@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1F3_RORg: (2016-11-24 )
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
Atome Classification :
(60 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460-.......-.-470.......480.......490.......500.....-..510......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDRA
P
Q
R
Q
H
R
A
S
R
E
L
L
A
AKKTHT
S
Q
I
E
V
I
P
C
K
ICGDKSSG
I
H
Y
G
V
I
T
CE
G
C
K
G
F
F
R
R
S
Q
RC
N
A
A
YSCTRQQNCPIDRTSR
N
R
C
Q
H
C
R
L
Q
K
C
L
A
LGMS
R
D
A
V
K
F
G
R
M
S
K
K
Q
R
D
S
L
H
A
E
V
Q
K
Q
L
Q
Q
R
Q
Q
Q
Q
QEP
V
V
KTPPAGAQGA
D
T
L
T
Y
T
LGLPDGQLPLGSSPDLPEASACPPG
L
L
KASGSGPSYSN
N
L
A
KAGLNGA
S
C
H
L
E
YSPERGKAE
G
R
E
S
F
Y
STGSQL
T
P
D
R
CGL
R
F
E
EHRHPGLGELGQGPDSYGSPSFRSTPEAP
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
NIF
S
R
E
E
VT
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
CQND
Q
I
V
L
L
KAG
A
M
E
V
V
L
V
R
M
C
R
A
YNADN
R
T
V
F
F
EGKY
G
G
M
E
L
F
R
AL
G
C
S
E
L
I
S
S
I
F
D
FSHSLSALHFSE
D
E
I
A
L
Y
T
A
L
V
L
I
NAHRPG
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
KLPP-K-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
QAAF
P
P
L
Y
K
E
L
FS-TETESPVGLSK
17
PsiBlast_PDB
85.94
100%
-181
- C3 -
4YPQ
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
13
PsiBlast_PDB
85.93
100%
-173
- C3 -
3KYT
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
37
PsiBlast_CBE
85.64
100%
-178
- C3 -
5G44
4
A:
[22-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
8
PsiBlast_PDB
85.55
99%
-179
- C3 -
4NIE
3
RORG_HUMAN
A:
[17-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-
T
----------
27
PsiBlast_CBE
85.47
100%
-176
- C3 -
4WPF
1
RORG_HUMAN
D:
[19-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-
T
E
---------
1
PsiBlast_PDB
85.43
100%
-180
- C3 -
5EJV
1
A:
[7-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
11
PsiBlast_PDB
85.31
100%
-172
- C3 -
4WLB
3
RORG_HUMAN
A:
[17-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
32
PsiBlast_CBE
85.16
100%
-174
- C3 -
4WLB
2
B:
[17-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
4
PsiBlast_PDB
85.15
100%
-169
- C3 -
4S14
1
A:
[4-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
36
PsiBlast_CBE
85.12
100%
-177
- C3 -
5G45
2
A:
[22-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
43
PsiBlast_CBE
84.89
99%
-170
- C3 -
5C4O
4
?
A:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
H
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
7
PsiBlast_PDB
84.78
100%
-173
- C3 -
4WPF
1
RORG_HUMAN
A:
[19-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-
T
E
---------
40
PsiBlast_CBE
84.64
99%
-172
- C3 -
5C4U
4
A:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
H
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
28
PsiBlast_CBE
84.64
99%
-169
- C3 -
4NIE
3
B:
[17-261]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-
T
----------
42
PsiBlast_CBE
84.47
99%
-174
- C3 -
5C4S
3
RORG_HUMAN
A:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
H
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
16
PsiBlast_PDB
84.47
100%
-174
- C3 -
4XT9
1
?
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
6
PsiBlast_PDB
84.39
100%
-165
- C3 -
3L0L
1
RORG_HUMAN
A:
[2-248]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
14
PsiBlast_PDB
84.24
100%
-172
- C3 -
3L0J
1
A:
[1-243]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
3
PsiBlast_PDB
84.24
99%
-172
- C3 -
5IZ0
1
A:
[9-252]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
T-----------
24
PsiBlast_CBE
84.22
99%
-176
- C3 -
5IZ0
1
?
D:
[9-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
38
PsiBlast_CBE
84.14
100%
-170
- C3 -
5G43
1
RORG_HUMAN
A:
[22-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
25
PsiBlast_CBE
84.06
99%
-172
- C3 -
5IZ0
1
?
B:
[7-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
26
PsiBlast_CBE
84.02
100%
-159
- C3 -
3L0L
1
B:
[1-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
19
PsiBlast_PDB
83.78
100%
-174
- C3 -
5APH
2
RORG_HUMAN
A:
[22-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
21
PsiBlast_CBE
83.73
100%
-172
- C3 -
5EJV
1
?
B:
[8-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-
T
----------
39
PsiBlast_CBE
83.58
100%
-176
- C3 -
5G42
1
RORG_HUMAN
A:
[22-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
41
PsiBlast_CBE
83.23
99%
-171
- C3 -
5C4T
8
A:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
H
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
20
PsiBlast_PDB
83.23
100%
-172
- C3 -
5APJ
1
A:
[22-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
12
PsiBlast_PDB
83.02
100%
-169
- C3 -
4WQP
1
RORG_HUMAN
A:
[20-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
---------------------
10
PsiBlast_PDB
82.62
100%
-166
- C3 -
4QM0
2
RORG_HUMAN
A:
[6-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
---------------------
106
HHSearch
82.54
100%
-174
- C3 -
5APH
2
RORG_HUMAN
A:
[28-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-
G
----------
34
PsiBlast_CBE
81.83
100%
-164
- C3 -
5APK
1
?
B:
[23-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
-------------------
29
PsiBlast_CBE
81.75
100%
-162
- C3 -
4QM0
2
C:
[6-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
----------
Q
A
A
F
P
P
L
Y
K
E
L
F
S
------------
18
PsiBlast_PDB
81.66
100%
-175
- C3 -
5APK
1
A:
[23-244]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
47
PsiBlast_CBE
81.54
100%
-182
- C3 -
4ZOM
1
?
C:
[6-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
55
PsiBlast_CBE
81.37
100%
-187
- C3 -
5ETH
1
?
B:
[3-223]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
--------------------------------
48
PsiBlast_CBE
81.13
100%
-180
- C3 -
4ZOM
1
B:
[3-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
9
PsiBlast_PDB
80.78
100%
-176
- C3 -
4NB6
1
RORG_HUMAN
A:
[7-227]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
30
PsiBlast_CBE
80.69
100%
-176
- C3 -
4NB6
1
B:
[7-228]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
--------------------------------
49
PsiBlast_CBE
80.63
100%
-169
- C3 -
4ZOM
1
RORG_HUMAN
A:
[3-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
--------------------------------
56
PsiBlast_CBE
80.50
100%
-183
- C3 -
5ETH
1
A:
[5-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
31
PsiBlast_CBE
80.16
100%
-173
- C3 -
4WQP
1
B:
[21-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
50
PsiBlast_CBE
80.13
100%
-183
- C3 -
4ZJW
1
RORG_HUMAN
A:
[6-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
---------------------------------
44
PsiBlast_CBE
79.23
98%
-181
- C3 -
5IXK
1
?
B:
[9-228]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
--------------------------------
53
PsiBlast_CBE
79.12
100%
-157
- C3 -
4ZJR
1
?
B:
[3-222]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
-----------------------------------
45
PsiBlast_CBE
78.63
98%
-178
- C3 -
5IXK
1
A:
[10-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
--------------------------------
15
PsiBlast_PDB
78.46
100%
-166
- C3 -
3B0W
1
RORG_HUMAN
A:
[1-215]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
----------------------------------------
51
PsiBlast_CBE
78.43
100%
-172
- C3 -
4ZJR
1
?
D:
[3-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
--------------------------------------
52
PsiBlast_CBE
78.09
100%
-169
- C3 -
4ZJR
1
?
C:
[3-221]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
------------------------------------
54
PsiBlast_CBE
78.07
100%
-172
- C3 -
4ZJR
1
A:
[3-219]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
--------------------------------------
33
PsiBlast_CBE
77.77
100%
-167
- C3 -
3B0W
1
B:
[1-217]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
--------------------------------------
22
PsiBlast_CBE
77.75
100%
-169
- C3 -
5AYG
1
B:
[4-222]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
-------------------------------------
2
PsiBlast_PDB
77.43
100%
-168
- C3 -
5AYG
1
RORG_HUMAN
A:
[4-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
---------------------------------------
46
PsiBlast_CBE
76.80
100%
-166
- C3 -
4ZOM
1
?
D:
[4-218]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
-
I
L
A
K
L
P
P
-
K
-
G
K
L
R
S
L
C
S
Q
H
V
---------------------------------------
59
PsiBlast_CBE
69.69
52%
-135
- C3 -
1S0X
1
A:
[11-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
F
Q
G
P
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
-
D
G
I
L
T
K
L
I
C
-
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
-------------
57
PsiBlast_CBE
69.69
53%
-123
- C3 -
4S15
2
B:
[2-249]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
-
D
G
I
L
T
K
L
I
C
-
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
T
-
S
E
F
E
-------
60
PsiBlast_CBE
69.68
52%
-136
- C3 -
1N83
1
A:
[11-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
L
F
Q
G
P
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
-
D
G
I
L
T
K
L
I
C
-
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
-------------
58
PsiBlast_CBE
68.91
53%
-135
- C3 -
4S15
2
RORA_HUMAN
A:
[2-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
-
D
G
I
L
T
K
L
I
C
-
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
T
------------
105
HHSearch
65.44
54%
-165
- C3 -
1N83
1
A:
[62-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
D
G
-
I
L
T
K
L
I
C
K
V
-
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
-------------
108
HHSearch
65.18
54%
-154
- C3 -
1NQ7
1
RORB_RAT
A:
[47-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
A
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
G
M
Q
M
F
K
A
L
G
S
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
L
D
D
E
-
T
L
A
K
L
I
A
K
I
-
P
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
Q
S
H
P
D
I
V
N
T
L
F
P
P
L
Y
K
E
L
F
N
------------