@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR5A2_LRH1: (2016-04-07 )
MSSNSDTGDLQESLKHGLTPIGAGLPDRHGSPIPARGRLVMLPKVETEALGLARSHGEQGQMPENMQVSQFKMVNYSYDEDLEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKRYTCIENQNCQIDKTQRKRCPYCRFQKCLSVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGSLQGYQTYGHFPSRAIKSEYPDPYTSSPESIMGYSYMDSYQTSSPASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKMADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHAKRA
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.-......420........430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSSNSD
T
G
D
L
Q
E
S
L
K
HGLTPIGAGLPDRHGSPIPAR
G
R
L
V
M
L
PKVE
T
E
A
L
G
L
A
R
SHGEQGQMPENMQ
V
S
Q
F
K
M
V
NYS
Y
D
E
D
L
E
E
L
C
P
VCGDKVSG
Y
H
Y
G
L
L
T
C
E
S
C
K
G
F
F
K
R
T
VQNNK
R
Y
T
C
IENQNCQI
D
K
T
QRKRC
P
Y
C
R
F
Q
K
C
L
S
VG
M
K
L
E
A
V
R
A
D
R
MRGGRNKFG
P
M
Y
K
R
D
R
A
L
K
Q
Q
K
K
A
L
I
R
ANGL
K
L
E
A
M
S
Q
V
I
Q
AMPSDL
T
I
S
S
A
I
Q
N
I
H
S
ASKGLPLNHAALPPTDYDRSPFVTSP
I
S
MTMPPHGSLQG
Y
Q
TYGHF
P
S
R
A
I
KSEYPDPYTSSP
E
S
I
M
G
Y
S
Y
M
D
SYQTSSPAS
I
P
H
L
I
L
E
L
LKCEPD
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
QAN
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
SSI
F
F
R
ELKV
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
VHGKEG
S
I
F
L
V
TGQQV
D
Y
-
S
I
I
A
S
QA
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
SLQF
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
LDVKNLE
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
TMCNY
P
Q
Q
T
E
K
F
G
Q
L
L
L
RLPE
I
R
A
I
SMQA
E
E
Y
L
Y
Y
K
HLNGDV
P
Y
N
N
L
L
I
E
M
L
HAKRA
21
PsiBlast_CBE
96.45
99%
-133
- C2 -
4DOR
1
B:
[14-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
23
PsiBlast_CBE
95.83
100%
-134
- C2 -
4ONI
2
B:
[12-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
A
1
PsiBlast_PDB
94.88
99%
-140
- C2 -
1YUC
3
NR5A2_HUMAN
A:
[13-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
24
PsiBlast_CBE
94.56
99%
-138
- C2 -
3PLZ
2
B:
[16-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
-
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
-
3
PsiBlast_PDB
94.47
100%
-137
- C2 -
4ONI
4
NR5A2_HUMAN
A:
[11-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
5
PsiBlast_PDB
93.92
100%
-143
- C2 -
1ZDU
2
A:
[3-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
-------
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
22
PsiBlast_CBE
92.53
99%
-137
- C2 -
1YUC
4
B:
[14-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
4
PsiBlast_PDB
92.51
99%
-131
- C2 -
4RWV
7
A:
[5-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
6
PsiBlast_PDB
92.45
99%
-144
- C2 -
1YOK
1
A:
[15-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
---
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
7
PsiBlast_PDB
92.41
99%
-142
- C2 -
3PLZ
1
NR5A2_HUMAN
A:
[16-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
--------
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
8
PsiBlast_PDB
92.00
99%
-138
- C2 -
4DOS
4
A:
[1-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
Q
A
G
-
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
10
PsiBlast_PDB
91.67
87%
-132
- C2 -
1PK5
-
NR5A2_MOUSE
A:
[318-559]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
S
N
R
N
R
Q
E
K
L
S
A
F
G
L
L
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
A
H
G
K
E
G
T
I
F
L
V
T
G
E
H
V
D
Y
-
S
T
I
I
S
H
T
E
-
V
A
F
N
N
L
L
S
L
A
Q
E
L
V
V
R
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
S
D
V
K
N
L
E
N
L
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
V
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
L
R
A
I
S
K
Q
A
E
D
Y
L
Y
Y
K
H
V
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
-
12
PsiBlast_PDB
90.51
88%
-133
- C2 -
1ZH7
-
NR5A2_MOUSE
A:
[1-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
S
N
R
N
R
Q
E
K
L
S
A
F
G
L
L
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
A
H
G
K
E
G
T
I
F
L
V
T
G
E
H
V
D
Y
-
S
T
I
I
S
H
T
E
-
V
A
F
N
N
L
L
S
L
A
Q
E
L
V
V
R
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
S
D
V
K
N
L
E
N
L
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
V
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
K
Q
A
E
D
Y
L
Y
Y
K
H
V
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
A
2
PsiBlast_PDB
89.36
99%
-141
- C2 -
4DOR
1
NR5A2_HUMAN
A:
[14-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
-------------------------
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
11
PsiBlast_PDB
88.91
87%
-129
- C2 -
3F5C
-
NR5A2_MOUSE
A:
[318-560]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
S
N
R
N
R
Q
E
K
L
S
A
F
G
L
L
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
A
H
G
K
E
G
T
I
F
L
V
T
G
E
H
V
D
Y
-
S
T
I
I
S
H
T
E
-
V
A
F
N
N
L
L
S
L
A
Q
E
L
V
V
R
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
S
D
V
K
N
L
E
N
L
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
V
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
L
R
A
I
S
K
Q
A
E
D
Y
L
Y
Y
K
H
V
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
A
9
PsiBlast_PDB
87.73
97%
-145
- C2 -
4IS8
-
NR5A2_HUMAN
A:
[1-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E
Q
A
------
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
-
S
I
I
A
S
H
T
E
-
V
A
F
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
---
L
L
I
E
M
L
H
A
---
15
PsiBlast_PDB
76.14
60%
-116
- C2 -
4QK4
6
STF1_HUMAN
A:
[20-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
Q
V
R
A
R
I
L
G
S
L
Q
E
--
P
T
K
S
R
P
D
Q
P
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
-
T
T
V
A
T
Q
A
G
-
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
S
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
Q
T
14
PsiBlast_PDB
75.37
60%
-113
- C2 -
4QJR
1
STF1_HUMAN
A:
[20-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
Q
V
R
A
R
I
L
G
S
L
Q
E
--
P
T
K
S
R
P
D
Q
P
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
-
T
T
V
A
T
Q
A
G
-
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
S
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
Q
T
13
PsiBlast_PDB
74.45
61%
-113
- C2 -
1YP0
1
STF1_MOUSE
A:
[15-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
Q
V
R
A
R
I
V
G
C
L
Q
E
P
A
K
S
R
S
--
D
Q
P
A
P
F
S
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
L
D
H
I
Y
R
Q
V
Q
Y
G
K
E
D
S
I
L
L
V
T
G
Q
E
V
E
L
-
S
T
V
A
V
Q
A
G
-
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
H
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
L
I
L
F
S
L
D
V
K
F
L
N
N
H
S
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
C
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
Q
-
26
PsiBlast_CBE
74.23
60%
-115
- C2 -
1ZDT
1
STF1_HUMAN
B:
[16-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
Q
V
R
A
R
I
L
G
S
L
Q
E
--
P
T
K
S
R
P
D
Q
P
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
-
T
T
V
A
T
Q
A
G
-
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
S
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
--
16
PsiBlast_PDB
74.13
60%
-123
- C2 -
1YOW
1
STF1_HUMAN
A:
[17-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
D
Q
V
R
A
R
I
L
G
C
L
Q
E
--
P
--------
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
-
T
T
V
A
T
Q
A
G
-
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
C
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
---
182
PsiBlast_CBE
60.30
33%
-108
- C2 -
1S9Q
2
ERR3_MOUSE
A:
[61-249]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
C
D
L
A
D
R
E
L
V
V
I
I
G
W
A
K
H
I
P
G
F
S
T
L
S
L
A
D
Q
M
S
L
L
Q
S
A
W
M
E
I
L
I
L
G
V
V
Y
R
S
L
S
F
E
D
E
----
L
V
Y
A
D
--
D
Y
-
I
M
D
E
D
Q
S
K
L
A
G
L
L
D
L
N
N
A
I
L
Q
L
V
K
K
Y
K
S
M
K
L
E
K
E
E
F
V
T
L
K
A
I
A
L
A
N
S
D
S
M
H
I
E
D
V
E
A
V
Q
K
L
Q
D
V
L
H
E
A
L
Q
D
Y
E
A
G
Q
H
M
E
D
P
R
R
A
G
K
M
L
M
T
L
P
L
L
R
Q
T
S
T
K
A
V
Q
H
F
Y
N
I
K
L
E
G
-
V
P
M
H
K
L
F
L
E
M
L
E
A
---
35
PsiBlast_CBE
56.95
41%
-116
- C2 -
4N5G
1
?
C:
[50-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
-
V
K
D
G
-
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
-
A
I
F
D
R
V
L
T
---
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
--
31
PsiBlast_CBE
53.89
41%
-115
- C2 -
4N8R
1
?
C:
[50-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
-
V
K
D
G
-
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
-
A
I
F
D
R
V
L
T
---
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
---
32
PsiBlast_CBE
53.14
41%
-112
- C2 -
4N8R
1
?
B:
[50-239]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
C
Q
A
A
D
K
Q
L
F
T
L
V
E
W
A
K
R
I
P
H
F
S
E
L
P
L
D
D
Q
V
I
L
L
R
A
G
W
N
E
L
L
I
A
S
F
S
H
R
S
I
A
-
V
K
D
G
-
I
L
L
A
T
G
L
H
V
H
R
N
S
A
H
S
A
G
V
G
-
A
I
F
D
R
V
L
T
---
E
L
V
S
K
M
R
D
M
Q
M
D
K
T
E
L
G
C
L
R
A
I
V
L
F
N
P
D
S
K
G
L
S
N
P
A
E
V
E
A
L
R
E
K
V
Y
A
S
L
E
A
Y
C
K
H
K
Y
P
E
Q
P
G
R
F
A
K
L
L
L
R
L
P
A
L
R
S
I
G
L
K
C
L
E
H
L
F
F
F
K
L
I
G
D
T
P
I
D
T
F
L
M
E
M
L
E
A
P
--