@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1H2_LXRb: (2015-05-07 )
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEE
E
P
E
R
KRKKGPA
P
K
M
L
G
H
E
L
C
R
VCGDKASG
F
H
Y
N
V
LSCE
G
C
K
G
F
F
R
R
S
V
V
RGGA
R
R
Y
A
CRGGGT
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
AG
M
R
E
Q
CVL
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
SQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGE
G
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
QCNKRSFSDQPKVTPWPLGADPQS
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
QV
P
G
F
L
QLGRED
Q
I
A
L
L
K
AS
T
I
E
I
M
L
L
E
T
A
R
RYNH
E
T
E
C
I
T
F
L
K
D
FTYSK
D
D
F
H
RAG
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
RLGLDDA
E
Y
A
L
L
I
A
I
N
I
FSADRPNVQEPG
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
RIKR
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
HSE
Q
V
F
A
L
R
LQDKKL
P
P
L
L
S
E
I
WDVHE
10
PsiBlast_PDB
75.91
97%
-119
- C6 -
3L0E
1
NR1H2_HUMAN
A:
[11-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
S
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
S
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
S
S
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
A
D
A
A
L
P
P
L
L
S
E
I
W
D
V
H
E
31
PsiBlast_CBE
75.64
100%
-116
- C6 -
1PQ6
2
NR1H2_HUMAN
B:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
30
PsiBlast_CBE
75.42
100%
-130
- C6 -
1PQ6
1
NR1H2_HUMAN
D:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
P
L
--------
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
---
K
L
P
P
L
L
S
E
I
W
D
V
H
-
4
PsiBlast_PDB
75.35
100%
-123
- C6 -
1PQ6
2
NR1H2_HUMAN
A:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
----
P
K
V
T
P
W
P
-----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
33
PsiBlast_CBE
74.79
98%
-120
- C6 -
4DK8
1
NR1H2_HUMAN
C:
[5-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
-----
P
K
V
T
P
W
P
L
-------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
7
PsiBlast_PDB
74.69
100%
-118
- C6 -
3KFC
1
NR1H2_HUMAN
A:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
23
PsiBlast_CBE
74.68
100%
-117
- C6 -
3KFC
1
NR1H2_HUMAN
B:
[11-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
--------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
8
PsiBlast_PDB
74.68
99%
-113
- C6 -
1P8D
1
NR1H2_HUMAN
A:
[7-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
32
PsiBlast_CBE
74.65
99%
-112
- C6 -
1P8D
1
NR1H2_HUMAN
B:
[7-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
---
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
22
PsiBlast_CBE
74.62
100%
-115
- C6 -
3KFC
1
NR1H2_HUMAN
D:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
------
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
6
PsiBlast_PDB
74.57
100%
-118
- C6 -
1PQC
1
NR1H2_HUMAN
A:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
29
PsiBlast_CBE
74.55
100%
-112
- C6 -
1PQ9
2
NR1H2_HUMAN
B:
[11-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
--
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
25
PsiBlast_CBE
74.52
100%
-118
- C6 -
1PQC
1
NR1H2_HUMAN
C:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
----
K
V
T
P
W
P
L
----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
24
PsiBlast_CBE
74.49
100%
-129
- C6 -
1PQC
1
NR1H2_HUMAN
D:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
------
V
T
P
W
-------
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
---
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
----
K
L
P
P
L
L
S
E
I
W
D
---
11
PsiBlast_PDB
74.48
96%
-120
- C6 -
4DK7
1
NR1H2_HUMAN
A:
[3-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
P
L
-----
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
26
PsiBlast_CBE
74.42
100%
-112
- C6 -
1PQC
1
NR1H2_HUMAN
B:
[11-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
--
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
2
PsiBlast_PDB
74.32
100%
-122
- C6 -
1UPV
1
NR1H2_HUMAN
A:
[15-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
-----------
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
28
PsiBlast_CBE
74.29
100%
-115
- C6 -
1PQ9
2
NR1H2_HUMAN
C:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
----
K
V
T
P
W
P
L
----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
9
PsiBlast_PDB
74.28
98%
-117
- C6 -
4DK8
1
NR1H2_HUMAN
A:
[4-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
---
K
V
T
P
W
P
-----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---
27
PsiBlast_CBE
74.13
100%
-130
- C6 -
1PQ9
2
NR1H2_HUMAN
D:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
------
V
T
P
W
-------
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
---
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
----
K
L
P
P
L
L
S
E
I
W
D
---
3
PsiBlast_PDB
73.76
100%
-117
- C6 -
1UPW
1
NR1H2_HUMAN
A:
[15-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
-----------
V
T
P
W
P
L
G
A
D
P
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
5
PsiBlast_PDB
73.60
100%
-117
- C6 -
1PQ9
2
NR1H2_HUMAN
A:
[12-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
W
P
-------
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
---