@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1H3_LXRa: (2017-01-06 )
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLWLGAPVPDIPPDS
A
V
E
LWKPGAQDASSQAQGGS
S
C
I
L
R
E
EARMPHSAGGTAGVGLEAAEP
T
A
L
L
TRAEPPSEPTEIR
P
Q
KRKKGPA
P
K
M
L
G
N
E
L
C
S
VCGDKASG
F
H
Y
N
V
LSCE
G
C
K
G
F
F
R
R
S
V
I
KGA
H
Y
I
CHSGGHC
P
M
D
T
Y
M
R
R
K
C
Q
E
C
R
L
R
K
C
R
Q
AGM
R
E
E
CVL
S
E
E
Q
I
R
L
K
K
L
K
R
Q
E
E
E
QAHATSLPPRASSPPQILPQL
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
CNRRSFSDRLRVTPWPMAPDPH
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
QL
P
G
F
L
QLSRED
Q
I
A
L
L
KTS
A
I
E
V
M
L
LETSRRYNPGSE
S
I
T
F
L
K
DFSY
N
R
E
D
F
A
KAG
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
LQLNDA
E
F
A
L
L
I
A
I
S
I
FSADRP
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
SIHHPHDR
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
HSE
Q
V
F
A
L
R
LQDKKL
P
P
L
L
S
E
I
WDVHE
9
PsiBlast_PDB
80.62
95%
-121
- C2 -
3FAL
1
NR1H3_MOUSE
B:
[23-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
----
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
21
PsiBlast_CBE
80.54
100%
-127
- C2 -
5AVI
1
?
C:
[40-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-----------
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
22
PsiBlast_CBE
80.52
100%
-120
- C2 -
3IPU
1
NR1H3_HUMAN
B:
[41-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
24
PsiBlast_CBE
80.45
95%
-118
- C2 -
3FC6
1
NR1H3_MOUSE
D:
[24-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
3
PsiBlast_PDB
80.44
100%
-121
- C2 -
3IPU
1
NR1H3_HUMAN
A:
[40-281]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
----
P
H
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
25
PsiBlast_CBE
80.37
95%
-119
- C2 -
3FAL
1
NR1H3_MOUSE
D:
[23-264]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
8
PsiBlast_PDB
80.32
95%
-125
- C2 -
3FC6
1
NR1H3_MOUSE
B:
[24-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
4
PsiBlast_PDB
80.23
100%
-128
- C2 -
5AVI
1
?
A:
[40-282]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-----------
R
V
T
P
W
P
----
P
H
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
23
PsiBlast_CBE
80.01
100%
-130
- C2 -
3IPS
1
NR1H3_HUMAN
B:
[41-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
----------
L
R
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
10
PsiBlast_PDB
79.81
98%
-113
- C2 -
2ACL
-
NR1H3_MOUSE
B:
[2-242]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
W
P
I
A
P
D
P
Q
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
2
PsiBlast_PDB
79.19
100%
-129
- C2 -
3IPS
1
NR1H3_HUMAN
A:
[41-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
T
P
W
P
------
S
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
-
5
PsiBlast_PDB
79.07
100%
-128
- C2 -
5AVL
1
?
A:
[40-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
T
P
W
--------
R
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
47
HHSearch
78.64
100%
-130
- C2 -
3IPQ
1
NR1H3_HUMAN
A:
[41-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------
T
P
W
P
--------
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
1
PsiBlast_PDB
78.64
100%
-130
- C2 -
3IPQ
1
NR1H3_HUMAN
A:
[41-281]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------
T
P
W
P
--------
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--
7
PsiBlast_PDB
75.65
99%
-119
- C2 -
1UHL
1
NR1H3_HUMAN
B:
[1-240]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
------------------
E
A
R
Q
Q
R
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
---
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
D
K
K
L
P
P
L
L
S
E
I
W
D
V
--