@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3B3_ERRg: (2016-04-07 )
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380-----.........390.......400.---.....---.410.......420.......430.......440.......450......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDS
V
E
L
CLPESFS
L
H
Y
E
E
E
L
L
C
RMSNKDRH
I
D
S
S
C
S
S
F
IKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGS
G
P
V
R
K
L
Y
D
D
C
S
S
T
IVEDP
Q
T
K
C
E
Y
M
L
NS
M
P
K
R
L
C
L
V
C
GDIASGYHYGVA
S
C
E
A
C
K
A
F
F
K
R
TIQGN
I
E
YSCPAT
N
E
C
E
I
T
K
R
R
R
K
S
C
Q
A
C
R
F
M
K
C
L
K
V
G
M
L
K
EGVR
L
D
R
VRG
G
R
Q
K
Y
K
R
RIDAENSPYL
N
P
Q
LVQ
P
A
K
K
P
Y
N
K
I
V
S
H
L
LVAEPE
K
I
Y
AMPDPTVP
D
S
D
I
K
A
L
T
T
L
C
D
LADR
E
L
V
V
I
I
GWAKHIPGF
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
SLSFED
E
L
V
YADDYIMDE
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
SMKLEKE
E
F
V
T
L
K
A
I
A
LANSDSM-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E---AGQH
M
---
E
D
P
R
R
AG
K
M
L
M
T
L
P
L
LRQT
S
T
K
A
V
Q
H
F
Y
N
I
K
LEGKV
P
M
H
K
L
F
L
E
M
L
EAKV
2
PsiBlast_PDB
90.90
99%
-120
- C5 -
2ZAS
2
ERR3_HUMAN
A:
[17-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
3
PsiBlast_PDB
90.86
99%
-119
- C5 -
2ZBS
-
ERR3_HUMAN
A:
[232-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
281
HHSearch
90.60
100%
-119
- C5 -
2E2R
4
ERR3_HUMAN
A:
[19-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
1
PsiBlast_PDB
90.50
99%
-118
- C5 -
2E2R
4
ERR3_HUMAN
A:
[17-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
13
PsiBlast_PDB
90.09
100%
-120
- C5 -
2P7G
1
ERR3_HUMAN
A:
[28-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
--
12
PsiBlast_PDB
90.04
100%
-119
- C5 -
2P7A
1
ERR3_HUMAN
A:
[27-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
--
5
PsiBlast_PDB
89.97
100%
-118
- C5 -
2GP7
-
ERR3_HUMAN
A:
[7-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
36
PsiBlast_CBE
89.84
100%
-118
- C5 -
2EWP
1
ERR3_HUMAN
B:
[1-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
--
17
PsiBlast_PDB
89.75
100%
-119
- C5 -
2EWP
1
ERR3_HUMAN
A:
[1-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
--
11
PsiBlast_PDB
89.62
100%
-122
- C5 -
1TFC
-
ERR3_HUMAN
A:
[26-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
7
PsiBlast_PDB
89.29
100%
-117
- C5 -
2GPP
1
ERR3_HUMAN
A:
[5-229]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
-
4
PsiBlast_PDB
89.21
100%
-121
- C5 -
1KV6
-
ERR3_HUMAN
A:
[7-228]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
--
6
PsiBlast_PDB
89.07
100%
-115
- C5 -
2GPO
-
ERR3_HUMAN
A:
[7-230]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
34
PsiBlast_CBE
89.02
100%
-119
- C5 -
2EWP
1
ERR3_HUMAN
D:
[3-223]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
---
35
PsiBlast_CBE
88.14
100%
-116
- C5 -
2EWP
1
ERR3_HUMAN
C:
[2-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
--
8
PsiBlast_PDB
87.94
100%
-120
- C5 -
2GPU
1
A:
[6-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
---
30
PsiBlast_CBE
87.46
100%
-114
- C5 -
1S9P
1
D:
[3-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
K
V
33
PsiBlast_CBE
87.29
100%
-126
- C5 -
2EWP
1
E:
[5-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
-----------
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
---
15
PsiBlast_PDB
86.60
100%
-113
- C5 -
1S9Q
2
ERR3_MOUSE
A:
[25-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
-
V
P
M
H
K
L
F
L
E
M
L
E
A
--
32
PsiBlast_CBE
86.55
100%
-113
- C5 -
1S9P
1
ERR3_MOUSE
B:
[3-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
--------
16
PsiBlast_PDB
84.80
100%
-111
- C5 -
1S9P
1
ERR3_MOUSE
A:
[2-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
-----------
31
PsiBlast_CBE
84.45
100%
-112
- C5 -
1S9P
1
ERR3_MOUSE
C:
[3-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
K
V
P
M
H
K
L
F
L
E
------
14
PsiBlast_PDB
83.48
100%
-109
- C5 -
2P7Z
1
ERR3_HUMAN
A:
[28-234]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
-----------------
28
PsiBlast_CBE
83.27
100%
-110
- C5 -
1VJB
1
ERR3_HUMAN
B:
[26-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
----------------
10
PsiBlast_PDB
81.52
100%
-114
- C5 -
1VJB
1
ERR3_HUMAN
A:
[27-234]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
K
I
V
S
H
L
L
V
A
E
P
E
K
I
Y
A
M
P
D
P
T
V
P
D
S
D
I
K
A
L
T
T
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
L
V
Y
A
D
D
Y
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
-------
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
---
A
G
Q
H
M
---
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
-----------------
19
PsiBlast_PDB
80.01
61%
-119
- C5 -
3K6P
1
ERR1_HUMAN
A:
[16-245]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
P
-------
H
L
P
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
-------
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
A
G
R---
G
G
---
A
E
R
R
-
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
-
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
M
289
HHSearch
78.93
64%
-116
- C5 -
3K6P
1
ERR1_HUMAN
A:
[23-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
P
-------
H
L
P
A
V
A
T
L
C
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
-------
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
---
A
G
R
--GG-
A
E
R
R
-
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
-
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
M
39
PsiBlast_CBE
78.81
60%
-112
- C5 -
2PJL
1
ERR1_HUMAN
A:
[15-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
---------
L
P
A
V
A
T
L
S
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
-------
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
A
G-----------
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
-
38
PsiBlast_CBE
78.33
60%
-111
- C5 -
2PJL
1
ERR1_HUMAN
B:
[15-244]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
G
P
V
N
A
L
V
S
H
L
L
V
V
E
P
E
K
L
Y
A
M
---------
L
P
A
V
A
T
L
S
D
L
F
D
R
E
I
V
V
T
I
S
W
A
K
S
I
P
G
F
S
S
L
S
L
S
D
Q
M
S
V
L
Q
S
V
W
M
E
V
L
V
L
G
V
A
Q
R
S
L
P
L
Q
D
E
L
A
F
A
E
D
L
V
L
D
E
E
G
A
R
A
A
G
L
G
E
L
G
A
A
L
L
Q
L
V
R
R
L
Q
A
L
R
L
E
R
E
E
Y
V
L
L
K
A
L
A
L
A
N
S
D
S
V
-------
H
I
E
D
A
E
A
V
E
Q
L
R
E
A
L
H
E
A
L
L
E
Y
E
AG-----------
R
R
R
A
G
R
L
L
L
T
L
P
L
L
R
Q
T
A
G
K
V
L
A
H
F
Y
G
V
K
L
E
G
K
V
P
M
H
K
L
F
L
E
M
L
E
A
M
-
172
PsiBlast_CBE
71.12
35%
-107
- C5 -
3OS9
2
ESR1_HUMAN
C:
[18-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
---------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
TFSST
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
---
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
-----
V
V
P
S
Y
D
L
L
L
E
M
L
D
A
--
171
PsiBlast_CBE
69.69
35%
-109
- C5 -
3OS9
2
D:
[18-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
----------
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
R
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
L
L
F
A
P
N
L
L
L
D
R
N
Q
-----
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T-------
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
---
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
-------
V
P
S
Y
D
L
L
L
E
M
L
----