@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
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Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : WNK2_HUMAN: (2015-10-22 )
MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPAPDGGPREEAAATVRKEDEGAAEAKPEPGRTRRDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIESGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQPKEQQDVGSPDKARGPPVPLQVQVTYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPVQEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCEGAFGGGRLEGRAARKHHRRSTRARSRQERASRPRLTILNVCNTGDKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILQAERETFIEQMKDVMDKAEDMLSEDTDADRGSDPGTSPPHLSTCGLGTGEESRQSQANAPVYQQNVLHTGKRWFIICPVAEHPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRAACGAVFLSLFSAESAQSKQPPDSAPYKDQLSSKEQPSFLASQQLLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGLTSELETSQPLAETHEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKLRTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLALPPVPKEAVSGRVQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSMLGYDRDGRQVASDSHVVPSVPQDVPAFVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASHPQTLGARALGSPRKRPEQQDVSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEAPSSPDVKLAVRRAQTASSIEVGVGEPVSSDSGDEGPRARPPVQKQASLPVSGSVAGDFVKKATAFLQRPSRAGSLGPETPSRVGMKVPTISVTSFHSQSSYISSDNDSELEDADIKKELQSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPTGRRRKTSKSKLKAGKLLNPLVRQLKVVASSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQPCSVRASLSSDICSGLASDGGGARGQGWTVYHPTSERVTYKSSSKPRARFLSGPVSVSIWSALKRLCLGKEHSSRSSTSSLAPGPEPGPQPALHVQAQVNNSNNKKGTFTDDLHKLVDEWTSKTVGAAQLKPTLNQLKQTQKLQDMEAQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARRNQVWFGLRVPPTACCGHSTQPRGGQRVGSKTASFAASDPVRS
Atome Classification :
(63 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......-220.......230.......240.......250.......260.......270.......280.....----..290-.......300.......310.......320.......330........340.......-350..---...-..360.......----370----.......380.......390.......400.......410.......420.---......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDGDGGRRDVPGTLMEPGRGAGPAGMAEPRAKAARP
G
P
Q
R
F
L
R
R
S
V
V
ESDQEEPPGLEAAEAPGPQP
P
Q
P
L
Q
R
R
V
L
L
L
C
K
T
R
R
L
I
A
E
RARGRPAAPAP
A
A
L
V
AQPGAPGAPADAGPEPVGTQEPGPD
P
I
A
A
A
VETAPAPDGG
P
R
E
E
A
A
A
T
VRKEDEGAAEAKPEPGRTRRDEPEEEED
D
E
D
D
L
K
A
V
A
T
SLDG
R
F
L
K
F
D
I
E
LGRG
S
F
K
T
V
Y
KGLDTE
T
W
V
-
E
V
A
W
C
ELQD
R
K
L
T
K
L
E
R
Q
R
F
K
E
E
A
E
M
L
K
GLQHP
N
I
V
R
F
Y
D
F
W
ESSAKG
K
R
C
I
V
L
V
T
E
L
MTS
G
T
L
K
T
Y
L
----
K
R
FKV-M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
L
F
L
HTRTP
P
I
I
H
RDLKCD
N
I
F
I
-TGPTG
S
V
K
IG
D
L
G
L
A
T
L
K
-
R
A
S
F
A
---
K
S
V-IGTPEFM
A
P
E
M
Y
----
E
E
H
----YDES
V
D
V
Y
A
F
G
M
C
M
L
E
MATSEY
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
TCGIKPASFEKVHD---P
E
I
K
E
I
I
G
E
C
ICKN
K
E
E
R
Y
E
I
K
D
L
L
S
H
A
FFAEDT
G
V
R
V
E
L
AEEDHGRK
S
T
I
A
L
R
L
W
VE
D
P
K
K
LKGKPKDN
G
A
I
E
F
T
F
DLEKE
T
P
D
E
V
A
Q
E
M
I
E
SGFFHE
S
D
V
K
I
V
A
K
S
I
R
D
R
V
A
L
I
Q
W
R
R
E
RIWPALQP
K
E
QQDVGSPDKARGPPV
P
L
Q
V
Q
V
T
Y
HAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQG
S
T
V
YSDSQSSQ
Q
S
V
M
L
GSLADAAPSPA
Q
C
V
CSPPVSEGPVL
P
Q
SLPSLGAYQQPTAAPGLPVGSVPAPAC
P
P
S
L
Q
Q
HFPD
P
A
M
SFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLA
P
A
S
QVGAPAQLKPLQMPQA
P
L
Q
P
L
A
QVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFS
P
A
V
ILPSLAAPLPPASPALP
L
Q
A
V
KLPHPPGAPLAM
P
C
R
TIVPNAPAT
I
P
L
L
A
VAPP
G
V
A
A
L
S
I
H
S
A
V
A
QLPGQPVYPAAFPQMAPTDVPPSPH
H
T
V
Q
NMRATPPQPALPPQPTLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATPGS
Q
I
L
LGHPA
P
Y
A
V
D
VAAQVPTVPVP
P
A
A
VLSPPL
P
E
V
LLPA
A
P
E
L
L
P
QF
P
S
S
L
A
T
V
S
A
S
V
QSVPTQ
T
A
TLLPPANPPLPGGPGIASPC
P
T
V
Q
L
T
VEPV
Q
E
E
QASQDKPPGL
P
Q
S
C
E
SYGGSDVTSGK
E
L
S
D
SCEGAFGGGRLE
G
R
A
A
R
K
H
H
R
R
S
T
R
A
R
S
R
Q
E
RASRP
R
L
T
I
L
N
VCNTGD
K
M
V
E
C
Q
L
ETHN
H
K
M
V
T
F
K
F
DLDGD
A
P
D
E
I
A
T
Y
M
V
E
H
D
F
I
L
Q
A
E
R
E
T
F
I
E
Q
M
K
D
V
M
D
K
A
E
D
M
L
SEDTDADRGSDPGTSPPHLSTCGLGT
G
E
E
S
RQSQANAP
V
Y
Q
Q
N
VLHTG
K
R
W
F
I
I
C
PVAEHPAPEAPESSPPLPLSSLPPEASQGPCRGLTLPCLPWRRA
A
C
G
A
V
F
L
S
L
F
SAESAQSKQPPDSAP
Y
K
D
QLSSKE
Q
P
S
F
L
A
S
Q
Q
L
L
S
QAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQ
G
L
T
S
ELETSQP
L
A
ETHEAPL
A
V
Q
P
L
V
V
GLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPL
L
P
A
A
V
G
A
V
S
L
A
T
SQLPSPPLGPTVPPQPP
S
A
LESDGEGPPPRV
G
F
V
D
S
T
I
K
S
L
D
E
K
L
R
T
L
L
Y
Q
EHVPTSSASAGTPVEVGDRD
F
T
LEPLRGDQ
P
R
S
EVCGGDLALPPV
P
K
E
AVSGRVQLPQ
P
L
V
E
KSELAPTR
G
A
V
M
EQGTSSSMTAESSP
R
S
MLGYDRDG
R
Q
VASDSHVVPSVPQDV
P
A
FVRPARVEPTDRDGGEAGESSAEPPPSDMGTVGGQASH
P
Q
T
L
G
A
RALGSPRKRP
E
Q
QDVS
S
P
A
K
T
V
G
R
F
S
V
V
STQD
E
W
TLASPHSLRYSAPP
D
V
Y
LDEAPSSPD
V
K
L
A
V
R
RAQTASSIEVGVGEPVSSDSGDEGPRARPP
V
Q
K
QASLPVSG
S
V
A
G
D
F
V
K
K
A
T
A
F
L
QRPSRAGSLGPET
P
S
RVGMKV
P
T
I
S
V
T
SFHSQSSYISSDNDSEL
E
D
A
D
I
K
K
E
L
Q
S
L
R
E
K
H
L
K
E
I
S
E
L
Q
S
Q
Q
K
Q
E
I
E
A
L
Y
R
R
LGKPLPPNV
G
F
F
HTAPPTGRRRKT
S
K
SKL
K
A
G
K
L
L
N
P
L
V
R
Q
L
K
V
V
A
SSTGHLADSSRGPPAKDPAQASVGLTADSTGLSGKAVQTQQP
C
S
V
R
A
S
L
S
S
D
I
C
S
G
L
ASDGGGARGQ
G
W
T
V
YHPTSE
R
V
T
YKSSSKP
R
A
RFLSGPV
S
V
S
I
W
S
A
L
K
R
L
CLGKEHSSRSSTSSLAPGPEPGPQP
A
L
H
V
Q
A
Q
VNNSNNKKGT
F
T
D
D
L
H
K
L
V
D
E
W
TSKTV
G
A
A
Q
L
K
P
T
L
N
Q
L
K
Q
T
Q
K
L
Q
D
M
E
AQAGWAAPGEARAMTAPRAGVGMPRLPPAPGPLSTTVIPGAAPTLSVPTPDGALGTARR
N
Q
V
W
F
G
LRVP
P
T
ACCGHSTQPRGGQRVGSKTASFAASDPVRS
3
PsiBlast_PDB
86.34
82%
-80
- C1 -
3FPQ
4
WNK1_RAT
A:
[17-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
L
K
F
D
I
E
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
V
-
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
S
E
R
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
----
K
R
F
K
V
-
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
-
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
K
-
R
A
S
F
A
---
K
A
V
-
I
G
T
P
E
F
M
A
P
E
M
Y
----
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
Y
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
Y
S
I
K
D
L
L
N
H
A
F
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.23
33%
-70
- C1 -
3C4C
1
B:
[20-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
-------------------
S
G
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
62.07
34%
-60
- C1 -
4E26
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
----F--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
61.57
34%
-63
* C1 *
4KSP
1
BRAF_HUMAN
A:
[21-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.48
34%
-66
- C1 -
3PPK
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.30
34%
-61
- C1 -
5CT7
1
?
B:
[21-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
--------------------
G
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
61.29
33%
-65
- C1 -
4WO5
1
BRAF_HUMAN
A:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
-K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
--F--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
----
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
61.25
33%
-76
- C1 -
3OMV
1
B:
[44-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
-----
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
HVQE
T
K
F
Q
M
-
F
Q
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
--
V
K
I
G
D
F
G
L
A
T
V
-------------P
T
G
S
V
L
W
M
A
P
E
V
I
----
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
NCP
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
61.07
33%
-65
- C1 -
3C4C
1
BRAF_HUMAN
A:
[20-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
------------------
S
G
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
60.91
34%
-60
- C1 -
4FC0
1
BRAF_HUMAN
A:
[21-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M---
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
60.83
34%
-66
- C1 -
4H58
1
BRAF_HUMAN
A:
[16-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S-------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
60.71
34%
-66
- C1 -
4EHG
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
----------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
60.68
33%
-68
- C1 -
3OG7
1
BRAF_HUMAN
A:
[32-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
A
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
---
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
-------------------
G
S
I
L
W
M
A
P
E
V
I
----
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
60.44
33%
-68
- C1 -
4WO5
1
B:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
----------------
G
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
60.34
34%
-60
- C1 -
4MBJ
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
60.17
34%
-63
- C1 -
4MBJ
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
60.15
33%
-72
- C1 -
3OMV
1
RAF1_HUMAN
A:
[44-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
M
T
-----
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
HVQE
T
K
F
Q
M
-
F
Q
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
--
V
K
I
G
D
F
G
L
A
T
V
-------------P
T
G
S
V
L
W
M
A
P
E
V
I
----
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
NCP
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
59.94
34%
-59
- C1 -
3TV4
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
HQF
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
59.84
34%
-69
- C1 -
3PRF
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
59.83
34%
-62
- C1 -
5CT7
1
?
A:
[21-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
-----------------
G
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
59.47
34%
-63
- C1 -
3PSD
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
59.44
34%
-59
- C1 -
3PSD
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
59.41
34%
-57
- C1 -
3PPK
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
59.31
34%
-65
- C1 -
4EHE
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.14
33%
-66
- C1 -
4FK3
1
BRAF_HUMAN
A:
[32-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
------------------
S
G
S
I
L
W
M
A
P
E
V
I
----
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
58.97
34%
-62
- C1 -
4G9C
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
-----------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
58.96
33%
-64
- C1 -
4JVG
1
D:
[24-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S--------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.92
34%
-62
- C1 -
4EHE
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
HQF
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
58.88
34%
-61
- C1 -
3PSB
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
58.84
34%
-60
- C1 -
3II5
1
B:
[43-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
58.81
34%
-62
- C1 -
4EHG
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
---------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
58.79
33%
-67
- C1 -
4JVG
1
BRAF_HUMAN
C:
[24-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
------------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
58.76
34%
-67
- C1 -
4E4X
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
58.66
34%
-63
- C1 -
3SKC
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
58.44
34%
-61
- C1 -
3PPJ
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
58.43
34%
-59
- C1 -
3D4Q
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.40
34%
-64
- C1 -
3IDP
1
B:
[36-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
----------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.32
33%
-68
- C1 -
4JVG
1
BRAF_HUMAN
B:
[24-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-----------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
58.03
34%
-61
- C1 -
3PRF
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
G
S
I
L
W
M
A
P
E
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
58.02
33%
-67
- C1 -
4JVG
1
BRAF_HUMAN
A:
[24-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
K
S--------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
58.00
34%
-64
- C1 -
3SKC
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
----------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
57.86
34%
-64
- C1 -
4G9C
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
57.76
34%
-60
- C1 -
1UWJ
1
B:
[16-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
K
--------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
57.72
34%
-64
- C1 -
1UWH
1
BRAF_HUMAN
A:
[16-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
A
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
57.62
34%
-61
- C1 -
3PSB
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
57.44
34%
-57
- C1 -
3IDP
1
BRAF_HUMAN
A:
[36-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
----------------
G
S
I
L
W
M
A
P
E
V
I
R
MQ--
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
57.43
34%
-58
- C1 -
3TV6
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
57.31
34%
-64
- C1 -
3TV6
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
---------
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
57.13
34%
-62
- C1 -
3II5
1
BRAF_HUMAN
A:
[43-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
57.10
34%
-63
- C1 -
4E4X
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
57.01
34%
-69
- C1 -
5C9C
1
?
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-----------------
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
56.96
34%
-60
- C1 -
3PPJ
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
56.70
34%
-62
- C1 -
1UWH
1
B:
[16-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
--
S
T
A
P
Q
---
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
56.65
34%
-59
- C1 -
3D4Q
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.65
34%
-58
- C1 -
4PP7
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
56.62
34%
-62
- C1 -
3PRI
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
56.60
34%
-63
- C1 -
4PP7
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.58
34%
-63
- C1 -
3PRI
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------
L
-
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
56.54
34%
-63
- C1 -
1UWJ
1
BRAF_HUMAN
A:
[16-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
K
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
56.31
34%
-63
- C1 -
4MNF
1
B:
[56-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
----------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
55.79
34%
-61
- C1 -
4MNF
1
BRAF_HUMAN
A:
[56-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
----------------
S
I
L
W
M
A
P
E
V
I
----
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
55.24
34%
-59
- C1 -
4G9R
1
BRAF_HUMAN
A:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
K
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
53.17
34%
-55
- C1 -
4G9R
1
B:
[44-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
-----
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
HIIE
T
K
F
E
M
-
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
-
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
K
--------------
G
S
I
L
W
M
A
P
E
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------