@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3B2_ERRb: (2016-04-07 )
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKAWARADSLQEWRPLEQVPSPLHRATKRQHVHFLTPLPPPPSVAWVGTAQAGYHLEVFLPQRAGWPRAA
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370......---.380.--......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
D
D
R
H
L
G
S
S
C
G
S
FIKTEPSSPSS
G
I
D
A
LSHHSPSGSSDASG
G
F
G
L
A
LGTHANGLDSPP
M
F
AGAGLGGT
P
C
R
K
S
Y
E
D
C
A
S
G
IMEDS
A
I
K
C
E
Y
M
L
N
A
I
P
K
R
L
C
L
V
C
G
D
IASGYHYGVA
S
C
E
A
C
K
A
F
F
K
R
TIQGN
I
E
YSCPAT
N
E
C
E
I
T
K
R
R
R
K
S
C
Q
A
C
R
F
M
K
C
L
K
V
G
M
L
K
EGVR
L
D
R
VRG
G
R
Q
K
Y
K
R
RLDSESS
P
Y
L
S
L
Q
ISPPAKK
P
L
T
K
I
V
S
Y
L
L
VAEPD
K
L
Y
AMPPPGMPE
G
D
I
K
A
L
T
T
L
C
D
LADR
E
L
V
V
I
I
GWAKHIPGFSSLSL
G
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
I
V
Y
R
SLPYDD
K
L
V
Y
A
E
DYIM
D
E
E
H
S
R
L
A
G
L
L
E
L
Y
R
A
I
L
Q
L
V
R
R
Y
K
K
LKV
E
K
E
E
F
V
T
L
K
A
L
A
LANSDS
M
Y
I
E
D
L
E
A
V
Q
K
L
Q
D
L
L
H
E
A
L
Q
D
Y
E
---
L
S
Q
R
H--EEPWRT
G
K
L
L
L
T
L
P
L
L
R
Q
T
A
A
K
A
V
Q
H
F
Y
S
V
K
LQGKV
P
M
H
K
L
F
L
E
M
L
E
A
K
A
WARA
D
S
L
Q
EWR
P
L
E
QV
P
S
P
L
H
R
A
TKR
Q
H
V
H
F
LTPLPPPPS
V
A
W
V
GTAQA
G
Y
H
L
E
V
F
L
PQRAGWPRAA
13
PsiBlast_PDB
90.43
79%
-131
- C5 -
2P7G
1
ERR3_HUMAN
A:
[28-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
2
PsiBlast_PDB
89.37
76%
-131
- C5 -
2ZAS
2
ERR3_HUMAN
A:
[17-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
-------------------------------------------------------------------
3
PsiBlast_PDB
88.89
76%
-130
- C5 -
2ZBS
-
ERR3_HUMAN
A:
[232-458]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
C
------------------------------------------------------------------
6
PsiBlast_PDB
88.71
79%
-127
- C5 -
2GPO
-
ERR3_HUMAN
A:
[7-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
-------------------------------------------------------------------
12
PsiBlast_PDB
88.64
79%
-131
- C5 -
2P7A
1
ERR3_HUMAN
A:
[27-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
11
PsiBlast_PDB
88.19
79%
-133
- C5 -
1TFC
-
ERR3_HUMAN
A:
[26-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
-------------------------------------------------------------------
34
PsiBlast_CBE
88.13
78%
-128
- C5 -
2EWP
1
ERR3_HUMAN
D:
[3-223]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
----------------------------------------------------------------------
17
PsiBlast_PDB
88.03
78%
-132
- C5 -
2EWP
1
ERR3_HUMAN
A:
[1-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
1
PsiBlast_PDB
88.00
76%
-130
- C5 -
2E2R
4
ERR3_HUMAN
A:
[17-243]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
C
------------------------------------------------------------------
36
PsiBlast_CBE
87.65
78%
-131
- C5 -
2EWP
1
ERR3_HUMAN
B:
[1-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
8
PsiBlast_PDB
87.62
79%
-132
- C5 -
2GPU
1
A:
[6-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
----------------------------------------------------------------------
5
PsiBlast_PDB
87.60
79%
-128
- C5 -
2GP7
-
ERR3_HUMAN
A:
[7-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
-------------------------------------------------------------------
7
PsiBlast_PDB
87.27
79%
-129
- C5 -
2GPP
1
ERR3_HUMAN
A:
[5-229]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
--------------------------------------------------------------------
4
PsiBlast_PDB
87.17
79%
-132
- C5 -
1KV6
-
ERR3_HUMAN
A:
[7-228]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
299
HHSearch
86.98
79%
-134
- C5 -
2E2R
4
ERR3_HUMAN
A:
[22-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
C
------------------------------------------------------------------
33
PsiBlast_CBE
86.60
78%
-136
- C5 -
2EWP
1
E:
[5-223]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
----------
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
----------------------------------------------------------------------
35
PsiBlast_CBE
86.46
78%
-129
- C5 -
2EWP
1
ERR3_HUMAN
C:
[2-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
20
PsiBlast_PDB
85.93
63%
-139
- C5 -
1XB7
-
ERR1_HUMAN
A:
[15-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
-----------
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
A
G----------
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
32
PsiBlast_CBE
85.66
78%
-123
- C5 -
1S9P
1
ERR3_MOUSE
B:
[3-219]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
---------------------------------------------------------------------------
30
PsiBlast_CBE
85.63
78%
-125
- C5 -
1S9P
1
D:
[3-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
-------------------------------------------------------------------
15
PsiBlast_PDB
83.76
79%
-126
- C5 -
1S9Q
2
ERR3_MOUSE
A:
[25-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
-
V
P
M
H
K
L
F
L
E
M
L
E
A
---------------------------------------------------------------------
14
PsiBlast_PDB
83.59
79%
-121
- C5 -
2P7Z
1
ERR3_HUMAN
A:
[28-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.13
78%
-123
- C5 -
1S9P
1
ERR3_MOUSE
A:
[2-216]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
------------------------------------------------------------------------------
19
PsiBlast_PDB
83.03
63%
-131
- C5 -
3K6P
1
ERR1_HUMAN
A:
[16-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
P
-------
H
L
P
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
A
G
R---
G
G
--
A
E
R
R
-
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
-
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
M
-------------------------------------------------------------------
31
PsiBlast_CBE
82.80
78%
-122
- C5 -
1S9P
1
ERR3_MOUSE
C:
[3-221]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
-------------------------------------------------------------------------
38
PsiBlast_CBE
81.89
63%
-123
- C5 -
2PJL
1
ERR1_HUMAN
B:
[15-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
---------
L
P
A
V
A
T
L
S
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
AG----------
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
--------------------------------------------------------------------
28
PsiBlast_CBE
81.79
79%
-122
- C5 -
1VJB
1
ERR3_HUMAN
B:
[26-235]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
-----------------------------------------------------------------------------------
39
PsiBlast_CBE
81.08
63%
-125
- C5 -
2PJL
1
ERR1_HUMAN
A:
[15-244]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
---------
L
P
A
V
A
T
L
S
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
A
G----------
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
--------------------------------------------------------------------
10
PsiBlast_PDB
80.82
79%
-124
- C5 -
1VJB
1
ERR3_HUMAN
A:
[27-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
--
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
------------------------------------------------------------------------------------
307
HHSearch
80.38
65%
-126
- C5 -
3K6P
1
ERR1_HUMAN
A:
[29-246]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
P
E
K
L
Y
A
M
P
-------
H
L
P
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
---
A
G
R
--GG
A
E
R
R
-
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
-
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
M
-------------------------------------------------------------------