@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1B3_RARg: (2016-04-07 )
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Atome Classification :
(32 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAT
N
K
E
R
L
F
AAGALGPGSGYPGAGFPFAFPGALRGSP
P
F
E
ML
S
P
S
FRGLGQPD
L
P
K
E
M
A
S
L
S
V
E
TQSTSSEEMVPSSPSPPPPPRVYK
P
C
F
V
CNDKSSGYHYGVSS
C
E
G
C
K
G
F
F
R
R
S
I
QKN
M
V
Y
T
CHRDKNC
I
I
N
K
V
T
R
N
R
C
Q
Y
C
R
L
Q
K
C
F
E
VGM
S
K
E
A
V
RNDR
N
K
K
K
K
E
V
KEEGSPDSYEL
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
LGKYTTNSSAD
H
R
V
Q
L
DLG
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
RLPGFTGL
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
CTRYTPEQD
T
M
TFSDG
L
T
L
N
R
T
QMHNAGF
G
P
L
T
D
L
V
F
A
FAG
Q
L
LPLEMDDTE
T
G
L
L
S
A
I
C
L
ICGDRMDLEE
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
RRRPSQP
Y
M
F
P
R
M
L
M
K
I
TDLRGISTKGA
E
R
A
I
T
L
K
M
EIPGPM
P
P
L
I
R
E
M
LENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
232
HHSearch
91.00
100%
-133
- C4 -
1FCY
2
RARG_HUMAN
A:
[3-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
9
PsiBlast_PDB
90.70
100%
-130
- C4 -
1FD0
2
RARG_HUMAN
A:
[1-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
6
PsiBlast_PDB
90.70
100%
-131
- C4 -
1FCY
2
RARG_HUMAN
A:
[2-236]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
8
PsiBlast_PDB
90.64
100%
-131
- C4 -
1FCZ
2
RARG_HUMAN
A:
[1-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
3
PsiBlast_PDB
90.63
100%
-127
- C4 -
4LBD
1
RARG_HUMAN
A:
[26-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
N
------------------------------------
7
PsiBlast_PDB
90.56
100%
-131
- C4 -
1FCX
2
RARG_HUMAN
A:
[1-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
4
PsiBlast_PDB
90.53
100%
-129
- C4 -
1EXA
2
RARG_HUMAN
A:
[5-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
1
PsiBlast_PDB
90.40
100%
-124
- C4 -
2LBD
1
RARG_HUMAN
A:
[26-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
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I
A
D
Q
I
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A
A
C
L
D
I
L
M
L
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T
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Y
T
P
E
Q
D
T
M
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F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
N
P
-----------------------------------
5
PsiBlast_PDB
89.91
100%
-129
- C4 -
1EXX
2
RARG_HUMAN
A:
[5-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
-------------------------------------
2
PsiBlast_PDB
89.49
100%
-121
- C4 -
3LBD
1
RARG_HUMAN
A:
[26-262]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
Q
L
E
E
L
I
T
K
V
S
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
Q
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
S
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
M
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
G
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
M
D
L
E
E
P
E
K
V
D
K
L
Q
E
P
L
L
E
A
L
R
L
Y
A
R
R
R
R
P
S
Q
P
Y
M
F
P
R
M
L
M
K
I
T
D
L
R
G
I
S
T
K
G
A
E
R
A
I
T
L
K
M
E
I
P
G
P
M
P
P
L
I
R
E
M
L
E
N
------------------------------------
23
PsiBlast_CBE
86.09
86%
-128
- C4 -
4DM6
1
RARB_HUMAN
B:
[24-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
------------------------------------
20
PsiBlast_PDB
85.91
83%
-134
- C4 -
1DKF
1
RARA_HUMAN
B:
[1-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
---
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
------------------------------------
22
PsiBlast_CBE
85.86
86%
-126
- C4 -
4DM8
1
RARB_HUMAN
B:
[24-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
------------------------------------
25
PsiBlast_CBE
85.73
85%
-128
- C4 -
4JYH
1
RARB_HUMAN
B:
[23-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-------------------------------------
24
PsiBlast_CBE
85.63
85%
-127
- C4 -
4JYI
1
RARB_HUMAN
B:
[23-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-------------------------------------
26
PsiBlast_CBE
85.44
85%
-124
- C4 -
4JYG
2
RARB_HUMAN
B:
[22-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-------------------------------------
15
PsiBlast_PDB
85.38
85%
-131
- C4 -
4JYH
1
RARB_HUMAN
A:
[23-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-------------------------------------
16
PsiBlast_PDB
85.30
85%
-127
- C4 -
4JYI
1
RARB_HUMAN
A:
[23-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-------------------------------------
12
PsiBlast_PDB
85.08
86%
-126
- C4 -
4DM6
1
RARB_HUMAN
A:
[22-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
17
PsiBlast_PDB
84.76
81%
-125
- C4 -
3A9E
1
RARA_HUMAN
B:
[25-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
T
L
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
13
PsiBlast_PDB
84.74
86%
-125
- C4 -
4DM8
1
RARB_HUMAN
A:
[22-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
--
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
226
HHSearch
84.66
83%
-128
- C4 -
3KMR
1
RARA_HUMAN
A:
[27-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
28
PsiBlast_CBE
84.66
83%
-127
- C4 -
4DQM
1
RARA_HUMAN
C:
[1-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
14
PsiBlast_PDB
84.56
85%
-129
- C4 -
4JYG
1
RARB_HUMAN
A:
[23-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
E
M
T
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
M
E
-------------------------------------
18
PsiBlast_PDB
84.44
82%
-128
- C4 -
3KMR
1
RARA_HUMAN
A:
[27-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
11
PsiBlast_PDB
84.26
86%
-126
- C4 -
1XAP
1
RARB_HUMAN
A:
[28-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
---
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
------------------------------------
29
PsiBlast_CBE
83.74
83%
-126
- C4 -
4DQM
1
RARA_HUMAN
A:
[1-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
-------------------------------------
224
HHSearch
82.65
83%
-117
- C4 -
1XDK
1
RARB_MOUSE
B:
[30-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
--------------------------
10
PsiBlast_PDB
82.39
84%
-117
- C4 -
1XDK
1
RARB_MOUSE
B:
[30-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
--------------------------
21
PsiBlast_CBE
82.17
84%
-118
- C4 -
1XDK
1
RARB_MOUSE
F:
[30-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
D
D
L
T
E
K
I
R
K
A
H
Q
E
T
F
P
S
L
C
Q
L
G
K
Y
T
T
N
S
S
A
D
H
R
V
R
L
D
L
G
L
W
D
K
F
S
E
L
A
T
K
C
I
I
K
I
V
E
F
A
K
R
L
P
G
F
T
G
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
T
F
A
N
Q
L
L
P
L
E
M
D
D
T
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
E
P
T
K
V
D
K
L
Q
E
P
L
L
E
A
L
K
I
Y
I
R
K
R
R
P
S
K
P
H
M
F
P
K
I
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
I
P
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
G
H
E
P
L
T
P
S
--------------------------
19
PsiBlast_PDB
79.23
82%
-121
- C4 -
3KMZ
5
RARA_HUMAN
B:
[26-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
---------------------------------------------------
27
PsiBlast_CBE
79.13
82%
-120
- C4 -
3KMZ
6
RARA_HUMAN
A:
[26-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
E
V
G
E
L
I
E
K
V
R
K
A
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
T
N
N
S
S
E
Q
R
V
S
L
D
I
D
L
W
D
K
F
S
E
L
S
T
K
C
I
I
K
T
V
E
F
A
K
Q
L
P
G
F
T
T
L
T
I
A
D
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
R
Y
T
P
E
Q
D
T
M
T
F
S
D
G
L
T
L
N
R
T
Q
M
H
N
A
G
F
G
P
L
T
D
L
V
F
A
F
A
N
Q
L
L
P
L
E
M
D
D
A
E
T
G
L
L
S
A
I
C
L
I
C
G
D
R
Q
D
L
E
Q
P
D
R
V
D
M
L
Q
E
P
L
L
E
A
L
K
V
Y
V
R
K
R
R
P
S
R
P
H
M
F
P
K
M
L
M
K
I
T
D
L
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
M
E
---------------------------------------------------