@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : M_NR1F1_RORA: (2016-04-07 )
MESAPAAPDPAASEPGSSGSEAAAGSRETPLTQDTGRKSEAPGAGRRQSYASSSRGISVTKKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSTYMDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRALCGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
Atome Classification :
(38 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MESAPAAPDPAASEPGSSGSEAAAGSRETPLTQDTGRKSEAPGAGR
R
Q
SYASSSR
G
I
S
V
T
KKTHT
S
Q
I
E
I
I
P
C
K
ICGDKSSG
I
H
Y
G
V
I
T
CE
G
C
K
G
F
F
R
RSQQSNATYSCPRQKN
C
L
IDRTSR
N
R
C
Q
H
C
R
L
Q
K
C
L
A
VGMS
R
D
A
V
K
F
G
R
M
S
K
K
Q
R
D
S
L
Y
A
E
V
Q
K
H
R
M
Q
Q
Q
Q
R
D
HQQQPGEAEPLTP
T
Y
N
ISAN
G
L
T
E
L
H
D
D
L
S
T
Y
MDGHTPEGSKADS
A
V
S
S
F
Y
L
D
IQPSPDQSGLDINGIKPEPICDYTPASGFF
P
Y
C
SFTNGETSPT
V
S
M
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
CQND
Q
I
V
L
L
KAG
S
L
E
V
V
F
I
R
M
C
R
A
FDSQN
N
T
V
Y
FDGKYA
S
P
D
V
F
K
SLG
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
MHL
T
E
D
E
I
A
L
F
S
A
F
V
L
MSA
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
NHRED
G
I
L
T
K
L
I
C
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
LHF
P
P
L
Y
K
E
L
F
T
S
EFEPAMQIDG
2
PsiBlast_PDB
93.29
100%
-141
- C2 -
1N83
1
A:
[18-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
D
G
I
L
T
K
L
I
C
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
------------
67
HHSearch
93.03
100%
-142
- C2 -
1N83
1
A:
[20-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
D
G
I
L
T
K
L
I
C
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
------------
3
PsiBlast_PDB
92.57
100%
-140
- C2 -
1S0X
1
A:
[18-258]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
D
G
I
L
T
K
L
I
C
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
------------
21
PsiBlast_CBE
90.63
100%
-134
- C2 -
4S15
2
B:
[2-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
D
G
I
L
T
K
L
I
C
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
T
S
E
F
E
P
A
-----
1
PsiBlast_PDB
90.45
100%
-138
- C2 -
4S15
2
RORA_HUMAN
A:
[2-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
A
E
L
E
H
L
A
Q
N
I
S
K
S
H
L
E
T
C
Q
Y
L
R
E
E
L
Q
Q
I
T
W
Q
T
F
L
Q
E
E
I
E
N
Y
Q
N
K
Q
R
E
V
M
W
Q
L
C
A
I
K
I
T
E
A
I
Q
Y
V
V
E
F
A
K
R
I
D
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
S
L
E
V
V
F
I
R
M
C
R
A
F
D
S
Q
N
N
T
V
Y
F
D
G
K
Y
A
S
P
D
V
F
K
S
L
G
C
E
D
F
I
S
F
V
F
E
F
G
K
S
L
C
S
M
H
L
T
E
D
E
I
A
L
F
S
A
F
V
L
M
S
A
D
R
S
W
L
Q
E
K
V
K
I
E
K
L
Q
Q
K
I
Q
L
A
L
Q
H
V
L
Q
K
N
H
R
E
D
G
I
L
T
K
L
I
C
K
V
S
T
L
R
A
L
C
G
R
H
T
E
K
L
M
A
F
K
A
I
Y
P
D
I
V
R
L
H
F
P
P
L
Y
K
E
L
F
T
-----------
8
PsiBlast_PDB
81.63
53%
-130
- C2 -
4NIE
3
RORG_HUMAN
A:
[17-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
T
----------
6
PsiBlast_PDB
80.91
62%
-134
- C2 -
1NQ7
1
RORB_RAT
A:
[1-244]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
S
E
I
D
R
I
A
Q
N
I
I
K
S
H
L
E
T
C
Q
Y
T
M
E
E
L
H
Q
L
A
W
Q
T
H
T
Y
E
E
I
K
A
Y
Q
S
K
S
R
E
A
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
G
M
Q
M
F
K
A
L
G
S
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
L
D
D
E
T
L
A
K
L
I
A
K
I
P
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
Q
S
H
P
D
I
V
N
T
L
F
P
P
L
Y
K
E
L
F
N
-----------
15
PsiBlast_PDB
80.68
52%
-126
- C2 -
3L0L
1
RORG_HUMAN
A:
[3-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
22
PsiBlast_CBE
80.49
53%
-127
- C2 -
4NIE
3
B:
[17-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
T
----------
28
PsiBlast_CBE
80.12
52%
-125
- C2 -
3L0L
1
B:
[3-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
27
PsiBlast_CBE
79.98
52%
-125
- C2 -
4WLB
2
B:
[16-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
4
PsiBlast_PDB
79.92
61%
-132
- C2 -
1K4W
1
RORB_RAT
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
S
E
I
D
R
I
A
Q
N
I
I
K
S
H
L
E
T
C
Q
Y
T
M
E
E
L
H
Q
L
A
W
Q
T
H
T
Y
E
E
I
K
A
Y
Q
S
K
S
R
E
A
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
G
M
Q
M
F
K
A
L
G
S
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
L
D
D
E
T
L
A
K
L
I
A
K
I
P
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
Q
S
H
P
D
I
V
N
T
L
F
P
P
L
Y
K
E
L
F
N
-----------
17
PsiBlast_PDB
79.53
53%
-130
- C2 -
3L0J
1
A:
[2-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
5
PsiBlast_PDB
79.22
61%
-131
- C2 -
1N4H
1
RORB_RAT
A:
[8-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
M
S
E
I
D
R
I
A
Q
N
I
I
K
S
H
L
E
T
C
Q
Y
T
M
E
E
L
H
Q
L
A
W
Q
T
H
T
Y
E
E
I
K
A
Y
Q
S
K
S
R
E
A
L
W
Q
Q
C
A
I
Q
I
T
H
A
I
Q
Y
V
V
E
F
A
K
R
I
T
G
F
M
E
L
C
Q
N
D
Q
I
L
L
L
K
S
G
C
L
E
V
V
L
V
R
M
C
R
A
F
N
P
L
N
N
T
V
L
F
E
G
K
Y
G
G
M
Q
M
F
K
A
L
G
S
D
D
L
V
N
E
A
F
D
F
A
K
N
L
C
S
L
Q
L
T
E
E
E
I
A
L
F
S
S
A
V
L
I
S
P
D
R
A
W
L
L
E
P
R
K
V
Q
K
L
Q
E
K
I
Y
F
A
L
Q
H
V
I
Q
K
N
H
L
D
D
E
T
L
A
K
L
I
A
K
I
P
T
I
T
A
V
C
N
L
H
G
E
K
L
Q
V
F
K
Q
S
H
P
D
I
V
N
T
L
F
P
P
L
Y
K
E
L
F
N
-----------
16
PsiBlast_PDB
79.05
53%
-132
- C2 -
3KYT
1
A:
[2-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
23
PsiBlast_CBE
79.02
52%
-124
- C2 -
4WPF
1
RORG_HUMAN
D:
[19-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
T
E
---------
7
PsiBlast_PDB
78.14
52%
-124
- C2 -
4S14
1
A:
[4-248]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
19
PsiBlast_PDB
78.12
53%
-127
- C2 -
4XT9
1
?
A:
[2-243]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
13
PsiBlast_PDB
78.01
52%
-123
- C2 -
4WLB
3
RORG_HUMAN
A:
[16-262]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
P
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
-----------
9
PsiBlast_PDB
77.94
52%
-120
- C2 -
4WPF
1
RORG_HUMAN
A:
[19-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
T
E
---------
10
PsiBlast_PDB
77.84
52%
-127
- C2 -
4YMQ
2
?
A:
[22-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
P
P
L
Y
K
E
L
F
S
G
K
I
L
H
R
L
L
Q
D
S
12
PsiBlast_PDB
76.20
52%
-119
- C2 -
4QM0
2
RORG_HUMAN
A:
[6-239]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
--------------------
14
PsiBlast_PDB
75.77
52%
-121
- C2 -
4WQP
1
RORG_HUMAN
A:
[20-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
H
L
H
P
I
V
V
Q
A
A
F
--------------------
24
PsiBlast_CBE
75.53
52%
-121
- C2 -
4QM0
2
C:
[6-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
----------
Q
A
A
F
P
P
L
Y
K
E
L
F
S
G
N
S
--------
26
PsiBlast_CBE
75.07
52%
-120
- C2 -
4WQP
1
B:
[21-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
--------------------------------
31
PsiBlast_CBE
74.83
52%
-121
- C2 -
4ZOM
1
?
C:
[6-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
--------------------------------
32
PsiBlast_CBE
74.61
52%
-123
- C2 -
4ZOM
1
B:
[3-224]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
--------------------------------
25
PsiBlast_CBE
74.29
52%
-118
- C2 -
4NB6
1
B:
[7-228]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
-------------------------------
34
PsiBlast_CBE
74.23
52%
-125
- C2 -
4ZJW
1
RORG_HUMAN
A:
[6-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
--------------------------------
37
PsiBlast_CBE
74.16
52%
-117
- C2 -
4ZJR
1
?
B:
[3-222]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
----------------------------------
33
PsiBlast_CBE
73.98
52%
-121
- C2 -
4ZOM
1
RORG_HUMAN
A:
[3-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
Q
-------------------------------
11
PsiBlast_PDB
73.73
52%
-119
- C2 -
4NB6
1
RORG_HUMAN
A:
[7-227]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
Q
I
F
--------------------------------
18
PsiBlast_PDB
73.45
53%
-124
- C2 -
3B0W
1
RORG_HUMAN
A:
[2-215]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
---------------------------------------
35
PsiBlast_CBE
73.30
52%
-121
- C2 -
4ZJR
1
?
D:
[2-219]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
-------------------------------------
29
PsiBlast_CBE
73.16
53%
-121
- C2 -
3B0W
1
B:
[2-217]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
-
S
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
-------------------------------------
36
PsiBlast_CBE
73.03
52%
-114
- C2 -
4ZJR
1
?
C:
[2-221]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
R
L
-----------------------------------
30
PsiBlast_CBE
72.91
52%
-120
- C2 -
4ZOM
1
?
D:
[4-218]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
--------------------------------------
20
PsiBlast_PDB
72.24
52%
-119
- C2 -
4ZJR
1
A:
[3-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
L
T
E
I
E
H
L
V
Q
S
V
C
K
S
Y
R
E
T
C
Q
L
R
L
E
D
L
L
R
Q
R
S
N
I
F
S
R
E
E
V
T
G
Y
Q
R
K
S
M
W
E
M
W
E
R
C
A
H
H
L
T
E
A
I
Q
Y
V
V
E
F
A
K
R
L
S
G
F
M
E
L
C
Q
N
D
Q
I
V
L
L
K
A
G
A
M
E
V
V
L
V
R
M
C
R
A
Y
N
A
D
N
R
T
V
F
F
E
G
K
Y
G
G
M
E
L
F
R
A
L
G
C
S
E
L
I
S
S
I
F
D
F
S
H
S
L
S
A
L
H
F
S
E
D
E
I
A
L
Y
T
A
L
V
L
I
N
A
H
R
P
G
L
Q
E
K
R
K
V
E
Q
L
Q
Y
N
L
E
L
A
F
H
H
H
L
C
K
T
H
R
Q
S
-
I
L
A
K
L
P
P
K
-
G
K
L
R
S
L
C
S
Q
H
V
E
-------------------------------------