@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR5A1_STF1: (2016-11-26 )
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGRAIKSEYPEPYASPPQPGLPYGYPEPFSGGPNVPELILQLLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTVATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT
Atome Classification :
(22 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.........260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDY
S
Y
DE
D
L
D
E
L
C
PVCGDKVSG
Y
H
Y
G
L
L
T
C
E
S
C
K
G
F
F
K
R
T
VQNNK
H
Y
T
CTESQSCKI
D
K
T
QRKRC
P
F
C
R
F
Q
K
C
L
T
VG
M
R
L
E
A
V
R
A
D
R
MRGGRNKFG
P
M
Y
K
R
D
R
A
L
K
Q
Q
K
K
A
QIRAN
G
F
K
LETGPPMGVPPPPPPAPDYVLPPSLHGPEPKGLAAGPPAGPLGDFGAPALPMAVPGAHGPLAGYLYPAFPGR
A
I
KSEYPEPYASPPQPGLPYGYPEPFSGGP
N
V
P
E
L
I
L
Q
L
LQLEP
D
E
D
Q
V
R
A
R
I
L
G
C
L
QE--PTKSRPDQ
P
A
A
F
G
L
L
C
R
MA
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
QHGKEG
S
I
L
L
V
TGQ
E
V
E
L
T
T
V
A
T
Q
A
G
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
QLD
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
LNN
H
I
L
V
K
D
A
Q
EKAN
A
A
L
LD
Y
T
LCHYPH
C
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
HLGNEMPR
N
N
L
L
I
E
M
L
Q
AKQT
2
PsiBlast_PDB
95.08
99%
-160
- C3 -
4QK4
6
STF1_HUMAN
A:
[2-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
P
N
V
P
E
L
I
L
Q
L
L
Q
L
E
P
D
E
D
Q
V
R
A
R
I
L
G
S
L
Q
E
--
P
T
K
S
R
P
D
Q
P
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
T
T
V
A
T
Q
A
G
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
S
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
Q
T
1
PsiBlast_PDB
94.79
99%
-160
- C3 -
4QJR
1
STF1_HUMAN
A:
[2-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
G
P
N
V
P
E
L
I
L
Q
L
L
Q
L
E
P
D
E
D
Q
V
R
A
R
I
L
G
S
L
Q
E
--
P
T
K
S
R
P
D
Q
P
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
T
T
V
A
T
Q
A
G
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
S
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
Q
T
21
PsiBlast_CBE
93.12
99%
-160
- C3 -
1ZDT
1
STF1_HUMAN
B:
[1-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
V
P
E
L
I
L
Q
L
L
Q
L
E
P
D
E
D
Q
V
R
A
R
I
L
G
S
L
Q
E
--
P
T
K
S
R
P
D
Q
P
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
T
T
V
A
T
Q
A
G
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
S
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
--
3
PsiBlast_PDB
92.70
99%
-175
- C3 -
1YOW
1
STF1_HUMAN
A:
[2-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
V
P
E
L
M
L
Q
L
L
Q
L
E
P
D
E
D
Q
V
R
A
R
I
L
G
C
L
Q
E
--
P
--------
A
A
F
G
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
F
D
H
I
Y
R
Q
V
Q
H
G
K
E
G
S
I
L
L
V
T
G
Q
E
V
E
L
T
T
V
A
T
Q
A
G
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
L
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
I
I
L
F
S
L
D
L
K
F
L
N
N
H
I
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
C
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
---
4
PsiBlast_PDB
87.31
93%
-155
- C3 -
1YP0
1
STF1_MOUSE
A:
[15-239]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
D
Q
V
R
A
R
I
V
G
C
L
Q
E
--
P
A
K
S
R
S
D
Q
P
A
P
F
S
L
L
C
R
M
A
D
Q
T
F
I
S
I
V
D
W
A
R
R
C
M
V
F
K
E
L
E
V
A
D
Q
M
T
L
L
Q
N
C
W
S
E
L
L
V
L
D
H
I
Y
R
Q
V
Q
Y
G
K
E
D
S
I
L
L
V
T
G
Q
E
V
E
L
S
T
V
A
V
Q
A
G
S
L
L
H
S
L
V
L
R
A
Q
E
L
V
L
Q
L
H
A
L
Q
L
D
R
Q
E
F
V
C
L
K
F
L
I
L
F
S
L
D
V
K
F
L
N
N
H
S
L
V
K
D
A
Q
E
K
A
N
A
A
L
L
D
Y
T
L
C
H
Y
P
H
C
G
D
K
F
Q
Q
L
L
L
C
L
V
E
V
R
A
L
S
M
Q
A
K
E
Y
L
Y
H
K
H
L
G
N
E
M
P
R
N
N
L
L
I
E
M
L
Q
A
K
Q
-
28
PsiBlast_CBE
78.42
60%
-43
- C3 -
3PLZ
2
B:
[16-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
-
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
-
14
PsiBlast_PDB
78.07
60%
-93
- C3 -
3PLZ
1
NR5A2_HUMAN
A:
[16-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
E--------
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
27
PsiBlast_CBE
77.29
59%
-44
- C3 -
4PLE
3
NR5A2_HUMAN
C:
[3-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
-
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
10
PsiBlast_PDB
76.79
59%
-42
- C3 -
4PLE
7
NR5A2_HUMAN
A:
[2-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
5
PsiBlast_PDB
76.62
59%
-43
- C3 -
4RWV
7
A:
[5-247]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
15
PsiBlast_PDB
76.59
59%
-37
- C3 -
4DOS
4
A:
[1-242]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
25
PsiBlast_CBE
76.23
59%
-44
- C3 -
4PLE
6
G:
[2-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
23
PsiBlast_CBE
76.07
59%
-40
- C3 -
4DOR
1
B:
[14-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
24
PsiBlast_CBE
76.06
59%
-41
- C3 -
1YUC
4
B:
[14-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
6
PsiBlast_PDB
75.97
59%
-38
- C3 -
4ONI
4
NR5A2_HUMAN
A:
[11-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
--
16
PsiBlast_PDB
75.95
59%
-40
- C3 -
5SYZ
1
?
A:
[4-242]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
--
N
L
L
I
E
M
L
H
A
---
22
PsiBlast_CBE
75.74
59%
-34
- C3 -
4ONI
2
B:
[12-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
K
R
A
13
PsiBlast_PDB
75.06
60%
-49
- C3 -
1YOK
1
A:
[15-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
---
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
11
PsiBlast_PDB
75.02
59%
-42
- C3 -
5L11
1
?
A:
[4-240]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
---
N
L
L
I
E
M
L
-----
26
PsiBlast_CBE
74.96
59%
-37
- C3 -
4PLE
7
NR5A2_HUMAN
E:
[1-241]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
----
7
PsiBlast_PDB
74.84
59%
-34
- C3 -
1YUC
3
NR5A2_HUMAN
A:
[13-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ
A
N
R
S
K
H
E
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---
12
PsiBlast_PDB
73.77
60%
-52
- C3 -
1ZDU
2
A:
[3-242]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
H
L
I
L
E
L
L
K
C
E
P
D
E
P
Q
V
Q
A
K
I
M
A
Y
L
Q
Q
EQ-------
K
L
S
T
F
G
L
M
C
K
M
A
D
Q
T
L
F
S
I
V
E
W
A
R
S
S
I
F
F
R
E
L
K
V
D
D
Q
M
K
L
L
Q
N
C
W
S
E
L
L
I
L
D
H
I
Y
R
Q
V
V
H
G
K
E
G
S
I
F
L
V
T
G
Q
Q
V
D
Y
S
I
I
A
S
Q
A
G
A
T
L
N
N
L
M
S
H
A
Q
E
L
V
A
K
L
R
S
L
Q
F
D
Q
R
E
F
V
C
L
K
F
L
V
L
F
S
L
D
V
K
N
L
E
N
F
Q
L
V
E
G
V
Q
E
Q
V
N
A
A
L
L
D
Y
T
M
C
N
Y
P
Q
Q
T
E
K
F
G
Q
L
L
L
R
L
P
E
I
R
A
I
S
M
Q
A
E
E
Y
L
Y
Y
K
H
L
N
G
D
V
P
Y
N
N
L
L
I
E
M
L
H
A
---