@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : WNK3_HUMAN: (2015-10-22 )
MATDSGDPASTEDSEKPDGISFENRVPQVAATLTVEARLKEKNSTFSASGETVERKRFFRKSVEMTEDDKVAESSPKDERIKAAMNIPRVDKLPSNVLRGGQEVKYEQCSKSTSEISKDCFKEKNEKEMEEEAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLETDTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTPIKKTREKKPAGCLEERRDSQCKSMGNVFPQPQNTTLPLAPAQQTGAECEETEVDQHVRQQLLQRKPQQHCSSVTGDNLSEAGAASVIHSDTSSQPSVAYSSNQTMGSQMVSNIPQAEVNVPGQIYSSQQLVGHYQQVSGLQKHSKLTQPQILPLVQGQSTVLPVHVLGPTVVSQPQVSPLTVQKVPQIKPVSQPVGAEQQAALLKPDLVRSLNQDVATTKENVSSPDNPSGNGKQDRIKQRRASCPRPEKGTKFQLTVLQVSTSGDNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLESEKEKFVEELRAIVGQAQEILHVHFATERATGVDSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSLQHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVRAVPAECEGLTKQASIFIPVYPCHQTASQADALMSHPGESTQTSGNSLTTLAFDQKPQTLSVQQPAMDAEFISQEGETTVNTEASSPKTVIPTQTPGLEPTTLQPTTVLESDGERPPKLEFADNRIKTLDEKLRNLLYQEHSISSIYPESQKDTQSIDSPFSSSAEDTLSCPVTEVIAISHCGIKDSPVQSPNFQQTGSKLLSNVAASQPANISVFKRDLNVITSVPSELCLHEMSSDASLPGDPEAYPAAVSSGGAIHLQTGGGYFGLSFTCPSLKNPISKKSWTRKLKSWAYRLRQSTSFFKRSKVRQVETEEMRSAIAPDPIPLTRESTADTRALNRCKAMSGSFQRGRFQVITIPQQQSAKMTSFGIEHISVFSETNHSSEEAFIKTAKSQLVEIEPATQNPKTSFSYEKLQALQETCKENKGVPKQGDNFLSFSAACETDVSSVTPEKEFEETSATGSSMQSGSELLLKEREILTAGKQPSSDSEFSASLAGSGKSVAKTGPESNQCLPHHEEQAYAQTQSSLFYSPSSPMSSDDESEIEDEDLKVELQRLREKHIQEVVNLQTQQNKELQELYERLRSIKDSKTQSTEIPLPPASPRRPRSFKSKLRSRPQSLTHVDNGIVATGKSCLINELENPLCVESNAASCQQSPASKKGMFTDDLHKLVDDWTKEAVGNSLIKPSLNQLKQSQHKLETENWNKVSENTPSTMGYTSTWISSLSQIRGAVPTSLPQGLSLPSFPGPLSSYGMPHVCQYNAVAGAGYPVQWVGISGTTQQSVVIPAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
Atome Classification :
(67 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-...-....150--.......160.......170.-........180......-.190........200.......210.......220.......230.......240--...----.---.....250.......260.......270.......280..-.....290.......300--...--...-----.-310.......-320..----.....330.......340.....-..350.......--360.......370...---....380.......390.------..---....400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATDSGDPASTEDSEKPDGISFENRVP
Q
V
A
A
T
L
T
V
E
A
R
LKEKNSTFSASG
E
T
V
E
R
K
R
F
F
R
K
SVEMTEDDKVAESSP
K
D
E
R
I
K
A
A
MNIP
R
V
D
KL
P
S
N
V
LRGGQE
V
K
Y
E
Q
CSK
S
T
S
E
I
S
K
D
C
F
K
EK
N
E
K
E
M
E
E
E
A
E
M
K
A
V
ATSP-SG
R
-
F
L
K
F
D
I
E--LGR
G
A
F
K
T
V
Y
KGLDTE
T
W
--
V
-
E
V
A
W
C
ELQDRKL
T
K
A
E
Q
-
Q
R
-
F
K
E
E
A
E
M
L
K
GLQHP
N
I
V
R
F
Y
D
S
W
E
S
I
LKGK
K
C
I
V
L
V
T
E
L
MTS
G
T
L
K
T
Y
L
K
----
R
FK----V---M
K
P
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
HTRTP
P
I
I
H
RDLKCD
N
I
F
I
T-GPTG
S
V
K
I
G
D
L
G
L
A
T
L
M
R
--
T
S
F
--
A
K
S
-----V-IGTPEFM
A
P
E
-
M
Y
E
E
H
----YDES
V
D
V
Y
A
F
G
M
C
M
L
E
MATSEY
P
-
Y
S
E
C
Q
N
A
A
Q
I
Y
R
--
K
V
TSGIKPASFNKVT
D
---
P
E
V
K
E
I
I
E
G
C
I
RQNKSE
R
------
L
S
---
I
R
D
L
L
N
H
A
FFAEDTG
L
R
V
E
LAEEDDCSNS
S
L
A
L
R
L
W
VE
D
P
K
K
LKGKHKDN
E
A
I
E
F
S
F
NLETD
T
P
E
E
V
A
Y
E
M
V
K
SGFFHES
D
S
K
A
V
A
K
S
I
R
D
RVT
P
I
K
K
TREKKPA
G
C
L
E
E
R
R
D
S
Q
C
K
S
M
G
NVFPQPQNTTLPLAPAQQTGAE
C
E
E
T
E
V
D
Q
H
V
R
Q
Q
L
L
Q
R
K
P
Q
Q
H
C
S
SVTGDNLSEAGA
A
S
V
I
HSDTSSQP
S
V
A
YSSNQ
T
M
G
S
Q
M
V
S
NIPQAEVNVPGQIY
S
S
Q
Q
L
V
G
H
Y
Q
Q
V
S
G
L
Q
K
HSKLTQP
Q
I
L
P
L
VQGQ
S
T
V
L
P
V
H
VLGPTVVSQPQVSPL
T
V
QKVPQIKPVSQPVG
A
E
Q
Q
A
A
LL
K
P
D
L
V
R
S
L
N
Q
D
V
ATTKENVSSPDNPSGN
G
K
Q
D
R
I
K
Q
R
R
ASCPRPEKG
T
K
F
Q
L
T
V
L
Q
V
STSGD
N
M
V
E
C
Q
L
ETHN
N
K
M
V
T
F
K
F
DVDGD
A
P
E
D
I
A
D
Y
M
VED
N
F
V
L
E
S
E
K
E
K
F
V
E
E
L
R
A
I
V
G
Q
A
Q
E
I
L
H
V
H
FATERATGV
D
S
I
T
VDSNSSQTGSS
E
Q
V
Q
I
NSTSTQTSNESAPQSSPV
G
R
W
R
F
C
I
N
Q
T
IRNRETQSP
P
S
L
Q
H
S
M
S
AVPGRHPLPSPKNTSNKEISR
D
T
L
L
T
IENNPC
H
R
A
LFTSKSEHKDVVDG
K
I
S
E
CASVETKQ
P
A
I
L
Y
Q
VEDN
R
Q
I
M
A
PVTNSSSYST
T
S
V
R
AV
P
A
ECEGLTKQ
A
S
I
F
I
P
VYPCHQ
T
A
S
Q
A
D
A
L
M
SHPGESTQTSGN
S
L
T
T
L
A
FDQKPQT
L
S
VQQPAM
D
A
E
F
I
SQEGE
T
T
VNTEASSP
K
T
V
I
PTQTPGLEPTTLQP
T
T
VLESDGERPPKLEFAD
N
R
I
K
T
L
D
E
K
L
R
N
L
L
Y
Q
EH
S
I
S
SIYPESQKD
T
Q
SIDSPFSSSAEDTLSCPV
T
E
V
I
A
I
SHCGIKDSPVQSP
N
F
Q
Q
T
G
S
K
L
L
S
N
V
AASQPA
N
I
S
V
F
K
R
D
L
N
V
I
T
SV
P
S
E
L
C
L
H
E
MSSDASLPGDPEAYPAAVSSG
G
A
I
H
L
QTGG
G
Y
F
G
L
S
F
TCPSLKNPI
S
K
K
S
W
T
R
K
L
K
S
W
A
Y
R
L
R
Q
S
T
S
F
F
K
R
S
KVRQV
E
T
E
E
M
R
S
AIAPDPIPLTRESTA
D
T
R
A
L
N
R
C
K
AMSGSFQRG
R
F
Q
V
I
T
IPQQQSAKMTSFGI
E
H
I
S
V
FSETNHS
S
E
E
A
F
I
K
T
A
KS
Q
L
V
E
IEPATQNPKTSF
S
Y
E
K
L
Q
A
L
Q
E
T
C
K
ENKGVPKQGDN
F
L
S
FSAACETDVSSVT
P
E
K
E
F
E
E
TSATGSSMQS
G
S
E
L
L
L
K
E
R
E
I
LTAGKQPSSD
S
E
F
S
A
S
LAGSGK
S
V
AKTGPESNQCLPH
H
E
E
Q
A
Y
A
Q
T
Q
S
S
L
F
YSPSSPMSSDDESEIE
D
E
D
L
K
V
E
L
Q
R
L
R
E
K
H
I
Q
E
V
V
N
L
QTQQ
N
K
E
L
Q
E
L
Y
E
R
L
R
S
I
KDSKTQSTEIPLPPASPRR
P
R
S
F
K
S
K
L
R
SRP
Q
S
L
T
HVDN
G
I
VATG
K
S
C
L
I
N
ELEN
P
L
C
VESN
A
A
SCQQSPASKKGM
F
T
D
D
L
H
K
L
V
D
D
W
T
K
E
A
VGNSLIK
P
S
L
N
Q
L
K
Q
S
Q
HKLETENWNKVSENTPSTMG
Y
T
S
T
W
I
S
S
L
S
Q
I
RGAVPTSLPQGLSLPSFPGP
L
S
SYGMP
H
V
C
Q
YNAVAGAGY
P
V
Q
W
V
GISGTTQ
Q
S
V
V
I
PAQSGGPFQPGMNMQAFPTSSVQNPATIPPGPK
3
PsiBlast_PDB
85.20
85%
-74
- C1 -
3FPQ
4
WNK1_RAT
A:
[17-287]
---------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
-
D
G
R
-
F
L
K
F
D
I
E
--
I
G
R
G
S
F
K
T
V
Y
K
G
L
D
T
E
T
T
--
V
-
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
S
E
R
-
Q
R
-
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
Y
D
S
W
E
S
T
V
K
G
K
K
C
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
K
----
R
F
K
----
V
---
M
K
I
K
V
L
R
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
-
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
K
R
--
A
S
F
--
A
K
A
-----
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
-
Y
S
E
C
Q
N
A
A
Q
I
Y
R
--
R
V
T
S
G
V
K
P
A
S
F
D
K
V
A
I
---
P
E
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
------
Y
S
---
I
K
D
L
L
N
H
A
F
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
58.67
32%
-55
- C1 -
3PPK
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
58.37
32%
-52
- C1 -
3PSD
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.27
32%
-47
- C1 -
5CT7
1
?
B:
[20-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
-------------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
58.26
32%
-63
- C1 -
3C4C
1
B:
[20-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
------------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
58.05
32%
-63
- C1 -
4WO5
1
BRAF_HUMAN
A:
[40-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE-
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
--FEQ--
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
58.04
32%
-52
- C1 -
4MBJ
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
57.80
32%
-49
* C1 *
4KSP
1
BRAF_HUMAN
A:
[20-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
------------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
57.73
32%
-55
- C1 -
3C4C
1
BRAF_HUMAN
A:
[20-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
-----------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
57.48
32%
-50
- C1 -
3PSB
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
57.41
32%
-55
- C1 -
4EHE
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
HQF
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
57.25
32%
-52
- C1 -
4EHG
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
---------------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
56.96
32%
-48
- C1 -
5CT7
1
?
A:
[20-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
56.92
32%
-53
- C1 -
4H58
1
BRAF_HUMAN
A:
[15-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
---------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
56.73
32%
-51
- C1 -
3PPJ
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
56.58
32%
-56
- C1 -
4E4X
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
56.57
32%
-51
- C1 -
4B6L
1
PLK3_HUMAN
A:
[3-265]
-------------------------------------------------------------------------------------------------------------------------------------------
T
D
P
R
S
G
R
T
Y
L
K
G
R
L
---
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
--
S
-
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
Q
R
E
K
-
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
E
D
----
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
---
R
H
T
----
L
---
L
E
P
E
V
-
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
--
I
L
H
R
D
L
K
L
G
N
F
F
I
T
--
E
N
M
E
L
K
V
G
D
F
G
L
A
A
R
L
E
PP
E
Q
R
--
K
K
T
-----
I
-
C
G
T
P
N
Y
V
A
P
E
V
L
L
R
Q
G
----
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
-
F
-
E
T
A
D
L
K
E
T
Y
R
C
I
K
Q
V
H
Y
T
L
P
A
S
L
S
L
-------
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
------
P
S
---
I
D
Q
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
56.43
31%
-55
- C1 -
3OMV
1
RAF1_HUMAN
A:
[44-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
--
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
-
Q
A
-
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
VQET
K
F
Q
----
M
---
F
Q
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
--
V
K
I
G
D
F
G
L
A
T
V
------------------P
T
G
S
V
L
W
M
A
P
E
-
V
I
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
-
Y
S
H
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
NCP
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
PL
F
P
Q
I
L
S
---
S
I
E
L
L
Q
H
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
56.41
32%
-53
- C1 -
4EHE
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
-------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
56.39
32%
-50
- C1 -
3IDP
1
B:
[35-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
---------------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
56.33
32%
-48
- C1 -
3PSD
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
56.27
32%
-50
- C1 -
3TV4
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
HQF
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
56.21
32%
-46
- C1 -
4FC0
1
BRAF_HUMAN
A:
[20-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
------------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
55.99
32%
-59
- C1 -
4JVG
1
BRAF_HUMAN
C:
[24-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE
T
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
L
A
-----------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
55.94
32%
-48
- C1 -
4E26
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
------FEQ--
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
55.85
32%
-50
- C1 -
3TV6
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
55.79
32%
-49
- C1 -
3D4Q
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
55.73
32%
-45
- C1 -
3II5
1
B:
[42-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.64
32%
-42
- C1 -
3IDP
1
BRAF_HUMAN
A:
[35-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
---------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
55.58
32%
-51
- C1 -
4G9C
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
55.42
32%
-55
- C1 -
3PRF
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
55.39
32%
-49
- C1 -
3PSB
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
55.33
32%
-59
- C1 -
4WO5
1
B:
[40-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE
T
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
L
A
T
---------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
55.16
32%
-52
- C1 -
3TV6
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
---------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
55.14
32%
-53
- C1 -
4MBJ
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
55.11
32%
-51
- C1 -
4MNF
1
B:
[55-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
55.07
32%
-62
- C1 -
4JVG
1
BRAF_HUMAN
B:
[24-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE
T
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
L
A
T
----------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
54.96
32%
-53
- C1 -
3SKC
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
54.95
32%
-53
- C1 -
4EHG
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
54.93
31%
-58
- C1 -
3OMV
1
B:
[44-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
--
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
-
Q
A
-
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
VQET
K
F
Q
----
M
---
F
Q
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
--
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
T
--
V
K
I
G
D
F
G
L
A
T
V
------------------P
T
G
S
V
L
W
M
A
P
E
-
V
I
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
-
Y
S
H
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
Y
K
NCP
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
PLFPQI
L
S
---
S
I
E
L
L
Q
H
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
54.89
31%
-64
- C1 -
3OG7
1
BRAF_HUMAN
A:
[32-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
AS---
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
------------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.80
32%
-50
- C1 -
3PRI
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
54.75
32%
-49
- C1 -
3PRI
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
54.73
32%
-47
- C1 -
3PPK
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.73
32%
-57
- C1 -
3P86
1
CTR1_ARATH
A:
[44-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
I
G
A
G
S
F
G
T
V
H
R
A
----
E
W
HG
S
-
D
V
A
V
K
I
L
M
E
Q
D
F
H
A
E
R
V
-
N
E
-
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
----
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
----
K
S
G
----
A
R
E
Q
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
-
K
K
Y
-
T
V
K
V
C
D
F
-------------------------
G
T
P
E
W
M
A
P
E
V
L
R
D
E
P
----
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
L
Q
Q
P
-
W
G
N
L
-
N
P
A
Q
V
V
A
--
A
V
G
F
K
C
K
R
L
E
I
P
R
N
L
N
---
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
------
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
54.72
32%
-53
- C1 -
4E4X
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
54.67
32%
-49
- C1 -
4G9C
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
54.65
32%
-49
- C1 -
4MNF
1
BRAF_HUMAN
A:
[55-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
54.49
32%
-49
- C1 -
3PPJ
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
54.27
32%
-50
- C1 -
3D4Q
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
54.24
32%
-48
- C1 -
1UWJ
1
B:
[15-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
K
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
53.76
32%
-48
- C1 -
3PRF
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.67
32%
-58
- C1 -
3PPZ
1
CTR1_ARATH
A:
[44-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
I
G
A
G
S
F
G
T
V
H
R
A
----
E
W
HG
S
-
D
V
A
V
K
I
L
M
E
----
A
E
R
V
-
N
E
-
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
M
G
A
----
V
T
Q
P
P
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
H
----
K
S
G
----
A
REQ
L
D
E
R
R
R
L
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
-
K
K
Y
-
T
V
K
V
C
D
F
G
L
S
R
L
K
A
--
S
T
F
LS
S
K
S
-----
A
-
A
G
T
P
E
W
M
A
P
E
V
L
R
D
E
P
----
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
L
Q
Q
P
-
W
G
N
L
-
N
P
A
Q
V
V
A
--
A
V
G
F
K
C
K
R
L
E
I
P
R
N
L
N
---
P
Q
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
------
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
53.57
32%
-58
- C1 -
4FK3
1
BRAF_HUMAN
A:
[32-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASE
T
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
-----------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
53.43
31%
-52
- C1 -
1UWH
1
BRAF_HUMAN
A:
[15-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
53.26
32%
-54
- C1 -
5C9C
1
?
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
----------------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
52.93
32%
-54
- C1 -
4PP7
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
-------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
52.84
31%
-50
- C1 -
1UWH
1
B:
[15-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-----------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
52.67
32%
-60
- C1 -
4JVG
1
BRAF_HUMAN
A:
[24-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
----------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
52.59
32%
-52
- C1 -
3SKC
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
---------------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
52.59
32%
-47
- C1 -
3II5
1
BRAF_HUMAN
A:
[42-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------Q----
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
52.49
32%
-49
- C1 -
4PP7
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
R
W
--
S
G
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
51.81
32%
-43
- C1 -
4G9R
1
B:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIE
T
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
K
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
51.40
32%
-48
- C1 -
1UWJ
1
BRAF_HUMAN
A:
[15-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
K
--
S
---------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
50.67
32%
-56
- C1 -
4JVG
1
D:
[24-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
ASET
K
F
E
----
M
---
K
K
---
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
--
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
-
K
--
S
----------------
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
E
--
M
V
G
R
G
S
L
S
P
D
L
S
K
V
R
S
NCP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
S
---
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.50
31%
-47
- C1 -
2WQN
1
NEK7_HUMAN
A:
[34-282]
------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
I
E
KK
I
G
R
G
Q
F
S
E
V
Y
R
A
A
C
L
L
D
G
--
V
-
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
-
R
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
Y
A
S
F
--
I
E
D
N
E
L
N
I
V
L
--
E
L
A
D
A
G
D
L
S
R
M
I
K
----
H
F
K
K
Q
KR
L
---
I
P
E
R
T
V
W
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
R
--
V
M
H
R
D
I
K
P
A
N
V
F
I
T
-
A
-
T
G
V
V
K
L
G
D
L
--------------------------
T
P
Y
Y
M
S
P
E
R
I
H
E
N
G
----
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F
Y
---
M
N
L
Y
S
L
C
K
--
K
I
E
Q
C
D
Y
P
P
L
P
S
D
H
Y
S
---
E
E
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
------
P
D
---
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
49.31
32%
-43
- C1 -
4G9R
1
BRAF_HUMAN
A:
[43-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------
R
--
I
G
S
G
S
F
G
T
V
Y
K
G
----
K
W
H-
G
-
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
-
Q
A
-
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-----
Y
S
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
IIET
K
F
E
----
M
---
I
K
---
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
--
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-
E
K
--
S
---------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
-
Y
S
N
I
N
N
R
D
Q
I
I
F
--
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
R
S
NCP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
------
P
L
---
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------