@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3C3_PRGR: (2017-01-06 )
MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLFPRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAAAHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTVMDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLGPPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPPYLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHNYLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPVGVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
Atome Classification :
(31 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTELKAKGPRAPHVAGGPPSPEVGSP
L
L
CRPAAGPFPGSQTSDTLPEV
S
A
I
P
I
SLDGLLFPRPCQGQDPSDE
K
T
Q
D
Q
Q
S
L
S
D
V
E
G
A
Y
S
R
A
E
ATRGAGGSSSSPPEKDS
G
L
L
D
S
V
L
D
T
L
LAPSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAA
P
A
T
Q
R
V
L
S
P
L
M
SRSGCKVGDSSG
T
A
A
A
H
K
V
LPRGL
S
P
A
R
Q
LLLPASESPHWSGAPVKPSPQ
A
A
A
V
E
V
EEEDGSESEESAGPLLKGKPRALGGAAAGGGAAAVPPGAAAG
G
V
A
L
VPKEDSRFSA
P
R
V
A
L
V
EQDAPMAPGRS
P
L
A
T
T
V
M
D
F
IHVPILP
L
N
H
A
L
L
A
A
R
T
R
Q
L
L
EDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPDCAYPPDAEPKDDAYPLYSDFQPPA
L
K
I
KEEEEGAEASARSP
R
S
Y
L
V
AGANPAAFPDFPLGPPPPLPPRATPSRPGE
A
A
V
TAAPASASVSSASSSG
S
T
L
E
C
I
L
Y
KAEGAPPQQGPFAPPPCKAPGASGCLLPRDGLPSTSASAAAAGAA
P
A
L
Y
P
ALGLNGLPQLG
Y
Q
A
A
V
L
KEGLPQVY
P
P
Y
L
N
YLRPDSEASQSPQY
S
F
E
S
L
P
Q
K
I
C
L
I
CGDEASG
C
H
Y
G
V
L
TCG
S
C
K
V
F
F
K
R
A
MEGQH
N
Y
L
CAGRN
D
C
I
V
D
K
I
RRKNC
P
A
C
R
L
R
K
C
C
Q
AGMVLGG
R
K
F
K
K
F
N
K
V
R
V
V
R
A
L
D
A
VALPQPVGVPN
E
S
Q
A
L
S
Q
RFTFSPGQD
I
Q
L
I
P
P
L
I
N
L
L
MSIEP
D
V
I
Y
AGHDNTKPD
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
SLPGFRNLHIDD
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
GLGWR
S
Y
KHVS
G
Q
M
L
Y
FA
P
D
L
IL
N
E
Q
R
MKE
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
QVS
Q
E
E
F
L
C
M
K
V
L
L
L
L
NTI
P
L
E
GLR
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
IGLRQKGVV
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
SRALSVE
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
LFHKK
9
PsiBlast_PDB
96.13
100%
-125
- C2 -
1A28
1
PRGR_HUMAN
A:
[5-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
13
PsiBlast_PDB
95.78
100%
-126
- C2 -
1E3K
1
PRGR_HUMAN
A:
[7-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
8
PsiBlast_PDB
95.56
100%
-124
- C2 -
4APU
1
PRGR_HUMAN
A:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
24
PsiBlast_CBE
95.43
100%
-125
- C2 -
4A2J
1
B:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
6
PsiBlast_PDB
95.32
100%
-122
- C2 -
3ZRB
3
PRGR_HUMAN
A:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
26
PsiBlast_CBE
95.24
100%
-121
- C2 -
3ZRA
1
B:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
33
PsiBlast_CBE
95.01
100%
-124
- C2 -
1ZUC
1
PRGR_HUMAN
A:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
2
PsiBlast_PDB
94.98
100%
-124
- C2 -
3G8O
1
PRGR_HUMAN
A:
[12-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
-
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
22
PsiBlast_CBE
94.82
100%
-128
- C2 -
3G8O
1
B:
[13-262]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
25
PsiBlast_CBE
94.77
100%
-128
- C2 -
3ZRB
2
B:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
16
PsiBlast_PDB
94.74
100%
-128
- C2 -
1ZUC
1
B:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
27
PsiBlast_CBE
94.61
100%
-126
- C2 -
3ZR7
5
B:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
----
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
29
PsiBlast_CBE
94.60
100%
-128
- C2 -
3HQ5
2
B:
[5-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
7
PsiBlast_PDB
94.57
100%
-127
- C2 -
4A2J
1
PRGR_HUMAN
A:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
4
PsiBlast_PDB
94.56
100%
-126
- C2 -
3ZR7
6
PRGR_HUMAN
A:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
31
PsiBlast_CBE
94.55
100%
-125
- C2 -
3D90
1
B:
[8-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
15
PsiBlast_PDB
94.55
100%
-126
- C2 -
1SR7
1
PRGR_HUMAN
A:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
84
HHSearch
94.53
100%
-126
- C2 -
1SQN
1
PRGR_HUMAN
A:
[10-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
1
PsiBlast_PDB
94.53
100%
-126
- C2 -
1SQN
1
PRGR_HUMAN
A:
[10-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
30
PsiBlast_CBE
94.52
100%
-124
- C2 -
1A28
1
B:
[6-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
34
PsiBlast_CBE
94.31
100%
-126
- C2 -
1SR7
2
B:
[9-257]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
35
PsiBlast_CBE
94.20
100%
-128
- C2 -
3KBA
1
B:
[2-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
23
PsiBlast_CBE
94.08
100%
-126
- C2 -
4APU
1
B:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
5
PsiBlast_PDB
93.95
100%
-126
- C2 -
3ZRA
1
PRGR_HUMAN
A:
[10-259]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
32
PsiBlast_CBE
93.77
100%
-126
- C2 -
1E3K
1
B:
[8-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
14
PsiBlast_PDB
93.66
100%
-121
- C2 -
3D90
1
PRGR_HUMAN
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
--
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--
21
PsiBlast_CBE
93.56
100%
-126
- C2 -
1SQN
1
B:
[11-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
-
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
K
12
PsiBlast_PDB
93.06
100%
-131
- C2 -
3HQ5
2
PRGR_HUMAN
A:
[5-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
---
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
-
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
-
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
L
S
V
E
F
P
E
M
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
10
PsiBlast_PDB
91.53
100%
-122
- C2 -
2OVH
1
A:
[4-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
---------
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
11
PsiBlast_PDB
91.26
100%
-124
- C2 -
2OVM
1
A:
[5-255]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
A
--------
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
K
-
17
PsiBlast_PDB
89.92
100%
-118
- C2 -
4OAR
1
A:
[7-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
P
P
L
I
N
L
L
M
S
I
E
P
D
V
I
Y
A
G
H
D
N
T
K
P
D
T
S
S
S
L
L
T
S
L
N
Q
L
G
E
R
Q
L
L
S
V
V
K
W
S
K
S
L
P
G
F
R
N
L
H
I
D
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
M
V
F
G
L
G
W
R
S
Y
K
H
V
S
G
Q
M
L
Y
F
A
P
D
L
I
L
N
E
Q
R
M
K
E
S
S
F
Y
S
L
C
L
T
M
W
Q
I
P
Q
E
F
V
K
L
Q
V
S
Q
E
E
F
L
C
M
K
V
L
L
L
L
N
T
I
P
L
E
G
L
R
S
Q
T
Q
F
E
E
M
R
S
S
Y
I
R
E
L
I
K
A
I
G
L
R
Q
K
G
V
V
S
S
S
Q
R
F
Y
Q
L
T
K
L
L
D
N
L
H
D
L
V
K
Q
L
H
L
Y
C
L
N
T
F
I
Q
S
R
---------
M
S
E
V
I
A
A
Q
L
P
K
I
L
A
G
M
V
K
P
L
L
F
H
--