@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : WNK4_HUMAN: (2015-10-22 )
MLASPATETTVLMSQTEADLALRPPPPLGTAGQPRLGPPPRRARRFSGKAEPRPRSSRLSRRSSVDLGLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPGSREPLRVPEAVALERRREQEEKEDMETQAVATSPDGRYLKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKVKIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREKLRKARELEALPPEPGPPPATVPMAPGPPSVFPPEPEEPEADQHQPFLFRHASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGVPSSLAESHLCLPSAFALSIPRSGPGSDFSPGDSYASDAASGLSDVGEGMGQMRRPPGRNLRRRPRSRLRVTSVSDQNDRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPSNEELQSSTSLEHRSWTAFSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFSPISSQVSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPSTSSFPSTTAAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEPQVGGSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQKKEIEDLYSRLGKQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGSSTGSQEQRASKGVTFAGDVGRM
Atome Classification :
(74 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.-----......180...---....190........200.......210..-.-....220.......230....--..-.240.......----250.......260....----.----..---270.----.....--.280.......290.......300.......310.......320.....-.-.330--.---...-...340....-..----.350---........360.......370..---.....380.......390.......400.--.---..-.....410.......420-.........430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLASPAT
E
T
T
V
L
M
SQTEADLALRPPPPLGTAGQPRLGPP
P
R
R
A
R
RFSGKAEPR
P
R
S
S
R
LSRRSSV
D
L
GLLSSWSLPASPAPDPPDPPDSAGPGPARSPPPSSKEPPEGTWTEGAPVKAAEDSARPELPDSAVGPGSREPLRV
P
E
A
V
A
L
E
R
R
R
E
Q
E
E
K
E
D
M
E
T
Q
A
V
A
TSPDG
R
Y
-----
L
K
F
D
I
E
IGRG
S
F
---
K
T
V
Y
RG-LDTD
T
T
V
E
V
A
W
C
E
L
Q
T
R
K
L
S
R
A
E
-
R
-
Q
R
F
S
E
E
V
E
M
L
KGLQHP
N
I
V
R
F
--
Y
D
-
S
W
K
S
V
L
RGQ
V
C
----
I
V
L
V
T
E
L
MTS
G
T
L
K
T
Y
L
----
R
----
R
F
---
R
EM
K
----
P
R
V
L
Q
--
R
W
S
R
Q
I
L
R
G
L
H
F
L
H
SRV
P
P
I
L
H
RDLKCD
N
V
F
I
TGPTG
S
V
K
IG
D
L
G
L
A
T
L
-
K
-
R
A
S
F
--
A
---
K
S
V-IGTPEFM
A
P
E
-
M
Y
----
E
E
K
----
Y
D
E
A
V
D
V
Y
A
F
G
M
C
M
L
E
MATSEY
P
---
Y
S
E
C
Q
N
A
A
Q
I
Y
R
K
V
TSGRKPNS
F
H
KV--K--
I
---
P
E
-
V
K
E
I
I
E
G
C
I
RTDKNE
R
---
F
T
I
Q
D
L
L
A
H
A
F
F
R
EER
G
V
H
V
E
LAEEDDGEKP
G
L
K
L
W
L
R
M
E
D
ARRGGRPRD
N
Q
A
I
E
F
L
F
Q
L
G
R
D
A
A
E
E
V
A
Q
E
M
V
A
L
G
L
V
CEA
D
Y
Q
P
V
A
R
A
V
R
E
R
V
A
A
I
Q
R
K
R
E
K
L
R
K
A
R
E
L
EALPPEPGPPPATVPMAPGPPSVFPPEPEEPEADQHQ
P
F
L
F
R
HASYSSTTSDCETDGYLSSSGFLDASDPALQPPGGV
P
S
S
L
A
E
SHLCLP
S
A
F
A
LSIPRSGPGSDFSPGDS
Y
A
S
D
A
A
S
G
L
S
D
V
G
E
G
M
G
QMRRPPGR
N
L
R
RRPRS
R
L
R
V
T
SVSDQN
D
R
V
V
E
C
Q
L
QTHN
S
K
M
V
T
F
R
F
DLDGD
S
P
E
E
I
A
A
A
M
V
Y
N
E
FILPSER
D
G
F
L
R
R
I
R
E
I
I
Q
R
V
E
T
L
L
KRDTGPMEAAEDTLSPQEEPAPLPALPVPLPDPS
N
E
E
L
Q
SSTSLEH
R
S
W
T
A
FSTSSSSPGTPLSPGNPFSPGTPISPGPIFPITSPPCHPSPSPFS
P
I
S
S
Q
VSSNPSPHPTSSPLPFSSSTPEFPVPLSQCPWSSLPTTSPPTFSPTC
S
Q
V
TLSSPFFPPCPSTSSFPS
T
T
A
A
P
L
L
S
L
A
S
A
F
S
L
A
V
M
T
V
A
Q
S
LLSPSPGLLSQSPPAPPSPLPSLPLPPPVAPGGQESPSPH
T
A
EVESEASPPPARPLPGEARLAPISEEGKP
Q
L
V
G
R
F
Q
VTSSKEPAEPLPLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGG
P
E
T
R
E
A
L
A
ESDR
A
A
EGLGAGVEEEGDDGKEPQVGGSPQPLSHPS
P
V
W
M
NYS
Y
S
S
L
CLSSEESESSG
E
D
E
E
F
W
A
E
L
Q
S
L
R
Q
K
H
L
S
E
V
E
T
L
Q
T
L
Q
K
K
E
I
E
D
L
Y
S
R
LGKQPPPGI
V
A
P
A
A
M
L
S
S
R
Q
R
R
LSKGSFPT
S
R
RNSLQRSEPPGPGI
M
R
RNSLSGSSTG
S
Q
E
Q
R
ASKG
V
T
FAGDVGRM
3
PsiBlast_PDB
89.39
77%
-97
- C2 -
3FPQ
4
WNK1_RAT
A:
[17-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
V
G
M
S
N
D
G
R
F
-----
L
K
F
D
I
E
I
G
R
G
S
F
---
K
T
V
Y
K
G
-
L
D
T
E
T
T
V
E
V
A
W
C
E
L
Q
D
R
K
L
T
K
S
E
-
R
-
Q
R
F
K
E
E
A
E
M
L
K
G
L
Q
H
P
N
I
V
R
F
--
Y
D
-
S
W
E
S
T
V
K
G
K
K
C
----
I
V
L
V
T
E
L
M
T
S
G
T
L
K
T
Y
L
----
K
----
R
F
---
K
V
M
K
----
I
K
V
L
R
--
S
W
C
R
Q
I
L
K
G
L
Q
F
L
H
T
R
T
P
P
I
I
H
R
D
L
K
C
D
N
I
F
I
T
G
P
T
G
S
V
K
I
G
D
L
G
L
A
T
L
-
K
-
R
A
S
F
--
A
---
K
A
V
-
I
G
T
P
E
F
M
A
P
E
-
M
Y
----
E
E
K
----
Y
D
E
S
V
D
V
Y
A
F
G
M
C
M
L
E
M
A
T
S
E
Y
P
---
Y
S
E
C
Q
N
A
A
Q
I
Y
R
R
V
T
S
G
V
K
P
A
S
F
D
K
V
--
A
--
I
---
P
E
-
V
K
E
I
I
E
G
C
I
R
Q
N
K
D
E
R
---
Y
S
I
K
D
L
L
N
H
A
F
F
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
64.41
32%
-81
* C2 *
5CT7
1
?
A:
[11-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.32
31%
-81
- C2 -
2WQN
1
NEK7_HUMAN
A:
[21-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
R
P
D
M
G
Y
NTLAN
F
R
I
E
K
K
I
G
R
G
Q
F
---
S
E
V
Y
R
A
-
A
C
L
L
D
G
V
P
V
A
L
K
K
V
Q
I
F
D
L
M
D
A
K
A
R
-
A
D
C
I
K
E
I
D
L
L
K
Q
L
N
H
P
N
V
I
K
Y
--
Y
A
-
S
F
--
I
E
D
N
E
L
N
----
I
V
L
--
E
L
A
D
A
G
D
L
S
R
M
I
----
K
----
H
F
---
K
K
Q
K
RLIP
E
R
T
V
W
--
K
Y
F
V
Q
L
C
S
A
L
E
H
M
H
S
R
--
R
V
M
H
R
D
I
K
P
A
N
V
F
I
T
A
-
T
G
V
V
K
L
G
D
L
------------------------
T
P
Y
Y
M
S
P
E
R
I
H
----
E
N
G
----
Y
N
F
K
S
D
I
W
S
L
G
C
L
L
Y
E
M
A
A
L
Q
S
P
F--
Y
---
M
N
L
Y
S
L
C
K
K
I
E
Q
C
D
Y
P
P
L
P
S
D
H
--
Y
--
S
---
E
E
-
L
R
Q
L
V
N
M
C
I
N
P
D
P
E
K
R
---
P
D
V
T
Y
V
Y
D
V
A
K
R
M
H
A
C
T
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
63.12
32%
-78
- C2 -
3PPK
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
62.90
32%
-80
- C2 -
5CT7
1
?
B:
[11-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
-----------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
62.75
32%
-80
- C2 -
4EHG
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
-------------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
62.32
32%
-78
- C2 -
3TV4
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
--
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
62.20
32%
-76
- C2 -
4MBJ
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
---------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
61.74
32%
-80
- C2 -
3IDP
1
B:
[26-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
-------------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
61.60
32%
-75
- C2 -
3IDP
1
BRAF_HUMAN
A:
[26-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQ--
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
61.31
32%
-75
- C2 -
3II5
1
B:
[33-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
--------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
61.18
32%
-78
- C2 -
4KSP
1
BRAF_HUMAN
A:
[11-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
61.10
32%
-77
- C2 -
4FC0
1
BRAF_HUMAN
A:
[11-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
M---
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
60.56
32%
-77
- C2 -
3II5
1
BRAF_HUMAN
A:
[33-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
--------------
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
60.48
32%
-78
- C2 -
4E4X
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
---------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
60.34
32%
-76
- C2 -
3PPJ
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
60.22
32%
-74
- C2 -
4MBJ
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.10
32%
-75
- C2 -
3PPJ
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
59.95
32%
-74
- C2 -
4EHE
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
HQF
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
59.82
32%
-74
- C2 -
3PPK
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
59.75
34%
-85
- C2 -
3P86
1
CTR1_ARATH
A:
[39-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
I
K
E
K
I
G
A
G
S
F
---
G
T
V
H
R
A
-
E
W
H
G
S
D
V
A
V
---
K
I
L
M
E
Q
D
F
H
A
E
-
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
--
M
---------
G
A
V
T
QPP
N
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
----
H
----
K
S
G
A
R
E
Q
L
D
----
E
R
R
R
L
--
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
N
L
K
S
P
N
L
L
V
D
K
K
Y
-
T
V
K
V
C
D
F
-----------------------
G
T
P
E
W
M
A
P
E
-
V
L
R
---
D
E
P
----
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
L
Q
Q
P
---
W
G
N
L
-
N
P
A
Q
V
V
A
A
V
G
F
K
C
K
R
L
E
I
P
R
N
--
L
--
N
---
P
Q
-
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
PS
F
A
T
I
M
D
L
L
R
P
L
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
59.62
32%
-75
- C2 -
3PSB
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
59.61
32%
-74
- C2 -
4E26
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
------F--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
59.53
32%
-75
- C2 -
3PSD
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
59.39
32%
-74
- C2 -
3TV6
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.35
32%
-75
- C2 -
3PSB
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
59.34
32%
-78
- C2 -
4G9C
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
59.28
32%
-76
- C2 -
3PRF
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------------
G
S
I
L
W
M
A
P
E
-
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
59.26
32%
-77
- C2 -
4E26
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S--------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
59.21
32%
-75
- C2 -
3TV6
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
-----------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
59.11
32%
-80
- C2 -
5C9C
1
?
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
--
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
--------------------
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.05
32%
-73
- C2 -
3D4Q
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
59.01
32%
-73
- C2 -
3PSD
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
59.01
32%
-76
- C2 -
3OG7
1
BRAF_HUMAN
A:
[22-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
---------
G
Y
S
T
AP
Q
-
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
AS---
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
----
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
58.97
32%
-74
- C2 -
4G9C
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
-------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
58.86
32%
-77
- C2 -
3SKC
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
-------------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
58.82
32%
-79
- C2 -
3PRF
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
58.55
32%
-80
- C2 -
4H58
1
BRAF_HUMAN
A:
[6-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S---------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
58.45
32%
-75
- C2 -
4EHG
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
------------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
58.33
32%
-77
- C2 -
4EHE
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.28
33%
-65
- C2 -
4WO5
1
BRAF_HUMAN
A:
[30-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE-
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
----F--
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
----
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
58.23
32%
-73
- C2 -
3D4Q
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
58.08
32%
-76
- C2 -
3TV4
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
HQF
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
57.98
32%
-72
- C2 -
1UWJ
1
B:
[6-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
-
K
----------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
57.98
32%
-76
- C2 -
4PP7
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
---------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.93
34%
-75
- C2 -
3PPZ
1
CTR1_ARATH
A:
[39-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
I
K
E
K
I
G
A
G
S
F
---
G
T
V
H
R
A
-
E
W
H
G
S
D
V
A
V
---
K
I
L
M
E
----
A
E
-
R
V
N
E
F
L
R
E
V
A
I
M
K
R
L
R
H
P
N
I
V
L
F
--
M
---------
G
A
V
T
QPPN
L
S
I
V
T
E
Y
L
S
R
G
S
L
Y
R
L
L
----
H
----
K
S
GAR
E
Q
L
D
----
E
R
R
R
L
--
S
M
A
Y
D
V
A
K
G
M
N
Y
L
H
N
R
N
P
P
I
V
H
R
D
L
K
S
P
N
L
L
V
D
K
K
Y
-
T
V
K
V
C
D
F
G
L
S
R
L
-
K
-
A
S
T
F
LS
S
---
K
S
A
-
A
G
T
P
E
W
M
A
P
E
-
V
L
R---
D
E
P
----
S
N
E
K
S
D
V
Y
S
F
G
V
I
L
W
E
L
A
T
L
Q
Q
P
---
W
G
N
L
-
N
P
A
Q
V
V
A
A
V
G
F
K
C
K
R
L
E
I
P
R
N
--
L
--
N
---
P
Q
-
V
A
A
I
I
E
G
C
W
T
N
E
P
W
K
R
P
S
F
A
T
I
M
D
L
L
R
P
L
I
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
57.65
32%
-74
- C2 -
1UWJ
1
BRAF_HUMAN
A:
[6-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
-
K
S---------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
57.64
32%
-75
- C2 -
3PRI
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
57.45
32%
-74
- C2 -
3SKC
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
57.36
32%
-75
- C2 -
3PRI
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
57.16
33%
-62
- C2 -
3C4C
1
BRAF_HUMAN
A:
[10-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
---------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
56.90
33%
-64
- C2 -
4CQE
1
?
A:
[8-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
-----
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
56.63
32%
-70
- C2 -
4G9R
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
-
K
----------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
56.58
32%
-69
- C2 -
4G9R
1
BRAF_HUMAN
A:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
-
K
S---------------
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
56.39
31%
-76
- C2 -
1UWH
1
BRAF_HUMAN
A:
[6-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
A
P
Q
-----------
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
56.33
33%
-70
- C2 -
4CQE
1
?
B:
[8-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
------
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
----------------------
G
S
I
L
W
M
A
P
E
-
V
I
----
R
--NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
55.87
33%
-63
- C2 -
4JVG
1
BRAF_HUMAN
C:
[14-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE
T
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
---------------------
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
55.85
32%
-73
- C2 -
4E4X
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
55.75
31%
-74
- C2 -
1UWH
1
B:
[6-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
A
P
Q
-----------
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
---------------
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
RMQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
55.41
33%
-65
- C2 -
4FK3
1
BRAF_HUMAN
A:
[22-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE
T
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
---------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
----
R
M
-NP--
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
55.19
32%
-66
- C2 -
4MNF
1
B:
[46-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIET
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
-------------------
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
A
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
54.74
33%
-67
- C2 -
3C4C
1
B:
[10-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
----------------------
S
G
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
54.64
32%
-61
- C2 -
4MNF
1
BRAF_HUMAN
A:
[46-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
E
-------------------
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DKNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
A
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
54.52
32%
-73
- C2 -
4PP7
1
B:
[34-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
Y
S
T
K
P
Q
L
----------
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
IIE
T
K
F
---
E
M
I
K
-------
L
I
--
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
D
L
-
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S
R
W
S
G
--
S
H
Q
F
E
Q
L
-
S
G
S
I
L
W
M
A
P
E
-
V
I
R
MQD
K
N
P
----
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
L
S
P
D
L
S
K
V
--
R
SN
C
---
P
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
L
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
54.48
33%
-68
- C2 -
4WO5
1
B:
[30-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE
T
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
-------------------
G
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
54.05
33%
-62
- C2 -
4JVG
1
BRAF_HUMAN
A:
[14-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S----------------
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
54.03
33%
-64
- C2 -
4JVG
1
BRAF_HUMAN
B:
[14-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASE
T
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
--------------------
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
53.11
33%
-58
- C2 -
4JVG
1
D:
[14-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
G
Q
------
I
T
V
G
Q
R
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
L
N
V
T
A
P
T
P
Q
Q
-
L
-
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
MG
Y
S
-
T
-----
K
P
Q
L
A
----
I
V
--
T
Q
W
C
E
G
S
S
L
Y
H
H
L
----
H
ASET
K
F
----
E
M
K
----
K
--
L
I
--
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
--
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
-
E
D
N
T
V
K
I
G
D
F
G
L
A
T
V
-
K
S----------------
S
I
L
W
M
A
P
E
-
V
I
----
R
M
Q
DSNP
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
---
Y
S
N
I
N
N
R
D
Q
I
I
E
M
V
G
R
G
S
L
S
P
D
L
S
K
V
--
R
--
S
NCP
K
R
-
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
---
P
S
F
P
R
I
L
A
E
I
E
E
L
A
R
E
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
52.87
30%
-86
- C2 -
2XNO
13
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
-
S
D
G
K
I
L
V
---
W
K
E
L
D
Y
G
S
M
T
E
A
E
-
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
--
Y
D
---
R
I
I
D
R
T
N
T
T
----
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
----
E
R
---
Q
Y
L
D
----
E
E
F
V
L
--
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
-----
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
V
K
L
G
D
F
--------------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
-
R
E
G
K
F
R
R
I
P
Y
R
Y
S
D
-----------
E
-
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
---
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
52.77
30%
-86
- C2 -
2XNM
10
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
-
S
D
G
K
I
L
V
---
W
K
E
L
D
Y
G
S
M
T
E
A
E
-
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
--
Y
D
---
R
I
I
D
R
T
N
T
T
----
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
----
E
R
---
Q
Y
L
D
----
E
E
F
V
L
--
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
V
K
L
G
D
F
G
L
A
R
I
L--------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
R
-
S
----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
-
R
E
G
K
F
R
R
I
P
Y
R
Y
S
D
-----------
E
-
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
---
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
51.91
31%
-70
- C2 -
3OMV
1
RAF1_HUMAN
A:
[44-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
I
----
L
K
V
V
D
P
T
P
E
Q
-
F
-
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
-
Y
M
T
-----
K
D
N
----
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
----
H
-----
V
---
Q
E
T
K
----
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
-
T
V
K
I
G
D
F
G
L
A
T
V
----------------P
T
G
S
V
L
W
M
A
P
E
-
V
I
----
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
---
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
YK
N
--
C
---
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
---
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
51.58
30%
-84
- C2 -
2XNP
6
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
-
Y
G
R
C
Q
K
I
R
R
K
-
S
D
G
K
I
L
V
---
W
K
E
L
D
Y
G
S
M
T
E
A
E
-
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
--
Y
D
---
R
I
I
D
R
T
N
T
T
----
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
----
E
R
---
Q
Y
L
D
----
E
E
F
V
L
--
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
----
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
V
K
L
G
D
F
G
L
------------------
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
R
-------
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
-
R
E
G
K
F
R
R
I
P
Y
R
Y
S
D
-----------
E
-
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
---
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
50.64
30%
-90
- C2 -
2W5A
5
NEK2_HUMAN
A:
[14-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
-
S
D
G
K
I
L
V
---
W
K
E
L
D
Y
G
S
M
T
E
A
E
-
K
-
Q
M
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
--
Y
D
---
R
I
I
D
R
T
N
T
T
----
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
K
G
T
K
----
E
R
---
Q
Y
L
D
----
E
E
F
V
L
--
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
-
N
V
K
L
G
D
F
G
L
A
R
I
L---
T
S
F
--
A
---
K
T
F
-
V
G
T
P
Y
Y
M
S
P
E
Q
M
N
----
R
M
-----
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
P
P
FTA
F
S
Q
K
E
L
A
G
K
I
-
R
E
G
K
F
R
R
I
P
Y
R
Y
S
D
-----------
E
-
L
N
E
I
I
T
R
M
L
N
L
K
D
Y
H
R
---
P
S
V
E
E
I
L
E
N
P
L
I
L
E
H
H
H
H
H
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
49.87
31%
-75
- C2 -
3OMV
1
B:
[44-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
S
G
S
F
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
I
----
L
K
V
V
D
P
T
P
E
Q
-
F
-
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
--
M
G
-
Y
M
T
-----
K
D
N
----
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
----
H
-----
V
---
Q
E
T
K
----
F
Q
M
F
Q
LI
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
--
N
I
I
H
R
D
M
K
S
N
N
I
F
L
H
E
G
L
-
T
V
K
I
G
D
F
G
L
A
T
V
----------------P
T
G
S
V
L
W
M
A
P
E
-
V
I
----
R
M
Q
DNNP
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
---
Y
S
H
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
Y
A
S
P
D
L
S
K
L
YK
N
--
C
---
P
K
A
M
K
R
L
V
A
D
C
V
K
K
V
K
E
E
R
---
P
L
F
P
Q
I
L
S
S
I
E
L
L
Q
H
S
L
P
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------