@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ZAP70_HUMAN: (2015-10-22 )
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRDAMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPGSTQKAEAACA
Atome Classification :
(104 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190-.-.-.-....200-----..-----.....210.......220.......230.......240.......250....-...260.......270.......280.......290.......300....--...310....-...320.......330.......340.--......350.....--.-.---360.--.......370-..-.....380.......390.......400...-..-.-.-410.......420......-.-430-.--.-.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540..-.....550.......560.......570.......580.......590......--.600.......610.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPDPAAHL
P
F
F
YGSI
S
R
A
E
A
E
E
H
L
K
L
AGMA
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
FHHFP
I
E
RQLNG
T
Y
A
IAGGKAHC
G
P
A
E
L
C
E
F
YSRDPDGLPCNLRKPCNRPSGLEPQP
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
WKL
E
G
E
A
L
E
Q
A
I
I
SQA
P
Q
V
E
K
L
I
A
T
T
A
HERMP
W
Y
H
SSL
T
R
E
E
A
E
R
K
L
YSGAQTD
G
K
F
L
LRPR-K-E-Q-G
T
Y
A
L
S
L
-----
I
Y-----GK
T
V
Y
H
Y
LISQDKAG
K
Y
CIPEGT
K
F
D
T
L
W
Q
L
V
E
Y
L
K
LKAD
G
L
I
Y
C
L
K
E
ACPN-SSASNASGAAAPTLPAHPSTLT
H
P
Q
R
R
IDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYE-SPYS
D
P
E
E
LKDK
K
L
F
L
KRD
N
L
L
I
A
D
I
E--LGCGN
F
G
S
V
R
Q
G
V
Y
--
R
-
M
---
R
K
-
K
--
Q
I
D
V
A
I
K
V
L
K
-QG-TEKA
D
T
E
E
M
M
R
E
A
Q
I
M
H
QLDNP
Y
I
V
R
L
I
G
V
C
-
Q
A
-
E
-
A
-
L
M
L
V
M
E
MAGG
G
P
L
H
K
F
L
VG-K-R---E--E-I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
EKN
F
V
H
R
D
LAAR
N
V
L
L
VNRHY
A
K
I
S
DFGLSKALGADDS
Y
Y
TARSAGKWP
L
K
WYAPECI
N
F
RKFSSRS
D
V
W
S
Y
G
V
T
M
W
E
A
L
SYGQ
K
P
Y
K
KMK-G
P
E
V
M
A
F
I
EQGKRMECPPEC
P
P
E
L
Y
A
L
M
SD
C
W
I
Y
KWEDRPDF
L
T
V
E
Q
R
M
R
A
C
Y
Y
--
S
L
A
S
KVEGPPGSTQKAEAACA
1
PsiBlast_PDB
89.92
99%
-108
- C1 -
4K2R
1
ZAP70_HUMAN
A:
[2-609]
-
P
D
P
A
A
H
L
P
F
F
Y
G
S
I
S
R
A
E
A
E
E
H
L
K
L
A
G
M
A
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
F
H
H
F
P
I
E
R
Q
L
N
G
T
Y
A
I
A
G
G
K
A
H
C
G
P
A
E
L
C
E
F
Y
S
R
D
P
D
G
L
P
C
N
L
R
K
P
C
N
R
P
S
G
L
E
P
Q
P
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
W
K
L
E
G
E
A
L
E
Q
A
I
I
S
Q
A
P
Q
V
E
K
L
I
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
-
Q
-
G
T
Y
A
L
S
L
-----
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
-
S
---------------------------------------------
D
K
P
R
--
P
M
P
M
D
T
S
V
Y
E
-
S
P
Y
S
D
P
E
E
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
--
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
-
M
---
R
K
-
K
--
Q
I
D
V
A
I
K
V
L
K
-
Q
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
-
Q
A
-
E
-
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
---
E
--
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
-----------------
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
--
S
L
A
S
K
V
E
G
G
S
G
L
E
V
L
F
-----
2
PsiBlast_PDB
89.35
99%
-112
- C1 -
2OZO
1
ZAP70_HUMAN
A:
[2-606]
-
P
D
P
A
A
H
L
P
F
F
Y
G
S
I
S
R
A
E
A
E
E
H
L
K
L
A
G
M
A
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
F
H
H
F
P
I
E
R
Q
L
N
G
T
Y
A
I
A
G
G
K
A
H
C
G
P
A
E
L
C
E
F
Y
S
R
D
P
D
G
L
P
C
N
L
R
K
P
C
N
R
P
S
G
L
E
P
Q
P
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
W
K
L
E
G
E
A
L
E
Q
A
I
I
S
Q
A
P
Q
V
E
K
L
I
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
-
Q
-
G
T
Y
A
L
S
L
-----
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
--------------------------------------------------------
M
D
T
S
V
F
E
-
S
P
F
S
D
P
E
E
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
--
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
-
M
---
R
K
-
K
--
Q
I
D
V
A
I
K
V
L
K
-
Q
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
-
Q
A
-
E
-
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
---
E
--
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
--------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
--
S
L
A
S
K
V
E
G
G
S
A
L
E
V
A
------
125
HHSearch
89.06
99%
-110
- C1 -
2OZO
1
ZAP70_HUMAN
A:
[2-611]
-
P
D
P
A
A
H
L
P
F
F
Y
G
S
I
S
R
A
E
A
E
E
H
L
K
L
A
G
M
A
D
G
L
F
L
L
R
Q
C
L
R
S
L
G
G
Y
V
L
S
L
V
H
D
V
R
F
H
H
F
P
I
E
R
Q
L
N
G
T
Y
A
I
A
G
G
K
A
H
C
G
P
A
E
L
C
E
F
Y
S
R
D
P
D
G
L
P
C
N
L
R
K
P
C
N
R
P
S
G
L
E
P
Q
P
G
V
F
D
C
L
R
D
A
M
V
R
D
Y
V
R
Q
T
W
K
L
E
G
E
A
L
E
Q
A
I
I
S
Q
A
P
Q
V
E
K
L
I
A
T
T
A
H
E
R
M
P
W
Y
H
S
S
L
T
R
E
E
A
E
R
K
L
Y
S
G
A
Q
T
D
G
K
F
L
L
R
P
R
-
K
-
E
-
Q
-
G
T
Y
A
L
S
L
-----
I
Y
-----
G
K
T
V
Y
H
Y
L
I
S
Q
D
K
A
G
K
Y
C
I
P
E
G
T
K
F
D
T
L
W
Q
L
V
E
Y
L
K
L
K
A
D
G
L
I
Y
C
L
K
E
A
C
P
N
--------------------------------------------------------
M
D
T
S
V
F
E
-
S
P
F
S
D
P
E
E
L
K
D
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
--
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
-
M
---
R
K
-
K
--
Q
I
D
V
A
I
K
V
L
K
-
Q
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
-
Q
A
-
E
-
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
---
E
--
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
N
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
--------------
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
--
S
L
A
S
K
V
E
G
G
S
A
L
E
V
A
------
126
HHSearch
79.32
56%
-111
- C1 -
4FL3
1
KSYK_HUMAN
A:
[9-635]
---
S
A
N
H
L
P
F
F
F
G
N
I
T
R
E
E
A
E
D
Y
L
V
Q
G
G
M
S
D
G
L
Y
L
L
R
Q
S
R
N
Y
L
G
G
F
A
L
S
V
A
H
G
R
K
A
H
H
Y
T
I
E
R
E
L
N
G
T
Y
A
I
A
G
G
R
T
H
A
S
P
A
D
L
C
H
Y
H
S
Q
E
S
D
G
L
V
C
L
L
K
K
P
F
N
R
P
Q
G
V
Q
P
K
T
G
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
T
W
N
L
Q
G
Q
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
-
N
-
G
S
Y
A
L
C
L
-----
L
H
-----
E
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
-------------------------------------------------
R
E
--
A
L
P
M
D
T
E
V
F
E
-
S
P
F
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
-
N
E
A
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
-------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
4
PsiBlast_PDB
79.08
53%
-111
- C1 -
4FL3
1
KSYK_HUMAN
A:
[9-635]
---
S
A
N
H
L
P
F
F
F
G
N
I
T
R
E
E
A
E
D
Y
L
V
Q
G
G
M
S
D
G
L
Y
L
L
R
Q
S
R
N
Y
L
G
G
F
A
L
S
V
A
H
G
R
K
A
H
H
Y
T
I
E
R
E
L
N
G
T
Y
A
I
A
G
G
R
T
H
A
S
P
A
D
L
C
H
Y
H
S
Q
E
S
D
G
L
V
C
L
L
K
K
P
F
N
R
P
Q
G
V
Q
P
K
T
G
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
T
W
N
L
Q
G
Q
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
-
N
-
G
S
Y
A
L
C
L
-----
L
H
-----
E
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
---------------------------------------------------RE
A
L
P
M
D
T
E
V
F
E
-
S
P
F
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N
E
A
-
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
-------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
3
PsiBlast_PDB
78.10
54%
-108
- C1 -
4FL2
1
KSYK_HUMAN
A:
[10-636]
---
S
A
N
H
L
P
F
F
F
G
N
I
T
R
E
E
A
E
D
Y
L
V
Q
G
G
M
S
D
G
L
Y
L
L
R
Q
S
R
N
Y
L
G
G
F
A
L
S
V
A
H
G
R
K
A
H
H
Y
T
I
E
R
E
L
N
G
T
Y
A
I
A
G
G
R
T
H
A
S
P
A
D
L
C
H
Y
H
S
Q
E
S
D
G
L
V
C
L
L
K
K
P
F
N
R
P
Q
G
V
Q
P
K
T
G
P
F
E
D
L
K
E
N
L
I
R
E
Y
V
K
Q
T
W
N
L
Q
G
Q
A
L
E
Q
A
I
I
S
Q
K
P
Q
L
E
K
L
I
A
T
T
A
H
E
K
M
P
W
F
H
G
K
I
S
R
E
E
S
E
Q
I
V
L
I
G
S
K
T
N
G
K
F
L
I
R
A
R
-
D
-
N
-
N
-
G
S
Y
A
L
C
L
-----
L
H
-----
E
G
K
V
L
H
Y
R
I
D
K
D
K
T
G
K
L
S
I
P
E
G
K
K
F
D
T
L
W
Q
L
V
E
H
Y
S
Y
K
A
D
G
L
L
R
V
L
T
V
P
C
Q
K
I
G
T
Q
-----------------------------------------------RE
A
L
P
M
D
T
E
V
Y
E
-
S
P
Y
A
D
P
E
E
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N
E
A
-
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
5
PsiBlast_PDB
59.39
100%
-113
- C1 -
1U59
1
A:
[2-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
F
L
K
R
D
N
L
L
I
A
D
I
E
--
L
G
C
G
N
F
G
S
V
R
Q
G
V
Y
--
R
--------
K
--
Q
I
D
V
A
I
K
V
L
K
-
Q
G
-
T
E
K
A
D
T
E
E
M
M
R
E
A
Q
I
M
H
Q
L
D
N
P
Y
I
V
R
L
I
G
V
C
-
Q
A
-
E
-
A
-
L
M
L
V
M
E
M
A
G
G
G
P
L
H
K
F
L
V
G
-
K
-
R
---
E
--
E
-
I
P
V
S
N
V
A
E
L
L
H
Q
V
S
M
G
M
K
Y
L
E
E
K
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
N
R
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
G
A
D
D
S
Y
Y
T
A
R
S
A
G
K
W
P
L
K
W
Y
A
P
E
C
I
N
F
R
K
F
S
S
R
S
D
V
W
S
Y
G
V
T
M
W
E
A
L
S
Y
G
Q
K
P
Y
K
K
M
K
-
G
P
E
V
M
A
F
I
E
Q
G
K
R
M
E
C
P
P
E
C
P
P
E
L
Y
A
L
M
S
D
C
W
I
Y
K
W
E
D
R
P
D
F
L
T
V
E
Q
R
M
R
A
C
Y
Y
--
S
L
A
S
K
V
E
G
H
H
H
H
H
H
-------
129
HHSearch
54.62
37%
-102
- C1 -
2H8H
1
SRC_HUMAN
A:
[144-524]
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
Q
A
E
E
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
-
T
T
K
-
G
A
Y
C
L
S
V
-----
S
D
F
D
NAK
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
-
S
K
P
Q
T
---------
Q
-------------------
G
L
A
K
-----------------------------
D
-------
A
W
E
I
P
R
E
S
L
R
L
E
-
V
K
--
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
--------
G
--
T
T
R
V
A
I
K
T
L
K
-
P
G
-
T
M
--
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
G--
K
--
Y
-
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
E
--
D
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
--
S
T
E
P
Q
Y
Q
P
-------------
131
HHSearch
54.55
38%
-98
- C1 -
1OPK
3
ABL1_MOUSE
A:
[101-478]
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
--
G
I
N
G
S
F
L
V
R
E
S
-
E
S
S
-
P
-
G
Q
R
S
I
S
L
-----
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
H
Y
P
A
P
K
-
R
N
K
P
--------
T
I
Y
-------------------
G
V
---------------------------
S
P
N
Y
D
K
W
E
M
-------
E
R
T
D
I
T
M
K
-
H
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
------
K
-
Y
--
S
L
T
V
A
V
K
T
L
K
-
E
D
-
T
M
--
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
E
P
-
P
-
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
-
C
N
R
---
Q
--
E
-
V
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
--
D
T
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--
E
S
S
I
S
D
E
V
E
K
E
L
G
K
-------
52
PsiBlast_CBE
53.45
33%
-88
- C1 -
2FO0
4
ABL1_HUMAN
A:
[100-488]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
-
E
-
S
-
S
P
G
Q
R
S
I
S
L
-----
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
----------------------------
T
T
L
H
Y
P
--------------------
A
P
K
R
N
K
--
P
-----
T
V
Y
G
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
--------
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
------
K
-
Y
--
S
L
T
V
A
V
K
T
L
K
-
E
D
-
T
--
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---
Q
--
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
ES
S
I
S
D
E
V
E
K
E
L
G
----------
50
PsiBlast_CBE
53.45
33%
-89
- C1 -
1OPL
2
ABL1_HUMAN
A:
[142-530]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
-
E
-
S
-
S
P
G
Q
R
S
I
S
L
-----
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
----------------------------
T
T
L
H
Y
P
--------------------
A
P
K
R
N
K
--
P
-----
T
V
Y
G
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
--------
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
------
K
-
Y
--
S
L
T
V
A
V
K
T
L
K
-
E
D
-
T
--
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---
Q
--
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
ES
S
I
S
D
E
V
E
K
E
L
G
K
---------
30
PsiBlast_CBE
52.89
60%
-110
- C1 -
4FYN
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
-
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
17
PsiBlast_PDB
52.73
60%
-111
- C1 -
1XBC
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
----------------
10
PsiBlast_PDB
52.73
61%
-114
- C1 -
3TUC
1
A:
[16-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
P
K
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N
E
A
-
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
-------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
-------------------
27
PsiBlast_CBE
52.49
60%
-116
- C1 -
4FZ7
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
--
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
11
PsiBlast_PDB
52.46
61%
-112
- C1 -
3TUD
1
A:
[21-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N
E
A
-
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
------------------
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
H
----------------
8
PsiBlast_PDB
52.46
61%
-112
- C1 -
3VF8
1
A:
[21-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
------
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
26
PsiBlast_CBE
52.44
60%
-106
- C1 -
4GFG
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N
E
A
-
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
20
PsiBlast_PDB
52.36
60%
-113
- C1 -
3FQS
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
22
PsiBlast_CBE
52.34
60%
-114
- C1 -
4PUZ
1
KSYK_HUMAN
A:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
-------------------
39
PsiBlast_CBE
52.25
61%
-112
- C1 -
4PV0
1
A:
[1-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
--
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
---------------
36
PsiBlast_CBE
52.12
61%
-112
- C1 -
3SRV
2
B:
[6-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
--------------------
33
PsiBlast_CBE
52.11
60%
-111
- C1 -
5CXZ
2
?
A:
[11-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N------
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
T
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
-
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
H
H
---------------
37
PsiBlast_CBE
51.86
61%
-110
- C1 -
4DFN
1
A:
[1-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
----------------
35
PsiBlast_CBE
51.68
60%
-111
- C1 -
4RX8
3
A:
[12-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
T
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
-
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
H
H
H
--------------
32
PsiBlast_CBE
51.65
60%
-116
- C1 -
3FQH
1
B:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
----
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
-------------------
34
PsiBlast_CBE
51.62
60%
-118
- C1 -
4RX9
2
A:
[11-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
---
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
T
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
-
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
H
H
H
H
-------------
28
PsiBlast_CBE
51.61
60%
-112
- C1 -
4FZ6
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
--
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
49
PsiBlast_CBE
51.56
33%
-97
- C1 -
1OPL
1
ABL1_HUMAN
B:
[142-518]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
-
E
-
S
-
S
P
G
Q
R
S
I
S
L
-----
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
S
E
S
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
----------------------------
T
T
L
H
Y
P
--------------------
A
P
---------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
H
--------
K
--
L
G
G
G
Q
Y
G
E
V
Y
E
G
V
W
--
K
------
K
-
Y
--
S
L
T
V
A
V
K
T
L
K
-
E
D
-
T
--
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---
Q
--
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E----------------------
25
PsiBlast_CBE
51.54
60%
-109
- C1 -
4I0R
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
-
E
--
L
G
S
G
---
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
31
PsiBlast_CBE
51.52
60%
-108
- C1 -
4FL1
1
A:
[11-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
16
PsiBlast_PDB
51.33
60%
-113
- C1 -
1XBB
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
14
PsiBlast_PDB
51.23
60%
-112
- C1 -
4PX6
1
A:
[12-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
------
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
T
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
----------------
24
PsiBlast_CBE
51.17
60%
-110
- C1 -
4I0S
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
134
HHSearch
51.09
61%
-109
- C1 -
4FYO
1
A:
[11-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
------
H
-
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
29
PsiBlast_CBE
51.05
60%
-108
- C1 -
4FYO
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
127
HHSearch
51.03
36%
-97
- C1 -
1QCF
1
HCK_HUMAN
A:
[66-445]
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
E
T
E
E
W
F
F
K
G
I
S
R
K
D
A
E
R
Q
L
L
A
P
G
N
M
L
G
S
F
M
I
R
D
S
E
T
-
T
-
K
-
G
S
Y
S
L
S
V
-----
R
D
Y
D
PRQ
G
D
T
V
K
H
Y
K
I
R
T
L
D
N
G
G
F
Y
I
S
P
R
S
T
F
S
T
L
Q
E
L
V
D
H
Y
K
K
G
N
D
G
L
C
Q
K
L
S
V
P
C
M
S
-
S
K
P
Q
K
---------
P
W
E
--------------------
K
-----------------------------
D
-------
A
W
E
I
P
R
E
S
L
K
L
E
K
-
K
--
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
--
N
--------
K
--
H
T
K
V
A
V
K
T
M
K
-
P
G
-
S
M
--
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
Q
H
D
K
L
V
K
L
H
A
V
V
-
T
K
-
E
-
P
-
I
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-
D
E
G
---
S
--
K
-
Q
P
L
P
K
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--
E
D
N
E
Y
T
A
R
E
G
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
Y
T
--
A
T
E
S
Q
Y
E
E
I
P
-----------
19
PsiBlast_PDB
50.97
60%
-113
- C1 -
3FQH
1
KSYK_HUMAN
A:
[11-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
-----
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
------------------
23
PsiBlast_CBE
50.85
60%
-109
- C1 -
4I0T
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
-----
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
13
PsiBlast_PDB
50.80
61%
-110
- C1 -
3EMG
1
A:
[21-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
--
V
--
V
K
T
V
A
V
K
I
L
K
--------
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
----
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
-----------------------
18
PsiBlast_PDB
50.74
60%
-108
- C1 -
3FQE
1
A:
[11-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
H
H
-------------
12
PsiBlast_PDB
50.65
61%
-110
- C1 -
3TUB
1
A:
[20-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
N
E
A
-
N
D
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
-------------------
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
-------------------
38
PsiBlast_CBE
50.63
61%
-110
- C1 -
4DFL
2
A:
[1-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
---
T
V
K
K
G
Y
Y
--
Q
-
M
------
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
----------------
21
PsiBlast_CBE
50.54
60%
-111
- C1 -
4PUZ
1
B:
[11-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
K
-
V
--
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
---
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
9
PsiBlast_PDB
50.44
61%
-109
- C1 -
3VF9
1
A:
[22-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
Y
--
Q
-
M
---
K
--
V
--
V
K
T
V
A
V
K
I
L
-------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
-----------------
47
PsiBlast_CBE
50.38
32%
-94
- C1 -
4XEY
1
ABL1_HUMAN
B:
[7-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
H
S
W
Y
H
G
P
V
S
R
N
A
A
E
Y
L
L
S
S
G
--
I
N
G
S
F
L
V
R
E
S
-
E
-
S
-
S
P
G
Q
R
S
I
S
L
-----
R
Y
-----
E
G
R
V
Y
H
Y
R
I
N
T
A
S
D
G
K
L
Y
V
S
---
R
F
N
T
L
A
E
L
V
H
H
H
S
T
V
A
D
G
L
I
----------------------------
T
T
L
H
Y
P
--------------------
A
P
K
-------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
--------
K
--
L
------
E
V
Y
E
G
V
W
--
K
------
K
-
Y
--
S
L
T
V
A
V
K
T
L
-----
T
--
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---
Q
--
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
-----------------
102
PsiBlast_CBE
50.36
32%
-96
- C1 -
2SRC
1
SRC_HUMAN
A:
[67-428]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
-
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
-----
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
-
S
----------------------------------------------
K
P
Q
--
T
Q
G
L
A
K
D
A
W
E
-
I
P
---------------
R
E
S
L
R
L
-
E
V
K
--
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
-
R
-----
V
A
I
K
T
L
K
-
P
G
-
T
--
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
--
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------
103
PsiBlast_CBE
50.20
32%
-98
- C1 -
1Y57
1
SRC_HUMAN
A:
[67-428]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
-
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
-----
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
-
S
----------------------------------------------
K
P
Q
--
T
Q
G
L
A
K
D
A
W
E
-
I
P
---------------
R
E
S
L
R
L
-
E
V
K
--
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
-
R
-----
V
A
I
K
T
L
K
-
P
G
-
T
--
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
-
E
-
P
-
I
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
--
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------
106
PsiBlast_CBE
50.19
32%
-98
- C1 -
1KSW
1
SRC_HUMAN
A:
[67-428]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
-
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
-----
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
-
S
----------------------------------------------
K
P
Q
--
T
Q
G
L
A
K
D
A
W
E
-
I
P
---------------
R
E
S
L
R
L
-
E
V
K
--
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
-
R
-----
V
A
I
K
T
L
K
-
P
G
-
T
--
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
--
S
T
E
P
Q
Y
Q
P
G
E
N
L
---------
105
PsiBlast_CBE
50.17
32%
-94
- C1 -
4K11
1
SRC_HUMAN
A:
[65-426]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
Y
F
G
K
I
T
R
R
E
S
E
R
L
L
L
N
A
E
N
P
R
G
T
F
L
V
R
E
S
-
E
-
T
T
K
-
G
A
Y
C
L
S
V
S
D
F
D
N
A
K
-----
G
L
N
V
K
H
Y
K
I
R
K
L
D
S
G
G
F
Y
I
T
S
R
T
Q
F
N
S
L
Q
Q
L
V
A
Y
Y
S
K
H
A
D
G
L
C
H
R
L
T
T
V
C
P
T
-
S
----------------------------------------------
K
P
Q
--
T
Q
G
L
A
K
D
A
W
E
-
I
P
---------------
R
E
S
L
R
L
-
E
V
K
--
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
--
N
-
G
---
T
T
-
R
-----
V
A
I
K
T
L
K
-
P
G
-
T
--
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
-
S
E
-
E
-
P
-
I
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-
E
-
T
---
G
--
K
Y
L
R
L
P
Q
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
D
Y
F
T
--
S
T
E
P
Q
Y
Q
P
G
E
-----------
40
PsiBlast_CBE
48.78
61%
-100
- C1 -
4F4P
1
A:
[1-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
R
K
L
L
T
L
E
D
K
E
--
L
G
S
G
N
F
G
T
V
K
K
G
Y
---------------
V
K
T
V
A
V
K
I
L
K
------
P
A
L
K
D
E
L
L
A
E
A
N
V
M
Q
Q
L
D
N
P
Y
I
V
R
M
I
G
I
C
-
E
A
-
E
-
S
-
W
M
L
V
M
E
M
A
E
L
G
P
L
N
K
Y
L
Q
Q
-
N
-
R
---
H
----
V
K
D
K
N
I
I
E
L
V
H
Q
V
S
M
G
M
K
Y
L
E
E
S
N
F
V
H
R
D
L
A
A
R
N
V
L
L
V
T
Q
H
Y
A
K
I
S
D
F
G
L
S
K
A
L
R
A
D
E
N
Y
Y
K
A
Q
T
H
G
K
W
P
V
K
W
Y
A
P
E
C
I
N
Y
Y
K
F
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
A
F
S
Y
G
Q
K
P
Y
R
G
M
K
-
G
S
E
V
T
A
M
L
E
K
G
E
R
M
G
C
P
A
G
C
P
R
E
M
Y
D
L
M
N
L
C
W
T
Y
D
V
E
N
R
P
G
F
A
A
V
E
L
R
L
R
N
Y
Y
Y
--
D
V
V
N
E
G
---------------
82
PsiBlast_CBE
46.29
43%
-103
- C1 -
2J0K
1
FAK1_CHICK
A:
[398-646]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
54
PsiBlast_CBE
46.12
43%
-99
- C1 -
4EBV
3
A:
[46-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
111
PsiBlast_CBE
45.88
41%
-96
- C1 -
1JPA
1
B:
[16-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
P
N
E
A
V
--
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
--
K
--------
R
--
E
I
F
V
A
I
K
T
L
K
-
S
G
-
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
---
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
-
D
---
G
--
Q
-
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
--
N
P
N
S
L
K
---------------
71
PsiBlast_CBE
45.85
43%
-102
- C1 -
2J0M
1
?
B:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
112
PsiBlast_CBE
45.80
41%
-95
- C1 -
1JPA
1
EPHB2_MOUSE
A:
[16-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
D
P
N
E
A
V
--
R
E
F
A
K
E
I
D
I
S
C
V
K
I
E
Q
V
I
G
A
G
E
F
G
E
V
C
S
G
H
L
--
K
-
L
------
R
--
E
I
F
V
A
I
K
T
L
K
-
S
G
-
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
H
P
N
V
I
H
L
E
G
V
V
T
K
S
-
T
-
P
-
V
M
I
I
T
E
F
M
E
N
G
S
L
D
S
F
L
R
Q
-
N
-
D
---
G
--
Q
-
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
---------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
M
T
-
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
C
P
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
N
T
L
D
K
M
I
R
--
N
P
N
S
L
K
A
--------------
149
HHSearch
45.52
36%
-100
* C1 *
4AOJ
1
NTRK1_HUMAN
A:
[39-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
R
D
I
V
L
K
W
-
E
--
L
G
E
G
A
F
G
K
V
F
L
A
E
C
--
H
-
N
LLP------
K
M
L
V
A
V
K
A
L
K
-
E
A
-
S
-
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
-
T
E
-
G
R
P
-
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
-
H
-
G
PDP
G
--
P
-
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--
A
P
P
------------------
144
HHSearch
45.43
37%
-100
- C1 -
1MQB
1
EPHA2_HUMAN
A:
[38-308]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
E
I
H
P
S
C
V
T
R
Q
-
K
V
--
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
--
K
-
T
-----K
K
--
E
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
H
H
N
I
I
R
L
E
G
V
I
-
S
K
-
Y
K
P
-
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
R
E
-
K
-
D
---
G
--
E
-
F
S
V
L
Q
L
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
L
V
C
K
V
S
D
F
G
L
-----------------
K
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
L
S
-
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
D
K
L
I
R
--
A
P
D
S
L
K
T
L
A
D
F
----------
93
PsiBlast_CBE
45.40
43%
-97
- C1 -
4D4V
2
FAK1_CHICK
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
94
PsiBlast_CBE
45.33
43%
-99
- C1 -
4D4S
1
B:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
56
PsiBlast_CBE
45.24
43%
-102
- C1 -
4KAB
1
FAK1_HUMAN
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
61
PsiBlast_CBE
45.16
43%
-105
- C1 -
4GU9
1
FAK1_HUMAN
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
-----------------
92
PsiBlast_CBE
45.05
43%
-102
- C1 -
4D4V
2
B:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
53
PsiBlast_CBE
44.87
43%
-102
- C1 -
4EBW
1
A:
[46-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
----
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
-----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
78
PsiBlast_CBE
44.76
43%
-95
- C1 -
2J0J
1
FAK1_CHICK
A:
[398-646]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--
E
D
----------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
107
PsiBlast_CBE
44.73
41%
-89
- C1 -
2QOC
2
A:
[21-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
V
--
V
G
A
G
E
F
G
E
V
C
S
G
R
L
--
K
-
L
P--
S
K
-
K
--
E
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
-
K
-
P
-
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-
H
-
D
---
A
--
Q
-
F
T
V
I
Q
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
L
V
C
K
V
S
D
F
G
L
S
R
V
L
E
D
-----------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
---
E
Q
-----
I
V
--
S
I
L
D
K
L
I
R
N
P
G
S
L
K
I
I
T
S
A
A
A
59
PsiBlast_CBE
44.73
43%
-98
- C1 -
4K8A
1
FAK1_HUMAN
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
-------------------
87
PsiBlast_CBE
44.61
43%
-97
- C1 -
4D58
1
?
B:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P
--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
68
PsiBlast_CBE
44.52
43%
-94
- C1 -
4I4E
1
A:
[23-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P---
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
86
PsiBlast_CBE
44.30
43%
-98
- C1 -
4D5H
1
FAK1_CHICK
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
70
PsiBlast_CBE
44.28
43%
-94
- C1 -
2JKQ
1
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
143
HHSearch
44.23
35%
-94
- C1 -
4CKJ
16
A:
[12-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
E
F
P
R
K
N
L
V
L
G
K
-
T
--
L
G
E
G
E
F
G
K
V
V
K
A
T
A
--
F
-
H
LKG
R
A
-
G
--
Y
T
T
V
A
V
K
M
L
K
-
E
N
-
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
N
H
P
H
V
I
K
L
Y
G
A
C
-
S
Q
-
D
G
P
-
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-
S
-
R
---
K
VR
A
-
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
-
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
--
K
R
R
------------------
77
PsiBlast_CBE
44.21
43%
-99
- C1 -
3PXK
1
FAK1_HUMAN
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
Q
---------------
116
Fugue
44.08
37%
-98
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
--
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
--
R
G-----------
N
K
V
A
V
K
C
I
K
-------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
-
V
-E
E
-
G
-
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
-
R
-
G
R--
S
--
V
-
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L-
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
--
H
E
L
------------------
55
PsiBlast_CBE
44.08
43%
-94
- C1 -
4KAB
1
B:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
--
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
------------------
76
PsiBlast_CBE
44.02
43%
-98
- C1 -
3PXK
1
B:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
Q
---------------
63
PsiBlast_CBE
43.90
43%
-93
- C1 -
2IJM
1
FAK1_HUMAN
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
Q
E
--------------
81
PsiBlast_CBE
43.86
43%
-94
- C1 -
2J0K
1
FAK1_CHICK
B:
[398-646]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
72
PsiBlast_CBE
43.80
43%
-98
- C1 -
4KAO
1
B:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
58
PsiBlast_CBE
43.63
43%
-92
- C1 -
4K8A
1
B:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
------------------
99
PsiBlast_CBE
43.61
43%
-95
- C1 -
2JKO
1
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
64
PsiBlast_CBE
43.60
43%
-94
- C1 -
2ETM
1
B:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
Q
E
E
-------------
100
PsiBlast_CBE
43.43
43%
-93
- C1 -
2JKK
1
?
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P
--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
------------------
62
PsiBlast_CBE
43.40
43%
-96
- C1 -
2IJM
1
B:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
-----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
Q
E
E
-------------
60
PsiBlast_CBE
43.38
43%
-94
- C1 -
4GU9
1
B:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
-------------------
73
PsiBlast_CBE
43.25
43%
-98
- C1 -
4KAO
1
FAK1_HUMAN
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--------
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
69
PsiBlast_CBE
43.19
43%
-93
- C1 -
1MP8
1
A:
[23-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
97
PsiBlast_CBE
43.07
43%
-94
- C1 -
4C7T
1
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P
--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
------------------
57
PsiBlast_CBE
43.07
43%
-88
- C1 -
4K9Y
1
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--
E
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
-----------------
66
PsiBlast_CBE
42.96
43%
-95
- C1 -
4Q9S
1
A:
[23-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P-----
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
80
PsiBlast_CBE
42.81
43%
-96
- C1 -
2JKM
1
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P
--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
L
Q
----------------
74
PsiBlast_CBE
42.80
43%
-97
- C1 -
4GU6
1
B:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
----------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
110
PsiBlast_CBE
42.78
43%
-102
- C1 -
4CSV
1
?
A:
[18-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
L
G
S
G
Q
F
G
E
V
Y
E
G
----
K
-
W
---
R
N
-
Y
--
N
I
E
V
A
V
K
T
L
K
-
E
G
-
T
--
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
-
T
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C-----------
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
L
-----------------------
67
PsiBlast_CBE
42.61
43%
-99
- C1 -
4I4F
2
A:
[23-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P--------
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
79
PsiBlast_CBE
42.59
43%
-93
- C1 -
3BZ3
1
A:
[15-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P---------
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
---------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
Q
E
E
-------------
98
PsiBlast_CBE
42.06
43%
-93
- C1 -
4BRX
1
FAK1_CHICK
A:
[18-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P
--
E
N
-
P
--
A
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
F
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
------------------
114
PsiBlast_CBE
42.03
41%
-98
- C1 -
2R4B
1
ERBB4_HUMAN
A:
[46-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
-
G
---
E
T
-
V
--
K
I
P
V
A
I
K
I
L
N
--------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
-
L
S
-
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
-
K
---
D
--
N
-
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
-
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
--
D
P
Q
R
Y
L
V
I
Q
G
D
D
---------
48
PsiBlast_CBE
41.90
32%
-91
- C1 -
4XEY
1
ABL1_HUMAN
A:
[116-388]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
H
--------
K
--
L
G
G
----
E
V
Y
E
G
V
W
--
K
------
K
-
Y
--
S
L
T
V
A
V
K
T
L
K
-
E
D
-
T
--
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
H
P
N
L
V
Q
L
L
G
V
C
-
T
R
-
E
-
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
-
R
---
Q
--
E
-
V
N
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
--
Y
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
I
D
-
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
------------------
113
PsiBlast_CBE
41.85
41%
-99
- C1 -
2R4B
1
B:
[46-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
A
F
G
T
V
Y
K
G
I
W
V
P
E
-
G
---
E
T
-
V
--
K
I
P
V
A
I
K
I
L
---------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
H
P
H
L
V
R
L
L
G
V
C
-
L
S
-
P
-
T
-
I
Q
L
V
T
Q
L
M
P
H
G
C
L
L
E
Y
V
H
E
-
H
-
K
---
D
--
N
-
I
G
S
Q
L
L
L
N
W
C
V
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
N
H
V
K
I
T
D
F
G
L
A
R
L
L
E
G
D
E
K
E
Y
N
A
-
D
G
G
K
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
I
P
-
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
A
E
F
S
R
M
A
R
--
D
P
Q
R
Y
L
V
I
Q
G
D
D
---------
65
PsiBlast_CBE
41.71
43%
-88
- C1 -
2ETM
1
FAK1_HUMAN
A:
[20-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
P
--
E
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--
E
----------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
140
HHSearch
41.60
38%
-98
- C1 -
3POZ
1
A:
[22-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
G
S
G
A
F
G
T
V
Y
K
G
L
W
--
I
-
P
------
V
--
K
I
P
V
A
I
K
E
L
---------
A
N
K
E
I
L
D
E
A
Y
V
M
A
S
V
D
N
P
H
V
C
R
L
L
G
I
C
-
L
T
-
S
-
T
-
V
Q
L
I
T
Q
L
M
P
F
G
C
L
L
D
Y
V
R
E
-
H
-
K
---
D
--
N
-
I
G
S
Q
Y
L
L
N
W
C
V
Q
I
A
K
G
M
N
Y
L
E
D
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
T
P
Q
H
V
K
I
T
D
F
G
L
A
K
L
L
G
A
E
E
K
--------
K
V
P
I
K
W
M
A
L
E
S
I
L
H
R
I
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
S
K
P
Y
D
G
I
P
-
A
S
E
I
S
S
I
L
E
K
G
E
R
L
P
Q
P
P
I
C
T
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
R
E
L
I
I
E
F
S
K
M
A
R
--
D
P
Q
R
Y
L
V
I
Q
G
D
E
R
M
H
L
P
S
P
T
D
138
HHSearch
41.17
35%
-94
- C1 -
4OTW
1
A:
[20-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
L
G
S
G
V
F
G
T
V
H
K
G
V
W
--
I
-
P
---
E
G
-
E
S
I
K
I
P
V
C
I
K
V
I
E
-
D
K
-
S
G
R
Q
S
F
Q
A
V
T
D
H
M
L
A
I
G
S
L
D
H
A
H
I
V
R
L
L
G
L
C
-
P
G
-
S
-
S
-
L
Q
L
V
T
Q
Y
L
P
L
G
S
L
L
D
H
V
R
Q
-
H
-
R
---
G
--
A
-
L
G
P
Q
L
L
L
N
W
G
V
Q
I
A
K
G
M
Y
Y
L
E
E
H
G
M
V
H
R
N
L
A
A
R
N
V
L
L
K
S
P
S
Q
V
Q
V
A
D
F
G
V
A
D
L
L
P
P
D
----------
K
T
P
I
K
W
M
A
L
E
S
I
H
F
G
K
Y
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
E
P
Y
A
G
L
R
-
L
A
E
V
P
D
L
L
E
K
G
E
R
L
A
Q
P
Q
I
C
T
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
E
N
I
R
P
T
F
K
E
L
A
N
E
F
T
R
M
A
R
--
D
P
P
R
Y
L
V
I
K
------------
75
PsiBlast_CBE
40.21
43%
-89
- C1 -
4GU6
1
FAK1_HUMAN
A:
[21-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
--
M
-
S
----
N
-
P
--
A
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
H
P
H
I
V
K
L
I
G
V
I
-
T
E
-
N
-
P
-
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
-
R
-
K
---
Y
--
S
-
L
D
L
A
S
L
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
D
C
V
K
L
G
D
F
G
L
S
R
Y
M
--
E
D
S
T
Y
Y
K
A
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
V
K
-
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
S
T
I
L
E
--
E
E
K
A
Q
----------------
109
PsiBlast_CBE
39.83
43%
-94
- C1 -
4UEU
1
?
A:
[18-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
L
G
S
G
Q
F
G
E
V
Y
E
G
----
K
-
W
---
R
N
-
Y
--
N
I
E
V
A
V
K
T
L
K
-
E
G
-
T
--
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
-
T
K
-
E
-
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
-
G
---
H
--
T
-
V
N
A
Q
A
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
F
------------------------