@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1I1_VDR: (2016-04-07 )
MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSLRPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDVTKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLSNTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLEVFGNEIS
Atome Classification :
(73 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEAMAASTSLPDPGDFDRNV
P
R
I
C
GVCGDRAT
G
F
H
FNAM
T
C
E
G
C
K
G
F
F
R
R
S
MKR
K
A
L
F
TCPFNGD
C
R
ITKDN
R
R
H
C
Q
A
C
R
L
K
R
C
V
D
I
G
M
M
K
E
F
ILT
D
E
E
V
Q
R
K
R
E
M
I
L
K
R
K
E
E
E
A
L
K
D
SLRPKL
S
E
E
Q
Q
R
I
I
A
I
LLDAHHKTYDP
T
Y
S
D
F
CQFRP
P
V
R
VNDGGGSHPSRPNSRHTPSFSGDSSSSCSDHCIT
S
S
DMMDSSSFSNLDLSEEDSDDP
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
MIPGFRDLTSED
Q
I
V
L
L
KSS
A
I
E
V
I
M
LRSNESFTMDD
M
S
W
TCGNQD
Y
K
Y
R
V
S
D
V
TKAGH
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
KLNLHEEE
H
V
L
L
M
A
I
C
I
VSPDRPGV
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
RCRHPPPGS
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
SK
Q
Y
R
CLSFQPECSM
K
L
T
P
L
V
L
E
V
FGNEIS
18
PsiBlast_PDB
94.69
83%
-119
- C2 -
3A3Z
1
VDR_HUMAN
X:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
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Y
S
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Q
K
V
I
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F
A
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I
P
G
F
R
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L
T
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E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
17
PsiBlast_PDB
93.96
83%
-117
- C2 -
3CS6
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
20
PsiBlast_PDB
93.89
83%
-117
- C2 -
3A78
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
6
PsiBlast_PDB
93.80
83%
-117
- C2 -
3TKC
1
?
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
9
PsiBlast_PDB
93.75
83%
-121
- C2 -
1S19
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
34
PsiBlast_CBE
93.74
83%
-124
- C2 -
3W0Y
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
1
PsiBlast_PDB
93.67
83%
-123
- C2 -
1DB1
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
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I
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L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
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S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
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E
A
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D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
10
PsiBlast_PDB
93.57
83%
-121
- C2 -
1TXI
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
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L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
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Y
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F
A
K
M
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S
A
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F
T
M
D
D
M
S
W
T
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N
Q
D
Y
K
Y
R
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D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
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Q
V
G
L
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K
L
N
L
H
E
E
E
H
V
L
L
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A
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R
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G
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D
A
A
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A
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A
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L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
4
PsiBlast_PDB
93.56
83%
-117
- C2 -
3OGT
1
VDR_HUMAN
A:
[2-255]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
7
PsiBlast_PDB
93.49
83%
-122
- C2 -
4G2I
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
19
PsiBlast_PDB
93.46
83%
-117
- C2 -
3A40
1
VDR_HUMAN
X:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
28
PsiBlast_CBE
93.44
83%
-121
- C2 -
3AUQ
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
8
PsiBlast_PDB
93.36
83%
-120
- C2 -
1S0Z
1
VDR_HUMAN
A:
[7-259]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
3
PsiBlast_PDB
93.24
83%
-116
- C2 -
1IE9
1
VDR_HUMAN
A:
[1-255]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
30
PsiBlast_CBE
93.16
83%
-120
- C2 -
3A2I
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
70
PsiBlast_CBE
93.11
68%
-121
- C2 -
4FHI
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
38
PsiBlast_CBE
93.05
83%
-125
- C2 -
3AZ2
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
53
PsiBlast_CBE
92.99
68%
-121
- C2 -
4Q0A
2
VDRA_DANRE
C:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
5
PsiBlast_PDB
92.95
83%
-120
- C2 -
3KPZ
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
36
PsiBlast_CBE
92.91
83%
-125
- C2 -
3W0A
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
71
PsiBlast_CBE
92.89
68%
-121
- C2 -
4FHH
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
35
PsiBlast_CBE
92.84
83%
-125
- C2 -
3W0C
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
37
PsiBlast_CBE
92.83
83%
-123
- C2 -
3AZ3
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
15
PsiBlast_PDB
92.63
83%
-118
- C2 -
2HB8
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
29
PsiBlast_CBE
92.59
83%
-117
- C2 -
3P8X
1
VDR_HUMAN
A:
[22-276]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
31
PsiBlast_CBE
92.56
82%
-119
- C2 -
3A2J
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
F
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
F
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
39
PsiBlast_CBE
92.54
83%
-123
- C2 -
3AZ1
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
60
PsiBlast_CBE
92.50
68%
-121
- C2 -
4IA7
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
63
PsiBlast_CBE
92.48
68%
-119
- C2 -
4IA1
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
14
PsiBlast_PDB
92.42
83%
-118
- C2 -
2HB7
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
61
PsiBlast_CBE
92.24
68%
-121
- C2 -
4IA3
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
26
PsiBlast_CBE
92.24
83%
-118
- C2 -
3AX8
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
62
PsiBlast_CBE
92.22
68%
-120
- C2 -
4IA2
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
16
PsiBlast_PDB
92.22
83%
-116
- C2 -
3CS4
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
40
PsiBlast_CBE
92.20
82%
-119
- C2 -
3M7R
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
Q
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
12
PsiBlast_PDB
92.17
83%
-120
- C2 -
2HAR
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
--
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
24
PsiBlast_CBE
92.15
83%
-118
- C2 -
3WWR
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
----------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
66
PsiBlast_CBE
92.08
68%
-122
- C2 -
4G20
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
33
PsiBlast_CBE
92.02
83%
-121
- C2 -
3WGP
1
VDR_HUMAN
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
59
PsiBlast_CBE
91.95
68%
-119
- C2 -
2HBH
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
57
PsiBlast_CBE
91.93
68%
-122
- C2 -
2HCD
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
58
PsiBlast_CBE
91.92
68%
-121
- C2 -
2HC4
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
2
PsiBlast_PDB
91.92
83%
-121
- C2 -
1IE8
1
VDR_HUMAN
A:
[3-255]
-----------------------------------------------------------------------------------------------------------------------
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
---
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
21
PsiBlast_CBE
91.84
83%
-118
- C2 -
4PA2
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
32
PsiBlast_CBE
91.75
82%
-119
- C2 -
3B0T
1
VDR_HUMAN
A:
[1-254]
----------------------------------------------------------------------------------------------------------------------
A
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
13
PsiBlast_PDB
91.62
83%
-118
- C2 -
2HAS
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
-
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
65
PsiBlast_CBE
91.57
68%
-123
- C2 -
4G21
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
64
PsiBlast_CBE
91.57
68%
-120
- C2 -
4G2H
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
55
PsiBlast_CBE
91.51
68%
-124
- C2 -
3O1D
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
68
PsiBlast_CBE
91.37
68%
-120
- C2 -
4G1Y
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
25
PsiBlast_CBE
91.31
83%
-115
- C2 -
3VHW
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
----------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
69
PsiBlast_CBE
91.25
68%
-120
- C2 -
4G1D
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
56
PsiBlast_CBE
91.24
68%
-117
- C2 -
3DR1
1
VDRA_DANRE
A:
[5-301]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
23
PsiBlast_CBE
91.24
83%
-123
- C2 -
4ITE
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
11
PsiBlast_PDB
91.21
83%
-117
- C2 -
2HAM
1
VDR_HUMAN
A:
[6-259]
----------------------------------------------------------------------------------------------------------------------
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
G
G
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
-
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
27
PsiBlast_CBE
91.17
83%
-120
- C2 -
3AUR
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
54
PsiBlast_CBE
91.14
68%
-120
- C2 -
3O1E
1
VDRA_DANRE
A:
[5-302]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
-----------------------------------------------------------------
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
S
22
PsiBlast_CBE
90.92
83%
-118
- C2 -
4ITF
1
VDR_HUMAN
A:
[5-259]
---------------------------------------------------------------------------------------------------------------------
D
S
L
R
P
K
L
S
E
E
Q
Q
R
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
S
D
F
C
Q
F
R
P
P
V
R
V
N
D
--
G
---------------------------------------------------
S
V
T
L
E
L
S
Q
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----
67
PsiBlast_CBE
90.80
68%
-118
- C2 -
4G1Z
1
VDRA_DANRE
A:
[3-299]
---------------------------------------------------------------------------------------------------------------------------
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
A
H
H
K
T
Y
D
D
S
Y
S
D
F
V
R
F
R
P
P
V
R
----------------------------------------------------------------
R
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
A
E
D
Q
I
A
L
L
K
S
S
A
I
E
I
I
M
L
R
S
N
Q
S
F
S
L
E
D
M
S
W
S
C
G
G
P
D
F
K
Y
C
I
N
D
V
T
K
A
G
H
T
L
E
L
L
E
P
L
V
K
F
Q
V
G
L
K
K
L
K
L
H
E
E
E
H
V
L
L
M
A
I
C
L
L
S
P
D
R
P
G
V
Q
D
H
V
R
I
E
A
L
Q
D
R
L
C
D
V
L
Q
A
Y
I
R
I
Q
H
--
P
G
G
R
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
H
S
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
-
43
PsiBlast_CBE
89.93
75%
-125
- C2 -
1RK3
1
VDR_RAT
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
47
PsiBlast_CBE
89.84
75%
-127
- C2 -
3VRV
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
41
PsiBlast_CBE
89.84
75%
-120
- C2 -
2O4R
1
VDR_RAT
A:
[8-259]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
52
PsiBlast_CBE
89.65
75%
-126
- C2 -
2ZL9
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
46
PsiBlast_CBE
89.33
75%
-129
- C2 -
3VRW
1
VDR_RAT
A:
[18-267]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
----
45
PsiBlast_CBE
89.31
75%
-120
- C2 -
3A2H
1
VDR_RAT
A:
[12-263]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
50
PsiBlast_CBE
89.29
75%
-121
- C2 -
3VJS
1
VDR_RAT
A:
[18-269]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
42
PsiBlast_CBE
89.28
75%
-120
- C2 -
2O4J
1
VDR_RAT
A:
[8-259]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
48
PsiBlast_CBE
89.19
75%
-123
- C2 -
3VRU
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
51
PsiBlast_CBE
89.03
75%
-123
- C2 -
2ZLA
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
49
PsiBlast_CBE
88.83
75%
-124
- C2 -
3VJT
1
VDR_RAT
A:
[18-268]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
----------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
44
PsiBlast_CBE
88.34
75%
-120
- C2 -
1RJK
1
VDR_RAT
A:
[8-258]
--------------------------------------------------------------------------------------------------------------------------
K
L
S
E
E
Q
Q
H
I
I
A
I
L
L
D
A
H
H
K
T
Y
D
P
T
Y
A
D
F
R
D
F
R
P
P
V
R
M
---------------------------------------------------------------
P
L
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
---
199
HHSearch
84.60
94%
-130
- C2 -
2O4J
1
VDR_RAT
A:
[60-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
D
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
Q
S
F
T
M
D
D
M
S
W
D
C
G
S
Q
D
Y
K
Y
D
V
T
D
V
S
K
A
G
H
T
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
K
L
V
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
Q
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
F
Q
P
E
N
S
M
K
L
T
P
L
V
L
E
V
F
G
N
E
--
200
HHSearch
83.57
100%
-136
- C2 -
3B0T
1
VDR_HUMAN
A:
[56-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
L
P
H
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
A
K
M
I
P
G
F
R
D
L
T
S
E
D
Q
I
V
L
L
K
S
S
A
I
E
V
I
M
L
R
S
N
E
S
F
T
M
D
D
M
S
W
T
C
G
N
Q
D
Y
K
Y
R
V
S
D
V
T
K
A
G
H
S
L
E
L
I
E
P
L
I
K
F
Q
V
G
L
K
K
L
N
L
H
E
E
E
H
V
L
L
M
A
I
C
I
V
S
P
D
R
P
G
V
Q
D
A
A
L
I
E
A
I
Q
D
R
L
S
N
T
L
Q
T
Y
I
R
C
R
H
P
P
P
G
S
H
L
L
Y
A
K
M
I
Q
K
L
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
F
Q
P
E
C
S
M
K
L
T
P
L
V
L
E
V
F
G
----