@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1C1_PPARa: (2016-04-07 )
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
Atome Classification :
(23 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVDTESPLCPLSPLEAGDLES
P
L
S
E
E
F
L
Q
E
MG
N
I
Q
E
I
S
Q
SIGEDSSGSFGF
T
E
Y
Q
Y
LGSCPGSDG
S
V
I
T
DTLSPASSPS
S
V
T
YPVVPGSVDESPS
G
A
L
N
I
E
C
R
I
CGDKASGYHYGV
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
V
Y
DKCDRS
C
K
IQKKNR
N
K
C
Q
Y
C
R
F
H
K
C
L
S
VGMSHNAIRFGRMP
R
S
E
K
A
K
L
K
A
E
I
L
T
CEHDIEDS
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
NFNMN
K
V
K
A
R
V
I
L
SGKASNNP
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
NGIQNKEA
E
V
R
I
F
H
C
CQCT
S
V
E
T
V
T
E
L
T
E
F
A
K
AIPGFANLDLND
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
MNKD
G
M
L
V
A
YGN
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
IMEPKF
D
F
A
M
K
F
N
A
L
ELDD
S
D
I
S
L
F
V
A
A
I
I
CCGDRPGLLN
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
QSNHPDD
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
KTESD
A
A
L
H
P
L
L
Q
E
I
Y
R
DMY
13
PsiBlast_PDB
91.83
100%
-146
- C3 -
2P54
1
PPARA_HUMAN
A:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
27
PsiBlast_CBE
91.59
100%
-141
- C3 -
3ET1
1
PPARA_HUMAN
B:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
28
PsiBlast_CBE
91.56
99%
-148
- C3 -
2NPA
1
PPARA_HUMAN
C:
[199-468]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
---
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
26
PsiBlast_CBE
91.31
99%
-156
- C- -
3KDT
1
PPARA_HUMAN
B:
[4-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
25
PsiBlast_CBE
91.17
99%
-154
- C- -
3KDU
1
PPARA_HUMAN
B:
[4-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
6
PsiBlast_PDB
90.71
100%
-141
- C3 -
3SP6
1
PPARA_HUMAN
A:
[13-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
---
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
1
PsiBlast_PDB
90.60
100%
-145
- C3 -
1K7L
-
PPARA_HUMAN
A:
[22-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
11
PsiBlast_PDB
90.27
99%
-139
- C3 -
2NPA
1
PPARA_HUMAN
A:
[199-467]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
8
PsiBlast_PDB
90.21
100%
-143
- C3 -
3ET1
1
PPARA_HUMAN
A:
[22-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
5
PsiBlast_PDB
89.47
99%
-157
- C- -
3KDU
1
PPARA_HUMAN
A:
[7-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
3
PsiBlast_PDB
89.30
100%
-153
- C3 -
4CI4
1
PPARA_HUMAN
A:
[10-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
----------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
2
PsiBlast_PDB
89.30
100%
-145
- C3 -
4BCR
3
PPARA_HUMAN
A:
[10-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
24
PsiBlast_CBE
89.05
100%
-146
- C3 -
4BCR
3
PPARA_HUMAN
B:
[2-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
4
PsiBlast_PDB
88.85
99%
-160
- C- -
3KDT
1
PPARA_HUMAN
A:
[7-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
9
PsiBlast_PDB
87.95
100%
-143
- C3 -
2ZNN
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
7
PsiBlast_PDB
87.67
100%
-151
- C3 -
3G8I
1
PPARA_HUMAN
A:
[4-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
-------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
10
PsiBlast_PDB
87.62
100%
-142
- C3 -
3VI8
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
34
HHSearch
87.42
99%
-142
- C3 -
3VI8
1
PPARA_HUMAN
A:
[7-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
14
PsiBlast_PDB
87.12
100%
-149
- C3 -
3FEI
1
PPARA_HUMAN
A:
[1-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
--------------
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
29
PsiBlast_CBE
86.17
100%
-136
- C3 -
1KKQ
1
PPARA_HUMAN
D:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
30
PsiBlast_CBE
85.96
100%
-140
- C3 -
1KKQ
1
PPARA_HUMAN
C:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
31
PsiBlast_CBE
85.95
100%
-143
- C3 -
1KKQ
1
PPARA_HUMAN
B:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
12
PsiBlast_PDB
85.33
100%
-138
- C3 -
1KKQ
1
PPARA_HUMAN
A:
[1-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y