G
H
G
A
F
A
V
V
F
K
G
R
H
R
A
A
H
D
L
E
V
A
V
K
C
I
N
K
K
N
L
--
A
K
---
S
----
Q
T
L
-
L
G
K
-
E
I
K
I
L
K
E
L
K
H
E
N
I
V
A
L
Y
D
F
Q
E
M
--
A
N
S
V
Y
L
V
M
E
Y
C
N
G
G
D
L
A
D
Y
L
H
A
M
--------------------------------------
R
----
T
L
S
E
D
T
I
R
L
F
L
Q
Q
I
A
G
A
M
R
L
L
H
S
K
G
I
I
H
R
D
L
K
P
Q
N
I
L
-
L
S
N
PAGR
R
A
--
N
P
N
S
I
R
V
K
I
A
D
F
G
F
A
R
Y
L
Q
S
N
M
---
M
-
A
-
A
T
L
C
---
G
S
P
M
Y
M
A
P
E
V
I
M
S
--
Q
H
Y
-
D
G
K
A
D
L
W
S
I
G
T
I
V
Y
Q
C
L
T
G
K
A
P
F
Q
A
S
S
P
Q
D
L
R
L
F
Y
E
K
N
------------------
K
-
T
-
L
V
P
T
--
I
P
-----------
R
E
T
S
A
P
L
R
Q
L
L
L
A
L
L
Q
R
N
H
K
D
R
M
D
F
D
E
F
F
H
H
P
F
L
D
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
38.69
35%
-109
- C2 -
2NP8
1
AURKA_HUMAN
A:
[11-166]
----------
L
E
D
---
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
-
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
Q
L
--
E
K
---
A
----
G
V
E
H
Q
L
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
--
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
--------------------------------------
S
----
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
-
L
G
S
----
A
G
--
E
-----
L
K
I
A
D
F
G
W
S
V
H
-
A
P
S
S
---
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------