@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1H4_FXR: (2016-11-25 )
MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
M
QFQGLEN
P
I
QISPHCSCTP
S
G
F
F
M
E
M
M
SMKPAK
G
V
L
T
E
Q
V
AGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQ
Q
P
E
EWYS
P
G
I
Y
E
L
R
RM
P
A
E
T
LYQGET
E
V
AEMPVTKKPRMGASAGRIKG
D
E
L
C
V
V
CGDRASG
Y
H
YN
A
L
T
C
E
G
C
K
G
F
F
R
R
SITKN
A
V
Y
KCKNGG
N
C
V
M
D
M
Y
M
R
R
K
C
Q
E
C
R
L
R
K
C
K
E
M
G
M
L
A
E
C
M
Y
T
G
L
L
T
E
I
Q
C
K
S
K
R
L
R
K
N
V
K
Q
H
A
D
QTVNEDSEG
R
D
L
R
Q
V
T
S
T
T
K
S
C
R
E
KTELTP
D
Q
Q
T
L
L
H
F
I
M
D
SYNKQRM
P
Q
E
I
T
N
K
I
L
K
E
E
FSAEE
N
F
L
I
L
T
E
MAT
N
H
V
Q
V
L
V
E
F
T
K
KLPGFQTLDHED
Q
I
A
L
LKGS
A
V
E
A
M
F
L
R
S
A
E
I
F
N
KKLPSG
H
S
D
L
L
E
E
R
I
RNSGIS
D
E
YI
T
P
M
F
S
F
Y
K
S
I
G
E
LKM
T
Q
E
E
Y
A
L
L
T
A
I
V
I
LSP
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
IHQPEN
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
TF
N
H
H
H
A
E
M
L
M
S
WRVNDHKFT
P
L
L
C
E
IWDVQ
26
PsiBlast_CBE
94.17
99%
-154
- C4 -
3OMK
1
C:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
20
PsiBlast_PDB
94.17
99%
-147
- C4 -
3OOK
1
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
24
PsiBlast_CBE
94.00
99%
-149
- C4 -
3OOF
1
C:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
18
PsiBlast_PDB
93.33
99%
-147
- C4 -
3OMM
1
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
16
PsiBlast_PDB
93.31
99%
-142
- C4 -
3OLF
1
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
23
PsiBlast_CBE
93.06
99%
-146
- C4 -
3OOK
1
C:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
17
PsiBlast_PDB
93.02
99%
-146
- C4 -
3OMK
1
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
27
PsiBlast_CBE
92.91
99%
-147
- C4 -
3OLF
1
C:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
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D
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Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
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P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
15
PsiBlast_PDB
92.86
99%
-142
- C4 -
3OKI
1
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
19
PsiBlast_PDB
92.48
99%
-142
- C4 -
3OOF
1
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
25
PsiBlast_CBE
92.46
99%
-143
- C4 -
3OMM
1
C:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
28
PsiBlast_CBE
92.01
99%
-144
- C4 -
3OKI
1
C:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
14
PsiBlast_PDB
91.44
99%
-150
- C4 -
3OKH
2
A:
[5-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
-
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
48
HHSearch
91.28
100%
-139
- C4 -
4QE6
2
A:
[4-233]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
---
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
21
PsiBlast_CBE
91.19
100%
-139
- C4 -
3BEJ
1
B:
[10-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
9
PsiBlast_PDB
90.99
100%
-141
- C4 -
4QE6
2
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
---
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
8
PsiBlast_PDB
90.71
100%
-136
- C4 -
3RUU
1
A:
[1-229]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
4
PsiBlast_PDB
90.67
100%
-140
- C4 -
3HC5
1
A:
[4-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
3
PsiBlast_PDB
90.58
100%
-136
- C4 -
3DCU
1
A:
[7-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
1
PsiBlast_PDB
90.52
100%
-144
- C4 -
3BEJ
1
NR1H4_HUMAN
A:
[11-237]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
---
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
2
PsiBlast_PDB
90.48
100%
-136
- C4 -
3DCT
1
A:
[7-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
7
PsiBlast_PDB
90.31
100%
-127
- C4 -
3RUT
1
A:
[1-229]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
6
PsiBlast_PDB
90.25
99%
-155
- C4 -
3FLI
1
A:
[3-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
-------
F
T
P
L
L
C
E
I
W
D
V
-
5
PsiBlast_PDB
89.81
100%
-135
- C4 -
3RVF
1
A:
[5-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
Q
35
PsiBlast_CBE
89.29
94%
-140
- C4 -
1OSV
1
B:
[1-229]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
31
PsiBlast_CBE
88.81
98%
-131
- C4 -
3P88
1
A:
[1-229]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
E
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
Q
32
PsiBlast_CBE
88.77
99%
-132
- C4 -
3GD2
1
A:
[3-229]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
-
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
-
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
Q
13
PsiBlast_PDB
88.77
99%
-158
- C4 -
3FXV
1
A:
[5-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
A
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
-----
H
S
D
L
L
E
A
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
--
H
K
F
T
P
L
L
C
E
I
W
D
V
-
11
PsiBlast_PDB
88.61
100%
-158
- C4 -
1OSH
1
A:
[4-231]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
---------------
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
36
PsiBlast_CBE
88.60
94%
-143
- C4 -
1OSV
1
NR1H4_RAT
A:
[1-229]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
12
PsiBlast_PDB
88.55
100%
-150
- C4 -
3L1B
1
A:
[5-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
---------------
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
29
PsiBlast_CBE
88.13
99%
-125
- C4 -
3HC6
1
A:
[3-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
Q
10
PsiBlast_PDB
87.84
100%
-140
- C4 -
4QE8
5
NR1H4_HUMAN
A:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
--
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
----
K
F
T
P
L
L
C
E
I
W
D
V
Q
22
PsiBlast_CBE
87.43
100%
-137
- C4 -
4QE8
4
B:
[5-233]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
--
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
-----
K
F
T
P
L
L
C
E
I
W
D
V
Q
37
PsiBlast_CBE
87.36
94%
-137
- C4 -
1OT7
1
B:
[1-229]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
38
PsiBlast_CBE
86.86
94%
-130
- C4 -
1OT7
1
NR1H4_RAT
A:
[1-229]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
L
T
V
D
Q
Q
T
L
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
S
H
V
Q
I
L
V
E
F
T
K
R
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
A
G
H
A
D
L
L
E
E
R
I
R
K
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
V
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
Y
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
C
E
I
W
D
V
-
30
PsiBlast_CBE
86.80
99%
-134
- C4 -
3P89
1
A:
[4-228]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
--
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
D
V
-
34
PsiBlast_CBE
85.43
99%
-153
- C4 -
4OIV
1
NR1H4_HUMAN
A:
[1-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
----------------
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
F
T
P
L
L
E
E
I
W
---
33
PsiBlast_CBE
85.05
99%
-138
- C4 -
4OIV
1
B:
[1-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
-------
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
E
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
R
V
N
D
H
K
-
T
P
L
L
E
E
I
W
---
39
PsiBlast_CBE
80.91
100%
-130
- C4 -
4WVD
1
B:
[2-211]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
--
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
------------------
40
PsiBlast_CBE
80.06
100%
-128
- C4 -
4WVD
1
NR1H4_HUMAN
A:
[1-211]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
T
P
D
Q
Q
T
L
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
E
I
T
N
K
I
L
K
-
E
F
S
A
E
E
N
F
L
I
L
T
E
M
A
T
N
H
V
Q
V
L
V
E
F
T
K
K
L
P
G
F
Q
T
L
D
H
E
D
Q
I
A
L
L
K
G
S
A
V
E
A
M
F
L
R
S
A
E
I
F
N
K
K
L
P
S
G
H
S
D
L
L
E
E
R
I
R
N
S
G
I
S
D
E
Y
I
T
P
M
F
S
F
Y
K
S
I
G
E
L
K
M
T
Q
E
E
Y
A
L
L
T
A
I
V
I
L
S
P
D
R
Q
Y
I
K
D
R
E
A
V
E
K
L
Q
E
P
L
L
D
V
L
Q
K
L
C
K
I
H
Q
P
E
N
P
Q
H
F
A
C
L
L
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
M
L
M
S
W
------------------