@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1A1_THRa: (2016-04-07 )
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160------------------------.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290..-.....300........310.......320.......330.......340.......350.......360.......370....-...380.....--..390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEQKPSKVECGSDPEENSARSPDGKRKRKNGQ
C
S
L
KTSMSGYI
P
S
Y
LDKDE
Q
C
V
V
CGDKAT
G
Y
H
Y
R
C
I
T
C
E
G
C
K
G
F
F
R
R
T
I
Q
K
NLHP
T
Y
SCKYDS
C
C
V
I
D
K
I
T
R
N
Q
C
Q
L
C
R
F
K
K
C
I
A
V
G
M
A
M
D
L
V
LDD
S
K
R
V
A
K
R
K
L
I
E
Q
N
R
E
R
R
R
K
E
E
M
I
R
S
L
Q
QRPEP--------------------------TPEEW
D
L
I
H
I
A
TEAHRSTNAQG
S
H
W
K
Q
R
R
KFL
P
D
DIGQSPIVSMPDGDKV
D
L
E
A
F
S
E
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
KLP
M
F
SELPCED
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
YDPES
D
T
L
T
LSG
E
M
A
V
K
R
E
Q
LKNGG
L
G
V
-
V
S
D
A
I
F
-
E
L
G
K
SLSAFNLD
D
T
E
V
A
L
L
Q
A
V
L
L
MSTDRS
G
L
L
C
V
D
K
IEKSQ
E
A
Y
L
L
A
F
E
H
Y
V
N
H
R
KHNI
P
H
F
W
P
K
L
L
M
K
E
R
E
V
Q
S
-
S
I
LYKGAAAEG--RPGGSLGVHPEG
Q
Q
L
L
G
M
HVVQGP
Q
V
R
Q
L
E
Q
Q
LGEAGSLQGPVLQHQSPK
S
P
Q
Q
R
L
L
E
L
L
H
RSGI
L
H
A
R
AVCGEDDSSEADSPSSSEE
E
P
E
V
C
E
D
L
AGNAASP
1
PsiBlast_PDB
85.87
90%
-94
- C4 -
3UVV
1
THA_CHICK
A:
[4-225]
----------------------------------------------------------------------------------------------------------------------------------------------------
E
M
I
K
S
L
Q
H
R
P
S
P
--------------------------
S
A
E
E
W
E
L
I
H
V
V
T
E
A
H
R
S
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
--------
P
D
-
D
K
V
D
L
E
A
F
S
E
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
S
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
S
G
E
M
A
V
K
R
E
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
K
S
L
S
A
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
T
G
L
I
C
V
D
K
I
E
K
C
Q
E
T
Y
L
L
A
F
E
H
Y
I
N
Y
R
K
H
N
I
P
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
181
Fugue
82.56
71%
-87
- C4 -
1BSX
1
THB_HUMAN
A:
[10-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.02
79%
-104
- C4 -
1N46
1
THB_HUMAN
B:
[8-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
---
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
---------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
184
Fugue
81.28
30%
-78
- C4 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
----------------------
K
G
P
A
P
K
M
L
G
H
------------------
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
ASGPGASPGGSEAGSQGSGEGEGVQL
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
--
S
F
S
D
Q
P
K
V
T
P
W
P
L
G
A
D
P
-----
Q
S
R
D
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
-
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
--
R
L
Q
D
----------------------
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------
12
PsiBlast_PDB
81.15
80%
-100
- C4 -
1Q4X
2
THB_HUMAN
A:
[2-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
--------------
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
2
PsiBlast_PDB
80.91
78%
-91
- C4 -
1NQ1
1
THB_HUMAN
A:
[4-231]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
Q
K
F
L
P
D
D
I
G
Q
----------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
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I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
4
PsiBlast_PDB
80.81
78%
-96
- C4 -
1XZX
1
THB_HUMAN
X:
[22-249]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
------------
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
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V
D
F
A
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K
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E
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P
C
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I
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K
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C
C
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M
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R
A
A
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R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
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Y
Q
D
S
F
L
L
A
F
E
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N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.73
80%
-90
- C4 -
2J4A
1
THB_HUMAN
A:
[3-221]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
S
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
80.61
78%
-92
- C4 -
1Y0X
1
THB_HUMAN
X:
[22-249]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
------------
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.32
79%
-98
- C4 -
1NQ0
4
THB_HUMAN
A:
[4-226]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
T
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
----------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
80.03
80%
-93
- C4 -
3D57
1
THB_HUMAN
A:
[16-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
------
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
14
PsiBlast_PDB
79.96
80%
-91
- C4 -
2PIN
2
THB_HUMAN
A:
[2-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
------
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
23
PsiBlast_CBE
79.65
80%
-90
- C4 -
2PIN
2
THB_HUMAN
B:
[3-221]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
R
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.10
79%
-91
- C4 -
1NQ2
4
THB_HUMAN
A:
[5-227]
---------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
Q
K
S
I
G
H
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
--------
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
T
A
V
R
Y
E
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
10
PsiBlast_PDB
79.05
80%
-92
- C4 -
1NAX
1
THB_HUMAN
A:
[3-221]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
------------------------------------------------------------------------------------
8
PsiBlast_PDB
78.98
79%
-86
- C4 -
1N46
1
THB_HUMAN
A:
[8-226]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
---
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
I
V
N
A
P
E
G
G
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
21
PsiBlast_CBE
78.56
80%
-98
- C4 -
1BSX
1
THB_HUMAN
B:
[10-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
78.56
80%
-98
- C4 -
1BSX
1
THB_HUMAN
A:
[10-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
--------------------------
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
D
I
G
Q
A
P
--------
K
V
D
L
E
A
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
G
V
-
V
S
D
A
I
F
-
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
F
W
P
K
L
L
M
K
V
T
D
L
R
M
-
I
G
A
C
H
A
S
R
F
L
H
--
M
K
V
E
C
P
T
E
L
F
P
P
L
F
L
E
V
F
E
D
-----------------------------------------------------------------------------------
18
PsiBlast_PDB
70.57
29%
-89
- C4 -
3E00
1
RXRA_HUMAN
A:
[137-432]
-------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
--
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
-------------
K
R
E
A
V
Q
E
E
R
Q
R
------------
A
N
E
D
--------------------------
M
P
V
E
-----------
R
I
L
E
A
E
L
A
V
E
-----------------------------
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
-
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
-
I
G
L
K
C
L
E
H
L
F
F
--
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.27
29%
-90
- C4 -
3DZU
1
RXRA_HUMAN
A:
[137-432]
-------------------------------------------------
K
H
I
C
A
I
C
G
D
R
S
S
G
K
H
Y
G
V
Y
S
C
E
G
C
K
G
F
F
K
R
T
V
R
K
D
L
--
T
Y
T
C
R
D
N
K
D
C
L
I
D
K
R
Q
R
N
R
C
Q
Y
C
R
Y
Q
K
C
L
A
M
G
M
-------------
K
R
E
A
V
Q
E
E
R
Q
R
------------
A
N
E
D
--------------------------
M
P
V
E
-----------
R
I
L
E
A
E
L
A
-----------------------------
D
P
V
T
N
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
V
K
D
G
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
A
-
I
F
D
R
V
L
T
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
-
I
G
L
K
C
L
E
H
L
F
F
--
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
--------------------------------------------------------------------------------------