@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3A1_ERa: (2015-04-02 )
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKRSKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Atome Classification :
(147 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
M
T
L
HTKAS
G
M
A
L
L
H
Q
IQGNELEPLNRP
Q
L
KIPLERPLG
E
V
Y
LDSSK
P
A
V
YNYPEGA
A
Y
E
FNAAAAAN
A
Q
V
Y
GQTGLPYGPGS
E
A
A
AFGSNGLGGFPPLNSVSPS
P
L
M
L
LHPPPQLS
P
F
LQPHGQQV
P
Y
Y
LENEPS
G
Y
T
VREAGPPAFYRPNSDNRRQG
G
R
E
R
LASTNDKG
S
M
A
M
E
S
AKET
R
Y
C
A
V
C
NDYASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHNDYMCPATN
Q
C
TIDKNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
MMKGGIRKDRRG
G
R
M
L
K
H
K
RQRDDGEGRGEVGSAGDM
R
A
ANLWPSP
L
M
I
K
RSKKN
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
LDAEP
P
I
L
YSEYDPTRPF
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
RVP
G
F
V
D
L
T
LHDQ
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
SMEHPG
K
L
L
FAPN
L
L
L
DRNQ
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
ATSS
R
F
R
M
MNLQGE
E
F
V
C
L
K
S
I
I
L
LNS
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
KAGL
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
NK
G
M
E
H
L
Y
S
MKCKNVV
P
L
Y
D
L
L
L
E
M
L
D
A
HRLHAPTSRGGASVEET
D
Q
S
H
LATAGSTSSH
S
L
Q
K
Y
Y
I
TGEAEGFPATV
60
PsiBlast_CBE
96.95
100%
-138
- C6 -
1QKU
1
ESR1_HUMAN
A:
[1-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
172
PsiBlast_CBE
96.88
98%
-148
- C6 -
4MGC
3
B:
[8-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
92
PsiBlast_CBE
96.86
99%
-143
- C6 -
4MGD
1
ESR1_HUMAN
A:
[8-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
--
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
14
PsiBlast_PDB
96.82
99%
-144
- C6 -
2QSE
1
ESR1_HUMAN
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
---
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
76
PsiBlast_CBE
96.77
98%
-136
- C6 -
3Q95
1
B:
[6-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
-------------------------------------------
44
PsiBlast_CBE
96.66
100%
-139
- C6 -
2YJA
1
B:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
34
PsiBlast_CBE
96.62
99%
-144
- C6 -
2P15
1
B:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
95
PsiBlast_CBE
96.58
99%
-144
- C6 -
4MG7
2
ESR1_HUMAN
A:
[8-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
59
PsiBlast_CBE
96.50
100%
-144
- C6 -
1QKU
1
ESR1_HUMAN
B:
[4-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
29
PsiBlast_CBE
96.50
99%
-142
- C6 -
2QGW
1
B:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
158
PsiBlast_CBE
96.48
98%
-146
- C6 -
4MGA
1
ESR1_HUMAN
A:
[8-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
--
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
78
PsiBlast_CBE
96.41
100%
-138
- C6 -
1GWQ
1
B:
[1-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
16
PsiBlast_PDB
96.41
99%
-144
- C6 -
3Q95
1
ESR1_HUMAN
A:
[11-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
--
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
120
PsiBlast_CBE
96.40
98%
-145
- C6 -
2G5O
1
B:
[7-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
26
PsiBlast_CBE
96.39
99%
-147
- C6 -
2QSE
1
B:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
142
PsiBlast_CBE
96.28
98%
-141
- C6 -
2AYR
1
A:
[3-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
118
PsiBlast_CBE
96.22
100%
-148
- C6 -
1GWR
1
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
--
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
100
PsiBlast_CBE
96.16
99%
-145
- C6 -
4IWC
1
B:
[3-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
94
PsiBlast_CBE
96.14
99%
-147
- C6 -
4MG9
2
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
164
PsiBlast_CBE
96.11
98%
-151
- C6 -
3HM1
1
B:
[6-253]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
---------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
10
PsiBlast_PDB
96.11
99%
-148
- C6 -
2QGT
1
ESR1_HUMAN
A:
[9-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
122
PsiBlast_CBE
96.10
98%
-151
- C6 -
2G44
1
B:
[9-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
-------------------------------------------
146
PsiBlast_CBE
96.07
99%
-143
- C6 -
1X7E
1
ESR1_HUMAN
A:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
36
PsiBlast_CBE
96.06
100%
-146
- C6 -
2OUZ
1
A:
[6-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
58
PsiBlast_CBE
96.04
100%
-143
- C6 -
1QKU
1
C:
[4-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
9
PsiBlast_PDB
96.03
99%
-148
- C6 -
2QAB
1
ESR1_HUMAN
A:
[9-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
11
PsiBlast_PDB
96.01
99%
-148
- C6 -
2QGW
1
ESR1_HUMAN
A:
[9-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
69
PsiBlast_CBE
96.00
100%
-148
- C6 -
1YIM
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
112
PsiBlast_CBE
95.96
99%
-142
- C6 -
4IV2
1
B:
[3-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
56
PsiBlast_CBE
95.95
99%
-143
- C6 -
3HLV
1
B:
[7-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-----
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
99
PsiBlast_CBE
95.93
99%
-144
- C6 -
4IWF
1
ESR1_HUMAN
A:
[3-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
152
PsiBlast_CBE
95.90
99%
-151
- C6 -
4PP6
1
ESR1_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
79
PsiBlast_CBE
95.90
100%
-139
- C6 -
1GWQ
1
ESR1_HUMAN
A:
[1-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
31
PsiBlast_CBE
95.89
99%
-143
- C6 -
2QAB
1
B:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
101
PsiBlast_CBE
95.88
99%
-145
- C6 -
4IWC
1
ESR1_HUMAN
A:
[3-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
8
PsiBlast_PDB
95.86
99%
-143
- C6 -
2QA6
1
ESR1_HUMAN
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
163
PsiBlast_CBE
95.78
98%
-141
- C6 -
4MG5
2
ESR1_HUMAN
A:
[8-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
88
PsiBlast_CBE
95.76
100%
-142
- C6 -
1G50
1
ESR1_HUMAN
A:
[1-247]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
87
PsiBlast_CBE
95.74
100%
-144
- C6 -
1G50
1
ESR1_HUMAN
B:
[1-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
96
PsiBlast_CBE
95.68
99%
-148
- C6 -
4DMA
1
B:
[1-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
93
PsiBlast_CBE
95.68
99%
-137
- C6 -
4MGB
1
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
--
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
130
PsiBlast_CBE
95.67
98%
-147
- C6 -
1ZKY
1
B:
[8-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
80
PsiBlast_CBE
95.66
99%
-144
- C6 -
3L03
1
B:
[8-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
---
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
119
PsiBlast_CBE
95.62
100%
-144
- C6 -
1GWR
1
ESR1_HUMAN
A:
[2-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
123
PsiBlast_CBE
95.54
98%
-142
- C6 -
2G44
1
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
6
PsiBlast_PDB
95.48
99%
-139
- C6 -
2P15
1
ESR1_HUMAN
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
147
PsiBlast_CBE
95.46
99%
-147
- C6 -
4PPS
1
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
159
PsiBlast_CBE
95.44
98%
-147
- C6 -
4MG8
3
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
25
PsiBlast_CBE
95.42
99%
-146
- C6 -
2QXM
1
B:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
73
PsiBlast_CBE
95.38
100%
-145
- C6 -
1XP1
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
154
PsiBlast_CBE
95.36
98%
-148
- C6 -
3UUD
2
ESR1_HUMAN
A:
[4-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
170
PsiBlast_CBE
95.35
98%
-142
- C6 -
1PCG
1
B:
[1-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
97
PsiBlast_CBE
95.28
99%
-147
- C6 -
4DMA
1
ESR1_HUMAN
A:
[3-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
A
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
173
PsiBlast_CBE
95.19
98%
-149
- C6 -
4MGC
3
ESR1_HUMAN
A:
[9-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
-
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
90
PsiBlast_CBE
95.15
100%
-147
- C6 -
2IOG
1
A:
[1-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
77
PsiBlast_CBE
95.15
98%
-146
- C6 -
2QZO
1
B:
[10-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
103
PsiBlast_CBE
95.12
99%
-141
- C6 -
4IW8
1
ESR1_HUMAN
A:
[3-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
--
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
71
PsiBlast_CBE
95.08
100%
-146
- C6 -
1XP9
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
72
PsiBlast_CBE
95.05
100%
-145
- C6 -
1XP6
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
116
PsiBlast_CBE
95.04
99%
-139
- C6 -
4IU7
1
ESR1_HUMAN
A:
[2-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
124
PsiBlast_CBE
95.02
98%
-139
- C6 -
2FAI
1
B:
[7-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
195
HHSearch
95.00
100%
-146
- C6 -
2OCF
1
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
153
PsiBlast_CBE
94.99
98%
-145
- C6 -
3UUD
4
B:
[3-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
125
PsiBlast_CBE
94.96
98%
-148
- C6 -
2FAI
1
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
143
PsiBlast_CBE
94.90
98%
-143
- C6 -
1QKT
1
A:
[1-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
81
PsiBlast_CBE
94.84
99%
-146
- C6 -
3L03
2
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
55
PsiBlast_CBE
94.83
99%
-148
- C6 -
2QA8
1
B:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
176
PsiBlast_CBE
94.80
98%
-144
- C6 -
4MG8
3
B:
[6-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
145
PsiBlast_CBE
94.81
99%
-144
- C6 -
1X7E
1
B:
[1-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
70
PsiBlast_CBE
94.80
100%
-150
- C6 -
1XPC
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
161
PsiBlast_CBE
94.78
98%
-149
- C6 -
4MG6
1
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
66
PsiBlast_CBE
94.78
98%
-145
- C6 -
3OS8
1
ESR1_HUMAN
B:
[11-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
86
PsiBlast_CBE
94.77
100%
-143
- C6 -
1G50
1
C:
[1-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
148
PsiBlast_CBE
94.70
99%
-143
- C6 -
4PPS
1
ESR1_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
-
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
121
PsiBlast_CBE
94.69
98%
-145
- C6 -
2G5O
1
ESR1_HUMAN
A:
[7-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
128
PsiBlast_CBE
94.68
98%
-146
- C6 -
2B1Z
1
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
74
PsiBlast_CBE
94.66
100%
-147
- C6 -
1SJ0
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
--
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
32
PsiBlast_CBE
94.66
99%
-148
- C6 -
2QA6
1
B:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
177
PsiBlast_CBE
94.63
98%
-142
- C6 -
4MG7
2
B:
[6-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
131
PsiBlast_CBE
94.61
98%
-149
- C6 -
1ZKY
1
ESR1_HUMAN
A:
[7-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
115
PsiBlast_CBE
94.56
99%
-143
- C6 -
4IU7
1
B:
[3-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
--
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
------
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
162
PsiBlast_CBE
94.48
98%
-144
* C6 *
4MG5
4
B:
[6-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
57
PsiBlast_CBE
94.47
99%
-147
- C6 -
3HLV
1
ESR1_HUMAN
A:
[7-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
--
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
150
PsiBlast_CBE
94.44
99%
-155
- C6 -
4PPP
1
ESR1_HUMAN
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
67
PsiBlast_CBE
94.41
98%
-143
- C6 -
3OS8
1
ESR1_HUMAN
A:
[11-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
165
PsiBlast_CBE
94.39
98%
-150
- C6 -
3HM1
1
ESR1_HUMAN
A:
[9-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
144
PsiBlast_CBE
94.40
99%
-144
- C6 -
1X7R
1
A:
[2-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
V
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
129
PsiBlast_CBE
94.39
98%
-149
- C6 -
2B1V
1
ESR1_HUMAN
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
19
PsiBlast_PDB
94.39
99%
-148
- C6 -
2QA8
1
ESR1_HUMAN
A:
[9-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
------
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
15
PsiBlast_PDB
94.37
99%
-140
- C6 -
2QXM
1
ESR1_HUMAN
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
-----
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
84
PsiBlast_CBE
94.36
99%
-149
- C6 -
3UUC
1
ESR1_HUMAN
B:
[5-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
----------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
-------------------------------------------
106
PsiBlast_CBE
94.31
99%
-140
- C6 -
4IVY
1
B:
[3-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
175
PsiBlast_CBE
94.29
98%
-142
- C6 -
4MG9
2
B:
[7-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
---
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
174
PsiBlast_CBE
94.19
98%
-144
- C6 -
4MGA
1
B:
[6-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
68
PsiBlast_CBE
94.09
100%
-148
- C6 -
1YIN
1
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
53
PsiBlast_CBE
94.09
99%
-144
- C6 -
3OS8
1
ESR1_HUMAN
C:
[10-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
155
PsiBlast_CBE
94.08
98%
-149
- C6 -
3UUA
1
B:
[4-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
149
PsiBlast_CBE
94.05
99%
-155
- C6 -
4PPP
1
B:
[5-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
151
PsiBlast_CBE
93.97
99%
-150
- C6 -
4PP6
1
B:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
----------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
160
PsiBlast_CBE
93.95
98%
-145
- C6 -
4MG6
2
B:
[6-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
47
PsiBlast_CBE
93.92
99%
-139
- C6 -
3OSA
1
ESR1_HUMAN
B:
[11-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
-
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
-
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
139
PsiBlast_CBE
93.86
98%
-141
- C6 -
2Q70
1
ESR1_HUMAN
A:
[3-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
----
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
107
PsiBlast_CBE
93.73
99%
-144
- C6 -
4IVY
1
ESR1_HUMAN
A:
[2-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
---
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
64
PsiBlast_CBE
93.72
98%
-150
- C6 -
1XQC
1
ESR1_HUMAN
A:
[8-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
43
PsiBlast_CBE
93.69
100%
-143
- C6 -
3DT3
1
ESR1_HUMAN
A:
[10-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-------
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
--
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
--------------------------------------------
157
PsiBlast_CBE
93.67
98%
-149
- C6 -
4MGB
3
B:
[6-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
141
PsiBlast_CBE
93.62
98%
-145
- C6 -
2POG
1
ESR1_HUMAN
A:
[3-247]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
---------------------------------------------
52
PsiBlast_CBE
93.53
99%
-148
- C6 -
3OS8
1
D:
[10-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
82
PsiBlast_CBE
93.49
99%
-147
- C6 -
3UUC
1
D:
[6-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
--
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
---------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
---
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
P
-------------------------------------------
20
PsiBlast_PDB
93.45
99%
-148
- C6 -
2QZO
1
ESR1_HUMAN
A:
[9-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
-------
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
----------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
171
PsiBlast_CBE
93.44
98%
-150
- C6 -
1PCG
1
ESR1_HUMAN
A:
[1-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
-
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
-----------
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
S
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
113
PsiBlast_CBE
93.43
99%
-143
- C6 -
4IV2
1
ESR1_HUMAN
A:
[3-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
-------------
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
23
PsiBlast_CBE
93.31
100%
-143
- C6 -
1R5K
1
ESR1_HUMAN
B:
[13-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------
45
PsiBlast_CBE
93.22
99%
-148
- C6 -
3OSA
1
D:
[10-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
-----
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
46
PsiBlast_CBE
93.14
99%
-146
- C6 -
3OSA
1
ESR1_HUMAN
C:
[10-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
62
PsiBlast_CBE
92.98
98%
-147
- C6 -
1XQC
1
ESR1_HUMAN
C:
[8-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
135
PsiBlast_CBE
92.86
98%
-148
- C6 -
2R6W
1
ESR1_HUMAN
A:
[3-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
98
PsiBlast_CBE
92.75
99%
-152
- C6 -
4IWF
1
B:
[4-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
4
PsiBlast_PDB
92.49
100%
-144
- C6 -
1R5K
2
ESR1_HUMAN
A:
[13-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
D
--------------------------------------------------
17
PsiBlast_PDB
92.27
100%
-144
- C6 -
2IOK
1
ESR1_HUMAN
A:
[6-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
-------
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-----
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------
133
PsiBlast_CBE
92.26
98%
-144
- C6 -
2R6Y
1
ESR1_HUMAN
A:
[3-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
-------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-----
V
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
83
PsiBlast_CBE
92.17
99%
-144
- C6 -
3UUC
1
ESR1_HUMAN
C:
[5-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
--
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
--------
Y
D
L
L
L
E
M
L
D
--------------------------------------------------
5
PsiBlast_PDB
92.08
99%
-140
- C6 -
1A52
1
ESR1_HUMAN
A:
[10-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------
50
PsiBlast_CBE
92.05
99%
-144
- C6 -
3OS9
1
ESR1_HUMAN
B:
[11-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
51
PsiBlast_CBE
91.99
99%
-146
- C6 -
3OS9
1
ESR1_HUMAN
A:
[12-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
-
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
24
PsiBlast_CBE
91.93
99%
-138
- C6 -
1A52
1
B:
[9-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
E
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------
22
PsiBlast_CBE
91.84
100%
-143
- C6 -
1R5K
1
C:
[13-251]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
----
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------
168
PsiBlast_CBE
91.71
98%
-146
- C6 -
2I0J
1
ESR1_HUMAN
B:
[3-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
-------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
134
PsiBlast_CBE
91.59
98%
-150
- C6 -
2R6W
1
B:
[3-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
--------
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
--------
P
L
Y
D
L
L
L
E
M
L
D
A
-------------------------------------------------
35
PsiBlast_CBE
91.59
100%
-143
- C6 -
2IOK
1
B:
[6-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-------
P
L
Y
D
L
L
L
E
M
L
---------------------------------------------------
61
PsiBlast_CBE
91.23
98%
-147
- C6 -
1XQC
1
D:
[8-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
85
PsiBlast_CBE
91.19
99%
-146
- C6 -
3UUC
1
ESR1_HUMAN
A:
[4-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
---
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
---
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
------
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-------
Y
D
L
L
L
E
M
L
---------------------------------------------------
63
PsiBlast_CBE
91.14
98%
-151
- C6 -
1XQC
1
ESR1_HUMAN
B:
[8-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
---------
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------
132
PsiBlast_CBE
91.03
98%
-148
- C6 -
2R6Y
1
B:
[3-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
-----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
------
P
L
Y
D
L
L
L
E
M
L
D
--------------------------------------------------
114
PsiBlast_CBE
91.00
99%
-150
- C6 -
4IUI
1
B:
[6-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
----
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
--------
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
166
PsiBlast_CBE
90.68
98%
-146
- C6 -
2I0J
1
D:
[3-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------
L
Y
D
L
L
L
E
M
L
D
A
H
------------------------------------------------
181
PsiBlast_CBE
89.20
99%
-145
- C6 -
2JF9
5
ESR1_HUMAN
A:
[24-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
---------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
179
PsiBlast_CBE
88.90
99%
-142
- C6 -
2JF9
4
C:
[24-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
-----------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
------------------------------------------------------------------
182
PsiBlast_CBE
88.54
99%
-137
- C6 -
2BJ4
1
ESR1_HUMAN
A:
[24-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
178
PsiBlast_CBE
87.95
99%
-137
- C6 -
2JFA
1
ESR1_HUMAN
A:
[24-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
------------------------------------------------------------------
140
PsiBlast_CBE
87.12
98%
-137
- C6 -
2POG
1
B:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
167
PsiBlast_CBE
86.80
98%
-140
- C6 -
2I0J
1
ESR1_HUMAN
C:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
138
PsiBlast_CBE
86.77
98%
-138
- C6 -
2Q70
1
B:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
169
PsiBlast_CBE
86.61
98%
-140
- C6 -
2I0J
1
ESR1_HUMAN
A:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
180
PsiBlast_CBE
86.08
99%
-147
- C6 -
2JF9
3
ESR1_HUMAN
B:
[24-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
--------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
--------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
------------------------------------------------------------------
137
PsiBlast_CBE
85.66
98%
-142
- C6 -
2QE4
1
ESR1_HUMAN
A:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
-----
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
-----------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
136
PsiBlast_CBE
85.26
98%
-143
- C6 -
2QE4
1
B:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
S
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
S
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
---------
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
-------------------------------------------------------------------
Add PDB User Result:
(3 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
M
T
L
HTKAS
G
M
A
L
L
H
Q
IQGNELEPLNRP
Q
L
KIPLERPLG
E
V
Y
LDSSK
P
A
V
YNYPEGA
A
Y
E
FNAAAAAN
A
Q
V
Y
GQTGLPYGPGS
E
A
A
AFGSNGLGGFPPLNSVSPS
P
L
M
L
LHPPPQLS
P
F
LQPHGQQV
P
Y
Y
LENEPS
G
Y
T
VREAGPPAFYRPNSDNRRQG
G
R
E
R
LASTNDKG
S
M
A
M
E
S
AKET
R
Y
C
A
V
C
NDYASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHNDYMCPATN
Q
C
TIDKNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
MMKGGIRKDRRG
G
R
M
L
K
H
K
RQRDDGEGRGEVGSAGDM
R
A
ANLWPSP
L
M
I
K
RSKKN
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
LDAEP
P
I
L
YSEYDPTRPF
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
RVP
G
F
V
D
L
T
LHDQ
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
SMEHPG
K
L
L
FAPN
L
L
L
DRNQ
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
ATSS
R
F
R
M
MNLQGE
E
F
V
C
L
K
S
I
I
L
LNS
G
V
Y
T
F
L
S
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
KAGL
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
NK
G
M
E
H
L
Y
S
MKCKNVV
P
L
Y
D
L
L
L
E
M
L
D
A
HRLHAPTSRGGASVEET
D
Q
S
H
LATAGSTSSH
S
L
Q
K
Y
Y
I
TGEAEGFPATV
219
-
99%
-149
- C6 -
3UU7
2
A:
[5-248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
K
S
-----
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
220
-
99%
-147
- C6 -
4TUZ
5
A:
[8-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
-
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
L
----------------------------------------------
221
-
99%
-144
- C6 -
4TV1
8
A:
[4-247]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
-
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
-
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
--------
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
-
K
N
V
V
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-----------------------------------------------